* Played with in ''Webcomic/ElGoonishShive'': Outside of being written by Dan Shive, the title is [[WordSaladTitle meaningless]]. However, long after it started, there was a gag strip with a ''[[http://www.egscomics.com/?date=2003-08-13 single panel]]'' featuring a goon - and this was said to completely justify the title, even though he [[http://www.ookii.org/Egs/Statistics?character=HiredGoon#HiredGoon has never appeared again]] and most probably never will.
* ''[[DominicDeegan Dominic Deegan: Oracle For Hire]]'' ...until the end of the first year. And then again. And then stopped again.
* ''Webcomic/ChainmailBikini'' -- Sapphire was the only character in the entire comic to ever wear a ChainmailBikini, and she got killed off halfway through.
* ''Webcomic/BobAndGeorge'' {{averted}} this when the originally planned comic failed and the Mega Man sprite comic, originally used simply for filler, proved more popular by merging portions of the Bob and George plot, including characters, with the Mega Man sprite comic. Bob and George were even given PlotArmor as long as they were in the title, which lead to a joke of a character "dying" thus leading to his name being removed from the title.
** ''Bob and George'' is a very interesting example. The Mega Man sprite comic originally had no mention of the title characters at all; according to the author's notes for the first few hundred comics, he hadn't planned on making Bob and George characters at all once the strips became 100% Mega Man sprite comics. But he realized that he already had a developing fanbase and it was too late to change the comic title, and he didn't want to keep a title that was irrelevant to the story, so he added Bob and George, completely changing the story. So he tried so hard to avert this trope that he ended up drastically changing his comic and adding in two characters that ended up being way more important than Mega Man.
* ''Webcomic/EightBitTheater'' was [[WhatCouldHaveBeen originally]] going to feature several video game parodies, an idea abandoned by Clevinger when the Final Fantasy comic became popular; hence the title which seems to suggest more 8-bit stories that were never made (and never will be).
** This was slightly averted by the brief side comic Field of Battle (included in the 8-Bit archives [[http://www.nuklearpower.com/2005/08/01/field-of-battle-chapter-1/ here]]), which features the sprite comic style but is otherwise unconnected to ''8-Bit Theater''.
* ''Webcomic/MSPaintAdventures'':
** Only the first panel of the first adventure is done in MSPaint. The rest are done in Photoshop and [[AdobeFlash Flash]].
-->'''Andrew Hussie:''' I am ''so good'', I can emulate pressure sensitivity with MS Paint.
** Thoroughly zig-zagged by {{Homestuck}}, being both a title reflecting the state of the protagonists at the beginning and a reference to Videogame/{{Earthbound}}, as the protagonists are very often stuck in places which could be considered home, but not always.
* The Sluggy part of ''Webcomic/SluggyFreelance'' never meant anything, but the Freelance used to refer to Torg's job as a freelance web guy. Now he works for an advertising firm. What the title actually meant is a bit of a RunningGag during [[BreakingTheFourthWall Fourth Wall Breaking fillers strips]].
** Finally given meaning when it's revealed that [[spoiler: Bun-bun used to be a god named Sluggy, but he declared, after a near-apocalypse, that he was going freelance]].
* ''Webcomic/TheWhiteboard''. Although the comic started as doodles on a whiteboard, it stopped after only ''five'' "strips", and there was one later on to celebrate a holiday, for a grand total of ''six'' -- less than three and a half ''permil'' [[note]]10 permil is 1 percent[[/note]] of the now 1700+ strip {{archive| panic}}.
* ''PolkOut'', where polking out (Named after James K. Polk) is a phrase the Polkster coined to refer to pulling out when the job is done. This was to refer to the rotating comics which have long since stopped doing any rotating. It just ''might'' apply again [[WordOfGod in the near future]].
* Hey guys, remember when ''{{Lilformers}}'' was actually about ''{{Transformers}}''?
* What exactly is all over the house in ''AllOverTheHouse''?
* Christian Weston Chandler's ''{{Sonichu}}'' comic is named for a [[SonicTheHedgehog Sonic]][=/=][[Franchise/{{Pokemon}} Pikachu]] hybrid that the creator made. Said character was DemotedToExtra in the third issue. However, considering how Sonichu is also the name of the species he's part of, it's not that much of an artifact considering the SpotlightStealingSquad has the ability to morph into a Sonichu.
* WebComic/{{Jix}} is named for a character, but several story arcs have nothing to do with her. Often times, her human friend Lauren takes over the story. This trope is sometimes lampshaded by the characters knowing Jix's change to her any of her other personalities isn't permanent because of the name of the comic, thus breaking the fourth wall.
* ''[[http://americangothicdaily.com/ American Gothic Daily]]''. It was, initially, but ScheduleSlip set in. Sometimes it isn't even quarterly.
* When it first started in 2007, ''Webcomic/ThisIsNotFiction'' was titled after the main character's favourite novel. But in the 2010 rewrite, the book makes but one brief appearance and is never named, making the title rather mysterious to new readers.
* IrregularWebcomic was originally intended to be a fun side project for the creator that he would update simply whenever he got the time. It went on to become one of the most consistently regular webcomics of all time, until its end in 2011... upon which it has still be regularly updated every day with longer scientific/mathematic posts on Sundays and reruns with new commentary of old strips other days.
* Inverted in ''CoachRandom''. The character in the title shows up in the penultimate official strip. This was lampshaded.
* ''Webcomic/{{Oglaf}}'' appeared in exactly two early comics of the strip that bears his name.
* ''Webcomic/LookingForGroup'' was originally conceived as a ''WorldOfWarcraft'' parody, and the name was fitting. But over time, the series began moving away from ''Warcraft'' by parodying other fantasy franchises and developing its own universe. Nowadays, the strip is more of a {{Dramedy}}, and parody gags of any kind are few and far between.
* ''Webcomic/GirlsWithSlingshots'': The two main characters are still female, but the Slingshots in question are drinks. The Slingshot is the specialty beverage of a drag bar where Jamie and Hazel went once, and had one Slingshot each. Neither the bar nor the beverage has been mentioned since.