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* A rather unique example happens in the game ''VideoGame/{{Portal}}'', where [=GLaDOS=] might have been modeled after a bound and gagged woman hanging upside down (as demonstrated [[http://www.game-ism.com/2008/04/04/still-alive-shes-free/ in this fan art]]), making her even creepier.
** ''Portal 2'' revealed that this is very likely true: [=GLaDOS=] was formerly the secretary of the man who founded Aperture Science, whose dying wish was to have her [[BrainUploading brain uploaded]] into the computer mainframe so she could continue running the company in his stead. Some infamous DummiedOut dialogue suggests that this was done against her will.
* Princess Alexia from Alundra 2 is like this for almost a 1/3 of the game after she gets captured by the BigBad who plans to marry her against her will.
* Lan's teacher: Ms. Mari is bound and gagged by Higsby during the second act of VideoGame/MegamanBattleNetwork.
* Unusual for the ''VideoGame/{{Myst}}'' series, with its distinct lack of violence, in ''VideoGame/MystIV'', a preteen girl, Yeesha, is kidnapped and later seen, first in flashbacks and later in person, tied and strapped to a chair, with rope reinforcing the straps. In a flashback, she struggles mightily and appears to be crying. She's also played by a live action actress, due to the game's use of FMV crossed with prerendered backgrounds.
* ''VideoGame/GrabbedByTheGhoulies'' has so many tied up people scattered around the mansion in so many ways that it probably counts as FetishFuel. Tied in almost any method you can think of. [[http://img.jeuxvideo.fr/00155169-photo-grabbed-by-the-ghoulies.jpg Example 1]] [[http://xboxmedia.ign.com/xbox/image/ghoulies_052303_09_640w.jpg Example 2]] The game itself, however, was a massive flop.
* In ''VideoGame/MysticWarriors'' one of the five playable characters is captured and bound and gagged at the beginning of the game by the EvilCorporation.
* Happens at least once per game in the ''VideoGame/MonkeyIsland'' series...except for the first game. This is ironic because the first game actually centered around a kidnapping and subsequent rescue attempt.
* iPod Touch game ''Wild Wild Train'' features cutscenes telling a story of a damsel in distress. The cutscenes are done using actual photographs of actual actors playing the damsel, villain and hero, all of whom are silent film stereotypes. And the damsel is tied up and gagged and blindfolded, quite well. It's enough to make you wonder...
* Occurs near the end of ''Runaway: A Twist of Fate''. Gina (one of the playable characters) ends up bound and gagged by the BigBad; pretty standard, nothing really remarkable. However, something unusual happens when she escapes. Rather than taking off the gag completely, she takes it out of her mouth and wears it as a stylish neckerchief for the rest of the game. Fits in pretty nicely with the game's sense of humor.
* The fan RPGMaker game ''VideoGame/DIDNapper'' revolves around tying and gagging girls in a anime-style medieval setting.
** Unsurprisingly, Suki and Carol's cameo in ''VideoGame/RakenzarnTales'' also involves this happening to them.
* ''VisualNovel/AceAttorneyInvestigations'':
** After [[spoiler: being knocked out by the Proto Badget]], Miles Edgeworth wakes up locked in a small room and tied to a pole. While he's freed five minutes later by Kay, this scene spawned a lot of happy fangirls. This was after he was handcuffed when he's suspected of murder earlier that day. Poor guy.
** In the sequel, when [[spoiler:Yumihiko Ichiyanagi]] is kidnapped, he's bound hand and foot, gagged, and locked in a dark room at the back of a garage -- and this ''after'' being crammed into a box and thrown into the trunk of a car. It ''looks'' a little goofy (embarrassing if nothing else), but is treated as genuinely traumatic.
* In ''VideoGame/RedDeadRedemption'', you can lasso and hogtie bounty targets so you can bring them in alive. Or you can do it to anyone, just for fun. You get an achievement for killing a tied-up woman by leaving her on the train tracks, old-fashioned villain style, as seen [[http://www.youtube.com/watch?v=W8_Fm3XaTdI here]].
* In ''VideoGame/RuleOfRose'', this happens to Jennifer in an early part of the game as well as in the opening {{cutscene}}. The scene repeats itself much later in the game, except that this time Jennifer is also gagged with a fistful of red crayons.
-->'''Imps:''' A bright red crayon just for you! Lots and lots and lots for you!
* Early in ''VideoGame/WanderingHamster'', Bob gets tied up [[spoiler:by Skeppio and Rathmara]] to summon Jormungandling and kill him. They [[HopelessBossFight fail]] and Bob ends up [[WombLevel in his belly]].
* In ''VisualNovel/YoJinBo'', Mon-Mon asks you to tie Yo's hands so he doesn't thrash around [[spoiler: while he's sewing the gunshot wound closed]]. The result is very much DoesThisRemindYouOfAnything.
* Has happened to VideoGame/MaxPayne at least once in his career.
-->'''Max Payne:''' He had a baseball bat and I was tied to a chair. Pissing him off was the smart thing to do.
* In ''VideoGame/BatmanArkhamCity'', you find Harley Quinn tied to a pole and gagged close to the end of the game. You can ungag/gag her as many times as you want. You have to ungag her once to unlock a side-mission. After that, it's just for your own amusement and to hear her yell at you to stop doing that.
* Though not with the gag, [[VideoGame/BlazBlue Relius Clover]] during his Astral invoked this when used against some characters. Of course, this being [[MadScientist him]], it invoked a far worse image. The only person he ever gags was [[BadassGrandpa Valkenhayn]] and it was justified because restraining a werewolf without a gag is disastrous.
* Lance, more "gagged" than "bound", at Vivi's salon in ''VideoGame/BrainDead13''. And he will remain that way until you choose the facial.
* ''AtlantisTheLostTales'': Anna, when she is about to be sacrificed.
* ''VideoGame/BanzaiPecan'' has a level full of this.
* Happens to Jason and Grant in the beginning of ''VideoGame/FarCry3''.
* Carmelita Fox is sometimes shown to tied up throughout the ''Franchise/SlyCooper'' games. Of course, she is only seen gagged in the animated short ''Timing is Everything''.
** At one point in the third game, Murray is captured by General Tsao's mooks and tied to a bomb. He is saved by Penelope's RC.
* [[ThoseTwoGuys Cronk and Zephyr]] are tied together near the beginning of ''VideoGame/RatchetAndClankIntoTheNexus'' when taken captive. [[spoiler: They don't survive when the ship they are on is blown up]].
* in ''VisualNovel/SuperDanganRonpa2'', the fifth victim, [[spoiler:Nagito Komaeda,]] is found tied up and gagged with a piece of tape. The most bizarre part of it? [[spoiler: ''He did it to himself.'']]
* [[{{TheHero}} Nathan Drake]], when captured by Rameses and his crew, finds himself tied to a chair at the beginning of chapter 12 in ''VideoGame/Uncharted3DrakesDeception''. Using his fighting skills, he escapes. Sully gets tied up, as well, [[spoiler: though it was actually a dummy dressed like Sully being used to lure Nate into a trap]].
* Princess Monica Grania Bilseia in ''SuperRobotWarsGaiden'' is captured by Saphine Grace, who ties her up and gags her with a ball gag.