!!Vincent Law
->Voiced by KojiYusa (JP), Creator/LiamOBrien (EN)
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* [[spoiler:AmnesiacGod]]
* AntiHero: He starts off as a weak-willed, low-status immigrant just trying to make good for himself.
* BadAss: He doesn't realize it for a long while, but once he does the gloves come ''off''.
** BadassCreed: Are the last lines of the series, but damn - it's a badass way to close a series.
--> '''Vincent''': "[[spoiler: I am Ergo Proxy - the agent of death.]]"
* [[spoiler:BecomeARealBoy]]: Like Pino in this respect [[spoiler: and also why he hopefully will also survive on contact with sunlight]].
* BewareTheNiceOnes
* BerserkerTears: Vincent is prone to these while in proxy form. Usually while killing another proxy.
* BrokenTears: Several times over the course of the series. Most noteable is when Vincent is lying on the ground weeping after Proxy One forces him to face the fact that he is a proxy.
* TheChosenOne: Hoody said that Vincent was this to the rest of the commune dwellers when they started to suspect him. [[spoiler: Then it ended up sort of being true...]]
* {{Determinator}}
* DoomMagnet: [[spoiler: Well, he is the agent of death.]]
* EyesAlwaysShut: Starts out this way, but they open after he becomes less meek.
* FanservicePack: Over the course of the series, he gets better looking and even seems to grow several inches taller.
* HorrifyingHero
* TheKirk
* [[spoiler:JekyllAndHyde: Initially, Ergo Proxy comes across as his SuperpoweredEvilSide and is a distinct entity from the meek Vincent.]]
* NiceGuy
* PapaWolf: Do NOT mess with Pino. Seriously, don't.
* [[spoiler:SplitPersonalityMerge]]: Something like this at the end of the series [[spoiler: as he finally has both Ergo Proxy's powers and Vincent's personality.]]
* TookALevelInBadass: Several, even!

!!'''Re-L Meyer'''
->Voiced by Rie Saito (JP), [[MeganHollingshead Karen Thompson]] (EN)
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* ActionGirl
* AntiHero: She's a bit cold emotionally and has a definite mean streak, but there's no question she's one of the good guys.
* BadassLongcoat: Arguably subverted; despite her competence at her job, she's nowhere near as badass as she presents herself, a fact that becomes apparent [[spoiler: after leaving Romdeau. This is bitterly lampshaded by Iggy after he contracts the Cogito virus, when he [[TheReasonYouSuckSpeech calls her out]] on acting like a badass government agent when she's really kind of a spoiled brat. Just how accurate this is is ambiguous, however; it could just be the rantings of a wounded friend taken for granted for too long.]] And despite all that, she still remains tough as nails throughout ensuing events.
* {{The Comically Serious}}
* DeadpanSnarker
* DefrostingIceQueen: Hell of a slow thaw, though.
* EeriePaleSkinnedBrunette: Everyone else has normal skin tones, whereas Re-l is straight black and white.
* EmotionlessGirl
* {{Good is Not Nice}}
* {{Goth}}: She's something of a [[DeadpanSnarker snarky]], gloomy goth, dressing in all black and wearing lots of eyeshadow.
* IntelligenceEqualsIsolation: She chafes at Romdeau, where much of the human population are so coddled and helpless that they're effectively automata.
* JerkWithAHeartOfGold
* MsFanservice: Not as much as other female characters in anime, but is particularly prominent when [[spoiler:Ergo Proxy has flashbacks of their first meeting in her bathroom.]]
** Of course, given that [[spoiler: the flashback is from his POV, it's combined with MaleGaze.]]
* TheSpock
* SuperOCD: It's been speculated that Re-l might have OCD, judging from the way she conducted an earlier investigation of Vincent's room (she lined up a cup on a stand in the mirror image of another) and the way that she behaved in episode 16. However, the former case could be the result of years of strict government training and the latter a result of CabinFever.
* {{Tsundere}} or SugarAndIcePersonality
* UsedToBeASweetKid: Judging from some old videos from Daedalus, Re-l seemed to be pretty cheerful growing up. Then she just became... [[{{Goth}} gloomy.]]
* [[WellDoneSonGuy "Well Done, Granddaughter" Chick]]: In the end, Re-l just wants her grandfather's love and recognition.
* WhenSheSmiles: At the end of episode 16, upon seeing Re-l give a true smile, Vincent is seen blushing.


!!'''Pino'''
->Voiced by Akiko Hajima (JP), Rachel Hirschfeld (EN)
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* [[BecomeARealBoy Become A Real Girl]]: See MeaningfulName. It's kind of implied that this does happen in a literal sense, and it's necessary for the series to have a happy ending of any kind [[spoiler: as otherwise, she'd be killed by ultraviolet light like all autoreives]].
* CreepyChild: Before Character Development.
* TheMcCoy
* MeaningfulName: She shares a name with Pino of ''Manga/BlackJack'', and for both of them the name alludes to Literature/{{Pinocchio}} and their status as an artificial child.
* RobotGirl

!!'''Iggy'''
->Voiced by Kiyomitsu Mizuuchi (JP), Creator/TravisWillingham (EN)
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* [[AmbiguouslyGay Ambiguously Gay.]] Later episodes reveal that Re-l deliberately chose him to sound this way.
* [[spoiler:KilledOffForReal]]
* [[spoiler: {{Yandere}}]]: Becomes this later in the series [[spoiler: after getting the Cogito Virus]].

!!'''Raul Creed'''
->Voiced by Hikaru Hanada (JP), Creator/PatrickSeitz (EN)
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* AntiHero: He means well. Really.
* [[spoiler:AxCrazy: Post SanitySlippage.]]
* BadassLongcoat
* {{Break the Haughty}}
* {{Cry for the Devil}}
* DarkMessiah
* DeadpanSnarker
* {{Determinator}}
* InspectorJavert: Shades of it anyway.
* ItsPersonal
* [[spoiler:KilledOffForReal]]
* NietzscheWannabe
* [[spoiler:SanitySlippage]]
* TheStoic: Until [[spoiler: he goes [[Main/{{AxCrazy}} completely insane]]. ]]
* {{Well Intentioned Extremist}}

!!Daedalus Yumeno
->Voiced by Creator/SanaeKobayashi (JP), Creator/YuriLowenthal (EN)
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* CreepyMonotone
* CrossDressingVoices: He's voiced by a woman in the Japanese, German, ''and'' French dub of the series.
* [[spoiler:KilledOffForReal]]
** [[spoiler: DroppedABridgeOnHim]]
* MadScientist
* StalkerWithACrush
* {{Yandere}}


!!'''[[spoiler: Proxy One]]'''
->Voiced by HochuOtsuka (JP), DameonClarke (EN)
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* BigBad
* LargeHam
* TheManBehindTheMan
* ManipulativeBastard
* {{Ubermensch}}
* WoobieDestroyerOfWorlds
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