* There was a study in Russia of a man (left unnamed, referred to as Mr. X in the study) who had [[http://en.wikipedia.org/wiki/Hyperthymesia hyperthymesia]], meaning he was born [[PhotographicMemory without the ability to forget anything.]] Phone numbers, bank accounts, scripts and books, snippets of conversation, emotions both good and bad, sensations both good and bad... well, you get the picture. He was almost normal until his mid-20s, when the information overload started getting to him. He committed suicide at the age of 32.
** Jill Price is famous for having the same ability as the man above. Initially, the ability to remember everything in your life sounds tremendously useful. Teacher gives a lecture? Hey, no problem, you remember it! Unfortunately, it doesn't work that way. Jill's ability, as with most people who have this, is ''autobiographical memory only''. She can remember that on X date thirty years before she was sitting in a high-school class at 10:15 AM listening to a lecture on history. But she can't remember the lecture itself, she only remembers where she was, what she was doing, what she was wearing, etc. -- autobiographical information. Actual ''useful'' information? No.
* Cells in the body, for various reasons, can only divide a certain number of times; this is essentially why we age. But some cells are blessed with the ability to keep dividing forever! The downside? Well, they're called ''cancer'' cells.
** Henrietta Lacks found a way to live forever -- as a spreading strain of ''immortal'' human cells! Now the [=HeLa=] cells are seen as more of a nuisance since they're apparently all over the place -- and they like to corrupt other samples of other cells.
*** And note that even the 'found' part was much less cheerful then it sounds. Namely, Lacks got cancer, doctors took her cells for diagnosis, but ended up using them for extensive biological testing- ''without her permission''. She died in poverty, without ever knowing that her cell line was being used all around the world, often used to help develop very profitable drug.
* Al Yageneh went from one storefront to a nationwide franchise when his delicious soups were featured in an episode of ''Series/{{Seinfeld}}''. Unfortunately, because of that same episode, [[NeverLiveItDown Al Yageneh will forever be known as the Soup Nazi]]. It's apparently turned him into a semi-recluse.
* People with the rare condition CIPA: Congenital Insensibility to Pain, which essentially takes the form of a complete loss of the sense of touch. Can't feel heat or cold, aren't even slowed down by sucking chest wounds, pretty awesome crimefighting power right? Well, it would be if they [[RequiredSecondaryPowers also had a healing factor to go with it]]. As is, they risk permanently destroying their bodies at any time because they don't even notice it's hurt. Or that their hand in sizzling on the grill at the moment. Or that they haven't eaten in 5 days. Or that they need to ''pee''. On a hot day, they may pass out or even die because their body doesn't figure it should be sweating.
** There's an article on the NYT about [[http://www.nytimes.com/2012/11/18/magazine/ashlyn-blocker-feels-no-pain.html?hp&pagewanted=all a girl with CIPA]]. Imagine having a child who's chewed off part of her own tongue, or runs on broken ankles, or sits covered in biting ants. There's then an anecdote from an adult woman with CIPA whose pelvis ''shattered during childbirth'' and was bleeding internally, and only felt a kind of stiffness.
* Blood type Oľ: the universal donor, the [[InfinityPlusOneSword Infinity Plus One Blood]] of medicine. With it, you one can donate blood to anyone (barring the presence of extremely rare additional factors). Oh, and your body is only capable of receiving Oľ blood, nothing else, [[TooAwesomeToUse so hospitals can barely use the stuff in transfusions because they have to save it for Oľ patients.]] There is a ''small'' surplus of Oľ blood, thanks to generous Oľ donors who give more frequently and not so generous donors who realize it sells for more.
** On the other hand, blood plasma inverts the recipient/donor relationship. Oľ blood plasma can only be donated to other Oľ people and Oľ people can take blood plasma of any type. AB+ blood plasma becomes the universal donor and also can only take blood plasma from other AB+ donors. It's good to donate blood whatever your blood type is!
* Savant syndrome, in come cases. The notable being Kim Peek (the "real-life" basis for the RainMan).
* Having absolute pitch has a few downsides, leading some people to regard it as this. One twentieth-century musicologist actually tried to get rid of it, by playing the developments of Beethoven piano sonatas over and over in all possible keys.
** Relative pitch really helps when it comes to singing, especially from memory. It sucks whenever someone is singing around a person with relative pitch, and the singer is slightly (or not-so-slightly) flat or sharp. The person with relative pitch can ALWAYS tell.
* [[http://en.wikipedia.org/wiki/Lizzie_Vel%C3%A1squez Lizzie Velasquez]] is a woman who suffers from a rare disease called neonatal progeroid syndrome (NPS). She consumes as much as 8,000 calories a day, yet is still extremely thin at only 56 lbs (25.4 kg or 4 stone).
** [[http://en.wikipedia.org/wiki/Tom_Staniford Tom Staniford]] has a similar condition.
* [[http://en.wikipedia.org/wiki/Brooke_Greenberg Brooke Greenberg]] may hold the secret to immortality, or the very least how aging works. She has stayed the same physical and mental age for years. That age? 9 months to 1 year old.
** She passed away on October 23, 2013, so "holding the secret to immortality" is right out.
* There are genetic conditions which result in increased muscle mass in comparison to the general public. The downside? Your heart and lungs do not scale accordingly, putting constant increased stress on them, which guarantees a shorter life expectancy.
* Many animals experience this. Cheetahs are a particular example: [[FragileSpeedster They are extremely fast and agile, but give up virtually all their endurance and physical toughness]], so while it's relatively easy for them to catch a meal, keeping it is problematic. And they have to eat a LOT.
** Conversely, anacondas and other large constrictors can swallow prey as big as they are, and go for months without eating. The catch? They ''need'' that downtime in order to regenerate their stomach lining, which tears itself apart with ulcers trying to digest its meal before it starts rotting inside the snake.
** Flying is generally considered awesome. Unfortunately for the birds, this requires extensive adaptation with hollow, fragile bones, extensive lungs, and a hyperactive diet to fuel everything (sparrows are said to eat twentyfive times its own weight each day). They literally have no room for anything else but flying.
* Synesthesia. This is when peoples' senses are linked in intricate ways, like seeing a different colour every time you hear a different sound, or associating a certain emotion with a number. The variations are possibly endless. Sounds cool at first, but it can also be negative. For example, you might taste chocolate every time you saw the colour brown, but what if you associated it with poop instead?
* Louis Gossett Jr. said his Best Supporting Actor Academy Award (for ''Film/AnOfficerAndAGentleman'') ended up being this. Sure, an Oscar is a wonderful achievement for an actor, but Gossett said that it put him in acting limbo, since smaller productions didn't think they could afford him (since he's an Oscar winner) and big productions didn't think he could carry a movie on his own (since he won for ''Supporting'' Actor). A lot of Best Supporting Actor/Actress winners have trouble finding work afterwards.
* Sir Alec Guinness's work in ''StarWars''. He was perhaps the only person associated with the film, aside from George Lucas, who actually thought the film would be successful, but he never imagined it would become one of the biggest movies of all time, overshadowing the entire rest of his career to the point where he ended up equated in the popular consciousness exclusively with the character of Obi-Wan Kenobi. [[IAmNotSpock He was not happy about that bit.]]
* As anyone with hypersensitivity will tell you:SuperSenses = SensoryOverload = this trope.
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