* The Diablo Sauce in ''WesternAnimation/KimPossible'', which Ron uses packets of for hand warmers at one point. They're spicy enough to fry a robot's circuits.
* The Merciless Hot Pepper of Quetzalsacatenango, also known as the Guatemalan Insanity Pepper from ''WesternAnimation/TheSimpsons''. They're "grown deep in the jungle primeval by the inmates of a Guatemalan insane asylum." Homer has to lacquer his mouth and esophagus in order to eat one, and is ''still'' driven temporarily insane by its spiciness.
* Hermes from ''WesternAnimation/{{Futurama}}'', in the episode "The Six Million Dollar Mon", spilled a drop of sauce from his wife's spicy curry goat, and it ate its way through the dining-room table, the floor, two other residences underneath, and on down to Robot Hell, where it scalded the Robot Devil. [[BizarreTasteInFood Hermes himself thought it needed more hot sauce]].
** Fortunately, this ends up saving him later on in the episode; years of his wife's overly spicy cooking somehow made his ''skin'' extremely spicy, and when AxCrazy robot Roberto eats a piece... [[ImMelting he melts]].
* The Mexican Death Sauce from the missing ''WesternAnimation/BeavisAndButthead'' episode "Down Mexico Way".
** This one deserves expanding a bit. When in Mexico, our {{Anti Hero}}es decide to try the local cuisine. While waiting, they [[KickTheDog torment a dog]] by force-feeding it the bottle of "Killer Hot Sauce" on their table. This pisses off the Mexican cook, who reaches for the "Mexican Death Sauce" (which is in a bottle with smoke coming out of it) and puts it on their tacos. Cue FireBreathingDiner. (This scene even provides the page image for that trope.)
* The "Pure Jalapini Concentrate" Pete tried to use on Goofy in the 2-part opening of ''WesternAnimation/GoofTroop'', though it only succeeded in setting ''Pete's'' mouth on fire.
* On ''WesternAnimation/SpongeBobSquarePants'', Sandy threatens [=SpongeBob=] with a single drop of hot sauce to the tongue. A drop of hot sauce that talks.
-->''"By the powers of naughtiness, I command this particular drop of hot sauce to be really,'' really ''hot!"''
** After [=SpongeBob=] surrenders, she casually starts gulping the stuff down like it was lemonade.
* A staple for food-related pranks in ''WesternAnimation/LooneyTunes'' cartoons.
* As very spicy mustard (which features a different chemical than capsaicin to produce its spice) used to be much more common, some older works feature this instead of the modern hot sauce. ''WesternAnimation/TomAndJerry'' features this in several episodes.
** You can get very hot mustard as a condiment at your average Chinese take-out restaurant. WARNING: Do NOT eat more than a light glaze of this stuff on your food - unless you have a cold and you ''really'' want to clear out your sinuses.
** Very hot mustard is also commonly found in Russian cuisine. In Russia, you can buy this stuff in quite large jars cheaply.
* In ''WesternAnimation/AvatarTheLastAirbender'', Fire Nation fire flakes turn out to be, well, [[ExactlyWhatItSaysOnTheTin hot]], as Sokka finds out the hard way. [[BigEater Doesn't stop him from taking a liking to them, though.]]
** Mai can munch them down like popcorn!
* In ''WesternAnimation/MyLittlePonyFriendshipIsMagic'', Pinkie Pie apparently loves this. She likes to put it on ''cupcakes''. Her brand is so hot that, when Twilight Sparkle accidentally drank some, her tail and mane caught on fire.
** Pinkie Pie can't handle the spiciness of liquid rainbow (Yes, literal rainbows), however. She even breathes fire in several different colors!
* In the ''WesternAnimation/RockosModernLife'' episode "Flu-In-U-Enza," the [[MST3KMantra Enchanted Upchucks]] prepare a spicy concoction for Rocko to help him get better. It works.
* In the ''WesternAnimation/HeyArnold'' episode "On The Lam", Harold, Stinky, and Sid launch a rocket filled with vinegar, baking soda, and Stinky's bottle of Louisiana Hot Sauce, which they [[spoiler:believed to]] blow up an old police station with, when it was really [[spoiler:demolished by Ernie]].
* The "Honor Thy Ed" episode of ''WesternAnimation/EdEddNEddy'' starts with the Eds having set up a taco stand selling "tacos" made of paper plates, grass, and shredded crayons. After Ed, ExtremeOmnivore he is, eats several crayons thinking they are flavors, Edd humors him and takes a bite of one. He is disgusted and needs water, but the closest thing is Eddy's Brother's Armenian Secret Hot Sauce. He guzzles part of it and seems unfazed at first. Ed also consumes some. Eddy thinks the sauce didn't work and also eats some. It's at that moment the effect takes hold, however. We see a DiscretionShot from down the street as a tower of flame erupts from the stand and the Eds sticking their mouths on a sprinkler.
* "Grandpappy's Texas Tin-Horn Sizzlin' Salsa Sauce" in ''WesternAnimation/XiaolinShowdown''. Two bottles of it turn Dojo, a dragon who can normally only breath soot clouds, into a volcano.
* ''WesternAnimation/{{Chowder}}'' gets a whole episode based around this, considering it's a cartoon about food. The episode (aptly named "the Fire Breather") introduces the rarest and hottest peppers in the world, the Dancing Diablos. Peppers so hot that it turns your stomach into a furnace and makes you breath fire every time you open your mouth. Guess who decides to eat all of them?
-->Mung Dall: Chowder! Look what you did! [[MediumAwareness Now the animators have to draw all this fire!]]
* ComicStrip/{{Garfield}} had Grandma's sausage gravy in ''A Garfield Christmas''. It started out as Mom's normal gravy, but Grandma snuck in and added chili powder while whispering about how her gravy won first prize at the fair three years in a row while Mom's didn't even place. A bit later, Garfield comes in and gets some on his finger, then licks it. Cue the fire breath a second later, and then Garfield going "Perfect!".
** ''In Garfield and Friends,'' we see him using this on a horse named Certain Death.
* ''WesternAnimation/RegularShow'': When Mordecai and Rigby [[OfCorpseHesAlive try to pass off an unconscious Benson as awake]], they get him involved in a spicy food contest with a guy. Benson comes to just as the guy prepares a concoction he calls "Mississippi Queen", so he has Mordecai and Rigby drink it as well. At first they feel nothing, but suddenly start hallucinating and wake up the next morning in the park.
* ''WesternAnimation/TazMania'': In "Francis Takes a Stand", Francis switches Taz's lemonade recipe with a recipe for a Blazing Inferno Hellfire Sauce. Naturally, Francis ends up drinking more of the stuff than Taz does.
* ''WesternAnimation/{{Grossology}}'': Pink-Eye attempts to torture Lance Boil by force feeding 10 bottles of this stuff. It fails because Boil has replaced his stomach with an artificial digestive system.
* ''WesternAnimation/StormHawks'' gives us Skyside Shanty's signature extra potent, quadruple malt vinegar.
-->'''Junko:''' Kinda sour, but I like it.
-->'''Finn:''' What a shock.
* The super-hot chili peppers that prove to to be the best defence against the mutant raccoons in the ''WesternAnimation/CampLakebottom'' episode "High Plains Garbage Eater".
* In ''WesternAnimation/TheSmurfs'' episode "Gingerbread Smurfs", Brainy has Clumsy add volcanic lava juice to his recipe for making gingerbread cookies to make them really spicy. It is so powerful that it blows up the kitchen when it is added.
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