!!Hayden Tenno
An employee of the Agency who gets virus powers.

* BadassNormal: Before the transformation.
* BarrierWarrior
* CursedWithAwesome: Subverted. Though it appears that he likes these powers, he notably does ''not''.
-->'''[[spoiler:Nadia]]''': I'm sorry, I did this to you.
-->'''Hayden''': No, Mezner was right. I deserve this.
* DarkAndTroubledPast
* DeadlyDisc: The Glaive, which is Hayden's first Technocyte-induced superpower.
* FeelsNoPain: Has congenital analgesia, which is why [[TraumaticSuperpowerAwakening being corrupted by the Technocyte virus]] does not affect his sanity. [[SubvertedTrope He does show pain visibly]] at various points in the game, so it's likely that he's simply ''indifferent'' to pain rather than being ''insensitive'' to it. He still feels pain, he just doesn't register it the same way most people do.
* {{Invisibility}}

!!Robert Mezner
The main antagonist.

* AxCrazy
* BigBad

!!Nadia Sudek
Works for Mezner.

* DoubleWeapon
* TheDragon
* SamusIsAGirl: [[spoiler:She is Nemesis]].
* RedemptionEqualsDeath: [[spoiler:Sort of, as she does die as she is apologizing.]]
%%* WalkingSpoiler: Notice how all her trope entries are spoilers? Yeah.

!!Yargo Mensik
A sleeper agent stationed in Lasria.

* DarkAndTroubledPast: [[spoiler:His daughter died while treating people infected with the Technocyte virus. Yargo wants to avoid another outbreak however possible.]]