* ''Afterlife'' opens with one of these: [[MagnificentBastard Wesker]] versus [[GodModeSue Alice]]. During the second and third films, Alice transformed from the BadassNormal she was in the first film to a full-blown GodModeSue (even BlackHoleSue by ''Extinction'') who could win a fistfight with the friggin' [[VideoGame/ResidentEvil3Nemesis Nemesis]], use PsychicPowers gained from bonding with the T-Virus, and [[SpotlightStealingSquad stole the spotlight]] from canon [[BadAss badasses]] Jill Valentine and Claire Redfield. She even [[spoiler:assembled [[MesACrowd a clone army]] developed by Umbrella to take on the company itself.]] So, what happens in ''Afterlife''? [[spoiler:The clone army strikes at Umbrella's Tokyo HQ, but Wesker manages to kill two of the clones, evacuate to a CoolPlane, leave the facility, and annihilate both the facility and the Alice clones with a nuclear bomb. The original Alice jumps him on the plane, but he catches her off guard and injects her with a serum that destroys the T-Virus (which removes her God Mode powers) before ''[[NoHoldsBarredBeatdown he kicks her ass from one end of the plane to the other]].'' Yes, you read that right: Wesker ''beat the Sue out of Alice.'']] And for everyone who wanted to see that moment? It. Was. '''''Glorious.'''''
** You have...probably made some mistakes with your story if your hero getting the everloving shit beaten out of them by the villain in a CurbstompBattle is considered an Awesome Moment worth celebrating as if it were the villain receiving the beating. Then again, [[spoiler:an AuthorsSavingThrow combined with a TakeThatScrappy]] was a definite step in the right direction for the series.
* [[spoiler:Luther averts BlackDudeDiesFirst by somehow surviving zombies dragging him into the sewers. "Star power, bitches!"]]
* [[spoiler:In the climax, Bennet reaches for Alice's gun to stop her from fighting Wesker. As he reaches for it, K-Mart grabs the gun. When he asks, "Who the fuck're you?", she answers by pistol-whipping him cold.]]
* Alice [[spoiler:puts the Arcadia nuke into the V22 that Wesker jumps into to escape at the end of the movie. His eyes light up and his face remains the same, but you can tell that inside, he is nowhere near as calm and collected.]]
* The filmmakers deliberately wanted to make this film come off as faithful to the games and address complaints about the other movies. The Executioner, Majini, Wesker, Jill with the mind control spider, and the shot-for-shot remake of a ''VideoGame/ResidentEvil5'' cutscene are meta Moments of Awesome for ''them.''
* Even more epicness in the final boss fight. [[spoiler: Alice shoots her shotgun filled with coins at a dog. It kills the dog and the coins hit a window at the top of the area. A dog jumps at her while the glass is falling. She brings her leg up, and kicks a shard of glass at the dog. It kills it. Later on, Wesker is about to eat Alice. She takes the shotgun and shoots him, blowing a hole in his head. After that, Wesker is starting to get back up. Alice notices this, but Chris pushes him down, says "I don't think so" and Chris and Claire unload their pistols at him.]]
** [[spoiler: And he SURVIVES ALL THAT, PLUS the above mentioned plane nuke! They definitely kept Wesker as powerful as possible.]]
* As further evidence that writer/director Paul W.S. Anderson learned from past mistakes, Claire goes from doing pretty much nothing in the ''Extinction'' to having a legitimate Moment of Awesome of her own: the fight against [[VideoGame/ResidentEvil5 the Executioner Majini]] in the prison's shower room. The fight ''tears the room apart'' and climaxes with Claire grabbing Alice's sawed-off shotgun, sliding toward the Executioner, and shooting him point blank in the chest. Granted, [[spoiler:it only puts him down temporarily]], but it was still awesome.
** Alice and Claire finish the fight by using some DeadlyDodging to disarm the Executioner, then using Alice's "coin-operated" shotgun to [[YourHeadAsplode blow his head off]].
* Wesker headshots an Alice clone while she was freefalling, then later walks away from an explosion caused by the second Alice clone trying to invoke a TakingYouWithMe with only a few bruises.
* Wesker gets an epic combination of BadassBoast and PreAssKickingOneLiner before utterly stomping the Redfield siblings in that fight lifted nearly shot-for-shot from ''Resident Evil 5'':
->'''Wesker:''' Well, isn't this one big family reunion? Chris and Claire Redfield...you've really become quite an inconvenience for me.\\
'''Alice:''' I told you I'd be bringing a few friends.\\
'''Wesker:''' [[[TheGlassesComeOff removes sunglasses]]] ''You should have brought more.''
* [[spoiler:Bennet]] grabs a nearby scalpel and stabs Alice in the her forearm with it. [[LodgedBladeRecycling Alice pulls it out and uses it to stab]] the BigBad in the forehead.
** [[spoiler: And Wesker is only inconvenienced by said stabbing for a few seconds.]]