* All together now:
--> "Enough is '''enough'''! I have ''had'' it with these motherfuckin' ''snakes'' on this motherfuckin' ''plane''!"
** Probably because [[ExactlyWhatItSaysOnTheTin the title itself]] is a Moment of Awesome for movie titles.
** Plus, Samuel L. Jackson signed up for the film based solely on the title, which was meant to just be a placeholder until they could think of something less ridiculous. He then insisted it be kept.
* The effeminate male steward when he stuffs a coral snake into the microwave, turns it on, and laughs while the snake cooks and then explodes
** "YEAH! HAHAHA! Who's your daddy NOW, bitch?!"
* The [[{{Jerkass}} foul-tempered businessman]] finally becoming a [[KarmicDeath boa constrictor's]] lunch.
* Dr. Price, the snake expert found by the FBI. He doesn't go SpockSpeak, he doesn't lord his knowledge over them, he doesn't marvel at the snake's odd behavior, and he is very fast and rational because he knows people's lives ''are'' in danger here. As noted on the main page, this is what movie scientists ''should'' be.
** Also when they find the guy who gave Eddie Kim the snakes and the man is bitten by one that escapes in a scuffle, Price cheerfully tells him the species and it's lethality and withholds the anti-venom until the man agrees to cooperate with the FBI. ''He's how they got the evidence against Kim''.
* Tony, the martial artist passenger, he kills crazed poisonous snakes with his bare hands.