* ''Anime/MagicalGirlLyricalNanoha'' -- The "Lyrical" part was [[WordsCanBreakMyBones part of an incantation]] Nanoha used to activate her spells. By around the ''third episode'' of the first season, only one of her spells requires the incantation at all. It sticks around a little longer as OnTheNextEpisodeOfCatchPhrase, though even then it wasn't applied to the darker episodes. She then drops the practice altogether around the start of the second season.
** About the time of ''Anime/MagicalGirlLyricalNanohaStrikerS'', the series dropped any pretense of being a MagicalGirl show, but that part of the title wasn't replaced until ''Manga/MagicalRecordLyricalNanohaForce''.
** And Nanoha is only a secondary character in both ''Manga/MagicalGirlLyricalNanohaViVid'' and the above-mentioned ''Force'', but her name is still on the title.
*** And now that Magic itself is becoming SoLastSeason in ''Force'', the only appropriate words left in the title of that series is "Force" and "Record"!
* In ''Manga/DragonBall'', while the title {{plot coupon}}s are the driving force of the first series, as time goes on, the show becomes less about the aforementioned Dragon Balls and more about watching [[InactionSequence long-winded]] bouts between various superhuman beings. By ''Anime/DragonBallZ'', the balls are relegated to little more than a plot device the protagonists customarily fall back on when too many of their own [[DeathIsCheap die]]. This comes full circle in the follow-up anime series ''Anime/DragonBallGT'', where the Dragon Balls are the central focus again.
** This is even [[LampshadeHanging lampshaded]] after all the Dragon Balls have been gathered the first time, Shenron made his appearance and the Balls were lost again.
-->'''Oolong:''' What's going to happen to the [[MediumAwareness title of this manga]]...?
* A version appears in ''Manga/FistOfTheNorthStar'', although it's not the title of the series. Kenshiro's signature attack is the "Hundred Crack Fist of the North Star". But why "Hundred Crack?" Because in its first published appearance in a ''non-canonical'' prequel pilot, the move's entire purpose was to crack an enemy's hardened armor in a hundred places. Thus, it is the "hundred crack" fist. However, it was never used for this purpose in the main series, instead just making enemies [[YourHeadAsplode explode]] like everybody else.
* In the first chapter of ''[[Manga/YokohamaKaidashiKikou Record of a Yokohama Shopping Trip]]'' Alpha does indeed taking a shopping trip to Yokohama--which has no actual relevance to the rest of the series until the very last chapter, when she goes shopping again.
* Only the first few chapters of ''Manga/HighSchoolOfTheDead'' are set in a HighSchool. This is, however, mostly the result of a translation issue. A more accurate translation of the title is "Academy Apocalypse", which makes slightly more sense.
* When ''VideoGame/MeineLiebe'' ([[GratuitousGerman German for "My love"]]) went from DatingSim to anime they removed the female lead which leads to people mistaking it for a BoysLove series.
* Index, the title character of ''LightNovel/ACertainMagicalIndex'', gets DemotedToExtra within the first ten episodes. Albeit the occasional arc gives her more focus, but she never regains her importance of the first arc. She is, however, one of the most important characters of the series, so it's not as bad as other examples.
* The anime ''Anime/CandyBoy'' was originally released as an extra for a single of the same name. This is rather confusing to new viewers, as [[ImprobablyFemaleCast all of the]] [[YuriGenre characters are female]].
* ''Manga/ElfenLied'' is named after a German song of the same name, which was [[TitleDrop featured]] throughout the manga. The anime, however, dropped the song and left the name.
** "Elfen Lied" specifically translates as "Elven Song".
* ''Anime/YuGiOh5Ds'' was about five Signer Dragons... [[spoiler:until Crow's Black-Winged Dragon came along.]]
** The "Anime/YuGiOh" itself is an artifact; it means King of Games, and is the title because its main character (or rather, the main character's alter-ego) is invincible in any game. After Duel Monsters became the only game anyone played (from volume 8 of the manga on), the title started to make less sense. And the person titled "King of Games" isn't even present in the various spinoffs, [[spoiler:having moved on to the afterlife at the end of the original series]].
** Not exactly from volume 8 on. The Shadow RPG, Four Aces, and Dungeons Dragons & Dice weren't Duel Monsters. So one can say it ''only'' applies to the anime and its spin-offs. Granted, DDD showed up as DDM (Dungeon Dice Monsters) in the anime and so did the Shadow RPG, but in the anime they rewrote the DDD arc with Duel Monsters in mind and the tabletop aspect of the Shadow RPG was radically nerfed in favor of additional card battles and other anime-related changes.
* ''Webcomic/AxisPowersHetalia'' is beginning to lean this way, with very little of the new material focusing on WWII or even on [[AnthropomorphicPersonification Italy]]. This may be part of the reason the anime was renamed to ''Hetalia: World Series'' and later ''Hetalia: It's a Beautiful World,'' although the "World 8" are still used as "main characters" in anime marketing.
* ''Manga/SaintSeiya'' got that title because Seiya was TheProtagonist but new sagas don't even have him as a character, as they revolve around different Athena's saints, sometimes a century apart.
* ''Manga/GuruGuruPonChan''. The "Guru Guru" in the title refers to spinning, and only in volume 1 did Ponta spin to transform.
* The anime adaption of the ''LightNovel/HaruhiSuzumiya'' light novels, gets its title from the first novel, ''The Melancholy Of Haruhi Suzumiya'', however, the show adapts from 5 different books, each one with a different title. Currently it has adapted the first three books plus some short stories of the fifth and sixth novels.
** Averted by TheMovie based on the fourth novel, since it's named after the book.
* ''Manga/MarmaladeBoy'' got this twice: the original title referred to TheProtagonist as that would be a guy before the author decided to do a GenderFlip and got a female protagonist instead, though the manga subverts this by having said protagonist nickname her LoveInterest after marmalade in a TitleDrop. Furthermore, in Spain the anime was renamed "La Familia Crece", which means "The Family Grows" and refers to the first episode setting up the two families living together, though this isn't given a lot of attention during most of the show. There's even barely any FlirtyStepsiblings angst or the like.
* ''Manga/MedakaBox'': The box in the title plays less and less of a role as the series goes on. Initially, its role made sense as the series revolved around helping others with their day-to-day problems. Now, it's only occasionally used as a plot device.
* ''Manga/PandoraHearts'' takes its title from author Mochizuki Jun's debut oneshot, where a "Pandora" is a box that resides in the chest of anyone who contracts with an "abyss." In the series proper, the box is replaced with the incuse that appears on the chests of illegal contractors, "abysses" are now known as "chains," the Abyss is the name of the EldritchLocation where chains are born, and Pandora is the name of the organization that researches the Abyss.
* The sitcom ''Tensai Bakabon'' is initially about a comically stupid little boy named Bakabon and his adventures with his pals. It focuses so strongly on his point of view that his parents don't even get names, referred to only as "Papa" and "Mama." Over time, however, Bakabon's troublemaking father proves to be a much more popular character, to the point that the series soon revolves around him and his various schemes. Bakabon himself is demoted to his occasional sidekick. Despite this, the dad is still never given a name, and is called "Bakabon's Father" on merchandise.
* ''YuYuHakusho'' translates as "Ghost Files," and this reflects the actual stories at first; Yusuke, as a ghost, helps other ghosts. Before too long, it morphs into a fighting series similar to ''Anime/DragonBallZ''.
* Only the first fourteen episodes of SwordArtOnline are actually set in the eponymous video game, after which it's destroyed. Experiences from SAO do serve as plot points from time to time, though, and on a more basic level swords, skill with swords, and online games are important through the whole thing.