* In ''TabletopGame/{{Deadlands}}'', the Whateley family tree seems to drop nothing but bad apples. Part of the reason for this is the "selective breeding" instituted by the clan's [[TheLegionsOfHell otherworldly]] patron. Most of the residents of [[MeaningfulName Gomorra]], California can't figure out exactly what the relationship is between Nicodemus and Delores Whateley. Some think they're siblings. Some think they're married. Both are right. {{Squick}}. (Bonus prize: reading the Whateley Family Bible, complete with a family tree in the front, has driven some folks [[BrownNote insane]].)
* ''TabletopGame/DungeonsAndDragons''
** In the TabletopGame/{{Ravenloft}} supplement ''Dark Tales & Disturbing Legends'', a highborn woman magically transforms herself into the guise of her brother's bride so he won't "pollute" their bloodline with a commoner wife. [[spoiler: This being Ravenloft, the brother has his own twisted plans, so her deceit comes back to bite her.]]
** In the Edition 3.5 manual ''Exemplars Of Evil'', among the featured villains are the Tolstoff siblings, Edgar (an insane [[BodyHorror cancer mage]]) and Katharin (a [[TheVamp seductive enchantress]]), who serve an EldritchAbomination known as [[TheWormThatWalks Kyuss]] and, more concretely, their SealedEvilInACan grandfather who promised them to protect their forbidden love if they could help him out of his confinement. Their desperate love for each other would make them pitiable and somewhat sympathetic, if it weren't for [[SelfMadeOrphan the extremes]] [[MoralEventHorizon they are willing]] [[ImAHumanitarian to sink to]].
** In later versions, the principal draconic deities are Tiamat the Dragon Queen and her brother Bahamut. Tiamat is the goddess of evil dragons and Bahamut is the god of good dragons. They are fierce enemies, but Tiamat's hatred for her brother has developed into a depraved lust over the thousands of years they've been fighting. The feeling isn't mutual, however.
** In the TabletopGame/{{Eberron}} campain setting the god known as the Devourer raped his sister Arawai resulting in the birth of the goddess known as the Fury.
* ''TabletopGame/{{Warhammer}}''. Sigvald the Magnificent, a {{bishonen}} champion of Slaanesh, was born from a depraved Norscan chief turning his attentions towards his own sister. [[TheHedonist His life has only followed the trend set by his father]], though he far exceeds him -- his old man wanted to exile him from the tribe because, to the old man's disgust, Sigvald [[ImAHumanitarian enjoys the taste of human flesh]].
* ''TabletopGame/HollowEarthExpedition'' supplement ''Mysteries of the Hollow Earth''. In the city of El Dorado, the royal family are all descended from the Sun God. It is common for brothers and sisters to marry each other and have children to preserve their bloodline.