!!Vincent Law[[spoiler: /Ergo Proxy]]
->Voiced by Creator/KojiYusa (JP), Creator/LiamOBrien (EN)
Vincent Law is one of the main characters of the anime. At the beginning of the series Vincent is portrayed as a unimpressive immigrant technician from Mosk whose main goal is becoming a "Fellow Citizen" of the utopian city Romdeau. Vincent is forced into exile from Romdeau following criminal accusations into the desolate tundra of post-apocalyptic Earth. During the series he is joined by the child "AutoReive" Pino and the Intelligence Bureau investigator Re-L Mayer to uncover his past and his relationship to the titular Ergo Proxy.
[[caption-width-right:350:Vincent Law]]
* AchillesHeel: [[spoiler: As a Proxy Vincent is essentially indestructible to all forms of damage. There are really only two things that can kill a Proxy: FP weapons and UV radiation]]
* [[spoiler:AmnesiacGod]]
* AnguishedDeclarationOfLove: To Re-l Mayer
* AntiHero: He starts off as a weak-willed, low-status immigrant just trying to make good for himself.
* BadAss: He doesn't realize it for a long while, but once he does the gloves come ''off''.
** BadassCreed: Are the last lines of the series, but damn - it's a badass way to close a series.
--> '''Vincent''': "[[spoiler: I am Ergo Proxy - the agent of death.]]"
* [[spoiler:BecomeARealBoy]]: Like Pino in this respect [[spoiler: and also why he hopefully will also survive on contact with sunlight]].
* BewareTheNiceOnes: Vincent is even tempered, generous and kind to almost everyone he meets, until you threaten him or Pino.
* BerserkerTears: [[spoiler: Vincent is prone to these while in proxy form. Usually while killing another proxy.]]
* BrokenTears: Several times over the course of the series. Most noteable is when Vincent is lying on the ground weeping after Proxy One forces him to face the fact that he is a proxy.
* BungledSuicide: [[spoiler: Vincent attempts this by jumping from the dome exhaust pipe after being accused of treason, ending his goal of becoming a "fellow citizen".]]
* TheChosenOne: Hoody said that Vincent was this to the rest of the commune dwellers when they started to suspect him. [[spoiler: Then it ended up sort of being true...]]
* DarkAndTroubledPast: [[spoiler: As Ergo Proxy he constructed the Romdeau Dome only to abandon it to live with his lover, Monad Proxy.]]
* {{Determinator}}
* DoomMagnet: [[spoiler: Well, he is the agent of death.]]
* EyesAlwaysShut: Starts out this way, but they open after he becomes less meek.
* FanservicePack: Over the course of the series, he gets better looking and even seems to grow several inches taller.
* [[spoiler: GlowingEyesOfDoom:As Ergo Proxy]]
* GreenEyes: [[spoiler:When he finally opens them in episode three.]]
* HorrifyingHero: [[spoiler: As Ergo Proxy he is often referred to as "a monster".]]
* ItSucksToBeTheChosenOne: [[spoiler: Vincent has the habit of getting everyone he cares about killed, since he is the agent of death.]]
* TheKirk: To Re-L's Spock and Pino's Mccoy.
* [[spoiler:JekyllAndHyde: Initially, Ergo Proxy comes across as his SuperpoweredEvilSide and is a distinct entity from the meek Vincent.]]
* MeaningfulName: "Vincent" derives from the Latin word "Vincere", to win.
* NiceGuy: Vincent is pretty much a overall decent person wanting to help everyone from infected Autoreives to snarky goth girls.
* PapaWolf: Do NOT mess with Pino. Seriously, don't.
* ProtagonistWithoutAPast: Vincent has no memories from his past life in Mosk.
* PsychoticSmirk:
* QuestForIdentity: [[spoiler: The middle section of the series focuses on Vincent regaining his lost memories by traveling to the Mosk Dome.]]
* [[spoiler:RealityWarper: Implied during the conclusion of the series finale.]]
* [[spoiler: ReallySevenHundredYearsOld: Ergo Proxy was responsible for the creation of the Romdeau dome, making him roughly a thousand years old.]]
* [[spoiler:SplitPersonalityMerge]]: Something like this at the end of the series [[spoiler: as he finally has both Ergo Proxy's powers and Vincent's personality.]]
* ScrewDestiny: [[spoiler: Vincent decides to continue to live in the world after the re-population of the earth, despite the fact that Proxies are now no longer useful and will be killed when exposed to sunlight. It is implied in the final episode that Vincent has somehow changed his physical composition to survive.]]
* [[spoiler:SuperpowerLottery: Ergo Proxy is essentially a demi-god possessing SuperStrength, SuperSpeed, NighInvulnerability, {{Shapeshifting}}, and {{Immortality}}.]]
* SurvivorGuilt: [[spoiler: Vincent is indirectly responsible for getting the entire population of The Commune killed.]]
* TookALevelInBadass: Several, even!
* WhatTheHellHero

!!'''Re-L Meyer'''

->Voiced by Rie Saito (JP), [[Creator/MeganHollingshead Karen Thompson]] (EN)
Re-L is a Intelligence Bureau investigator tasked with locating and destroying Cogito infected AutoReives. One night after leaving an ongoing investigation she is confronted by a "monster" in her apartment. After this event she is caught in a net of conspiracies around the Cogito Virus, the Domed Cities and the mysterious "Proxies". While investigating she joins with the exiled Vincent Law and self aware AutoReive Pino to expose the truth.

[[caption-width-right:350:Re-l Mayer]]
* ActionGirl: takes down infected Autoreivs with her signature shotgun, [[spoiler: she even able to kill a Proxy with FP bullet.]]
* [[spoiler:AmbiguouslyHuman: It is subtly implied throughout the series that Re-l may not be human, but a imperfect clone of Monad Proxy, which would explain Vincent's inherent attraction to her.]]
* AntiHero: She's a bit cold emotionally and has a definite mean streak, but there's no question she's one of the good guys.
* ArbitrarySkepticism: [[spoiler: She refuses to believe that Vincent is a Proxy until witnessing his transformation firsthand.]]
* BadassLongcoat: Arguably subverted; despite her competence at her job, she's nowhere near as badass as she presents herself, a fact that becomes apparent [[spoiler: after leaving Romdeau. This is bitterly lampshaded by Iggy after he contracts the Cogito virus, when he [[TheReasonYouSuckSpeech calls her out]] on acting like a badass government agent when she's really kind of a spoiled brat. Just how accurate this is is ambiguous, however; it could just be the rantings of a wounded friend taken for granted for too long.]] And despite all that, she still remains tough as nails throughout ensuing events.
* BadassNormal:
* {{The Comically Serious}}
* DeadpanSnarker
* [[spoiler:DecoyProtagonist: Re-L is initially portrayed as the protagonist of the series by most of the promotional material, by episode four she is demoted to supporting character.]]
* DefrostingIceQueen: Hell of a slow thaw, though.
* EeriePaleSkinnedBrunette: Everyone else has normal skin tones, whereas Re-l is straight black and white.
* EmotionlessGirl: mild example, she has the tendency to be angered easily.
* {{Good is Not Nice}}: Vincent is well aware of this.
* {{Goth}}: She's something of a [[DeadpanSnarker snarky]], gloomy goth, dressing in all black and wearing lots of eyeshadow.
* ExcessiveEvilEyeshadow: Re-l isn't evil, but you couldn't tell that by looking at her.
* HotBlooded: Especially when compared to the rest of the citizens of Romdo.
* IcyBlueEyes:
* IntelligenceEqualsIsolation: She chafes at Romdeau, where much of the human population are so coddled and helpless that they're effectively automata.
* [[spoiler: FakingTheDead: Re-l fakes her death at the hands of Cogito infected Autoreivs, so that she can sneak out of Romdeau to pursue Vincent and uncover his connection with the Proxies.]]
* GreatDetective: Re-L works as a detective of the Romdeau Intelligence Bureau.
* JerkWithAHeartOfGold: She initially comes off as cold and arrogant, especially towards Vincent, but goes out of her way to rescue him.
* KissOfDistraction: She uses this on Vincent to distract him from the pistol loaded with [[spoiler: Proxy killing FP bullets]]
* MasculineGirlFeminineBoy: Re-L to Vincent
* MercyKill: [[spoiler: She kills the decapitated Cogito infected Iggy.]]
* MsFanservice: Not as much as other female characters in anime, but is particularly prominent when [[spoiler:Ergo Proxy has flashbacks of their first meeting in her bathroom.]]
** Of course, given that [[spoiler: the flashback is from his POV, it's combined with MaleGaze.]]
* Nepotism: Since her grandfather is the Regent Re-L is given a great deal more liberty than you're average citizen, [[spoiler: that is until her grandfather decides she's disobeyed him too many times and decides to have her assassinated.]]
* RuleAbidingRebel: All Re-L does is complain about the monotony of her dystopian city, but does nothing to change it.
* ScrewTheRulesImDoingWhatsRight: Re-L ignores her orders to end her investigation of the Proxies.
* SeekerArchetype: Re-l becomes obsessed with uncovering the nature of Proxies to the point that she is willing to discard her previous life.
* TheSpock: Re-L is rational and skeptical, playing off of Pino's childlike naivety.
* SpoiledBrat: She's the granddaughter of the regent and she has no qualms about using it to her advantage.
* SuperOCD: It's been speculated that Re-l might have OCD, judging from the way she conducted an earlier investigation of Vincent's room (she lined up a cup on a stand in the mirror image of another) and the way that she behaved in episode 16. However, the former case could be the result of years of strict government training and the latter a result of CabinFever.
* SweetTooth: She has a thing for ginger ale.
* {{Tsundere}}: towards Vincent Law. At the beginning of the series she doesn't pay any attention to the lowly immigrant, [[spoiler: once she learns his true nature o she frequently abuses him by to test the extent of his power.]]
* UnresolvedSexualTension: Towards Vincent Law
* UsedToBeASweetKid: Judging from some old videos from Daedalus, Re-l seemed to be pretty cheerful growing up. Then she just became... [[{{Goth}} gloomy.]]
* WeaponOfChoice: Her signature pump-action shotgun.
* [[WellDoneSonGuy "Well Done, Granddaughter" Chick]]: In the end, Re-l just wants her grandfather's love and recognition.
* WhenSheSmiles: At the end of episode 16, upon seeing Re-l give a true smile, Vincent is seen blushing.

->Voiced by Akiko Hajima (JP), Rachel Hirschfeld (EN)
Pino is one of the three main characters of Ergo Proxy. Pino is a "companion-type AutoReive" designed to act as a surrogate daughter to residents of Romdo who are prohibited from rearing children. During the course of the show Pino becomes infected with the Cogito Virus which gives her a consciousness and full range of emotions, as such Pino often behaves like a normal (if not hyperactive) young girl.

* [[BecomeARealBoy Become A Real Girl]]: See MeaningfulName. It's kind of implied that this does happen in a literal sense, and it's necessary for the series to have a happy ending of any kind [[spoiler: as otherwise, she'd be killed by ultraviolet light like all autoreives]].
* CheerfulChild: Throughout the series she's always optimistic regardless of the situation.
* CreepyChild: Before Character Development.
* CuriousAsAMonkey:
* TheMcCoy: She is childish and emotional in contrast to Re-L's stoic rationalism.
* MeaningfulName: She shares a name with Pino of ''Manga/BlackJack'', and for both of them the name alludes to Literature/{{Pinocchio}} and their status as an artificial child.
* PleaseWakeUp: [[spoiler: Can't understand that her friend Timothy has died.]]
* ThePollyanna:
* RobotGirl: She is a companion AutoReiv designed to be a couples surrogate child.

->Voiced by Kiyomitsu Mizuuchi (JP), Creator/TravisWillingham (EN)
Iggy is a supporting character within the series. Iggy is Re-L's loyal robotic entourage who acts as a personal assistant when she works as an inspector with the Bureau of Intelligence.
* [[spoiler: AIIsACrapshoot: DoubleSubverted. He gets infected with the Cogito virus when [[OffingTheOffspring Romdeau's ruler sics his Autoreivs on Re-L,]] but actually keeps his sanity for a time. Then Re-L orders him to go back to Romdeau on his own, [[SanitySlippage at which point it kicks in for real.]]]]
* [[spoiler: AlasPoorScrappy: InUniverse. Re-L clearly doesn't like being around him for much of his screentime, on account of believing him to be JustAMachine and her [[ArchnemesisDad grandfather's spy.]] It's only after [[WhatTheHellHero he rails on her]] [[AIIsACrapshoot under the effects of the Cogito virus,]] and has to [[ICannotSelfTerminate be put down]] [[DeathEqualsRedemption after saving her life]] that she shows any sincere affection towards him.]]
* [[AmbiguouslyGay Ambiguously Gay.]] Later episodes reveal that Re-l deliberately chose him to sound this way.
* JekyllAndHyde: [[spoiler: [[ICannotSelfTerminate As he lays dying in Re-L's lap,]] he continually shifts between his [[NiceGuy old personality,]] who [[TearJerker begs Re-L to forgive]] [[MyGodWhatHaveIDone him and not to hate him,]] and his [[{{Jerkass}} Cogito]] [[{{Yandere}} infected]] [[MoodSwinger self,]] who angrily [[NeverMyFault blames her for getting him killed.]] The possible implication being that even after developing sentience, it was the [[GollumMadeMeDoIt Cogito infection causing him to attempt his kidnapping and murder]] [[TragicMonster not Iggy]]]]
* JerkassHasAPoint: [[spoiler: Subverted. [[SanitySlippage After completely losing it,]] he chews out [[WhatTheHellHero Re-L essentially for thinking herself more Badass than she really is]], but whether one agrees with him or not, his "plan" [[WhatAnIdiot (consisting of dragging Re-L back to Romdeau, where she'll likely be arrested and/or executed,]] [[ItCanThink and he'll likely be decomissioned for being infected)]] [[StepThreeProfit is so unbelievably half-baked,]] that his only response is to ignore Re-L for calling him out on it. [[MoralEventHorizon And that's not even getting into]] [[MurderTheHypotenuse trying to kill Vincent]] to keep Re-L for himself, basically decimating whatever point he could possibly have.]]
* [[spoiler:KilledOffForReal]]
* NiceGuy: [[{{Camp}} Peppy]], supporting, optimistic, and [[BigBrotherInstinct protective]], hard to see why [[JerkWithAHeartOfGold Re-L dislikes him at first.]] [[spoiler: [[AIIsACrapshoot Until]] [[SanitySlippage later]] [[TookALevelInJerkass that is.]]]]
* TheWatson: Iggy acts as this to Re-L during her time as a inspector.
* [[spoiler: {{Yandere}}]]: Becomes this later in the series [[spoiler: after getting the Cogito Virus]].

!!'''Raul Creed'''
->Voiced by Hikaru Hanada (JP), Creator/PatrickSeitz (EN)
* AntiHero: He means well. Really.
* [[spoiler:AxCrazy: Post SanitySlippage.]]
* BadassLongcoat
* {{Break the Haughty}}
* DarkMessiah:
* DeadpanSnarker
* {{Determinator}}
* InspectorJavert: Shades of it anyway.
* ItsPersonal: [[spoiler: Blames Vincent Law for the death of his wife and infant son.]]
* [[spoiler:KilledOffForReal]]: Gets shot by Real/Monad Proxy and then is killed by being impaled on broken glass.]]
* NietzscheWannabe
* NeverGotToSayGoodbye: [[spoiler: To his surrogate Autoreive daughter Pino.]]
* [[spoiler:SanitySlippage]]
* {{Tall Dark and Snarky}}
* TheStoic: Until [[spoiler: he goes [[Main/{{AxCrazy}} completely insane]]. ]]
* WellIntentionedExtremist: Starts as this. [[spoiler: [[MotiveDecay Descends into a]] WoobieDestroyerOfWorlds, before [[HeelRealization coming to his senses]] [[AlasPoorVillain in his final moments.]]]]

!!Daedalus Yumeno
->Voiced by Creator/SanaeKobayashi (JP), Creator/YuriLowenthal (EN)
* CreepyMonotone
* [[spoiler:KilledOffForReal]]
** [[spoiler: DroppedABridgeOnHim]]
* MadScientist:
* MeaningfulName: Named after the Greek mythological figure Daedalus, the expert craftsmen who constructs paper wings for him and his son, Icarus. [[spoiler: This is referenced in the series finale when Real/Monad Proxy flies towards the sun to commit suicide.]]
* NotGoodWithRejection: Re-L [[spoiler: and her clone Real]] choosing Vincent over him.
* StalkerWithACrush: Towards Re-L, [[spoiler:even going so far as to create a human-Proxy hybrid clone of her all for himself.]]
* ThePeepingTom: Possesses numerous recording of Re-L throughout her life.
* {{Yandere}}: Towards Re-L

!!'''[[spoiler: Proxy One]]'''
->Voiced by Creator/HochuOtsuka (JP), Creator/DameonClarke (EN)
* BigBad
* LargeHam
* GreyAndGrayMorality / EvilVersusEvil: [[spoiler: He's pretty much responsible for much of the story's events, and ultimately, Romdeau's destruction, but everything he's done is in retaliation for what the [[HumansAreBastards Crea]][[BiggerBad tors]] [[WhatTheHellHero have done]] [[YouHaveOutlivedYourUsefulness and are planning to do.]]]]
* KillAllHumans:
* TheManBehindTheMan
* ManipulativeBastard
* {{Ubermensch}}: Fits the bill. [[spoiler: He was created to heal the planet Earth, and then die so that it would be handed over to his Creators. Proxy One essentially decided "Fuck that", and instead rejected their plans and ideals, opting to create a proxy who could survive sunlight i.e. Ergo Proxy, both to ensure at least one Proxy survived the genocide, and as a big, fat screw you to the Creators.]]
* WoobieDestroyerOfWorlds: [[spoiler: He's part of a species of immortal demigods who are intended to [[YouHaveOutlivedYourUsefulness self-destruct when planet Earth heals up,]] as [[UngratefulBastard thanks for having fixed the mess their creators started in the first place.]] [[TurnedAgainstTheirMasters Understandably, he's a]] [[RageAgainstTheHeavens bit upset.]]]]
!!Monad Proxy
->Voiced by Creator/ SachikoKojim(JP), Creator/CarrieSavage(EN)
* WingedHumanoid