* Any time the Gauss Minigun is fired at something.
I was in the Junction City mission, the one where you have to assault a house defended by 25+ Reavers, and was confounded as to exactly *how* I was supposed to achieve the objective "Kill all the Reavers" without losing all my squad members in the process. That's when I decided to try something so insane that it HAD to work. I selected Chuck, my squad's Super Mutant, dosed him with drugs (two syringes of Psycho, one Afterburner Gum, and two Buffouts), gave him a dozen Super Stim Packs, and loaded him with a Browning M2 in either hand plus 300+ rounds of .50 cal ammunition. What happened next can best be described as resembling the theater massacre scene of the film "Inglorious Basterds" as well as the final shootout of "Scarface". Every. Reaver. Died. On at least one occasion, Chuck insta-killed five or six Reavers at a time with a single salvo of .50 cal fire. When the dust settled, the rest of my squad was huddled behind a piece of cover half a map away while Chuck was triumphantly standing alone and victorious amidst the corpses of dozens of Reavers. Needless to say, Super Mutants can be bona fide weapons of mass destruction if you know how to use them properly.