Though not a very plot-intensive game, there are still some twists that occur throughout the series. Thus, be warned that there be '''Spoilers Ahead!'''



!!Thomas Rogan
An AMS agent who was called to the Curien Mansion in 1998 by a distress call from his fiance, Sophie. Although it looks bad when Chariot appears to kill her prior to his battle with Rogan, she survives and together the two manage to have a daughter, Lisa. Twenty-one years after the Curien case, the world has collapsed due to the zombie outbreak detailed in the fourth game. Rogan leads an assault team on the EFI Research complex in order to track down the source of the disaster, but gets in over his head.

* BadassLongcoat: It even flows in the air while he's climbing a ladder.
* CrusadingWidower: Unless he gets the good ending.
* LastNameBasis: Always referred to as "Rogan," even by his fiance.
* {{Revenge}}: For Sophie.
* SpellMyNameWithAnS:
** Some ''[=HOTD1=]'' arcade cabinets spelled his last name as 'Rowgun.'
** A strange later-game example in ''House Of The Dead 4 Special''; while every other game has agreed on "Rogan", if G gets a high score, on the stage result screen, he'll comment that he's "Better than Logan."

An AMS agent and Rogan's partner during the 1998 Curien case. Together, he and Thomas managed to put an end (or so they thought) to Curien's most diabolical invention, the Magician. In the year 2000, he heads to Venice to quell a new outbreak happening in the streets, but is overwhelmed and injured. Despite this, he survives and later assists Kate Green after James Taylor sacrifices himself to stop "The World". Sixteen years later, he assists Lisa Rogan when she attempts to find the whereabouts of her father after his doomed mission to the EFI Research building.

He and Issac Washington were also the duo who put an end to Papa Ceasar's activities in 1991.

* BadassNormal
** EmpoweredBadassNormal: {{Jossed}}. The manual for the Saturn and PC ports tries to suggest that he's some kind of artificial human, but Sega went ahead and just ignored that.
* BreakoutCharacter: Started as the generic partner character for protagonist Rogan, but became popular enough to appear in every single game ''and'' be playable in all but one of them.
* CoolShades: Only in ''Overkill'', but he makes up for that by never taking them off.
* DueToTheDead: If you unlock his ending in ''4'', he is seen paying his respects to the [[HeroicSacrifice late James]] and swearing to fight the ZombieApocalypse "back to the source," [[CallForward as we see in]] ''[[CallForward III]]''.
* NoNameGiven
-->'''Isaac''':"You ever gonna tell anyone what that fuckin' "G" stands for?"\\
'''G''': "No."
** OneLetterName
* NotUsingTheZWord: He insists to Isaac that he refers to the zombies as "mutants".
* OddCouple: With Isaac Washington.
* TheStoic: In ''House of the Dead 1'', he's basically a robot (the home version manual tried to imply that he was a ''literal'' one). His personality becomes more apparent in each subsequent game, but he always remains cool under pressure.
* UnexplainedRecovery: You meet him at the beginning of ''House of the Dead 2'', where's he's been seriously wounded and urges you to go on without him, seeming to suggest that it's a BackForTheDead situation for him. In the best ending, Rogan shows up out of nowhere to tell you that he's fine, but even if that ending isn't canon, the fact that he's alive and well in the third and fourth games certainly settles it.

!!Sophie Richards
Thomas Rogan's fiancÚ at the time of the Curien Mansion incident and a researcher working for Dr. Curien. Later becomes Lisa Rogan's mother.

* [[AndThenJohnWasAZombie And Then Sophie Was A Zombie]]: If you get the worst ending in the first game.
* DistressedDamsel: Though she almost escapes the mansion by herself before Hanged Man swoops in and carries her back.
* LastWords: "You must stop Curien. Or else... something terrible will happen!"
* LittleDeadRidingHood: She wears a red coat over her lab coat, making her stand out against her other scientist collages. And unless you get the GoldenEnding, she will be dead.
* UnexplainedRecovery: In the true ending, if your score is high enough.
** If ''The House of the Dead 3'' is any indication, this ending is canon.

!!James Taylor
An AMS agent who was working on the Venice, Italy case. He was scheduled to meet G in Venice on February 26, 2000, until he ran afoul of Zeal. Together, he and his partner Gary discover the plot of Caleb Goldman and pursue a mission to track him down to the DBR Corporation headquarters. They put a stop to Goldman's plan to unleash the "Emperor", but fail to arrest Goldman.

Three years later, he and AMS agent Kate Green visit the European archives of the AMS, with James believing that the crisis from 2000 has not completely subsided. However, as they are researching the files within, an earthquake traps them underground. While waiting for a rescue squadron, they are suddenly overrun by new leagues of the undead. The pair fight their way back to the surface to discover that Goldman has enacted a plot from beyond the grave to launch a nuclear strike on the world. James returns to the DBR Corporation headquarters in order to reach Goldman's office on the fiftieth floor and stop the launch. However, Goldman has yet another failsafe, called "The World", which will be unveiled by the opening of "Pandora's Box". James and Kate battle The World in the courtyard of the DBR building, but are unsuccessful in destroying it. [[spoiler:James is left with no other option but to destroy the beast by blowing himself and the monster up together.]]

* [[spoiler:HeroicSacrifice: James takes his own life to stop the final phase of The World in ''4'', making him the only playable protagonist so far to be KilledOffForReal.]]

!!Lisa Rogan
Thomas and Sophie's daughter, who goes to the EFI Research building, along with Rogan's former partner G, to find her father after he disappeared two weeks prior on a mission to put an end to the disaster that ruined the world.

* ActionGirl
* TheHero: Of III.
* [[LikeFatherLikeSon Like Father Like Daughter]]: Takes after her zombie-slaughtering father far more than her DamselInDistress mother, despite her strained relationship with him.
* ShotgunsAreJustBetter

!!Kate Green
An AMS agent who assisted James Taylor in 2003. After she and James uncover Caleb Goldman's final plan, together they stop "The World" from coming to fruition. She later teams up with G in order to fight a newly-resurrected Magician.

* BadassNormal:
* NaiveNewcomer: Said to be new to AMS and working her first case with James. She gets the hang of things quickly enough, though.
* ScarfOfAsskicking: Wears a big houndstooth pattern scarf. Kicks a lot of ass.
* WhatHappenedToTheMouse: She joins with G after James' death.

!!Daniel Curien
The son of Roy Curien whose childhood illnesses inspired his father to research the essence of life and death. He believes he bears the responsibility to put an end to the evils unleashed on the world by Curien in his name.

* [[AndThenJohnWasAZombie And Then Daniel Was a Zombie]]: Should you get the bad ending in ''[=III=]''.
* [[IllGirl Ill Boy]]: As it shows in his backstory, he was the reason Curien started his research in the first place. Curien did succeed at that goal, at least.
* [[MadScientistsBeautifulDaughter Mad Scientist's Handsome Son]]
* TookALevelInBadass
* YoureNotMyFather: Daniel says this during the cutscene [[spoiler: after the Wheel of fate is defeated]].

!!Isaac Washington

* BadAss
* BaldOfAwesome
* BlaxploitationParody
* BoisterousBruiser: Compared to G.
* ClusterFBomb: Constantly.
** Drops the act a little when faced with Clement, a [[ParentalIncest literal motherfucker]]. Clement is the one character that he does ''not'' call a "motherfucker". G points out the {{irony}} of this (see JerkWithAHeartOfGold below).
* DualWielding / GunsAkimbo: In cutscenes, at least.
* EekAMouse: Is not a big fan of insects. Pointed out after the battle against The Crawler.
* EvenBadMenLoveTheirMamas: The reason why he wasn't infected by the virus is that he was with his mother. Of course, he won't admit it.
* JerkWithAHeartOfGold: For all the trash talk and swearing he does to everyone else, ''especially'' G, he has more of a heart than most would be led to believe. G points out that Isaac doesn't mean most of the things he says, hence why Isaac refuses to use the MF-word on Clement. What does G conclude? That Isaac sees G as a good friend. [[{{Tsundere}} Of course, Isaac won't admit it.]]
* SirSwearsALot: Oh ''so'' much.
* {{Tsundere}}: A ''[[ClusterFBomb very foul-mouthed one]]'', but by the end of the game, G notices it.
* YouKilledMyFather: Towards Papa Caesar.
** In TheStinger of OVERKILL, Caesar says in a tape recording that Washington's father is still alive.

!!Varla Guns

* ActionGirl: [[SubvertedTrope Subverted]]. She tries, but ends up failing.
** Gets promoted to one in the Extended Cut (at least, the parts where she was at while Isaac and G were doing their business).
* BuxomIsBetter: Holy crap yes! Though, according to Darling's mother, her tits are still "too small".
* BrainInAJar: Her fate at the end of the game.
* DisposableWoman: Discussed by Issac and G at the end of the game. She does seem to exist mostly to provide fanservice and motivation.
* DistressedDamsel: She's kidnapped by Papa Caesar and later by Warden Darling.
* {{Expy}}: She's both named after and closely resembles Tura Satana's character from ''Film/FasterPussycatKillKill''
* {{Gainaxing}}: Especially in the cutscene of chapter one when she arms herself.
* [[GetAHoldOfYourselfMan Get A Hold Of Yourself Woman]]: Slaps Candi after she lets out two [[BigNo Big Nos]].
* [[HoistByHisOwnPetard Hoist By Her Own Petard]]: Her drive for revenge led to her becoming a BrainInAJar. G claims that she's still alive.
* ItsPersonal: She wants to avenge her little brother Jasper, and later Candi.
* {{Revenge}}: Her motivation throughout the game. It's safe to say that her fate determined she failed to avenge both her brother and Candi.


!!Dr. Roy Curien
A genetic researcher who was pursuing a way to command the forces of life and death in order to save his dying son. Although he started with good intentions, he eventually succumbed to madness as he delved further into his research. He invented two means by which to control these forces: the Magician, a sentient and bio-mechanical android, and the Wheel of Fate. The Magician proved too unruly and independent to control and ultimately killed its creator. Curien's remains were brought to the EFI Research complex, where his Wheel of Fate device was housed. Over the span of twenty years, it would revive him and allow him to bring about the ultimate judgement upon mankind. He was eventually destroyed for good by the efforts of Lisa Rogan and his own son Daniel.

* BigBad: Of the first game (and also the third game).
* DrivenToVillainy: Implied in [=HOTD1=], and explored in [=HOTD3=]. Curien was just a normal scientist trying to solve the world's problems, but his son's sudden illness prompted him to go all the way to the bottom of the barrel to try and cure him. It cost him his coworkers and his sanity.
* EvilutionaryBiologist
* FinalBoss: You fight his resurrection in the third game.
* LegacyCharacter: The Wheel of Fate.
* LoveMakesYouEvil: His love for his son and desire for said son to be well causes his MadScientist gig.
* MadScientist
* NonActionBigBad: He only taunts you through the first game, getting killed by Magician.
* TheUnfought: In the first game. But not in the third.

!!Caleb Goldman
The CEO of the DBR Corporation and the real driving force behind Dr. Curien's research. He funded Curien's research in order to gain access to the wealth of genetic information Curien had so he would be able to employ them to his own end: to end the sin of mankind's mistreatment and destruction of the planet. When Curien was killed by the Magician, he retrieved the Magician (following its defeat by the AMS) and rebuilt it to serve him. He used it as a guard to protect the DBR headquarters, which is also where he housed his own monstrous creation: the Emperor. However, the Emperor was unsuccessful in turning away the AMS, and after its defeat, Goldman chose to end his life rather than be taken in by the AMS.

Three years later, he is revealed to have planted the seeds of destruction regardless of his death through a planned nuclear launch in 2003. James Taylor (one of the agents who stopped his original plan) and Kate Green deter this, but also uncover a second plot that would enact in case his nuclear missile did not launch, called "Pandora's Box".

* [[AndThenJohnWasAZombie And Then Goldman Was a Zombie]]: Should you get the "bad" ending in ''2'' and ''4''.
* BigBad: Of the whole series.
* BetterToDieThanBeKilled: Throws himself off the DBR skyscraper instead of surrendering to the AMS agents.
* ClaspYourHandsIfYouDeceive
* CorruptCorporateExecutive: Though not of the typical sort, using his vast power and knowledge to create zombies in order to cleanse the world.
* GaiasVengeance: What he wants to bring to fruition.
* KnightTemplar: Rather than wanting just destruction, he wants humans to devolve into their most basic form. Which happens to be Zombies.
* TheManBehindTheMan: Curien's main benefactor during the first game.
* MisanthropeSupreme: Is sick and tired of humans wrecking the environment.
* MyDeathIsJustTheBeginning: Despite dying in ''House of the Dead 2,'' he still sets numerous events in motion, as shown in ''House of the Dead 4.''
* NonActionBigBad: He sits behind a desk during much of ''The House of the Dead 2'' while feeding the AMS agents to his various creatures. When James and Gary arrive, he simply directs their attention to the Emperor, and when they defeat it, he jumps off the building.
* SunglassesAtNight: Is always shown wearing sunglasses.

!!Mysterious Man
* BiggerBad
* TheFaceless
* HiddenVillain

!!Papa Caesar

* BigBad: Who you're chasing throughout ''Overkill.'' It turns out he was working for Warden Darling.
* EvilSoundsDeep
* FauxAffablyEvil: Adopts this tone around Isaac and the other heroes.
* IHaveYourWife: Forces Jasper to work for him by threatening Varla.
* KickTheDog: How he treats Jasper (who, by the way, is paraplegic).
* KilledOffForReal: He gets electrocuted by Warden Darling when he [[YouHaveOutlivedYourUsefulness outlives his usefulness.]]
* ManOfWealthAndTaste
* ObviouslyEvil: And the [[LargeHam narrator]] couldn't make it more clear than this.
* PoliticallyIncorrectVillain: Seen how he treats Jasper.
* RedHerring:
* TrademarkFavoriteFood: Likes Chinese food. [[ObviouslyEvil And pain.]]
-->'''Caesar''': "I enjoy pain. It's like a good Chinese dinner, you know? With the sweet, and the sour? Expanding on that analogy, I will smile with delight, that's the sweet, [[FauxAffablyEvil as you scream for your fucking life]]. [[ToThePain Of course, that's the sour]]. [[VillainExitStageLeft Ciao!]]"

!!Warden Clement Darling

* BiggerBad: Although Caesar claims that he has powerful friends that present more of a threat than his "small-minded" ambitions. Said "powerful friends" are most likely Curien and Goldman.
* EvenBadMenLoveTheirMamas: In his case, though, it's a little ''too'' much.
* {{Gonk}}: Those eyes and those teeth.... uuuggh.
* TheManBehindTheMan: For Papa Caesar.
* ParentalIncest: He does everything out of love for his mother, but it isn't familial love...
* VillainousBreakdown: Goes through a rather calm one after Mother's death.


* AttackItsWeakPoint: They all have a specific weak spot, although some aren't always shown in their introduction.
* TarotMotifs[=/=]ThemeNaming: They're all named after Tarot cards; the only exceptions being the ''OVERKILL'' bosses.

!!The Chariot
A large zombie wearing a full suit of armor, who is the first boss fought in the first game.

* AnAxeToGrind: Wields a bardiche.
* AttackItsWeakPoint: The full body armor it wears makes it impervious... except for the very obvious gap in its chest.
* TacticalSuicideBoss: When it suffers enough damage, it breaks out of its armor... So now it's vulnerable everywhere.
** Sort of. Every part of his body is vulnerable in the second phase, but if you only shoot the same spot over and over he'll stop taking damage, so you ''must'' shoot pretty much every part of his body.
* WarmUpBoss

!!The Hangedman
A flying stone gargoyle who kidnaps Rogan's girlfriend and later attacks him and G on the roof. He's the second boss of the first game.

* BatOutOfHell: He can command a flock of zombie bats.
* DisneyVillainDeath: Twice.
* EvilLaugh
* FlunkyBoss: In the first phase.
* RecurringBoss: He harries you in the first two levels, serves as the boss of level two, and gets a brief rematch in before the final boss.
* VocalDissonance: Sounds like he ingested too much helium.
* WingedHumanoid

A big, spider-like zombie that tries to kill Rogan and G with its webs. The third boss of the first game.

* AbnormalAmmo: Shoot web balls at you.
* DeadlyLunge: Near the end.
* GiantSpaceFleaFromNowhere: Curien just sics it on you with ''no'' prior hints at its existence.
* GiantSpider

!!The Magician
Curien's most powerful creation, which is a mutant with [[PlayingWithFire fire control]] and psychic powers. The fourth ([[FinalBoss and final]]) boss of the first game. It later serves as the fifth boss of the second game, and the second (and once again final) boss of ''The House of the Dead 4 Special''.

* AchillesHeel: Its exposed spots. Specifically the right shin, left calf, right forearm, and left upper arm. Perhaps the only final boss in the series where despite the weak point being listed as 'unknown,' the weak point isn't blindingly obvious.
* BadassBaritone: More so in its later appearances.
* HornedHumanoid
* HumanoidAbomination
* FinalBoss: Curien's final project of the first game.
* PlayingWithFire: ''Hoo boy.'' Its ultimate attack is a literal rain of fire.
* RecurringBoss: Especially strange, considering it's first appearance had it kill it's creator. Goldman was apparently able to fix this problem for all future incarnations.
* TurnedAgainstTheirMasters: It's first words are announcing it will not obey any orders, and then it kills Curien.
* UnexplainedRecovery: For ''The House of the Dead 2'', and ''again'' for ''The House of the Dead 4 Special Edition''.
** Gets explained (sort of) if you fail to stop its last-ditch attack in ''The House Of The Dead 4 Special Edition''; it summons a '''''legion''''' of clones of itself, [[NonstandardGameOver and the game just ends there without even letting you TRY to fight them off]].

A small imp (Zeal) and a living suit of Armor (Kuarl), who are met in Venice by James and Gary. It's the first boss in ''The House of the Dead 2''.

* AchillesHeel: Kuarl is fully dependent on Zeal. If Zeal takes enough damage, Kuarl will fall.
* AnAxeToGrind: Kuarl.
* BrainsandBrawn: Zeal hides behind the hulking Kuarl and barks orders. Of course, after Kuarl dies, Zeal can still fly up to you and scratch your face off.
* DualBoss
* {{Expy}}: Of The Hanged Man (Zeal) and The Chariot (Kuarl).
* PreAssKickingOneLiner:
--> '''Zeal:''' "Seems like my advice had no effect. Suffer like G did!"
* RecurringBoss: You fight them again in the second-to-last level.
* RemovingTheHeadOrDestroyingTheBrain: Kuarl is an example where this trope doesn't work. Mainly because he doesn't have a head!
* ThoseTwoBadGuys

!!The Hierophant
An aquatic reptillian zombie armed with a trident. The second boss of the second game.

* AchillesHeel: Its chest opens on a regular basis to expose its heart.
* FishPeople
* FlunkyBoss: He'll summon [[PiranhaProblem piranhas]] to attack you as backup.
* InASingleBound: That guy can do some amazing jumps.
* ProngsOfPoseidon: His weapon is a rather wicked-looking trident.
* WarmUpBoss: His weak point is fairly obvious and pretty easy to hit, knocking him back.

!!The Tower
A Hydra-like mutant who dwells in the sewers of Venice. The third boss of the second game.

* OurDragonsAreDifferent: Apparently based on Dragons.
* PopQuiz: In ''The Typing of the Dead''. You get a question and have to type one of three answers. Type the wrong answer and it's -1 life.
* SandWorm: If you choose the right path, the second stage of the battle has the large blue worm burrow through a large sand pit arena.
* StockScream: Its roars are familiar.
* TurnsRed: After losing her four red heads.
* WakeUpCallBoss

A huge, chainsaw-wielding brute fought in a Coliseum. The fourth boss of the second game.

* AdvancingBossOfDoom: Chases you through a labyrinth, sometimes jumping over walls or smashing through them to surprise you.
* TheBrute: Doesn't do anything particularly fancy, it just chases you, jumping off of or smashing through walls to get at you.
* ChainsawGood: His weapon is a HUGE chainsaw with the word BLAME etched on both sides of the blade.
* ClimaxBoss
* TheDeterminator: He won't stop coming until he's dead.
* HeroKiller: Severely, and possibly fatally, wounds Harry.

!!The Emperor
A humanoid being made of shape shifting molten metal, and Goldman's last creature. The sixth (and final) boss of the second game.

* BlobMonster: With a physical form, though.
* DittoFighter: Copies several previous bosses to fight you.
* TheDragon: To Goldman.
* ExtraOreDinary: Manipulates molten metal to fight.
* FinalBoss
* HumanoidAbomination
* LightIsNotGood
* PopQuiz: In ''The Typing of the Dead'', he parodies the format that The Tower used three chapters ago, using questions with silly answers. This time ''all three answers'' to each question are considered correct, although they influence which of the MultipleEndings you get.
* RoboSpeak: "I am... I am..."

A huge skull-faced mutant dressed as a Security Guard and armed with a club. He'll chase G and Lisa for two levels. One of the bosses in the third game.

* TheBrute
* CarryABigStick: With skulls embedded in it.
* ClothingDamage: At low health, he loses his hat.
* EarlyBirdCameo: Appears in the opening sequence, where he knocks Thomas Rogan down, but is stopped by Curien's son.
* ImplacableMan: Hoo boy.
* {{Irony}}: He's the first boss seen in the game, and he's the hardest to kill in the whole series.
* RecurringBoss: Fights you across two stages.

!!The Fool
A mutated giant sloth who resides in a well-like cage inside the building. One of the bosses in the third game.

* AttackOfTheKillerWhatever
* GrievousHarmWithABody: Can shower you with his former meals. Aka Corpses.
* LightningBruiser: Yes, it's a giant sloth, but seems like the zombification had improved his muscles.

!!The Sun
A mutant giant plant with many tentacle-like roots and human faces on its stalk. One of the bosses in the third game.

* AttackOfTheMonsterAppendage: You see its roots and tentacles all over the place, but meet it later in the level.
* CombatTentacles
* FantasticFlora: It's a genetically mutated tree.
* ManEatingPlant
* ShoutOut: Resembles Plant 42 from ''VideoGame/ResidentEvil''.

!!The Wheel of Fate
[[caption-width-right:206:I shall destroy everything...and resurrect everything.]]
Curien's ultimate creation/transformation, it is a cybernetic monster surrounded by a metal ring. It manipulates electricity to fight. It's the final boss of ''The House of the Dead 3'', and is actually Dr. Roy Curien himself.

* ChromeChampion: His entire body seems to be composed of chrome metal. He has [[SpikesOfVillainy spines]] on his forearms and a sun emblem on his chest.
* [[spoiler: DefeatEqualsExplosion: The Wheel of Fate explodes upon defeat.]]
* FinalBoss: The ultimate threat to humanity itself -- or what's left of it.
* HumanoidAbomination
* IcyBlueEyes
* OneWingedAngel: Of Curien.
* RoboSpeak: His voice seems to be mechanized.
* ShockAndAwe: He has power over electricity, and whichever attack he uses depends on a "spin of the wheel".
* WellIntentionedExtremist: His goal is to "destroy everything and resurrect everything," and laments the planet's overpopulation upon defeat.

A huge, four-armed mutant that chases Kate and James in the sewers. The first boss of ''The House of the Dead 4'' and ''The House of the Dead 4 Special Edition''.

* FeedItABomb: His weak spot is his mouth.
* MultiarmedAndDangerous
* RecurringBossTemplate: See also Strength and Death for a similar boss fight.

!!The Lovers
A pair of mutated Tarantulas which attack Kate and James as they try to leave the underground via Elevator. The second boss of ''The House of the Dead 4''.

* AllWebbedUp: One of their attacks involve wrapping the players in silk.
* CoitusUninterruptus: Considering their name, and how they attack with smaller spiders, it's possible the two are copulating constantly throughout the battle.
* DualBoss: Albeit in terms of gameplay, they're fought as a single boss.
* GiantSpider: Times two.
* MookMaker: Can and will summon several spiders to help them.
* SpikesOfVillainy: The top spider's forelegs are covered in spikes.

!!The Empress
A powerful purple zombie armed with a ludicrously big double-chainsaw. He/she chases Kate and James on the train. The third boss of the fourth game.

* ActionGirl: "She" is deadly and has a female name, but is otherwise functionally genderless.
* DoubleWeapon: It breaks apart during the last part of the fight, forcing her to resort to DualWielding.
* EvilCripple
* ChainsawGood: Double it.
* RailroadTracksOfDoom: After her defeat, she falls from the train and gets hit by another one.

A morbidly obese, giant zombie that chases our heroes down the streets. He's so fat that bullets won't damage him. The fourth boss of the fourth game.

* AdvancingBossOfDoom: One Big Rolling Undead Fat Ball of Doom.
* BrightIsNotGood: Properly enough, since vividly colored frogs are also the most dangerous (see FrogsAndToads).
* FatBastard
* FrogsAndToads: For some reason, he makes toad noises as he's shot.
* GroundPound: In his first phase, if you fail to damage him fast enough, he jumps up into the air and squashes you under his backside.
* {{Kevlard}}[=/=]ImplacableMan: He can't be damaged by bullets; you can only stun him. You defeat him by dropping a clock tower on him.
* JigglePhysics: Disgustingly applied to his pendulous breasts and belly.
* NonindicativeName: He's more or less the incarnation of gluttony, basically the opposite of Temperance. WordOfGod has stated the inversion was deliberate.
* WalkingShirtlessScene

!!The Star
A humanoid mutant armed with kukri knives and a purple aura, which acts as a "test" of strength for Kate and James. When he dies, he wounds James with a shard of his body. He's a perfected model of The Magician, and the fifth boss of ''The House of the Dead 4''.

* BeamSpam: His main form of attack.
* BoomHeadshot: During his tornado attack, his head becomes a weak point. Lampshaded on the analysis window; while all other spots save for his chest are labeled "NO DAMAGE", his head is labeled "NO DAMAGE?" Yes, with a question mark.
* BrightIsNotGood
* ClothingDamage: Sadly, his BadassLongcoat is torn to shreds as you shoot him.
* TheDragon: To Goldman.
* DualWielding: Two glowing [[KukrisAreKool kukris]].
* EverythingsBetterWithSpinning: His final move.
* HumanoidAbomination
* PowerFloats
* PreAssKickingOneLiner: "Come, you must prove yourself in a test of strength...this was Goldman's parting wish."
* ScarsAreForever: Has a huge gush on his chest.
* ShoutOut: His red BadassLongcoat makes him similar to Dante from DevilMayCry.
* TakingYouWithMe: Explodes when killed. Is unknown if it was intentional or not.

!!The World
Goldman's last trick, which is a powerful, constantly-evolving monster made of ice. He's destroyed by James's sacrifice.

* [[AnIcePerson An Ice Insectoid Abomination]]
* AttackItsWeakPoint: The red spot on his chest.
* BadassBoast: "There is no hope... [[NintendoHard My hammer of death will rain down upon you!]]"
* EldritchAbomination: Looks like a giant humanoid fly made of ice and embedded in the ground.
* FinalBoss
* InstantAwesomeJustAddDragons: His second phase summons ice dragons.
* OneWingedAngel: Three times. But you have to face only two forms.
* PreAssKickingOneLiner: "There is no hope. My hammer of death shall rain down upon you."
* VocalDissonance: Despite its towering and grotesque appearance, it has the soft, withered voice of an elderly man. Ironically, it's probably the only voice in House of the Dead 4 that doesn't sound cheesy.
* WingedHumanoid

!!Dr. Jasper Guns, PhD
The first boss in OVERKILL, he's Varla's quadriplegic younger brother, who has injected himself with a PsychoSerum in order to kill Papa Caesar, but got distracted by G and Issac, allowing Caesar to escape. Unfortunately, Jasper ends up so far gone that he can't tell ally from enemy, and ends up attacking G and Issac instead.

* DeadlyUpgrade
* TheDogBitesBack: Tries this, but turns into more of a threat to Caesar's enemies than Caesar himself.
* MindOverMatter: He's gained telekinetic abilities from the PsychoSerum.
* MyBrainIsBig: Also acts as BodyHorror and AchillesHeel.
* OneWingedAngel
* PowerFloats
* RoboSpeak: He is unable to speak due to the disease, so he uses a computer to speak.
* TragicMonster

!!Coco and Sindy
Exclusive for the Playstation 3 version, they're Varla Guns' fellow coworkers who borrowed Varla's bike before getting infected. Appears as a fat woman and a skinny woman. Chronologically the second boss fought in the PS3 version.

* DualBoss
* {{Expy}}: Hands up if you thought of the Judgement from the second game in this fight.
* [[FatBastard Fat Bitch]]: Sindy.
* ThoseTwoGirls: Well, judging from how Varla refers to them.

!!The Screamer
Another creation of Caesar, who's released in a hospital in order to kill G and Isaac. Appears as a zombie girl with a mutilated face and powerful screams. The second boss in OVERKILL (third if you count the PS3 version).

* BodyHorror: You can clearly see her spine.
* ButterFace: Her face is awfully mutilated.
* {{Expy}}: Let her succeed in attacking you and you will get reminded of [[TheRing Sadako]].
* GroinAttack: Her weak points are her face and her crotch.
* MakeMeWannaShout: Guess why?
* MindRape: Apparently, that's what she does when she screams.
* [[HeWasRightThereAllAlong She Was Right There All Along]]: You find her in a room in the dungeons of the Hospital, but if you're careful enough, you can spot her stalking you through the building and running away.
** In the [[UpdatedRelease Director's Cut]] of the Playstation 3, she ''literally'' screams at both G and Isaac ''just when they get inside the hospital''.

!!Nigel and Sebastian
A pair of circus freaks mutated by the virus, who are now feeding on corpses in the circus. Nigel is the large guy, while Sebastian is the tumor-like thing embedded in his belly. The third boss of OVERKILL (fourth in the PS3 version).

* AppendageAssimilation
* BodyHorror: Freaks. Zombie freaks. What did you expect?
* DualBoss: Technically.
* IAmAHumanitarian: They're shown eating a corpse.
* NotQuiteDead: Sebastian after the boss fight, but he's gunned down almost instantly.
* TheSpeechless: Nigel doesn't speak.

!!Meat Katie
Exclusive in the PS3 version, it is a gigantic cow-like mutant who wields a butcher's knife in the butcher shop. Chronologically the fifth boss of the game.

* ALoadOfBull: Making her a mutant wasn't enough, so she was given a cow's skull and udders.
* {{BFS}}
* HeroKiller: As she dies, her cleaver falls on Candi's arm, severing it and causing her death.
* [[HoistByHisOwnPetard Hoist By Her Own Petard]]: Pushed back in her meat grinder.
* WasOnceAMan: When you see what her name is and where her weak spot is, you can see on the right side a picture of her as a human woman before she became a mutant.

!!The Crawler
A huge mutant similar to a bug, it attacks Isaac and G on the train. The fourth boss of OVERKILL (sixth in the PS3 version).

* BigCreepyCrawlies
* EarlyBirdCameo: Only in the PS3 version in Creeping Flesh, one level before his stage (which is Scream Train).
* GiantSpaceFleaFromNowhere: Almost word by word, just replace Space with Zombie and Flea with Mantis.
* SinisterScythe: Its arms, which doubles as its weak point. The weak point is changed in the PS3 version.

!!The Lobber
A massive frog-like mutant who's infesting the swamps. The fifth boss of OVERKILL (seventh in the PS3 version).

* BodyHorror: He's covered in pus-filled bubbles.
* FatBastard
* GiantSpaceFleaFromNowhere: Why is there an obese, giant [[NinjaPirateZombieRobot bubble-covered zombie-frog-man]] in that swamp!?
* HoistByHisOwnPetard: You can make him vulnerable by shooting his projectiles while he's still holding them.

A huge, mutated criminal who was executed for his many awful crimes. He's seen together with another similar mutant, who he kills. The sixth boss of OVERKILL (eighth in the PS3 version).

* ArmCannon: Rather, Crossbow. Doubles as his weakness.
* DualBoss: Subverted.
* EatTheDog: Amongst his various misdeeds, he and his partner ''ate'' the puppy of a poor child.
* FlunkyBoss
* MeaningfulName: Tu quoque Brute!?

Clement Darling's mother, who was exposed to the compound and had her brain put in Varla's body. She mutates to a giant, grotesque monster which births smaller mutants from her oversized vagina. The seventh and final boss of OVERKILL (ninth and [[BossRush tenth]] if you count the playable "Missing Reel" in the PS3 version).

* BodyHorror: The greatest case so far, considering that hers used to be Varla's body.
* BossRush: It was implied by G and Isaac that they had fought off Mother first before your real fight against her. Played straight in the Director's Cut of the PS3 version, where ''you'' get to experience it.
* FinalBoss: A two-form one...that has the first form cut out in a "Missing Reel".
** FinalExamBoss: Set up as one in ''Typing''. The prompt subverts this trope by instructing you to type ''anything'' "as long as you type like a motherfucker", meaning you can win simply by [[RapidFireTyping mashing "adsfadsfdasdsaf"]] and the like ''ad infinitum''. However, you'll also get "Type words associated with ''(character)''" prompts, and typing matching words will inflict a CriticalHit.
* FingerPokeOfDoom: She attacks by literally flicking you off, and also by flicking tires at you.
* FullFrontalAssault
* GettingCrapPastTheRadar: Her physical appearance, especially regarding her... cough cough...
* GuideDangIt: Only in the Director's Cut of the PS3 version; unless you paid attention to your surroundings, you wouldn't even know how to even ''damage'' Mother in the revealed "Missing Reel".
* MotherOfAThousandYoung: She can give birth to Pukers in a few seconds.
* OneWingedAngel: Accidental, though.