* His first escape from prison: He makes a tricycle and a death ray out of license plates and his binkie.
* His second escape from prison '''that we get to see''': [[spoiler:He gets his henchman to send a special watch into prison. [[BatmanGambit He knows that the warden will take the watch for himself]]. The watch is an image inducer, and it makes the warden look like Megamind. the guards drag him back to Megamind's cell, and Megamind takes the watch, locks them up, and dances out of prison disguised as the warden.]]
* Megamind's Killsat. That was one hell of a kaboom.
* After he defeats Metro Man, he takes over city hall. He just walks up to it and takes it. It is surrounded by armed police officers, barricades, helicopters. They all but put up a big neon sign saying; Megamind will most definitely kill us, but we'll do our duty staunchly. He has nothing but his sense of drama. He just walks up to them, apparently unarmed, and orders the officers to drop their guns. ''And they do!''
-->'''Megamind:''' DROP 'EM!!!
** Actually, he did have a bunch of lasers pointed at them.
* "You, robot! Yes, you! Bring out... ''[[MundaneMadeAwesome The Black Mamba!]]''
** The scene combines LetsGetDangerous with CrowningMusicOfAwesome to show just how fully Megamind accepts that being on the good side is overrated and embraces his dark side again.
* You know what the difference is between a villain and a ''super'' villain? '''[[http://www.youtube.com/watch?v=JQJJjcrwXQE PRESENTATION!]]'''
** And pretty much the entire ending in general. Special mention goes to Megamind transforming into Metroman in an attempt to stop Titan.
*** Everything between, "This is the real world, and you need to wake up!" and, [[spoiler:"The thing about bad guys? They always ''lose!''"]] is one long moment of awesome.
** It should be mentioned that He shows up for the battle with the ominous appearance of a giant Cloud of Doom, with a bloody ''laser light show'' shining over the ''entire city'', while Welcome to the Jungle plays loud enough to be heard from the outskirts of said city...and then he emerges from the Cloud of Doom riding a ''gigantic'' robotic version of his ''own head''! Can this get any more awesome!?
** Lets face it, Titan is scary. The very fact that he is an idiot makes him even scarier than a smart evil superman. When Megamind first challenges him, he taunts Titan and goads him into a fight. Which Megamind then proceeds to hand a CurbStompBattle, apparently only losing because he wanted to. And when he realizes Titan has no sense of justice, he makes his escape and he makes it fast. But that's not all. In full knowledge of how incredibly dangerous Titan was, he accepts his challenge again, culminating in the above grand entrance. Then, [[spoiler: Megamind (well, Minion pretending to be Megamind) rescues Roxanne on what is possibly the [[CoolBike coolest rocket bike ever]]. Then Megamind pretends to be Metroman to scare him off.]] Of course, Titan comes back with a vengeance, not having fallen for the disguise of Metro Man as Megamind slipped up by pronouncing Metro City 'Metrocity', and this is when Megamind really shines; [[spoiler: without planning anything ahead, he stays one step ahead of Titan all the way, taunting him into throwing him behind his invisible car, then diving into it, then when he rips the door off its handle, but Megamind keeps a hold of the door, laughs sheepishly, locks the door and hides behind it. Then, when he's falling from the sky he comes up with a last minute plan to save the day! This is what it mean when a supervillain has super intelligence!]]
** Special mention to the fact that, until he turns his back it looks like Megamind is effortlessly dodging all of Titan's attacks. He even carries out a conversation with Roxanne while the incredible dangerous monster tries to destroy him!
** Titan has the power, but Metroman and Megamind have been fighting their whole lives. And his experience shows. Especially during his first fight with Titan, where he backhands him, takes him out with a HeyYouHaymaker, ("You fell for the oldest evil trick in the book!") and then proceeds to duel him with street lights. Pretty much the only reason Titan beat him that time was because Megamind wanted to lose.
** The moment when Titan actually has Megamind ''IN HIS HANDS!'' Megamind takes a calculated risk, ''AND TAUNTS HIM!'' Not knowing whether Titan will crush him like a grape or fry his head with his heat vision, he decides to take the chance that he'll ''just'' punch him into a stone wall, landing him right where he needs to be, and ''HE [[DidYouJustFlipOffCthulhu TAUNTS]] [[BewareTheSuperman TITAN]]!
* "Ollo." [[{{DramaticGunCock}} *KCHACK*]]
* Megamind is falling to his death several hundred feet above the city.
--->'''Megamind:''' "So... this is how it ends... normally, I'd chalk this up as my last glorious failure..." ''*Notices large fountain underneath him, gets an idea*'' "But not ''''TODAY!'''' What could I say? Old habits die hard!" [[spoiler: *shoots self with the Dehydrator Ray*]].
* After Megamind strips Titan of his powers:
-->'''Megamind:''' "The thing about bad guys... They always '''''LOSE!!!!'''''"
* Roxie gets a few as well, most notably:
** Remaining unfazed enough to [[LampshadeHanging lampshade]] Megamind's deathtraps as he activated them.
** Being the only person willing to rebel against Megamind's rule.
** Standing up to Titan when both the superpowered characters had refused to do so.
--->'''Roxanne:''' I want to ''reason'' with you.
** Charging Titan with a street sign while he's got Megamind.
* Given that we've pretty much established Megamind is pretty much awesome on two legs, can we say Metroman gets one just for surviving so many fights with him?
* A massive black cloud forms, lasers cut across the sky, Guns 'N Roses plays, and a booming voice demands, "YOU DARE CHALLENGE MEGAMIND?"
* Yeah, pretty much any time Megamind makes an entrance.
** Even [[spoiler:when disguised as]] Metroman; "[[BigDamnHeroes Please]]. Let's have some respect for public transportation." *cheesy grin*
* Hell, the music's pretty awesome! AC/DC, [[MichaelJackson Bad]] and Music/GunsNRoses... all at the right moments too!
** Megamind not only loves music, he's also an awesome dancer, as seen in the ending.
* Megamind always seems able to come up with the perfect comeback to anything Titan throws at him:
--> Titan: This is the last time you make a fool out of me.
--> Megamind: I made you a hero. You did the fool thing all by yourself.
** Later:
---> Titan: No matter what side you're on, you're always the loser.
---> Megamind: There's a benefit to losing. You get to learn from your mistakes.
** not always though:
---> Titan:(repeatedly bashing Megamind's machine with a streetlight): AAAAHHHHH!
---> Megamind: Look, I'm really not sure where to go with that!
* [[spoiler:The day that Megamind scheduled to be his confrontation with Titan, Titan never shows up. He then breaks into Hal's apartment, demanding an answer. Hal shows Megamind all the stuff he stole with his new powers, which causes Megamind to berate him for screwing up the hero-villain dynamic. Hal complains that now that Roxanne, his co-worker that he had a crush on, dumped him to go out with "some intellectual dweeb" that there's no point in heroics. He also says that he doesn't care what "space dad" says about how he should live his life. Megamind then shows Hal that, through the use of his disguise watch, he is both space dad ''and'' the intellectual dweeb. Ouch!]]
* Metro Man's [[TimeStandsStill super speed]] scene. It's made perfectly clear that every confrontation he ever had with Megamind was just acting and if he took those things seriously Megamind could be behind bars within a literal second.
-->Once your death ray hit, I've never felt so alive.