Though not a very plot-intensive game, there are still some twists that occur throughout the series. Thus, be warned that there be '''Spoilers Ahead!'''


! The House of the Dead
!!Thomas Rogan
[[caption-width-right:240:''"Remember, Lisa. Believe in yourself, no matter what happens."'']]

An AMS agent who was called to the Curien Mansion in 1998 by a distress call from his fiancé, Sophie. Although it looks bad when Chariot appears to kill her prior to his battle with Rogan, she survives, and together the two manage to have a daughter, Lisa. Twenty-one years after the Curien case, the world has collapsed due to the zombie outbreak detailed in the fourth game. Rogan leads an assault team on the EFI Research complex in order to track down the source of the disaster, but gets in over his head.

* BadassLongcoat: It even flows in the air while he's climbing a ladder.
* CrusadingWidower: Unless he gets the good ending.
* LastNameBasis: Always referred to as "Rogan," even by his fiancé.
* {{Revenge}}: For Sophie.
* SpellMyNameWithAnS:
** Some ''[=HOTD1=]'' arcade cabinets spelled his last name as 'Rowgun.'
** A strange later-game example in ''House Of The Dead 4 Special''; while every other game has agreed on "Rogan", if G gets a high score, on the stage result screen, he'll comment that he's "Better than Logan."

!!Agent G
[[caption-width-right:320:''"How many times do I have to tell you ''[[NotUsingTheZWord not]]'' [[NotUsingTheZWord to use the z-word]]?"'']]

An AMS agent and Rogan's partner during the 1998 Curien case. Together, he and Thomas managed to put an end (or so they thought) to Curien's most diabolical invention, the Magician. In the year 2000, he heads to Venice to quell a new outbreak happening in the streets, but is overwhelmed and injured. Despite this, he survives and later assists Kate Green after James Taylor sacrifices himself to stop "The World". Sixteen years later, he assists Lisa Rogan when she attempts to find the whereabouts of her father after his doomed mission to the EFI Research building.

He and Issac Washington were also the duo who put an end to Papa Ceasar's activities in 1991.

* BadassBoast: An odd case, where Washington gives one on G's behalf.
--> '''Washington''': The G stands for ''genocide'', motherfucker!
* BadassGrandpa: By the time of ''III'' his hair is graying, but he still is kicking zombie ass.
* BadassNormal: He is the only character to make appearances in each game, and for good reason. Not even "suffering" at the hands of Judgement is enough to bring him down.
* BreakoutCharacter: Started as the generic partner character for protagonist Rogan, but became popular enough to appear in every single game ''and'' be playable in all but one of them.
* CoolShades: Only in ''Overkill'', but he makes up for that by never taking them off.
* DueToTheDead: If you unlock his ending in ''4'', he is seen paying his respects to the [[HeroicSacrifice late James]] and swearing to fight the ZombieApocalypse "back to the source," [[CallForward as we see in]] ''[[CallForward III]]''.
* EmpoweredBadassNormal: Hinted at, but {{Jossed}}. The manual for the Saturn and PC ports tries to suggest that he's some kind of artificial human, but Sega went ahead and just ignored that.
* MentorArchetype: In the third game, he more or less serves this role to Lisa. G is much older and has had over two decades of experience whereas Lisa's young and just getting started.
* NoNameGiven: He is only ever referred to as G. Overkill lampshades this, becoming a RunningGag as Washington comes up with names like Gwendolyn for him.
-->'''Isaac''': "You ever gonna tell anyone what that fuckin' "G" stands for?"\\
'''G''': "No."
* NotUsingTheZWord: He insists to Isaac that he refers to the zombies as "mutants".
* OddCouple: With Isaac Washington.
* OneLetterName: G, lampshaded in ''Overkill''.
* PrecisionFStrike: Gives a few of these every now and then in ''Overkill'' compared to [[SirSwearsALot Washington]], usually to mock the latter's habit, before going off in a ClusterFBomb rant with him in the final level.
-->'''G''': All you do is get pissed off at -- and with -- just about everything and everyone. I'm attempting conversation here with you.\\
'''Washington''': Conver-fucking-sation?\\
'''G''': Yes, conver-''motherfucking''-sation.
* TheStoic: In ''House of the Dead 1'', he's basically a robot (the home version manual tried to imply that he was a ''literal'' one). His personality becomes more apparent in each subsequent game, but he always remains cool under pressure.
* StraightMan: The StraightMan to Washington's SirSwearsALot.
* UnexplainedRecovery: You meet him at the beginning of ''House of the Dead 2'', where's he's been seriously wounded and urges you to go on without him, seeming to suggest that it's a BackForTheDead situation for him. In the best ending, Rogan shows up out of nowhere to tell you that he's fine, but even if that ending isn't canon, the fact that he's alive and well in the third and fourth games certainly settles it.

!!Sophie Richards
Thomas Rogan's fiancé at the time of the Curien Mansion incident and a researcher working for Dr. Curien. Later becomes Lisa Rogan's mother.

* AndThenJohnWasAZombie: If you get the worst ending in the first game.
* DistressedDamsel: Though she almost escapes the mansion by herself before Hanged Man swoops in and carries her back.
* LastWords: "You must stop Curien. Or else... something terrible will happen!"
* LittleDeadRidingHood: She wears a red coat over her lab coat, making her stand out against her other scientist collages. And unless you get the GoldenEnding, she will be dead.
* UnexplainedRecovery: In the true ending, if your score is high enough.
** If ''The House of the Dead 3'' is any indication, this ending is canon. A later interview by the director does indeed confirm that Sophie is Lisa's mother.

! The House of the Dead 2
!!James Taylor
->"This is exactly how it happened 3 years ago. The battle is starting again."

An AMS agent who was working on the Venice, Italy case. He was scheduled to meet G in Venice on February 26, 2000, until he ran afoul of Zeal. Together, he and his partner Gary discover the plot of Caleb Goldman and pursue a mission to track him down to the DBR Corporation headquarters. They put a stop to Goldman's plan to unleash the "Emperor", but fail to arrest Goldman.

Three years later, he and AMS agent Kate Green visit the European archives of the AMS, with James believing that the crisis from 2000 has not completely subsided. However, as they are researching the files within, an earthquake traps them underground. While waiting for a rescue squadron, they are suddenly overrun by new leagues of the undead. The pair fight their way back to the surface to discover that Goldman has enacted a plot from beyond the grave to launch a nuclear strike on the world. James returns to the DBR Corporation headquarters in order to reach Goldman's office on the fiftieth floor and stop the launch. However, Goldman has yet another failsafe, called "The World", which will be unveiled by the opening of "Pandora's Box". James and Kate battle The World in the courtyard of the DBR building, but are unsuccessful in destroying it. [[spoiler:James is left with no other option but to destroy the beast by blowing himself and the monster up together.]]

* HeroicSacrifice: [[spoiler:James takes his own life to stop the final phase of The World in ''4'', making him the only playable protagonist so far to be KilledOffForReal.]]
* LastWords: "Kate...don't...give up hope."
* ShutUpHannibal: When Goldman gives a MotiveRant, James is having none of it asking him if that all he has to say. In fact, this carries on to the next game.

!!Gary Stewart
->"Someday, until an answer is found..."

An AMS agent and James's partner during the 2000 Venice, Italy case. Together, they put a stop to Goldman's plan to unleash the "Emperor", but fail to arrest Goldman.

* FlatCharacter: Of the playable characters, he notably lacks any real character traits or personality.
* WhatHappenedToTheMouse: [=''HotD4''=] flashback aside, Gary hasn't been seen in the later sequels, including ''3'', where it's not made known whether he survived the apocalypse or not.

! The House of the Dead 3
!!Lisa Rogan
->"'Believe in yourself, Lisa.' I think I finally understand what that means now."

Thomas and Sophie's daughter, who goes to the EFI Research building, along with Rogan's former partner G, to find her father after he disappeared two weeks prior on a mission to put an end to the disaster that ruined the world.

* ActionGirl: The first female playable character in the series.
* [[TheHero The Heroine]]: Of III.
* LikeParentLikeChild: Takes after her zombie-slaughtering father far more than her DamselInDistress mother, despite her strained relationship with him.
* ShotgunsAreJustBetter: Her WeaponOfChoice is a SPAS-12 shotgun.

!!Daniel Curien
The son of Roy Curien whose childhood illnesses inspired his father to research the essence of life and death. He believes he bears the responsibility to put an end to the evils unleashed on the world by Curien in his name.

* AndThenJohnWasAZombie: Should you get the bad ending in ''[=III=]''.
* IllBoy: As it shows in his backstory, he was the reason Curien started his research in the first place. Curien did succeed at that goal, at least.
%%* [[MadScientistsBeautifulDaughter Mad Scientist's Handsome Son]]
* TookALevelInBadass: Goes from IllBoy to fighting off zombies in the final battle.
* YoureNotMyFather: Daniel says this during the cutscene [[spoiler:after the Wheel of Fate is defeated]].

! The House of the Dead 4
!!Kate Green
An AMS agent who assisted James Taylor in 2003. After she and James uncover Caleb Goldman's final plan, together they stop "The World" from coming to fruition. She later teams up with G in order to fight a newly-resurrected Magician.

%%* BadassNormal:
* GenkiGirl: She tries her best to maintain a positive attitude despite all the dangers she and James face.
* NaiveNewcomer: Said to be new to AMS and working her first case with James. She gets the hang of things quickly enough, though.
* ScarfOfAsskicking: Wears a big houndstooth pattern scarf. Kicks a lot of ass.
* WhatHappenedToTheMouse: She joins with G after James' death. Her fate by ''[=III=]'' is unknown, though she is set to be one of the Protagonists in Scarlet Dawn.

! VideoGame/TheHouseOfTheDeadOverkill
!!Isaac Washington

* BadassBoast: Delivers one on G's behalf in the final chapter:
--> "The 'G' stands for ''genocide'', motherfucker!"
%%* BaldOfAwesome
%%* BlaxploitationParody
* BoisterousBruiser: Compared to G.
* ClusterFBomb: The game held the ''Literature/GuinnessWorldRecords'' for the most of them thanks to him.
** Drops the act a little when faced with Clement, a [[ParentalIncest literal motherfucker]]. Clement is the one character that he does ''not'' call a "motherfucker". G points out the {{irony}} of this (see JerkWithAHeartOfGold below).
* CoolCar: Otherwise known as his "pride and joy". Unfortunately, when he tries to offer G a ride in it, it promptly [[EveryCarIsAPinto blows]] [[StuffBlowingUp up]].
* EekAMouse: Is not a big fan of insects. Pointed out after the battle against The Crawler.
* EstablishingCharacterMoment: He establishes what kind of agent he is with the very first line of spoken dialogue (along with a punch straight to G's jaw):
--> "What's up, ''[[SirSwearsALot motherfucker]]?''"
* EvenBadMenLoveTheirMamas: The reason why he wasn't infected by the virus is that he was with his mother. Of course, he won't admit it.
* GunsAkimbo: In cutscenes, at least.
* JerkWithAHeartOfGold: For all the trash talk and swearing he does to everyone else, ''especially'' G, he has more of a heart than most would be led to believe. G points out that Isaac doesn't mean most of the things he says, hence why Isaac refuses to use the MF-word on Clement. What does G conclude? That Isaac sees G as a good friend. [[{{Tsundere}} Of course, Isaac won't admit it.]]
* OOCIsSeriousBusiness: When he confronts [[ParentalIncest literal motherfucker]] Clement Darling, Isaac ceases his usual act of [[ClusterFBomb dropping MF-bombs all over the place]].
* SirSwearsALot: Oh ''so'' much.
* {{Tsundere}}: A ''[[ClusterFBomb very foul-mouthed one]]'', but by the end of the game, G notices it.
* YouKilledMyFather: Towards Papa Caesar. Although in TheStinger of OVERKILL, Caesar says in a tape recording that Washington's father is still alive.

!!Varla Guns

* ActionGirl: [[SubvertedTrope Subverted]]. She tries, but ends up failing.
** Gets promoted to one in the Extended Cut (at least, the parts where she was at while Isaac and G were doing their business).
* BuxomIsBetter: Holy crap yes! Though, according to Darling's mother, her tits are still "too small".
* BrainInAJar: Her fate at the end of the game.
* DisposableWoman: Discussed by Issac and G at the end of the game. She does seem to exist mostly to provide fanservice and motivation.
* DistressedDamsel: She's kidnapped by Papa Caesar and later by Warden Darling.
* {{Expy}}: She's both named after and closely resembles Tura Satana's character from ''Film/FasterPussycatKillKill''.
* {{Gainaxing}}: Especially in the cutscene of chapter one when she arms herself.
* GetAHoldOfYourselfWoman: Slaps Candi after she lets out two {{Big No}}s.
* HoistByTheirOwnPetard: Her drive for revenge led to her becoming a BrainInAJar. G claims that she's still alive.
* ItsPersonal: She wants to avenge her little brother Jasper, and later Candi.
* {{Revenge}}: Her motivation throughout the game. It's safe to say that her fate determined she failed to avenge both her brother and Candi.


! The House of the Dead
!!Dr. Roy Curien
[[caption-width-right:260:''"You... shall... all... die!"'']]

->"I must admit, I really respect your consistency. But you will never, '''''EVER''''', defeat me! Say hello to my masterpiece!"

A genetic researcher who was pursuing a way to command the forces of life and death in order to save his dying son. Although he started with good intentions, he eventually succumbed to madness as he delved further into his research. He invented two means by which to control these forces: the Magician, a sentient and bio-mechanical android, and the Wheel of Fate. The Magician proved too unruly and independent to control and ultimately killed its creator. Curien's remains were brought to the EFI Research complex, where his Wheel of Fate device was housed. Over the span of twenty years, it would revive him and allow him to bring about the ultimate judgement upon mankind. He was eventually destroyed for good by the efforts of Lisa Rogan and his own son Daniel.

* BigBad: Of the first game (and also the third game).
* DrivenToVillainy: Implied in [=HOTD1=], and explored in [=HOTD3=]. Curien was just a normal scientist trying to solve the world's problems, but his son's sudden illness prompted him to go all the way to the bottom of the barrel to try and cure him. It cost him his coworkers and his sanity.
* EvilutionaryBiologist: Averted, initially. He was actively seeking a cure for his son and, well, he did end up starting a ZombieApocalypse...
* FinalBoss: You fight his resurrection in the third game.
* JumpingOffTheSlipperySlope: Goes from trying to save his son and [[WasItReallyWorthIt questioning his actions when his staff objects]] to LaughingMad to seeking to destroy and resurrect everything.
* LegacyCharacter: The Wheel of Fate.
* LoveMakesYouEvil: His love for his son and desire for said son to be well causes his MadScientist gig.
* MadScientist: Well, he is responsible for discovering how to make zombies.
* NonActionBigBad: He only taunts you through the first game, getting killed by the Magician.
* TheUnfought: In the first game. But not in the third.

! The House of the Dead 2
!!Caleb Goldman
[[caption-width-right:290:''"Dogs of the AMS. It's time they made a move."'']]
->"Earth has evolved in a way so that is naturally regulates the population of any given species. Humans were once subject to this system, regardless of whether or not they knew it! Pandora's Box is opening..."

The CEO of the DBR Corporation and the real driving force behind Dr. Curien's research. He funded Curien's research in order to gain access to the wealth of genetic information Curien had so he would be able to employ them to his own end: to end the sin of mankind's mistreatment and destruction of the planet. When Curien was killed by the Magician, he retrieved the Magician (following its defeat by the AMS) and rebuilt it to serve him. He used it as a guard to protect the DBR headquarters, which is also where he housed his own monstrous creation: the Emperor. However, the Emperor was unsuccessful in turning away the AMS, and after its defeat, Goldman chose to end his life rather than be taken in by the AMS.

Three years later, he is revealed to have planted the seeds of destruction regardless of his death through a planned nuclear launch in 2003. James Taylor (one of the agents who stopped his original plan) and Kate Green deter this, but also uncover a second plot that would enact in case his nuclear missile did not launch, called "Pandora's Box".

* AndThenJohnWasAZombie: Should you get the "bad" ending in ''2'' and ''4''.
* BetterToDieThanBeKilled: Throws himself off the DBR skyscraper instead of surrendering to the AMS agents.
* BigBad: Of the whole series.
* ClaspYourHandsIfYouDeceive: His default pose as he sits behind his desk.
* CorruptCorporateExecutive: Though not of the typical sort, using his vast power and knowledge to create zombies [[KnightTemplar in order to cleanse the world]].
* EvilLaugh: "HMM HMM HMM HMM HMM. People of the AMS, I am Goldman."
* FauxAffablyEvil: Frequently and mockingly calls the agents "friends" as they approach him, and calls Strength his "present" for them.
* GaiasVengeance: What he wants to bring to fruition; or rather what he's trying to prevent. Goldman believes that if nature had its way then all of humanity would have been destroyed.
* KnightTemplar: Rather than wanting just destruction, he wants human populations to be decreased so nature doesn't just up and kill everyone.
* TheManBehindTheMan: Curien's main benefactor during the first game.
* MisanthropeSupreme: Is sick and tired of humans wrecking the environment.
* MyDeathIsJustTheBeginning: Despite dying in ''House of the Dead 2,'' he still sets numerous events in motion, as shown in ''House of the Dead 4.''
* NonActionBigBad: He sits behind a desk during much of ''The House of the Dead 2'' while feeding the AMS agents to his various creatures. When James and Gary arrive, he simply directs their attention to the Emperor, and when they defeat it, [[DisneyVillainDeath he jumps off the building]].
* RedEyesTakeWarning: In the bad ending of ''4'', his eyes start to grow red as he transforms into a zombie.
* SinisterShades: Is always shown wearing sunglasses.
* ThisIsTheFinalBattle: Says this before the battle with the [[FinalBoss Emperor]].
* VillainousLegacy: His actions ensure zombies will continue to plague humanity long after his death in ''2''.
* WellIntentionedExtremist: When humanity was plagued by increasing warfare, disease, and natural disaster; he saw these things as signs that humanity is on the brink of utter destruction. While his methods are without a doubt evil; he never wanted to exterminate mankind but rather perform a culling of humans; in order to reign in what he saw was humanity's rampant breeding. Goldman concludes that while Pandora's boxes must be opened there must be hope in order for humanity to survive. In the 4th game his nuclear plot was a gambit to lure the AMS to the old DBR and stop The World from being released on humanity as he was unable to do so himself.

! The House of the Dead 3
!!Mysterious Man
* EvilCripple: His most defining feature is a limp.
%%* TheFaceless
* GreaterScopeVillain: Implied.
* HiddenVillain: Has yet to encounter any of the heroes in person.

! The House of the Dead: OVERKILL
!!Papa Caesar
[[caption-width-right:350:''"We shall celebrate this tonight with take-out Chinese."'']]

* BigBad: Who you're chasing throughout ''Overkill.'' It turns out he was working for Warden Darling.
%%* EvilSoundsDeep
* FauxAffablyEvil: Adopts this tone around Isaac and the other heroes.
* IHaveYourWife: Forces Jasper to work for him by threatening Varla.
* KickTheDog: How he treats Jasper (who, by the way, is paraplegic).
* KilledOffForReal: He gets electrocuted by Warden Darling when he [[YouHaveOutlivedYourUsefulness outlives his usefulness.]]
* LovesTheSoundOfScreaming: According to his Chinese dinner analogy, describing it as the "sweet".
%%* ManOfWealthAndTaste
* ObviouslyEvil: And the [[LargeHam narrator]] couldn't make it more clear than this.
* PoliticallyIncorrectVillain: Seen in how he treats Jasper.
* RedHerring: He's set up to be the BigBad and for Washington to avenge his father's death, [[spoiler:but Caesar dies more than halfway through the game]].
* TrademarkFavoriteFood: Likes Chinese food. [[ObviouslyEvil And pain.]]
-->'''Caesar''': "I enjoy pain. It's like a good Chinese dinner, you know? With the sweet, and the sour? Expanding on that analogy, I will smile with delight, that's the sweet, [[FauxAffablyEvil as you scream for your fucking life]]. [[ToThePain Of course, that's the sour]]. [[VillainExitStageLeft Ciao!]]"

!!Warden Clement Darling

* EvenBadMenLoveTheirMamas: In his case, though, it's a little ''too'' much.
* {{Gonk}}: Those eyes and those teeth.... uuuggh.
* TheManBehindTheMan: For Papa Caesar.
* ParentalIncest: He does everything out of love for his mother, but it isn't familial love...
* PsychopathicManchild: "I want my mommy!"
* UnwittingInstigatorOfDoom: He was the one who found the mutant compound under his prison, but just wanted to use it to extend his mother's life. Unfortunately after his death, it got into the hands of Dr. Curien and [[ZombieApocalypse well...]]
* VillainousBreakdown: Goes through a rather calm one after Mother's death.

! General Tropes
* AttackItsWeakPoint: They all have a specific weak spot, although some aren't always shown in their introduction.
* NoticeThis: Regardless of whether or not their weakpoints are shown, there's usually some sort of visual cue that lets you know about it during battle. In extreme cases (such as with The Tower) a giant crosshair will shine on screen to indicate them.
* ThemeNaming: They're all named after [[TarotMotifs Tarot cards]]; the only exceptions being the ''OVERKILL'' bosses.

! The House of the Dead
!!The Chariot
A large zombie wearing a full suit of armor, who is the first boss fought in the first game. [[spoiler: He later returns as the first boss in ''House of the Dead: Scarlet Dawn''.]]

* AnAxeToGrind: Its strong enough to wield an enormous bardiche pole arm as a one handed weapon.
* AttackItsWeakPoint: The full body armor it wears makes it impervious... except for the very obvious gap in its chest. Once it breaks down, though, every part of its body is susceptible. [[spoiler: The Chariot in ''Scarlet Dawn'' doesn't have a hole in its armor, so instead the weak points are gaps that the armor doesn't cover.]]
* TheDeadCanDance: He has a very odd gyrating walk cycle that makes it seem like he's dancing as he fights you. It's never clear why, although the way he uses these movements to smoothly wind up his slashes in [[spoiler: ''Scarlet Dawn'']] suggests it's some kind of rhythmic battle stance.
* GasMaskMooks: It's metal helmet is modeled after a gas mask.
* GlowingEyesOfDoom: [[spoiler: In ''House of the Dead: Scarlet Dawn'', going along with it's extremely high body temperature.]]
* GrievousHarmWithABody: [[spoiler:In ''Scarlet Dawn'', it announces itself by tossing corpses at you.]]
* HeroKiller: The first time you meet it, it strikes Sophie (whom it holds hostage) off the room with his bardiche. If you get the normal or bad endings, Sophie then dies or gets turned into a zombie after this.
* KingMook: Unlike every other boss in the series, after it loses it's armor it's essentially a giant zombie with more health. It's only remaining gimmick after that is once you strip a part of him to the bone, it stops taking damage.
* MyBloodRunsHot: [[spoiler: Unlike in its original incarnation, The Chariot in ''House of the Dead: Scarlet Dawn'' has flesh that glows bright red with heat underneath its armor, to the point that steam rises out between the gaps.]]
* ShedArmorGainSpeed: In both of its appearances it moves significantly faster once it's lost its armor.
* TacticalSuicideBoss: Played with. When it suffers enough damage, it breaks out of its armor... So now it's vulnerable everywhere, but if you only shoot the same spot over and over he'll stop taking damage, so you ''must'' shoot pretty much every part of his body.
* TookALevelInBadass: [[spoiler: In ''House of the Dead: Scarlet Dawn'', Chariot returns as a much, much stronger boss with a significantly tougher armored skeleton. While bullets were enough to plink off his armor in the first game, it now takes an ''RPG'' to blow off enough of his armor to get at his vulnerable flesh, and even then, his attacks have become much more difficult to dodge and he's gained far more of them, like flinging projectiles at you with his bardiche.]]
* WarmUpBoss: His easy to hit weak point lets him be an easy introduction to how the games bosses work.

!!The Hangedman
->"Nobody leaves here alive!"

A flying stone gargoyle who kidnaps Rogan's girlfriend and later attacks him and G on the roof. He's the second boss of the first game.

* BatOutOfHell: He can command a flock of zombie bats.
* DisneyVillainDeath: Does this to two of Curien's scientists by picking them up in his talons and dropping them from a very high height. [[HoistByHisOwnPetard However, he later suffers the same fate. Twice]].
* EvilLaugh: A very high pitched and very evil laugh.
* FlunkyBoss: In the first phase, he hangs back and attacks by summoning a swarm of zombie bats. If Hangedman himself is shot enough times at this point, the bats all drop out of the air and die at once, causing him to attack.
* FlyCrazy: He flies faster than a stone statue has the right to.
* HeyItsThatSound: Believe it or not, during his boss fight the Hamgedman clearly uses [[ a sound clip]] from [[ the second boss]] of ''VideoGame/VirtuaCop 2''.
* KidnappingBirdOfPrey: At the beginning of the first level, it grabs Sophie in front of the agents and flies away with her in its claws.
* NightVisionGoggles: While not very apparent on its in-game model, the offical artwork shows that it wears goggles with long lenses that stick out in the front.
* RecurringBoss: He harries you in the first two levels, serves as the boss of level two, and gets a brief rematch in before the final boss.
* VocalDissonance: Sounds like he ingested too much helium.
* WingedHumanoid: His bat wings let him fly, despite being made of stone.

!!The Hermit
A giant, spider-like zombie that is summoned by Curien as a distraction for Rogan and G while he escapes down to his laboratory, and tries to kill the duo with its webs and massive claws. The third boss of the first game.

* AbnormalAmmo: In the second stage of the fight, it fires web balls at you from a distance.
* AbsurdlySpaciousSewer: Hermit is fought inside a maintenance tunnel that's somehow big enough to accommodate it and an entire elevator system leading to Curien's laboratory.
* BoomHeadshot: Its head is its weak point, but as the fight goes on, it will cover it up with its front legs as it closes in. There's even [[ a bit of official art]] showing a close-up of the creature with [[{{Gorn}} its head partially-blown open]].
* DeadlyLunge: Its main form of attack involves it crawling quickly toward you and lunging with its claws.
* GetBackHereBoss: After the first stage of the battle-- in which it attacks from the upper part of the maintenance tunnel-- Hermit drops down into the lower section with a screech, requiring you to go in afterward to kill it properly.
* GiantSpaceFleaFromNowhere: Curien just sics it on you with ''no'' prior hints at its existence. However, it does make sense that this would be the case, given that he was using it to distract you whilst he escaped back to his laboratory.
* GiantSpider: A giant ''zombie'' spider, albeit with elements (most notably, its armour and claws) from spider crabs.
* KilledOffForReal: Given that it's the only previous boss who is not fought again in the final chapter, it can be assumed that unlike Chariot and Hangedman, it stayed dead after being killed.
* WolverineClaws: Has very large forked claws on its front legs that it of course, uses to slash with.

!!The Magician
[[caption-width-right:260:Who are you? Nobody gives me instructions! I shall destroy everything!]]

Curien's most powerful creation, which is a mutant with [[PlayingWithFire fire control]] and psychic powers. The fourth ([[FinalBoss and final]]) boss of the first game. It later serves as the fifth boss of the second game, and the second (and once again final) boss of ''The House of the Dead 4 Special''.

* AchillesHeel: Its exposed spots. Specifically the right shin, left calf, right forearm, and left upper arm. Perhaps the only final boss in the series where despite the weak point being listed as 'unknown,' the weak point isn't blindingly obvious.
* BadassBaritone: More so in its later appearances.
* BodyHorror: Though he is resurrected in ''The House of the Dead 2'', his body apparently stays rotten as it was, because there are visible ''[[NauseaFuel maggots]]'' surrounding it.
* FinalBoss: Curien's final project of the first game.
* GetBackHereBoss: The Magician moves around. ''A lot''. You don't actually need to run around (since your character's stuck in a stationary position), but the general feeling is there.
* HornedHumanoid: To go with the satanic appearance.
* HumanoidAbomination: It's a skinless (though armored), demonic, fire spewing monster.
* ItCanThink: As Curien found out the hard way. He's one of the few mutants in the series to display capacity for intelligent thought.
* LegacyBossBattle: Especially strange, considering its first appearance had it kill its creator. Goldman was apparently able to fix this problem for all future incarnations.
* PlayingWithFire: ''Hoo boy.'' Its ultimate attack is a literal rain of fire.
* SuperSpeed: Either this or TeleportSpam. Especially in 4, where the camera has trouble keeping up with him.
* TurnedAgainstTheirMasters: Its first words are announcing it will not obey any orders, and then it kills Curien.
* UnexplainedRecovery: For ''The House of the Dead 2'', and ''again'' for ''The House of the Dead 4 Special Edition''.
** Gets explained (sort of) if you fail to stop its last-ditch attack in ''The House Of The Dead 4 Special Edition''; it summons a '''''legion''''' of clones of itself, [[NonstandardGameOver and the game just ends there without even letting you TRY to fight them off]].

! The House of the Dead 2
->"I've already taken care of G, this is only the beginning!"

A small imp (Zeal) and a living suit of Armor (Kuarl), who are met in Venice by James and Gary. It's the first boss in ''The House of the Dead 2''.

* AchillesHeel: Kuarl is fully dependent on Zeal. If Zeal takes enough damage, Kuarl will fall.
* AnAxeToGrind: Kuarl.
* BigGuyLittleGuy: Kuarl is the big guy while Zeal is the little guy.
* BrainsAndBrawn: Zeal hides behind the hulking Kuarl and barks orders. Of course, after Kuarl dies, Zeal can still fly up to you and scratch your face off.
* CherryTapping: Kuarl isn't completely invincible and his health can be slowly chipped away with rapid fire. As a bonus, Zeal with frequently fly right into the crossfire.
* DualBoss: Technically, but they tend to attack one at a time.
* {{Expy}}: Of The Hangedman (Zeal) and The Chariot (Kuarl).
* PreAssKickingOneLiner:
--> '''Zeal:''' "Seems like my advice had no effect. Suffer like G did!"
** Zeal gains another one during the second encounter:
--> '''Zeal:''' "Sir Goldman has given me a second chance. [[YouShallNotPass Don't even think you can get past me]]!"
* RecurringBoss: You fight them again in the second-to-last level.
* RemovingTheHeadOrDestroyingTheBrain: Kuarl is an example where this trope doesn't work. Mainly because he doesn't have a head!
* ScratchDamage: You can lower their health by shooting at Kuarl, but doing so depletes his health at such a slow rate that you're better off focusing on Zeal.
* ThoseTwoBadGuys: Assuming Kuarl isn't just a puppet controlled by Zeal.

!!The Hierophant
An aquatic reptillian zombie armed with a trident. The second boss of the second game.

* AchillesHeel: Its chest opens on a regular basis to expose its heart.
* BadBoss: Implied to be this when if you reach Sunset Bridge, it destroys it with some of its fellow zombies.
* FishPeople: More like amphibian people, but the idea is there.
* FlunkyBoss: He'll summon [[PiranhaProblem piranhas]] to attack you as backup.
* InASingleBound: That guy can do some amazing jumps.
* ProngsOfPoseidon: His weapon is a rather wicked-looking trident.
* WarmUpBoss: His weak point is fairly obvious and pretty easy to hit, knocking him back.

!!The Tower
A Hydra-like mutant who dwells in the sewers of Venice. The third boss of the second game.

* HydraProblem: Averted. The boss has several snake heads, but destroying one won't make another respawn. Instead, you just need to hunt for the blue-colored one (which seems to be the actual Tower, since once you take them all down, you will have another showdown with just it).
* OurDragonsAreDifferent: Apparently based on Dragons.
* PopQuiz: In ''The Typing of the Dead''. You get a question and have to type one of three answers. Type the wrong answer and it's -1 life.
* SandWorm: If you choose the right path, the second stage of the battle has the large blue worm burrow through a large sand pit arena.
* StockScream: Its roars are familiar.
* TurnsRed: After losing her four red heads.
* WakeUpCallBoss: Adds a second phase with a harder to hit weak point, upping the ante.

A huge, chainsaw-wielding brute fought in a Coliseum. The fourth boss of the second game.

* AdvancingBossOfDoom: Chases you through a labyrinth, sometimes jumping over walls or smashing through them to surprise you.
* AnAxeToGrind: Has two axes embedded in its body, which it can pull out to [[ThrowingYourSwordAlwaysWorks throw at you]].
* BoomHeadshot: His weak point. However, opportunities to shoot him in the head are rare due to him always holding his chainsaw in front of it.
* TheBrute: Doesn't do anything particularly fancy, it just chases you, jumping off of or smashing through walls to get at you.
* ChainsawGood: His weapon is a '''huge''' chainsaw with the word BLAME etched on both sides of the blade.
%%* ClimaxBoss
* TheDeterminator: He won't stop coming until he's dead.
* {{Expy}}: To [[Franchise/TheTexasChainsawMassacre Leatherface]].
* HeroKiller: Severely, and possibly fatally, wounds Harry.

!!The Emperor
->"I am... I am... I am the one...who rules over nature...I shall destroy...and hate mankind.... I am...the Emperor!"
A humanoid being made of shape shifting molten metal, and Goldman's last creature. The sixth (and final) boss of the second game.

* BlobMonster: With a physical form, though.
* DittoFighter: Copies several previous bosses to fight you.
* TheDragon: To Goldman.
* ExtraOreDinary: Manipulates molten metal to fight.
* FinalBoss: Of the second game.
* HumanoidAbomination: A translucent, horned, shapeshifting blob of metal with a visible organic heart.
%%* LightIsNotGood
* PopQuiz: In ''The Typing of the Dead'', he parodies the format that The Tower used three chapters ago, using questions with silly answers. This time ''all three answers'' to each question are considered correct, although they influence which of the MultipleEndings you get.
* PredecessorVillain: Literally. He and The World are both parts of the same experiment, but The Emperor was released too early so Goldman can show off, as in "beta test". His defeat thus prevents the protagonists from discovering that Goldman had in fact built ''another'' being...
* RoboSpeak: "I am... I am..."
* VoluntaryShapeshifting: Since he's made of molten metal, much like the [[Film/Terminator2JudgmentDay T-1000]].

! The House of the Dead 3
A huge skull-faced mutant dressed as a Security Guard and armed with a club. He'll chase G and Lisa for two levels. One of the bosses in the third game.

* TheBrute: Another large, muscular zombie, now as a series tradition.
* CarryABigStick: With skulls embedded in it.
* ClothingDamage: At low health, he loses his hat.
* {{Determinator}}: Won't stop at anything to get to G and Lisa.
* EarlyBirdCameo: Appears in the opening sequence, where he knocks Thomas Rogan down, but is stopped by Curien's son.
* ImplacableMan: Hoo boy.
* {{Irony}}: He's the first boss seen in the game, and he's the hardest to kill in the whole series.
* NiceHat: Wears a security guard's hat that can be shot off.
* RecurringBoss: Fights you across two stages.

!!The Fool
A mutated giant sloth who resides in a well-like cage inside the building. One of the bosses in the third game.

* AnimalsNotToScale: Normal sloths reach around two and half feet long at the biggest. The Fool, however, appears to be roughly the size of a grizzly bear, which makes it's speed all the more alarming as it closes in on you.
* AttackOfTheKillerWhatever: A sloth.
* CollapsingCeilingBoss: Said "ceiling parts" being the corpses hanging from it.
* {{Determinator}}: Even when it can only hang by one foot, it will make a flying leap for you.
* GrievousHarmWithABody: Can shower you with his former meals. Aka Corpses.
* LightningBruiser: Yes, it's a giant sloth, but seems like the zombification had improved his muscles.
* LogicalWeakness: Its weak spots aren't its head, but its feet. By shooting them down, it becomes unable to cling on the cage, and plummets to its death.
* WallCrawl: And how! The Fool can crawl along the sides of its cage faster than you can run away-- if you don't hit it's weak points in time, it will always catch up to you before too long.
* WolverineClaws: It has long claws for clinging onto the cage as well as for slashing you apart.

!!The Sun
A mutant giant plant with many tentacle-like roots and human faces on its stalk. One of the bosses in the third game.

* AttackOfTheMonsterAppendage: You see its roots and tentacles all over the place, but meet it later in the level.
* CombatTentacles: It will sic them on you [[{{Foreshadowing}} before you even know what they're attached to]].
* FantasticFlora: It's a genetically mutated tree with spiked spores, giant fanged protrusions, and killer vines.
* HeWasRightThereAllAlong: The entire first half of the stage is filled with vines and plant life, some of which tries to attack you. ALL of this vegetation is part of the Sun, making it one of the largest bosses in the series in terms of total biomass.
* ManEatingPlant: Not that many reasons why a zombie plant is trying to kill a person.
* ShoutOut: Resembles Plant 42 from ''VideoGame/ResidentEvil''.
* StationaryBoss: One of the few bosses in the series that doesn't move from its spot, justified because it's a tree.
* WhenTreesAttack: It resembles a large tree, although the skulls embedded into its trunk suggest human remains were used in its creation.

!!The Wheel of Fate
[[caption-width-right:206:I shall destroy everything...and resurrect everything.]]
Curien's ultimate creation/transformation, it is a cybernetic monster surrounded by a metal ring. It manipulates electricity to fight. It's the final boss of ''The House of the Dead 3'', and is actually Dr. Roy Curien himself.

* ChromeChampion: His entire body seems to be composed of chrome metal. He has [[SpikesOfVillainy spines]] on his forearms and a sun emblem on his chest.
* DefeatEqualsExplosion: The Wheel of Fate explodes upon defeat.
* FinalBoss: The ultimate threat to humanity itself -- or what's left of it.
* TheGambler: Keeping with his namesake's traits of fortune and chance, he will spin his ring around to randomly select from a handful of attacks to use on you, some of which are much harder to stop than others.
* GoldenSuperMode: Gains one when on his last legs.
* HumanoidAbomination: Bonus points for previously being human.
%%* IcyBlueEyes
* OneWingedAngel: Of Curien.
* RingsOfDeath: Is surrounded by a large metal ring made from the metal of his stasis tube. He can use it to attack you directly or fire electrical projectiles at you. The ring also acts a revolving shield, blocking your bullets if you shoot at the wrong time.
* RoboSpeak: His voice seems to be mechanized, especially compared to his voice when he was alive.
* ShockAndAwe: He has power over electricity, and whichever attack he uses depends on a "spin of the wheel".
* WasOnceAMan: Is / Was Dr. Curien himself.
* WellIntentionedExtremist: His goal is to "destroy everything and resurrect everything," and laments the planet's overpopulation upon defeat.

! The House of the Dead 4
A huge, four-armed mutant that chases Kate and James in the sewers. The first boss of ''The House of the Dead 4'' and ''The House of the Dead 4 Special Edition''. He also appears as the first boss of ''The House of the Dead EX'', though instead of defeating him, you need to brush his ([[BritishTeeth awfully dirty]]) teeth.

* ChainedByFashion: Has huge chains and manacles on each of his ankles and four wrists. It's likely that he was restrained in Pandora's Box and the first thing he did upon activation was break free.
* DivingKick: One of his two attacks is basically a flying stomp.
* FeedItABomb: His weak spot is his mouth. Chucking a grenade in there will instantly cancel whatever attack he's using.
* GrappleMove: The other of its two attacks is to grab the characters and attempt to lick them.
* MultiArmedAndDangerous: Four giant, muscular, ape-like arms.
* RecurringBoss: Fought twice, both times at the beginning of the ''The House of the Dead 4'' stories.
* RecurringBossTemplate: See also Strength and Death for a similar boss fight.
* ScaryTeeth: Spikes and all. In ''EX'', you need to ''brush'' it.
* WorstAid: In ''EX'', you take care of its dental problems by ''shooting its bad teeth out''.

!!The Lovers
A pair of mutated Tarantulas which attack Kate and James as they try to leave the underground via Elevator. The second boss of ''The House of the Dead 4''.

* AllWebbedUp: One of their attacks involves wrapping the players in silk.
* CoitusUninterruptus: Considering their name, and how they attack with smaller spiders, it's possible the two are copulating constantly throughout the battle.
* DualBoss: Albeit in terms of gameplay, they're fought as a single boss.
* GiantSpider: Times two.
* LegacyCharacter: To The Hermit from the first game.
* MookMaker: Can and will summon several spiders to help them.
* SpikesOfVillainy: The top spider's forelegs are covered in spikes.
* ShownTheirWork: The male spider is much smaller than the female, just like in real life. Its legs are much bigger than the female's, however.

!!The Empress
A powerful purple zombie armed with a ludicrously big double-chainsaw. He/she chases Kate and James on the train. The third boss of the fourth game.

* ActionGirl: "She" is deadly and has a female name, but is otherwise functionally genderless.
* DoubleWeapon: It breaks apart during the last part of the fight, forcing her to resort to DualWielding.
%%* EvilCripple
* ChainsawGood: Double it.
* RailroadTracksOfDoom: After her defeat, she falls from the train and gets hit by another one.
* RedEyesTakeWarning: Has a pair of glowing red eyes.

A morbidly obese, giant zombie that chases our heroes down the streets. He's so fat that bullets won't damage him. The fourth boss of the fourth game.

* AdvancingBossOfDoom: One Big Rolling Undead Fat Ball of Doom.
* AssKicksYou: Fail to damage him fast enough in his first phase and he stomps you with his butt.
* AttackOfTheFiftyFootWhatever: A several-story-tall fat zombie.
* BrightIsNotGood: Properly enough, since vividly colored frogs are also the most dangerous.
* DeadWeight: An ''[[FatBastard extremely fat]]'' and [[{{Kevlard}} extremely durable]] zombie.
* FatBastard: Ironically named.
* GroundPound: In his first phase, if you fail to damage him fast enough, he jumps up into the air and squashes you under his backside.
* ImplacableMan: The one boss where even hitting its weak point will only stun it as opposed to doing damage.
* IronicName: He's more or less the incarnation of gluttony, basically the opposite of Temperance. WordOfGod has stated the inversion was deliberate.
* JigglePhysics: Disgustingly applied to his pendulous breasts and belly.
* TheJuggernaut: And if the clock's face used to kill/[[InferredSurvival knock out]] Temperance wasn't there, he might still be chasing James and Kate.
* {{Kevlard}}: He can't be damaged by bullets; you can only stun him. You defeat him by dropping a clock tower on him.
* MagicPants: Somehow, the mutation left his pants undamaged despite causing him to become a giant monster ([[FanDisservice which is a good thing, by the way]]).
* RollingAttack: Attempts this during the second phase, both by rolling forward and later on backwards.
* SuperPersistentPredator: Almost the entire second half of Chapter 4 is the fight against Temperance, with the protagonists running away while Temperance tries to crush them.
* WalkingShirtlessScene: FanDisservice personified.

!!The Star
->"Come, you must prove yourself in a test of strength...this was Goldman's parting wish."

A humanoid mutant armed with kukri knives and a purple aura, which acts as a "test" of strength for Kate and James. When he dies, he wounds James with a shard of his body. He's a perfected model of The Magician, and the fifth boss of ''The House of the Dead 4''. He also appears as a boss and supporting character in the spin-off ''The House of the Dead EX''.

* AllLoveIsUnrequited: He falls in love with Zobiko in ''The House of the Dead EX'', but Zobiko is already in a committed relationship with Zobio.
* AscendedExtra: Has a far larger role in ''The House of the Dead EX'' compared to his essentially one-shot appearance in ''4''.
* BeamSpam: His main form of attack.
* BishonenLine: He's the most human boss that the series can offer, even surpassing the likes of The Wheel of Fate or The Magician. In fact, barring the rather pasty skin, he can pass off as a full human (while The Magician is obviously artificial due to his rather crudely satanic appearance). He's also one of the end bosses.
* BoomHeadshot: During his tornado attack, his head becomes a weak point. Lampshaded on the analysis window; while all other spots save for his chest are labeled "NO DAMAGE", his head is labeled "NO DAMAGE?" Yes, with a question mark.
* BrightIsNotGood: Has one of the gaudier color schemes among the bosses, but he's still a zombie trying to kill you.
* ButtMonkey: In ''The House of the Dead EX'', his constant attempts to impress Zobiko always fall flat to somebody else and causes him to injure himself. Particularly The World's third form.
* ClothingDamage: Sadly, his BadassLongcoat is torn to shreds as you shoot him.
* TheDragon: To Goldman.
* DualWielding: Two glowing [[KukrisAreKool kukris]].
* EverythingsBetterWithSpinning: His final move.
* FlawedPrototype: His Type number indicated he should be in the same class as the other four Heavenly Kings (The Magician, Emperor, World and Wheel of Fate) and he certainly does exhibit psychic powers similar to theirs. However he's weak enough that the PDA can scan him (which none of the others could) and his attacks, while powerful, are nowhere near the world-destroying levels that the four Heavenly Kings are capable of.
* HeelFaceTurn: In ''The House of the Dead EX'', he is one of the bosses, but after his defeat, promptly falls in love with Zobiko (the female protagonist) and goes on a great lengths to help her and Zobio, [[AmusingInjuries with humorous results]].
* InTheHood: His red coat comes with a hood.
* NoShirtLongJacket: He wears a red longcoat that's unzipped (or possibly having no zip at all), exposing the scar on his chest, which is his weak point. Actually, it's exactly like how Dante wore his in ''[[Franchise/DevilMayCry Devil May Cry 3]]'' (see the trope image for reference).
* PurpleIsPowerful: His swords and many of his attacks have a purple glow.
* PowerFloats: He's constantly floating during the fight.
* PreAssKickingOneLiner: Its one line amounts to this.
* ScarsAreForever: Has a huge gash on his chest.
* ShoutOut: His red BadassLongcoat makes him similar to Dante from ''Franchise/DevilMayCry''.
* TakingYouWithMe: Explodes when killed. Is unknown if it was intentional or not.

!!The World
[[caption-width-right:288:I am the ultimate being. There is no hope. My hammer of death shall rain down upon you.]]

Goldman's last trick, which is a powerful, constantly-evolving monster made of ice. He's destroyed by James's sacrifice. He also appears in ''The House of the Dead EX'', also as the final boss.

* AnIcePerson: Has ice based powers.
* AnAxeToGrind: That "hammer of death" quote wasn't just a metaphor. It can form a giant axe [[ElementalWeapon from ice]] and swing it at your face; fortunately, the axe can be shattered by shooting it enough.
* AttackItsWeakPoint: The red spot on his chest.
* BadassBoast: Its boast, in content and [[VocalDissonance delivery]], is perhaps the single most [[{{Pun}} chilling quote]] from the franchise.
* DamageSpongeBoss: What it loses in an obvious, easy to hit weak point, it makes up for in how much it can take.
* EldritchAbomination: Looks like a giant humanoid fly made of ice and embedded in the ground.
* EvilIsDeathlyCold: Creates ice that ''will'' harm you.
* FinalBoss: Of ''4''.
* {{Foil}}: Of The Magician. Both of them are the ultimate creations of their respective makers, but their powers are the exact opposite: The Magician controls fire, while The World is cryokinetic. What can be inferred from their dialogues also suggest a different personality: The Magician has a guttural BadassBaritone voice and actively taunts the protagonists, while The World has a soft, clear voice and generally stays silent during the battle. Then there's the fact that The World is stuck inside a floor, while The Magician is infamous for being a GetBackHereBoss...
** Plus, in the traditional tarot deck order, The Magician is the first ("I") card[[note]]not counting The Fool ("0") [[/note]], while The World is the last ("XXI").
** Also take note that you fight The World and The Magician in ''The House of the Dead 2'' in the exact same place: Goldman's Building's Courtyard.
* GoldenSuperMode: It gains this in the end, requiring a HeroicSacrifice to stop.
* InstantAwesomeJustAddDragons: His second phase summons ice dragons.
* LightIsNotGood: Get red then golden lighting as it becomes more dangerous.
* OneWingedAngel: Three times. But you have to face only two forms. However, you get to face his third form in ''The House of the Dead EX'' (though because nothing is taken seriously there, he's dumbed down a lot).
* PreAssKickingOneLiner: "I am the ultimate being. There is no hope. My hammer of death shall rain down upon you". Possibly the most serious, down-to-earth, and uncheesiest line uttered by any boss in the series.
* ShoutOut: Its appearance could be referencing Lucifer's plight at the end of ''Literature/TheDivineComedy''. Lucifer is found in Hell's coldest area, trapped up to his waist in the frozen Lake Cocytus, and has three sets of wings that are constantly flapping, thus keeping the lake's waters cold and making him eternally stuck in ice. Also, Lucifer has three heads, which could be referenced by The World's three forms.
* VocalDissonance: Despite its towering and grotesque appearance, it has the soft, withered voice of an elderly man. Ironically, it's probably the only voice in House of the Dead 4 that doesn't sound cheesy.
* WingedHumanoid: Four sets of inscectoid wings on the top half of a man.

! The House of the Dead: OVERKILL
!!Dr. Jasper Guns, [=PhD=]
The first boss in OVERKILL, he's Varla's quadriplegic younger brother, who has injected himself with a PsychoSerum in order to kill Papa Caesar, but got distracted by G and Issac, allowing Caesar to escape. Unfortunately, Jasper ends up so far gone that he can't tell ally from enemy, and ends up attacking G and Issac instead.

%%* DeadlyUpgrade
* TheDogBitesBack: Tries this, but turns into more of a threat to Caesar's enemies than Caesar himself.
* GeniusCripple: A quadriplegic [=PhD=].
* MindOverMatter: He's gained telekinetic abilities from the PsychoSerum.
* MyBrainIsBig: Also acts as BodyHorror and AchillesHeel.
* OneWingedAngel: Turns himself from a normal person into a telekinetic mutant to try and kill Caesar.
* PowerFloats: Must be the PsychoSerum talking.
* RoboSpeak: He is unable to speak due to the disease, so he uses a computer to speak.
* TragicMonster: He wants Papa Caesar dead as much as G and Issac do. Unfortunately, it didn't quite work out as planned.

!!Coco and Sindy
Exclusive for the Playstation 3 version, they're Varla Guns' fellow coworkers who borrowed Varla's bike before getting infected. Appears as a fat woman and a skinny woman. Chronologically the second boss fought in the [=PS3=] version.

* DualBoss: And like Judgement before them, one of them counts as the collective weak point.
* {{Expy}}:
** Hands up if you thought of the Judgement from the second game in this fight.
** Sindy also resembles Temperance, with all the disturbing jigglies and frustrating invulnerability to boot.
* FatAndSkinny: Sindy's the giant, fat one, Coco's the one that looks like [[Literature/TheLordOfTheRings Gollum]].
* ThoseTwoGirls: Well, judging from how Varla refers to them.

!!The Screamer
Another creation of Caesar, who's released in a hospital in order to kill G and Isaac. Appears as a zombie girl with a mutilated face and powerful screams. The second boss in OVERKILL (third if you count the [=PS3=] version).

* BodyHorror: You can clearly see her spine.
* ButterFace: Her face is awfully mutilated.
* {{Expy}}: Let her succeed in attacking you and you will get reminded of [[TheRing Sadako]].
* GroinAttack: Her weak points are her face and her crotch.
* MakeMeWannaShout: As expected from a mutant dubbed "[[ExactlyWhatItSaysOnTheTin The Screamer]]".
* MindRape: Apparently, that's what she does when she screams.
* SheWasRightThereAllAlong: You find her in a room in the dungeons of the Hospital, but if you're careful enough, you can spot her stalking you through the building and running away.
** In the [[UpdatedReRelease Director's Cut]] of the Playstation 3, she ''literally'' screams at both G and Isaac ''just when they get inside the hospital''.

!!Nigel and Sebastian
A pair of circus freaks mutated by the virus, who are now feeding on corpses in the circus. Nigel is the large guy, while Sebastian is the tumor-like thing embedded in his belly. The third boss of OVERKILL (fourth in the [=PS3=] version).

%%* AppendageAssimilation
* BodyHorror: Freaks. Zombie freaks. What did you expect?
* DualBoss: Technically.
* IAmAHumanitarian: They're shown eating a corpse.
* NotQuiteDead: Sebastian after the boss fight, but he's gunned down almost instantly.
* TheSpeechless: Nigel doesn't speak.

!!Meat Katie
Exclusive to the [=PS3=] version, it is a gigantic cow-like mutant who wields a butcher's knife in the butcher shop. Chronologically the fifth boss of the game.

* ALoadOfBull: Making her a mutant wasn't enough, so she was given a cow's skull and udders.
* AnAxeToGrind: Wields a giant meat cleaver.
* {{Expy}}: It's hard not to see similarities between her and Chariot.
* HeroKiller: As she dies, her cleaver falls on Candi's arm, severing it and causing her death.
* HoistByTheirOwnPetard: Pushed back in her meat grinder.
* WasOnceAMan: When you see what her name is and where her weak spot is, you can see on the right side a picture of her as a human woman before she became a mutant.

!!The Crawler
A huge mutant similar to a bug, it attacks Isaac and G on the train. The fourth boss of OVERKILL (sixth in the [=PS3=] version).

%%* BigCreepyCrawlies
* BodyHorror: It's implied from certain parts of its anatomy that it used to be ''[[WasOnceAMan human]]''.
* EarlyBirdCameo: Only in the [=PS3=] version in Creeping Flesh, one level before his stage (which is Scream Train).
* GiantSpaceFleaFromNowhere: Almost word by word, just replace Space with Zombie and Flea with Mantis.
* SinisterScythe: Its arms, which doubles as its weak point. The weak point is changed in the [=PS3=] version.
* SlayingMantis: Designed as such.

!!The Lobber
A massive frog-like mutant who's infesting the swamps. The fifth boss of OVERKILL (seventh in the [=PS3=] version).

* BodyHorror: He's covered in pus-filled bubbles.
%%* FatBastard
* GiantSpaceFleaFromNowhere: Why is there an obese, giant [[NinjaPirateZombieRobot bubble-covered zombie-frog-man]] in that swamp!?
* HoistByHisOwnPetard: You can make him vulnerable by shooting his projectiles while he's still holding them.

A huge, mutated criminal who was executed for his many awful crimes. He's seen together with another similar mutant, who he kills. The sixth boss of OVERKILL (eighth in the [=PS3=] version).

* ArmCannon: Rather, Crossbow. Doubles as his weakness.
* BaitAndSwitchBoss: No, you don't have to fight both giant mutant freaks at the same time.
* DualBoss: Subverted.
* EatTheDog: Amongst his various misdeeds, he and his partner ''ate'' the puppy of a poor child.
* FlunkyBoss: In addition to Brutus himself, a number of mutant mooks will attack during the fight.
* MeaningfulName: Tu quoque Brute!?

Clement Darling's mother, who was exposed to the compound and had her brain put in Varla's body. She mutates to a giant, grotesque monster which births smaller mutants from her oversized vagina. The seventh and final boss of OVERKILL (ninth and [[BossRush tenth]] if you count the playable "Missing Reel" in the [=PS3=] version).

* AttackOfTheFiftyFootWhatever: Temperance, eat your heart out.
* BodyHorror: The greatest case so far, considering that hers used to be Varla's body.
* BossRush: It was implied by G and Isaac that they had fought off Mother first before your real fight against her. Played straight in the Director's Cut of the [=PS3=] version, where ''you'' get to experience it.
* FinalBoss: A two-form one...that has the first form cut out in a "Missing Reel".
* FinalExamBoss: Set up as one in ''Typing''. The prompt subverts this trope by instructing you to type ''anything'' "as long as you type like a motherfucker", meaning you can win simply by [[RapidFireTyping mashing "adsfadsfdasdsaf"]] and the like ''ad infinitum''. However, you'll also get "Type words associated with ''(character)''" prompts, and typing matching words will inflict a CriticalHit.
* FingerPokeOfDoom: She attacks by literally flicking you off, and also by flicking tires at you.
%%* FullFrontalAssault
* GettingCrapPastTheRadar: Her physical appearance, especially regarding her... cough cough...
* GuideDangIt: Only in the Director's Cut of the [=PS3=] version; unless you paid attention to your surroundings, you wouldn't even know how to even ''damage'' Mother in the revealed "Missing Reel".
* MotherOfAThousandYoung: She can give birth to Pukers in a few seconds.
* OneWingedAngel: Accidental, though.