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* [[spoiler:''Film/OBrotherWhereArtThou'']]: Three refugees from a chain gang re-enact ''Literature/TheOdyssey'' in the Depression-era South.
* ''[[spoiler: Film/OceansEleven]]'': Man tries to get some money while humiliating his ex's current affair.
** ''[[spoiler: Film/OceansTwelve]]'': Men try to avoid prison... through stealing.
** ''[[spoiler: Film/OceansThirteen]]'': Men start an earthquake, torment a reviewer, and seduce a woman to avenge a conned friend.
** ''[[spoiler: Film/OceansEight]]'': [[DistaffCounterpart The man's sister]] tries to get some jewels while humiliating her ex.
* [[spoiler:''Film/{{Oculus}}'']]: An evil mirror kills people...or does it?
* [[spoiler:''Film/OfficeSpace'']]: One guy stops caring about his job, another wants to rob his employer, and a third just wants his stuff back.
* [[spoiler:''Film/{{Old}}'']]: A resort takes pleasure in getting their guests lost.
* [[spoiler:''Film/OldSchool'']]: Three men start a fraternity.
* [[spoiler:''Film/{{Oliver}}'']]: Prepubescent exceeds alloted institutional dietary requirements, which leads to him being sold as property and getting involved with thieves, hookers and psychopaths. It's a musical.
* [[spoiler:''WesternAnimation/{{Oliver And Company}}'']]: Music/BillyJoel and a homeless kid navigate New York City to help a hobo get a money. It's also a musical.
* [[spoiler: ''Film/TheOmen1976'']]: Satan puts his son up for adoption. Murder ensues.
* [[spoiler:''On the Town'']]: Gene, Frankie and some third guy have one day to see NYC.
* [[spoiler:''Film/{{Once}}'']]: A multi-cultural couple should get together for love of a vacuum cleaner, but they don't.
* [[spoiler:''Film/OnceUponATimeInTheWest'']]: A former criminal helps a dying crippled man accomplish his final wish in exchange for gaining a legitimate position in the crippled man's company. However, the former criminal's [[MoralEventHorizon past]] comes back to haunt him in the form of a guy who plays the harmonica.
** Or: Woman moves to the wild West to meet new family, gets UnwantedHarem. Not a romantic comedy.
** [[spoiler:''Film/AFistfulOfDynamite'']]: Man becomes an AccidentalHero while his partner blows up anything he sees.
** [[spoiler:''Film/OnceUponATimeInAmerica'']]: The histories of a group of former juvenile delinquents is explored. This is a movie about New York gangsters directed by a man famous for westerns.
* [[spoiler:''Film/OnceUponATimeInHollywood'']]: Washed-up actor and his friend roam around L.A., make some movies overseas, and unknowingly save the lives of their neighbors.
* [[spoiler:''Film/OneFlewOverTheCuckoosNest'']]: A petty criminal feigns insanity to get out of prison and is sent to a mental hospital, where he teaches the residents to play basketball and fish, and gives them chewing gum.
* [[spoiler:''Film/OneHourPhoto'']]: Creator/RobinWilliams works at a Wal-Mart clone and spends most of his time alone watching ''WesternAnimation/TheSimpsons''. It's a dramatic thriller.
* [[spoiler:''Film/OnTheWaterfront'']]: Two brothers start out together in life but arrive at separate destinations, one smashed up yet victorious, the other just hanging out.
* [[spoiler:''WesternAnimation/{{Onward}}'']]: A family film about two brothers who want to resurrect their dead father.
** Alternatively, two brothers spend their day with a disembodied pair of legs.
* [[spoiler:''Film/{{Oppenheimer}}'']]: A nuclear physicist wins a race by default when the opposing coach unexpectedly drops out. He then makes a surprisingly [[MemeticMutation lucrative marketing deal]] with [[Film/Barbie2023 a line of girls' dolls]].
** Or: ItSeemedLikeAGoodIdeaAtTheTime: TheMovie.
* ''[[spoiler: Film/{{Orphan}}]]'': A little girl is older than she looks.
* ''[[spoiler: Film/TheOrphanage]]'': Woman goes back to her childhood home, where her young son befriends some of her old friends from childhood.
* ''[[spoiler:Film/OsmosisJones]]'': A man throws up on a woman and later nearly dies while a [[BuddyCopShow Buddy Cop Movie]] happens inside him. NauseaFuel ensues.
* ''[[spoiler:Film/TheOthers2001]]'': Woman is pestered by the new inhabitants of her house.
* ''[[spoiler:Film/{{Outbreak}}]]'': A monkey kills people by giving them a roid-up version of the Ebola Virus.
* ''[[spoiler:WesternAnimation/OverTheHedge]]'': A thief is caught in the act and has to exploit a group of suffering foragers to escape execution.
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