* Van of ''GunXSword'' loves this sort of thing. Given that it's usually a green liquid, it's probably wasabi.
* The Tabasco soup from ''UruseiYatsura''.
** Or any of the [[AlienLunch Oni Cuisine]], really. At one point, Ataru eats a lollipop made of red hot peppers.
*** [[LethalChef Lum thought the peppers would be good because they were colorful.]]
* ''GalaxyFrauleinYuna:'' Yuri Cube's recipe for curry.
* One ''Anime/{{Naruto}}'' filler-arc featured the Curry of Life. So strong that it made ''[[ArrogantKungFuGuy Neji]]'' go SuperDeformed.
* ''Anime/RevolutionaryGirlUtena'' features 9,000,000,000x strength curry powder as part of [[TheOjou Nanami's]] evil scheme. [[spoiler: But nobody cooks with it.]]
* The short animated film ''Ghiblies'' features StudioGhibli employees going to a restaurant after work and vying to see who can eat the spiciest plate of curry. It ends with one of them blasting off like a rocket.
* Done as a one-off gag in the second season of ''{{Vandread}}''. Some of the girls (notably [[LoveInterest Dita]] and the new girl Misty) found out that the easiest way of [[strike:seducing]] winning Hibiki's love is ThroughHisStomach. Enter Jura who is legitimately trying to seduce Hibiki as well but is not a cook, so she asks [[BiTheWay her girlfriend]], Barnette, to do the cooking for her. Barnette isn't happy about this, of course, so she spikes the food with super-hot sauce. Enter [[ButtMonkey Bart]], hoping to find out what makes their food so very special. By the end of the episode, Bart had sworn to eat only nutrition pills from then on.
* A gag {{yonkoma}} from the 100th chapter of ''{{Eyeshield 21}}'' featured Hiruma going into a specialty cooking store. Sena and Monta initially think they've discovered Hiruma is secretly into cooking... until they learn all he bought was dozens of bottles of super-spicy hot sauce, presumably for some scheme of his.
* In the ''Anime/MaiHiME'' Blu-Ray special, Yukino puts some hot sauce onto a hot dog that glows bright yellow and seemingly causes the hot dog to melt before giving it to [[spoiler:Reito, in order to get revenge for the Obsidian Lord's evil deeds]].
* In the 4Kids dub of ''Manga/OnePiece'', Usopp's ''Kaen Boshi'' (Flame Star) is called ''Hot Salsa Star''.
* In one episode of ''Anime/{{Pokemon}}'', James and Jesse's scheme requires them to pose as Pokeblock tasters. James learns the hard way not to take too big a bite of a Tamato Berry (a Berry known for being ''very'' spicy) and it also exposes their scheme (because, as Officer Jenny puts it, a real Pokeblock taster wouldn't do something so dumb).
** One of their schemes involves serving up food with insane amounts of hot sauce to Ash as a means to distract him and snatch Pikachu. The only thing keeping them from a clean getaway is their decision [[KickThemWhileTheyAreDown to bombard the party from above]], which backfires when Charizard ends up in the crossfire and subsequently sends them flying.
* ''Anime/AngelBeats'' features Mapo Tofu, a [[http://rasamalaysia.com/recipe-ma-po-tofu/ real-world]] dish so spicy that nobody in school can stomach it... except for the resident EmotionlessGirl Tachibana, who finds it to be the only thing on the school menu worth eating. She likes it for the taste. The spiciness doesn't affect her in the least. When another character tries it, he's downing multiple glasses of water just to try and ease the suffering.
----