* ''Webcomic/{{Project 0}}'': Noor, just sending her out into the field gives even her teammates a scare.
* The Demi in ''Webcomic/TheOverture'' are an entire race of unstable psychopathic killers but none so much as Sophie. A [[{{CuteAndPsycho}} cute, sweet, little girl]] who tortures children in order to [[{{LovesTheSoundOfScreaming}} hear their screams]].
* ''Webcomic/SupernormalStep'' has [[HiddenAgendaVillain Mr. Kite]], who blends elements of Ax Crazy, TheMadHatter, and MagnificentBastard all at once.
-->Mr. Kite: Whatever. Nothing else [[IncendiaryExponent left to burn]], I'm bored, let's get out of here.
* {{MAG ISA}} -- [[http://mag-isa.thecomicseries.com/comics/pl/119816 Kyle]] is the epitome of AX... I mean... GUN CRAZY.
* In ''Webcomic/DevilBear'', [[http://www.thedevilbear.com/?p=21 Winnie the Pimp]] is brought back to life by well meaning friends but he CameBackWrong
* ''Webcomic/TowerOfGod'' - It is implied that the weapons of the [[EmpathicWeapon 13 Month series]] cause this, since [[YamatoNadeshiko Eurasia Enne Zahard]] started to go on a random killing spree after receiving the Colourless December. It also applies to Anak's Green April, which seems rather bloodthirsty and activates when Anak gets angry.
* Black Mage of ''Webcomic/EightBitTheater''. He's kinda the anti-WhiteMage.
** Also, White Mage in [[http://www.nuklearpower.com/2005/05/22/e3-05-dream-analysis/ this guest comic]].
* Belkar Bitterleaf of ''Webcomic/TheOrderOfTheStick'', described as "a Chaotic Evil halfling who is constantly trying to murder anyone who gets in his way! Or looks like they may possibly be thinking about getting anywhere sort of near his way at some unspecified future point, just to be sure."
--> "I AM A SEXY SHOELESS GOD OF WAR!!!"
-->"Yes, run, my little chunks of XP!"
** The BigBad, Xykon, who will (and has) kill anyone, for any reason, usually [[ForTheEvulz on a whim]].
* ''Webcomic/TheContinentals'': The escaped mental patient known as The Mangler, the sinister and psychotic Mr. Qwist (hired man of the equally bent Dr. Daniel Abbeline).
* The Infernomancer ([[FanNickname TIM]] for short) from ''Webcomic/DominicDeegan: Oracle for Hire.''
* Red of ''Webcomic/NoRestForTheWicked'', even if she is one of the protagonists.
* Bangladesh [=DuPree=] from ''Webcomic/GirlGenius'', although Baron Wulfenbach and his son Gilgamesh have some [[http://www.girlgeniusonline.com/comic.php?date=20070718 control]] over her... usually.
--> '''Klaus''': [=DuPree=]. When I say the words ''Alive and Unharmed'' -- do ''any'' neurons actually ''fire'' in that brain of yours?
--> '''Bang''': Um--No Sir!
--> '''Klaus''': I thought not.
** In fairness, that one wasn't her fault. [[spoiler: Skewering Zulenna, one of the students on Castle Wulfenbach, when it was very much not necessary and a potential political problem for the Baron, now, that was all her.]]
* Kamekaze Kate is a car racing Ax Crazy in ''Webcomic/{{Misfile}}''.
** At first at least after she was freed from her sister's influence she got a lot better. And her race with Ash ended in a traditional DefeatMeansFriendship moment, [[spoiler:that is Ash's defeat by Kate]]
* Richard from ''Webcomic/LookingForGroup'' sums himself up [[http://www.lfgcomic.com/video/fcbazH6aE2g in song]].
* ''Webcomic/ElectricRetard'' is full of them. One even happens to be a naked guy with an axe.
* Axel of the ''Webcomic/AnsemRetort'' seems to go out of his way to inflict grievous bodily harm on his "friends", and generally murders anyone who happens to exist anywhere within a hundred mile radius of himself.
-->'''Namine:''' You couldn't go 10 seconds of diplomatic immunity before murdering someone?!
-->'''Axel:''' I wasn't even listening to you. I just wanted to murder a dude.
** Larxene is, arguably, even crazier having destroyed Disney Land and everyone/thing inside it just because she wanted funnel cake.
* Cousin Dougal from ''Webcomic/PlatinumGrit'', a psychopathic immortal Scotsman who lives to stab.
* Oasis moves in and out of this in ''Webcomic/SluggyFreelance''. Her mental state is in tatters, and each [[BackFromTheDead apparent resurrection]] shifts it. Even in her more lucid moments, though, she realizes how close she is to violent mayhem. And heaven help anyone nearby if she activates [[OverrideCommand Override B-1]].
* David Willis, author of ''[[{{Walkyverse}} It's Walky!]]'', ventures into this from [[http://www.shortpacked.com/2006/comic/book-3-is-totally-gay/05-iacon-one-sketches/screwball/ time to time]].
* Il'haress Kharla'ggen Vloz'rezz from ''Webcomic/{{Drowtales}}'' is the personification off Ax Crazy. And considering that the [[ManBehindTheMan Woman Behind The Woman]] that was the only thing capable of keeping her in check and from going on an unstoppable killing spree [[DroppedABridgeOnHim was beheaded in a recent chapter]], she will most likely become further Ax Crazy still as the story progresses. Or, considering that it was this woman who originally drove her Ax Crazy, it's within the realm of possibility that she might calm down to just plain crazy.
* Butch from ''Webcomic/ChoppingBlock''.
* Lothar Hex from ''Webcomic/ExterminatusNow'' is psychopathic enough that he regularly attempts to cause harm to next door's dog for no reason, but in order to REALLY get him riled up, all you have to do is ruin his hat. At which point, don't expect too many of your limbs to still be attached.
* Mal from ''Webcomic/HeadTrip''.
* Mel Kelly from ''Webcomic/{{Narbonic}}''. Very.
* [[http://liliy.net/wam/cast/cast-galen/ Galen]] from ''[[Webcomic/TheAdventuresOfWiglafAndMordred Wiglaf and Mordred]]''. Her favorite "patients" seem to be her fellow teammates (or her daughters teammates, much to her daughters annoyance).
* Rowasu of ''Webcomic/{{Juathuur}}''. And when he is lucid, he is even scarier.
* Nina from ''Webcomic/VenusEnvy'' - starts out as a SociopathicHero of sorts who constantly threatens / injures people and is played mostly for laughs. [[FromBadToWorse Then she]] [[spoiler: stabs the main character.]]
* ''Webcomic/BittersweetCandyBowl'': Just [[http://fc04.deviantart.net/fs48/f/2009/228/b/c/Heeeeeere__s_Abbey__by_taeshilh.jpg imagine]][[Literature/TheShining ...]]
* [[spoiler:Gamzee]] singlehandedly turned the Troll's side of the story into a SlasherMovie when he goes off the deep end in ''Webcomic/{{Homestuck}}''. [[spoiler:Karkat eventually [[ThePowerOfFriendship manages to hug the crazy out of him]] though.]]
** Also, [[spoiler: Eridan]] goes off the [[JumpingOffTheSlipperySlope deep end]] too, murdering two of his friends in cold blood and single-handedly destroying any hope of his species long-term survival.
** Caliborn. He is entertained by death and wants to kill everyone, especially his sister Calliope.
** Jack Noir. At one point, he's stuck in jail with nothing but a pumpkin full of knives. He then proceeds to murder everyone around him, even when he's trying to keep at least one of them alive to open his cell.
** Meenah, also. To the point where she greets people by trying to kill them, and blew up herself and all her friends, as well.
*** In fairness, the latter action was committed to [[spoiler: save herself and her friends from being erased from existence by the Scratch]], so it's a bit ambiguous as to whether it qualifies.
* WebComic/AxeCop is pretty violent and armed with an Axe most of the time, but this is usually just bad news if you are a bad guy. However in [[http://axecop.com/index.php/acask/read/ask_axe_cop_50/ this strip]] he goes pretty Ax Crazy after the [[BerserkButton wrong candles are put on his cake]] and kills indiscriminately.
* [[MeaningfulName Chelsea Grinn]] from ''Chimneyspeak'' has been on a ten year long bloody carnage across the world all because [[DisproportionateRetribution she got bumped into and got a small scar on her nose.]]
* Webcomic/KarateBears are [[http://www.karatebears.com/search/label/axe pretty fond of axes.]]
* ''Webcomic/ABrokenWinter'' introduces us very early on to Kuroda's wife, who killed their son (according to WordOfGod) as a protest against killing children. In their words, "Logic at its finest". She also killed the family dog and tried to kill her husband too.
* In ''WebComic/CommanderKitty'', [[BigBad Zenith]] does ''not'' take it well to learn that {{Ridiculously Human Robot}}s and MixAndMatchCritters [[http://www.commanderkitty.com/2011/08/28/process-of-elimination/ are incapable of having children together]].
--> If I'm not perfect ''now'', I can always be the most perfect thing ''[[OmnicidalManiac left alive]]''.
* ''Webcomic/OlympusOverdrive'': Ares.
* ''WebComic/DragonBallMultiverse'': U13 Kakarotto. Come on, just [[http://www.dragonball-multiverse.com/en/page-605.html look at]] [[http://www.dragonball-multiverse.com/en/page-608.html his face.]] And that's just the tip of the iceberg. [[http://www.dragonball-multiverse.com/en/page-610.html I mean, seriously, holy shit.]]