* Used in TheSimpsons comic book. After WorkingOnTheChainGang, Sideshow Bob and Bart escape, chained together at the ankle. And while Bob tries to kill his long-time nemesis, Bart is GenreSavvy enough to point out that if Bob kills him while they're chained together, he'll have to drag Bart's body around as dead weight, and he'll be caught for sure. This forces Bob to keep Bart alive until he can break the chain.
* Piper and Trickster, a pair of semi-reformed DCComics supervillains, were handcuffed together after being arrested for complicity in the death of Flash. They escaped, but were unable to remove the handcuffs. The twist is that Piper is gay, and Trickster is, well, slightly homophobic.
** Slightly? Constantly making gay jokes is more like it. Near the end of the storyline, it seems like it's going to become Canon HoYay [[spoiler: just before Trickster does a HeroicSacrifice and jumps in front of a bullet aimed for Piper. Poor Piper then drags Trickster's body around with him for days for before giving in to necessity and cutting the corpse's hand off.]]
** WordOfGod claims that the storyline was [[FollowTheLeader intentionally based]] off of ''The Defiant Ones''.
* Hammer and Anvil are two villains in MarvelComics, one black and one white, connected with an alien device that gives them superpowers. Clearly inspired by the source material.
* The ''ComicBook/NintendoComicsSystem'' story ''[[http://www.smbhq.com/users/comics/smbf6.gif The Buddy System]]''.
* Spencer Smythe was a ''{{Spider-Man}}'' villain, who was hired by J. Jonah Jameson to create robots to catch Spider-Man. When he got fatal radiation poisoning because of his work, he blamed both Jameson and Spider-Man, and handcuffed the two of them together with a bomb scheduled to detonate in 24 hours.
* The ''MetalMen'' (except Tin) were once bound with a giant chain by evil robots. The chain is impossible to escape, even with their shapeshifting powers, as it expands and contracts with their every movement. Doc Magnus is especially unhappy to be chained to Platinum, as she's pretty much obsessed with him.
* A chainless variant appeared in ''ComicBook/{{Thunderbolts}}'', when Hawkeye, Plant Man, Headlok, and Cottonmouth escape from a prison truck. They're forced to stay very close to one another because of the bracelets on their arms, which will explode if they get a certain distance from one another. Cottonmouth, who is cannibalistic and part snake, tries to get around this at one point by killing the others as they slept, then chewing their arms off. Don't worry, he got caught in the act before anybody got hurt.
* At the end of Issue #2 of ComicBook/WWESuperstars, ProfessionalWrestling/JohnCena and ProfessionalWrestling/RandyOrton are seen tied together, and the first thing they say is "I hate you."
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