* ''VideoGame/{{Whiplash}}'', where the protagonists are animals escaping from a MegaCorp Testing Facility. The two characters, Spanx (a brain-fried weasel) and Redmond (a DeadpanSnarker rabbit who also happens to be NighInvulnerable due to chemical tests) are chained together, with Spanx using Redmond [[GrievousHarmWithABody as a flail]].
* A similar game mechanic was used in ''VideoGame/CrashTwinsanity'', where Crash and Cortex can latch on to a crystal and Crash can drag Cortex around the level, using him as a mallet and occasionally flinging him across gaps to trigger switches and whatnot.
* ''VideoGame/DivineDivinity'''s sequel ''VideoGame/BeyondDivinity'' uses the trope as its premise the protagonist becomes forced into {{Synchronization}} with a stereotypically villainous BlackKnight by a demon, and they work together with the shared goal of not only separating themselves from their rather disliked counterparts, but to get back at the demon who did it to them.
* In ''[[VideoGame/TheLegendOfSpyro The Legend of Spyro: Dawn of the Dragon]]'', Spyro spends the entire game chained to [[HeelFaceTurn former nemesis]] Cynder. From a gameplay perspective, the main purpose of the chain is to allow co-op play without splitting the screen. However, the chain is also used to solve certain puzzles (for example, one dragon grabs onto a wall and the other dragon swings on the chain to get higher; or one dragon grabs onto a raft while the other dragon flies ahead, pulling the raft forward).
* Though the 'chains' in this case are not physical, Bastila treats being forced to go off on a mission that would require spending time with the player character like this in ''VideoGame/KnightsOfTheOldRepublic''.
* Not so much chained but part of a gameplay mechanic of ''VideoGame/KnucklesChaotix'' revolves around something like this.
* In ''VideoGame/TheWorldEndsWithYou'', Neku becomes spiritually chained to different partners throughout the game. While there is nothing physically forcing them to stay together, the [[{{Mook}} Noise]] they encounter along the way can only be defeated by two people working together.
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