Although ''Webcomic/{{Femmegasm}}'' is a webcomic that references and borrows characters from many different types of media, the main focus is on the daily life of a group original characters. Some information about the leading cast can be found below.

!June July
One of the two leading females. She's impulsive Golden Lion Tamarin (a breed of monkey).
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* AbhorrentAdmirer: To Pembroke.
* AlliterativeName: June July
* CasanovaWannabe: June, in a rare female variety. Most people don't find monkeys with a large amount of distressingly long, thick body hair attractive, which means her attempts to get laid pretty much always end in rejection. [[spoiler: Well, [[ButLiquorIsQuicker there was that one time...]] ]]
* PutOnABus: She [[spoiler:quit the comic with Shelly]] in November 2011...
** TheBusCameBack: ...but came back in September 2012, determined to [[spoiler:take back their Main Character status by force if necessary]].

!Shelly Mander
The other main female character of the series. She's a naive Axolotl (a breed of salamander).
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* GogglesDoNothing
* HealingFactor: As an Axolotl, Shelly can regenerate all sorts of injuries, including lost appendages and parts of her brain. And as a cartoon character, can even recover from lethal ones. She's survived beheading, headshots, dismemberment, and ''being eaten and digested'', among other things.
* InnocentFanserviceGirl
* NonMammalMammaries: Zig-zagged. Her chest has a breast-like appearance, but given that she has mentioned having a cloaca, it is possible that she doesn't have actual nipples.
* PutOnABus: She, with June, [[spoiler:quit the comic]] in November 2011...
** TheBusCameBack: ...and came back in September 2012.
* SpeciesSurname: She's a breed of sala-Mander.

!Pembroke W. Korgi
The most important (and only) lead male character. Somewhat of an AuthorAvatar, but there are quite a few differences between the two. Mainly the facts that the artist isn't single, isn't homeless, and isn't a lizard.
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* ButtMonkey: A common punchline is the other cast members finding some way to abuse him.
* ADayInTheLimelight: He took center stage in January 2012 and left in June 2012, thanks to June and Shelly's departure and [[spoiler:Jazzy accidentally sending him to the underworld]], respectively.
* SpeciesSurname: Subverted, as he's named after a dog but his actual species is a reptile.

!Daisy
A female dachshund that's friends with the main cast. Her tendencies to act shy and withdrawn are usually played for laughs. She started out as a minor character, but eventually became one of the main characters, especially once June and Shelly left.
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%%no-context example* LovableCoward
%%no-context example* ShrinkingViolet

!Jennifur
A character imported from past comics by the author. She's an anthropomorphic mouse with blonde hair that runs the 'Bar None' tavern. Has been in cahoots with "Sparkles" for some time, and a recent story arc reveals that they used to be a couple in high school.
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%%no-context example* ButchLesbian

! Jimmy D. "Sparkles" Williams
A bombay cat, and the closest thing the comic's had to a BigBad thus far. Claims that his original goal was to get revenge on June for her actions in high school, but had to change it to stopping both June and Shelly from completely ruining Femmegasm. [[spoiler:Which was complete bullshit, but it got the girls to leave]].
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* TheBadGuyWins: Sparkles was last seen [[spoiler:drinking alcohol on the side of the street, resigned to the fact that he'll never be the star, but happy that at least June and Shelley lost their stardom thanks to him]].
* EmbarrassingNickname: Thanks to June causing a bucket of glitter to fall on him during high school.
* FourthWallObserver: Thanks to the author posting a photo of his real life inspiration on the blog.

! Jazzy Drive
A dog demon that, like Jennifur, originated in [[Webcomic/ImpyAndAevy a previous comic series]]. In the next-to-final story arc (Jan 2012 - June 2012), she offered free housing to Pembroke and Daisy in order to deal with her loneliness.
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%%no-context example* GenkiGirl
%%no-context example* InnocentFanserviceGirl
* MarshmallowHell: Given to [[http://www.aorange.com/?p=1597 Daisy]].
* StepfordSmiler: Revealed in [[http://www.aorange.com/?p=1605 this]] comic.