* ''Franchise/{{Pokemon}}'': the Spelon Berry; description: "So spicy is the Spelon Berry that, Fire type or not, Pokémon will try to breathe fire after eating a single one."
* The Jalapeņo in ''VideoGame/PlantsVsZombies'' can instantly burn all the zombies in a single lane.
* The curry item in ''VideoGame/SuperSmashBros Brawl'' (which technically made its debut in VideoGame/KirbysDreamLand) makes you spit fireballs that damage your enemies but not yourself. [[VideoGameCrueltyPotential Your character does a dance of pain while it's active, however...]]
* The original explanation for [[StreetFighter Dhalsim's]] fire-breathing abilities was that he ate a lot of spicy curry. [[RetCon This was later changed to a gift from Agni.]]
* The Dead Pepper, featured in ''VideoGame/FinalFantasyIX'' and ''FinalFantasyUnlimited''. When they were fed to chocobos, it drove them crazy and gave them supercharged abilities.
* In ''VideoGame/TalesOfMonkeyIsland'', there is a chili pepper so hot, you can't touch it with your bare hands without getting burnt. You have to hold it to your tongue for eleven seconds.
* ''WorldOfWarcraft'' has (sadly outdated) Dragon Chili, made from mystery meat and a small flame sac taken from baby dragon bodies. Every so often after eating it, the character will breathe a damaging cone of fire on anything they're fighting.
* The [[http://kol.coldfront.net/thekolwiki/index.php/Jabanero_pepper Jabaņero pepper]] in ''KingdomOfLoathing'' is evidently so spicy that "Just thinking about it makes your mouth hurt." Putting one in a spicy enchanted bean burrito, then eating one, gives one the (fairly useful) skill 'Chronic Indigestion'.
** The sauce in the [[http://kol.coldfront.net/thekolwiki/index.php/17-alarm_Saucepan 17-Alarm Saucepan]] is described thusly:
-->"You know those bottles of novelty hot sauce they sell, with the black labels and skulls and names like "Ed's Hot Sauce That Will Totally Murder Your Family"? Compared to this stuff, they're ketchup."
* In ''{{Quackshot}}'' and ''VideoGame/DeepDuckTrouble'', DonaldDuck can eat peppers to become explosively angry and invincible.
* ''VideoGame/JoeAndMac: Caveman Ninja'' includes a jalapeņo pepper as a food item. Eating it provides invincibility and a fire attack against enemies, as well as a humorous animation with Joe or Mac breathing fire.
* The {{Roguelike}} ''Omega'' has a szechuan pepper as a findable item. If you eat it, "your sinuses melt and run out of your ears"-- and you become immune to Sleep spells.
* In ''VideoGame/{{Persona 4}}'' Rise likes to put overwhelming amounts of spice in her food; one bite was enough to cause poor Yukiko to pass out.
* In ''VisualNovel/FateStayNight'' and spinoffs thereof, Kotomine Kirei's favorite food is blazing hot mapo doufu. [[AffablyEvil Which he offers to share with Shirou]].
* Some servers in ''VideoGame/SpaceStation13'' let you create ''ghostlier chilis'', a chili pepper hot enough to make whoever's foolish enough to eat one [[SpontaneousHumanCombustion burst into flames]]. If the botanist making one gets it just right, it can turn people to ash ''in a single bite''.
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