* The blink-and-you-miss-it scene in the intro where the class is rafting a river of lava and the volcano they're inside is beginning to erupt. Everyone looks understandably panicked. The Friz is smiling, cool as a cucumber, and the Bus is apparently just happy to be there. It's [[EstablishingSeriesMoment the entire show in one second]].
* In "The Busasaurus", [[TheSoCalledCoward Arnold]] single-handedly drives away a T-Rex, saving the class and getting back the lost egg he'd been after throughout the whole episode. He demonstrates some karate moves, but as Tim aptly observes, he didn't have to throw a single punch.
** "[[TranquilFury Excuse me... You can put the bus down now]]."
* [[YouAreInCommandNow D.A. taking command of the bus]] to deflect an asteroid from its course and save the Earth in "Out of this World".
* The erupting volcano in "Blows its Top", accompanied by ''[[SugarWiki/AwesomeMusic The 1812 Overture]]'', especially with D.A. riding it.
* Phoebe facing down Carlos's skepticism and insisting on giving water to the desert creatures in "All Dried Up". Of course, her good intentions are entirely misguided, but it's the first time she really stands up for what she believes in.
** Not to mention her gravity-defying slam dunk in "Gains Weight".
* Ms Frizzle is a walking, talking SugarWiki/MomentOfAwesome.
** Although one of her more notable moments is when she defeats Garth Sinew in the Teacherathalon, which is no small feat considering he had a team of his own. Granted, his focus on building up his strength may have caused him to neglect his stamina--a trait Ms. Frizzle has in abundance. Maybe there ''is'' a [[Series/DoctorWho second heart]] in her chest, hidden behind some kind of [[PerceptionFilter perception filter]].
* Any time the class sticks it to Janet. They're nice kids, but Janet manages to be so mean to them that she always asks for it.
** One of these moments that mixes with SugarWiki/{{Heartwarming|Moments}} is when Arnold takes off his helmet on Pluto to get her to come home with the others[[labelnote:context]]She refused to come home without her massive pile of space stuff she was taking as proof she'd been to space, even though it wouldn't fit on the bus[[/labelnote]].
*** Earlier in the same episode as that, after finding out the class's original field trip destination--a planetarium--was closed for the day, Janet begins bragging about how her teacher is better because she never makes these mistakes, leading to this exchange.
---->'''Arnold:''' (''Cutting off Janet'') ''Nobody'' is better than Ms. Frizzle.\\
'''Janet:''' Oh, yeah? [[CharacterCatchphrase Prove it!]]\\
'''Arnold:''' STOP THE BUS!!\\
(''Ms. Frizzle complies. Arnold storms to the front of the bus'')\\
'''Ms. Frizzle:''' Yes, Arnold?\\
'''Arnold:''' Isn't there... you know... someplace else you could take us?\\
'''Ms. Frizzle:''' You mean another planetarium?\\
'''Arnold:''' Well, sort of, but... bigger.\\
'''Ms. Frizzle:''' Bigger?\\
'''Arnold:''' You know, the... "Big One".\\
'''Ms. Frizzle:''' Oh, Arnold! Why didn't I think of that?
*** She then proceeds to pull the [[PlotSensitiveButton main lever]] to turn the bus into a spaceship to go to space. Keep in mind this is ''Arnold'' we're talking about. He ''hates'' these field trips, yet this time he willingly gets himself into one to show up his {{Jerkass}} cousin.
*** The fact that this is the very first time we see the bus live up to its name and do something magical. It truly lives up to its name!
*** And a bonus moment for The Friz, who isn't at all fazed by the planetarium being closed. Twenty bucks says that going up into space was her plan the whole time; she was just waiting for the right moment.
----