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[[quoteright:350:[[Franchise/TransformersGeneration1 https://static.tvtropes.org/pmwiki/pub/images/rsz_primevsmegatron_sml.jpg]]]]
[[caption-width-right:350:[[WesternAnimation/TheTransformersTheMovie One shall stand, one shall fall.]]]]
->''Now I hate him, and he hates me\\
What a wonderful animosity\\
[[HalfDressedCartoonAnimal Besides his hat he wears no clothes]]\\
Now I have someone to oppose\\
Yes, I have a nemesis!''
-->-- A song about '''Perry the Platypus''' and '''Dr Doofenshmirtz''', ''WesternAnimation/PhineasAndFerb'', My Nemesis.
!!The following have their own pages:
[[index]]
* ''ArchEnemy/Ben10''
* ''ArchEnemy/StarTrek''
* ''ArchEnemy/StarWars''
* ''ArchEnemy/TotalDrama''
[[/index]]
----
* ''Franchise/ActionMan'': Action Man has Dr. X in both television series.
** In the [[WesternAnimation/ActionMan1995 1995 series]], Dr. X is Action Man's patricidal adoptive brother.
** In the [[WesternAnimation/ActionMan2000 2000 series]], Dr. X pulls a GrandTheftMe on Action Man's friend Brandon.
* ''WesternAnimation/AdventuresOfTheGalaxyRangers'' had a pretty good sized RoguesGallery for an 80's cartoon, but two out of the four definitely had archenemies. The Queen of the Crowns had Zachary as an archenemy while Killbane and Shane had a long, nasty history that only got worse after most of the Supertroopers went renegade.
* ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius'': Jimmy has either King Goobot or Professor Calamitous. Goobot was the antagonist of [[WesternAnimation/JimmyNeutronBoyGenius the movie]], and an entire special-length episode was dedicated to his return in the series. He also serves as the main antagonist of the GrandFinale, in which he assembles the entirety of Jimmy's RoguesGallery to defeat him once and for all. However, those are his only 3 appearances in canon, whereas Jimmy faces off against Calamitous far more often. Professor Calamitous also served as the representative Jimmy Neutron villain in both ''[[WesternAnimation/TheJimmyTimmyPowerHour The Jimmy Timmy Power Hour: When Nerds Collide]]'' and two installments of ''VideoGame/NicktoonsUnite'', the former of which saw him teaming up with the other Nicktoon protagonists' nemeses and the latter of which saw him as the unambiguous BigBad.
** Ultra Lord has Robo-Fiend.
* ''WesternAnimation/AdventureTime'': [[Characters/AdventureTimeTheLich The Lich]] for Billy and [[Characters/AdventureTimeFinn Finn the Human]].
** Also, the [[Characters/AdventureTimeIceKing Ice King]] for Finn and Jake in the first two seasons, from later seasons Fern would then also be this. Martin making a good case for this as well.
** Jake has his own nemesis in the form of [[spoiler:Warren Ampersand]].
** Marceline's ''own father'' (Hunson Abadeer) is this to her.
** For [[Characters/AdventureTimePrincessBubblegum Princess Bubblegum]], it's something of a draw between The King of Ooo and Gumbald.
** Lemonhope has Lemongrab.
** Much like Marceline, Flame Princess has one in the form of her own father, Flame King.
** Normal Man has GOLB.
** BMO has AMO, who serves as something of an EvilCounterpart to him.
** Slime Princess has Blagertha, who tries to seize control of the Slime Kingdom for herself.
* In ''WesternAnimation/AladdinTheSeries'' Aladdin had [[HarmlessVillain Abis Mal]] and [[KnightOfCerebus Mozenrath]].
** In the [[WesternAnimation/{{Aladdin}} original movie]] and its sequels, Aladdin's archenemy is Jafar.
* ''WesternAnimation/TheAmazingWorldOfGumball'':
** Gumball Watterson, and to a lesser extent, Darwin, have Rob. In fact, he became Gumball's Archenemy because he had no other role to fulfill as the Universe deemed him a mistake. He [[CreateYourOwnVillain blames Gumball]] for this, [[NeverMyFault even though he had nothing to do with Rob's predicament]].
** Gumball also has his SadistTeacher Miss Simian.
* ''WesternAnimation/AlfredJKwak'' has Dolf, his [[SchoolyardBullyAllGrownUp school bully who grows up]] to become a [[ANaziByAnyOtherName fascist dictator]], an arms dealer, a corrupt politician, and the henchman of an oil magnate.
* In ''WesternAnimation/{{Amphibia}}'', Anne Boonchuy has King Andrias. While his antagonism doesn't come apparent to her until over halfway through the season, the king quickly earns Anne's hatred when he tries to kill Sprig by dropping him from his floating castle, and remorselessly stabs Marcy Wu when she used the Calamity Box to create a portal to Earth. The repeated attempted assassinations and Earth invasion plan only make this enmity worse. The fact that Anne ends up the only one who can really do anything about his plans makes this relationship mutual, especially in the FinalBattle where she expresses sympathy over his situation of losing his friendships while she restored hers. [[spoiler: Despite Andrias ultimately surrendering peacefully, she still makes it clear that she will never forgive him since he had his chances to stop.]]
* ''WesternAnimation/AmericanDad'' [[Characters/AmericanDadStanSmith Stan Smith]] has his high school bully Stelio Kontos.
** Generally, Santa Claus is the Arch Enemy of the Smiths.
** Played for laughs with one of [[Characters/AmericanDadRogerSmith Roger Smith's]] more infamous personas, Ricky Spanish. One episode revealed that another of Roger's personas, Jeannie Gold, is not only his arch enemy, but also...his sister!
* The Huntsman is Jake's Arch Enemy in ''WesternAnimation/AmericanDragonJakeLong''. Interestingly, he is only #4 on the Dragons' list of the top thirteen threats to the magical world. The #1 threat, the Dark Dragon, is Jake's ''Grandpa's'' Arch Enemy.
* ''WesternAnimation/{{Archer}}'':
** [[Characters/ArcherSterlingArcher Sterling Archer]] has Barry Dylan. Barry worked for the agency's rival ODIN and had prior grude against Archer for droping him off a building. [[spoiler: After he's turned into a cyborg, Barry kills both Archer's fiancée and the mostly likly candidate to be Archer's father. Weridly, after several years of tring to kill each other, they actual bury the hatchet in season 11]].
*** Archer gets a new arch enemy in season 12 in the form of Fabian Kingsworth, the head of IIA. Not only does Fabian routinely mock Archer and try to steal the agency's work, but he also [[spoiler:kidnaps Archer and brainwashes Barry in his attempts to create a protection rack against the entire world]].
* ''WesternAnimation/ArchiesWeirdMysteries'': Jughead Jones has Mr. Avericci, who puts Pop Tate's Chock'lit Shoppe (a restaurant which Jughead is the best customer of) out of business, turns his friends into mannequins, and eventually tries to kill him after Jughead keeps defying Avericci.
* ''WesternAnimation/AquaTeenHungerForce'': The Aqua Teens have the Mooninites, with them being the most reoccurring nuisance they face. They even lead their own LegionOfDoom in the Season 2 finale in an effort to destroy the team.
* WesternAnimation/AtomicBetty has Maximus I.Q., an EvilOverlord who she opposes on a regular basis, and who created three [[EvilTwin evil clones]] of her.
* The universe of ''WesternAnimation/AvatarTheLastAirbender'' and associated works has the Avatar operate as the force of good and guidance for their lifetime, so some Avatars wind up with multiple enemies, or oppose concepts or the state of society. Part of the role of the Avatar is to not be caught up in personal grudges and attachments. The Avatar Spirit, Raava the spirit of light and peace, does have her personal nemesis equal and opposite in Vaatu the spirit of darkness and chaos. The two were so linked that if one of the two killed the other, the defeated would be reborn from the victor in due time. The two were locked in eternal conflict until Wan interfered and became the first Avatar by upsetting their stalemate.
** For the series ''WesternAnimation/AvatarTheLastAirbender'', [[Characters/AvatarTheLastAirbenderAvatarAang Avatar Aang's]] challenge was the burden of responsibility and the concept of war. His villain was [[Characters/AvatarTheLastAirbenderFireLordOzai Fire Lord Ozai]], though the conflict was not personal for Aang. The {{deuteragonist}} [[Characters/AvatarTheLastAirbenderZuko Prince Zuko]] was pushed to see the Avatar as his arch-enemy, the obstacle whose defeat would supposedly allow him to reenter his father's good graces. However Zuko's conflict was also an internal one of ethics versus expectations. Character development for both Aang and Zuko meant [[spoiler:confronting the Fire Lord as a proxy for confronting themselves]].
*** Zuko has an antagonistic relationship with younger sister [[Characters/AvatarTheLastAirbenderPrincessAzula Princess Azula]]. [[spoiler:She becomes Zuko's final opponent in the series, while Aang is confronting Ozai.]]
** ''WesternAnimation/TheLegendOfKorra'' follows an arc villain format, where each of the four seasons represents a different conflict and lesson for Korra. [[Characters/TheLegendOfKorraAmon Amon]] was [[spoiler:an inherited grudge from an enemy of Avatar Aang,]] though even for him the personal conflict wasn't the center of his purpose. [[Characters/TheLegendOfKorraZaheer Zaheer]] and the Red Lotus were opposed to the concept of the Avatar, and authorities itself, and while they also were not personal, they left a long term psychological impact. [[Characters/TheLegendOfKorraKuvira Kuvira]] is directly referred to as Korra's {{foil}}, and was meant to embody a possible post-Avatar world. However the most personal and consistent nemesis of Korra, who ''did'' have a personal grudge against her, was her uncle, Unalaq:
*** Unalaq was opposing Korra's father since before she was born, and has actively been antagonizing Korra since she was discovered to be the Avatar, as he sided against Wan and Raava in their conflict with Vaatu, and believed humans and spirits should coexist. He is also the only villain to have menaced Korra throughout her life, [[spoiler:and even beyond it. He was responsible for the Red Lotus' kidnapping attempt on her as a child, inflicted the most lasting damage to her and the Avatar itself by severing her connection with all of her past lives, taught her Spiritbending, and was a part of what led her to believe Wan was wrong and the human and spirit worlds should be reconnected, effectively getting his goal for the next 10,000 years. Furthermore he became the only Dark Avatar, by freeing and fusing with Vaatu.]]
** Some Avatars do have a personal nemesis. This is most closely seen with Avatar Kuruk and the spirit Koh the Face Stealer, who stole his wife's face. Additionally, Avatar Roku had [[spoiler:his lifetime friend turned enemy and cause of his death, Fire Lord Sozin]].
* Babar has Rataxes in ''WesternAnimation/{{Babar}}'' although how much he is his literal ArchEnemy and his FriendlyEnemy may vary depending of the episode, Rataxes goes from trying to took over Babar's kingdom, kidnap him and the turtle king to avoid the passing of a treaty and threaten to declare war over an stolen good to just having a rivalry in sports' competitions.
** A more darker ArchEnemy, of course, is The Hunter, who literally killed his mother.
* ''WesternAnimation/BeavisAndButtHead'' have Principal [=Principal McVicker=], who is hostile towards the duo because of the trouble their antics cause.
* ''WesternAnimation/BobsBurgers''
** [[Characters/BobsBurgersBobBelcher Bob Belcher]] has [[{{Jerkass}} Jimmy Pesto]], Bob's business rival who frequently one-ups him. He also has one in [[ObstructiveBureaucrat Hugo Habercore]], the city health inspector who aims to get the restaurant shut down after Linda left him for Bob. That said, it's more one-sided on Hugo's end.
** [[Characters/BobsBurgersLouiseBelcher Louise Belcher]] has guidance councilor [[ChildHater Phillip Frond]], with his ideas always making her school life harder.
* ''WesternAnimation/TheBoondocks'':
** Huey Freeman has Uncle Ruckus. The former is an African-American left-wing activist, while the latter is an African-American (which he is [[IRejectYourReality in denial about]]) BoomerangBigot. The two of them outright fight in the season 2 premiere, with Ruckus stating he's been waiting for this ever since Huey came into town.
** Robert Freeman has Colonel H. Stinkmeaner. Stinkmeaner beat and humilated Robert in a fight, and Robert accidently kills Stinkmeaner in their rematch. However, Stinkmeaner's spirit would return to Earth by possessing the body of Tom [=DuBois=], seeking vengeance against Robert.
* ''WesternAnimation/BraveStarr'':
** Marshal [=BraveStarr=] has Tex Hex, one of his most recurring adversaries. Although [=BraveStarr=] and Tex Hex both have supernatural abilities, [=BraveStarr=] is the Marshall of New Texas, while Tex Hex is the leader of the Carrion Bunch outlaw gang responsible for much of the crime in New Texas.
** Shaman, [=BraveStarr=]'s mentor has Stampede, Tex Hex's master. Stampede is responsible for the deaths of his people. Shaman came to New Texas because of Stampede.
* The Evil Emperor Zurg to the title character of ''WesternAnimation/BuzzLightyearOfStarCommand''. Buzz's secondary archenemy is his former parter Warp Darkmatter. Buzz has also his AbhorrentAdmirer Gravitina and his evil AlternateSelf, [[ExactlyWhatItSaysOnTheTin Evil Buzz Lightyear]].
* [[TheUnfavorite Cat]] and [[RabidCop Rancid Rabbit]] from ''WesternAnimation/CatDog''.
** [=CatDog=] and the Greaser Dogs.
* ''WesternAnimation/CampLakebottom:'' Buttsquat to [=McGee=].
** Suzi to Gretchen.
* ''WesternAnimation/CampLazlo'': Lumpus and Edward both see Lazlo as theirs, although Lazlo is nothing but friendly and outgoing toward them.
%% * Doc Terror to the WesternAnimation/{{Centurions}}.
* ''WesternAnimation/ChalkZone'': Rudy Tabootie has his own creation Skrawl, who seeks revenge on Rudy for his grotesque appearance (even though it was Reggie Bullnerd and his friends who ruined his appearance).
* ''WesternAnimation/ChipNDaleRescueRangers'': The Rescue Rangers have [[CatsAreMean Fat Cat]] and [[MadScientist Professor Norton Nimnul]] as their most prominent enemies.
* ''WesternAnimation/{{Chowder}}'': Mung Daal has Endive, his large, condescending, and snobbish rival who seeks to screw Mung over whenever she can. "A Taste Of Marzipan" even had them start an outright food ''war'' just because Endive copied Mung's food fair recipe[[note]]Raspberry Chocolate Stroodle Doodles[[/note]] and the two tried to one-up each other.
* WesternAnimation/{{Clementine}} and her GuardianAngel Héméra have Malmoth, a demon after Clémentine's soul.
* ''WesternAnimation/CodeLyoko'': The Lyoko Warriors have X.A.N.A., a malevolent artificial intelligence who the Lyoko Warriors spend the entire series and the sequel series ''Series/CodeLyokoEvolution'' opposing.
** X.A.N.A. is also this to his creator Franz Hopper.
* [[CreepyChild The Delightful Children]] for the main operatives of the [[WesternAnimation/CodenameKidsNextDoor Kids Next Door]]. ''Especially'' [[TheLeader Numbuh 1]].
** Each operative has their own Arch-Enemies as well. Numbuh 1 had Father [[spoiler:who is his EvilUncle]] and [[GloryHound Chad aka Numbuh 274]], the former leader of the KND [[spoiler:who hated him because Numbuh 1 was considered to be a better operative than him (which was eventually proven true).]] Numbuh 2 had Mr. Fizz and Mushi Sanban, Numbuh 3 has Mr. Boss, Numbuh 4 with the [[IneffectualSympatheticVillain Toiletnator]] and [[TheBully Ernest]], and Numbuh 5 has her sister Cree.
* ''WesternAnimation/ConanTheAdventurer'': Conan has Wrath-Amon, an EvilSorcerer who [[TakenForGranite turned his family into stone]].
* [[CatsAreMean Katz]] and [[WesternAnimation/CourageTheCowardlyDog Courage]] had been battling each other from the beginning.
* Baron Silas Greenback, in henchman Stiletto's words, is the "[[{{Malapropism}} life long anniversary]]" of WesternAnimation/DangerMouse.
* ''WesternAnimation/DanVs'': Dan Mandel has Imposter Dan, who stole Dan's identity, which backfires on the imposter when the real Dan misses his court date, resulting in the imposter being imprisoned for six months. The vengeful Imposter Dan becomes a telemarketer to drive the real Dan crazy.
* Vlad Plasmius to the eponymous character in ''WesternAnimation/DannyPhantom''.
* ''WesternAnimation/{{Daria}}'': Daria Morgendorffer is often at odds with Ms. Angela Li, her corrupt and tyrannical principal.
* Often played for laughs in ''WesternAnimation/DarkwingDuck'', where Darkwing would frequently refer as his Arch Enemy/archrival/archnemesis ''any'' villain he would have met at least twice. Even a guys whose only power was to ''have a bunch of penguins at his service to commit robberies'' was once referred as his Arch-Enemy. However, from a serious point of view, at least three antagonists can be seen as his archenemies:
** [[PsychoElectro Megavolt]] initially owned the role, being both the first villain Darkwing chronogically faced (at least in his more "realistic" backstory), a personal enemy and one of the most recurring antagonists. He gradually lost the post to Negaduck however, to the point the recent comic sequel has him retired.
** [[EvilCounterpart Negaduck]] is mostly considered as the main Arch-Enemy, due to both being an evil counterpart of the hero, the leader of the [[PsychoRangers Fearsome Five]] and the most popular villain amongst fans.
** Taurus Bulba, while having only two appearances in the animated series, was the first villain seen onscreen, as well as one of the most fearsome and competent. His link to Gosalyn makes him a personnal villain. As such, he can be considered, in a way, as an Arch-Enemy
* ''WesternAnimation/DextersLaboratory'': Dexter has Mandark as his archrival, being his EvilCounterpart and intellectual equal
** Dee Dee's arch-nemesis is Lalavava, Mandark's sister... [[WhatHappenedToTheMouse for one episode, that is]].
* Emperor Krulos to Questar and the ''WesternAnimation/DinoRiders''.
* ''WesternAnimation/DragonsTheNineRealms'': Tom Kullersen and his dragon Thunder have Buzzsaw, who seeks revenge on Thunder for destroying his lumber company [[NeverMyFault even though it was Buzzsaw's own fault]].
* Captain Hero on ''WesternAnimation/DrawnTogether'' belatedly realized that the random homeless guy they ran over was "My... ARCH... ''NEMESIS''!"
** As an added, subtlety that would only be found on this show, his goal is not Captain Hero's destruction, but to get him to wash his balls. And has succeeded multiple times.
* ''WesternAnimation/TheDreamstone'': The Dream Maker, the head Dreammakers' Council, has Zordrak, a former Dreammaker who was exiled for using his powers for evil. Zordrak seeks to steal the Dreamstone from the Dream Maker so he can spread nightmares into the Sleeping World.
* In ''WesternAnimation/DuckTales1987'' [[Characters/DuckTales2017ScroogeMcDuck Scrooge McDuck]]'s arch [[TheRival rival]] is [[Characters/DuckTales2017FlintheartGlomgold Flintheart Glomgold]], but his most threatening nemesis is Magica de Spell. If you have to have an obsessive, [[ImplacableMan implacable]] arch nemesis, might as well be a sexy sorceress.
** Similarly, [[WesternAnimation/DuckTales2017 the remake]] has Magica de Spell as Scrooge's "most dangerous" enemy with her secretly plotting against Scrooge for all of Season 1, while Glomgold is a recurring HarmlessVillain who's obsessed with [[ComplexityAddiction overcomplicated revenge plots]] which tend to [[HoistByHisOwnPetard cartoonishly backfire]].
--->'''Glomgold:''' Wait, how did you know it was me?\\
'''Louie:''' It's always you.\\
'''Glomgold:''' AND IT ALWAYS WILL BE! AHAHAHAHAHA!
*** The remake also give Gizmoduck one as well. Ironically, it's one of the original characters meant to go against Scrooge, but Mark Beaks has clashed far more and is far more personal a foe with Fenton.
*** Also in the remake, Della Duck has General Lunaris.
** [[ComicBook/DisneyDucksComicUniverse In the comics]], he has three, Flimheart Glomgold, John D. Rockerduck and his most threatening nemesis is [[EvilOldFolks Blackheart Beagle]] who eventually recruits all the other recurring villains into his LegionOfDoom.
** With the reveal of him being the head of F.O.W.L. [[Characters/DuckTales2017BradfordBuzzard Bradford Buzzard]], the former chairman of Scrooge's board of directors, have become one of, if not the, big nemesis for Scrooge. Unlike with his other nemesis Scrooge does treat Bradford very seriously due to how well Bradford knows him and his secrets, to the point that he doubts for a time that he can win against him. Later it is revealed that Bradford is the one who arranged for Della to learn about the Spear of Selene and get lost into space, cementing him as Scrooge's most personnal and hated enemy.
* ''WesternAnimation/EdEddNEddy'': The Eds have the Kanker Sisters, their [[AbhorrentAdmirer Abhorrent Admirers]]. Eddy also has an antagonistic relationship with JerkJock Kevin. In one episode, Kevin used Eddy's EmbarrassingMiddleName to blackmail Eddy into humiliating himself, only for Kevin to tells the other kids Eddy's middle name anyways.
* Vicky and Crocker on ''WesternAnimation/TheFairlyOddParents'' fits this for Timmy. The former is the reason why he had his fairies in the first place.
** The episode "The Masked Magician" parodies the trope to Fairyland and back.
** The Crimson Chin ostensibly has The Bronze Kneecap, but he's a pretty minor character overall and much more attention is paid to The Chin's conflict with The Nega-Chin.
** For the fairies themselves, its their anti fairy counterparts.
* ''WesternAnimation/FamilyGuy'':
** Ernie the Giant Chicken and Carter Pewterschmidt to [[Characters/FamilyGuyPeterGriffin Peter Griffin]]. Though the latter is sometimes mutual and sometimes one-sided (on Carter's part).
** [[Characters/FamilyGuyGlennQuagmire Glenn Quagmire]] to [[Characters/FamilyGuyBrianGriffin Brian Griffin]]. They eventually patch things up, though there's still some lingering friction between them.
*** Quagmire [[spoiler:briefly had]] Jeffrey Fecalman, his sister Brenda's abusive boyfriend.
** [[Characters/FamilyGuyStewieGriffin Stewie Griffin's]] arch enemy was his half brother Bertram, [[spoiler: up until he was KilledOffForReal]]. You could also make a case for Lois Griffin, who Stewie was [[AntagonisticOffspring hellbent on killing]] in early seasons.
*** As of season 17, he has his classmate Doug as a SitcomArchNemesis.
** The Evil Monkey to Chris, up until it's revealed the Monkey was GoodAllAlong and just bad at making conversation.
** Joe Swanson had Bobby Briggs, who was responsible for crippling him.
* ''Franchise/FelixTheCat'': The Professor serves as Arch Enemy for Felix.
* ''WesternAnimation/FinalSpace'':
** The Lord Commander is one for the Galaxy One especially Avocato and Gary with holding the former's son hostage and ripping off the arm of the latter.
** Oreskis made enmity with Bolo after he gave Bolo's lover an STD. Invictus also functions as one for Bolo due to Invictus being behind the Titans' corruption.
** Wehrent became Ash Graven's archenemy after he ate her little sister.
* ''WesternAnimation/FostersHomeForImaginaryFriends'':
** Mac and Terrence
** Bloo and Berry
** Imaginary Man has one literally named Nemesis[[spoiler:ter]]
* ''WesternAnimation/{{Freakazoid}}'' is another example of a series where the Arch Enemy and the most dangerous enemy are not one and the same. The Lobe is the Arch Enemy, but Freakazoid's most genuinely threatening foe is CorruptCorporateExecutive Armando Gutierrez.
* In the ''WesternAnimation/{{Futurama}}'' movie ''Into the Wild Green Yonder'', the Encyclopod and the Dark One. Their species have been archenemies since time immemorial: the Encyclopods wish to preserve all life and the Dark Ones want to destroy it. [[spoiler:After the last Dark One is killed, the last Encyclopod reluctantly decides to preserve its ancient enemy's genetic code. Fortunately, the last Dark One's remains are immediately wholly destroyed making this impossible so the Encyclopod doesn't have to carry its worst enemy on its back.]]
** Farnsworth and Wermstorm, thanks to a A- Farnsworth gave to Wernstorm. Farnsworth can also have this with Mom depending on the episode.
* David Xanatos to Goliath in ''WesternAnimation/{{Gargoyles}}''. Though Xanatos fits best from a series standpoint, from a ''personal'' standpoint Demona, the Archmage, and Thailog might also want to claim that spot. From the same series, Tony Dracon is Elisa Maza's Arch Enemy (though he's not much of a threat to the Gargoyles themselves), while the line of Hunters consider themselves Demona's collective Arch Enemy (though in truth hers is probably [=MacBeth=]).
* ''WesternAnimation/GeneratorRex'': Rex Salazar has Van Kleiss, the BigBad of the first two seasons, a supporting antagonist in the third season, [[spoiler:and the killer of Rex's parents.]]
%% * Cobra Commander to Duke and the Franchise/GIJoe.
* In ''WesternAnimation/GravityFalls'', Gideon Gleeful and [[spoiler:Bill Cipher]] are archenemies to Dipper Pines and, in broader strokes, the rest of the Pines family.
** While the latter treats his feud with the Pines family as something like a amusing game at best, he has a far more personal, venomous hatred for the Time Baby, and the Time Baby isn't very fond of him either. [[spoiler:When Bill finally is able to manifest a physical form, the moment Time Baby shows up at his doorstep, he vaporizes Time Baby on the spot.]]
* ''WesternAnimation/GremlinsSecretsOfTheMogwai'': Sam Wing has Riley Greene, who ate his grandfather.
* ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'':
** Grim has Boogey, his high school bully who continues to torment him in the present and whose actions led to the falling out between Grim and his good friend Velma Green and in turn Grim being the Grim Reaper in the first place. Grim also has Jack O'Lantern, who [[DidYouJustScamCthulhu forced Grim to grant him eternal life]] centuries ago, [[DoNotTauntCthulhu causing Grim to retaliate]] by [[OffWithHisHead removing Jack's head]].
** Billy sees Jeff as his, although it's entirely one-sided and irrational as Jeff just wants Billy to love him. He could be said to have a true nemesis in the form of Sperg.
** Mandy has Mindy, her rival at school.
** For the trio as a whole, there's Eris and Nergal. Though, the latter became more of a [[SitcomArchNemesis Sitcom Arch-Nemesis]] in the later seasons
* ''WesternAnimation/{{Grossology}}'': Abby and Ty Archer have Lance Boil, a treacherous former member of the Grossologists who is repeatedly defeated by the duo.
* ''WesternAnimation/HeManAndTheMastersOfTheUniverse2021'':
** {{Invoked}} by the {{Sapient Cosmic Force}}s of Grayskull and [[TheDarkSide Havoc]]. If a person wields one of the powers, the other power will eventually find someone to wield it, creating a "Nemesis". To fully master either power, one ''must'' overcome their Nemesis in a final confrontation. As it happens, every Master of the Universe had a prior antagonistic relationship with who became their Dark Master Nemesis.
** Keldor kidnapped his nephew Adam and used him as a hostage to try and steal the Power of Grayskull. But where Keldor failed a SecretTestOfCharacter and was cursed with Havoc, Adam passed the test and was chosen for Grayskull. Events lead to Adam losing his memory and thus his family in Eternos thanks to Keldor, and years later as He-Man prevented Keldor from claiming the Power of Grayskull for good. Keldor then embraced Havoc and was transformed into Skeletor, who threatens all of Eternia in his powerlust.
** Evelyn took the StreetUrchin Teela under her wing to use her to steal artifacts related to the Power of Grayskull, a power Evelyn spent her entire life studying to obtain. Teela is eventually guided by the voice of the Guardian of Grayskull and is chosen by its power to become Sorceress, making her leagues stronger in magic than Evelyn. Evelyn is now DrivenByEnvy to use Havoc and prove herself the better spellcaster than someone who "lucked into" getting what she desired.
** Kronis was Duncan's EvilMentor who forced the boy to do all of his menial inventive work. Duncan was strictly under Kronis's thumb until the day he was ordered to burn down a village full of innocents, at which time he finally defected and became a Master of the Universe. Kronis doesn't like his apprentice turning against him and takes perverse delight in trying to kill his former ward.
** The beastopoid R'Qazz had captured and enslaved the sapient tiger Cringer in his youth to make him fight in BeastlyBloodsports. Cringer refused to fight, which lead to his insulting name and R'Qazz [[spoiler:declawing Cringer]]. Cringer eventually escaped, but still bears the physical and emotional scars from his imprisonment. Meanwhile, R'Qazz sees Cringer as the one that got away and is hellbent on having Cringer fight to the death for his amusement.
** A DrivingQuestion for Krass in season two is why she's the only Master of the Universe who ''doesn't'' have a Nemesis, which seems to relate to why she hasn't mastered the Power of Grayskull to the same level as her fellow Masters. [[spoiler:As it's revealed in the season two finale, Krass is her ''own'' Nemesis due to having [[YinYangBomb both powers within her]]]].
* ''WesternAnimation/{{Hercules}}'' has [[EverybodyHatesHades Hades]], his EvilUncle who tried to have him killed when he was a baby. [[spoiler:He is later indirectly responsible for the death of Meg, who is killed by a cyclops Hades sent to kill Hercules.]]
* ''Franchise/HowToTrainYourDragon'': Drago Bludvist to House Haddock. Bludvist is responsible for the deaths of both Valka's Bewilderbeast and Stoick the Vast, the latter of whom was killed by Hiccup's dragon Toothless under the hypnosis of Drago's Bewilderbeast.
** Hiccup Horrendous Haddock III had Dagur the Deranged, who sought vengeance on him after learning he deceived Dagur. Dagur eventually loses the position of Hiccup's archenemy to Viggo Grimborn, one of the few people capable of outsmarting Hiccup.
** Toothless has Grimmel the Grisly, who is responsible for the Night Fury genocide which made Toothless the LastOfHisKind. Grimmel also becomes this to Hiccup by trying to force him to hand Toothless over to him, burning his house, and threatening to "destroy everything [Hiccup] [loves]" if does not cooperate, which prompts Hiccup to migrate his people from Berk to the Hidden World.
* ''WesternAnimation/InfinityTrain'': MT has the Flecks, who spend the first two seasons relentlessly hunting her down. It seems to be particularly personal between her and Mace, the leader of the duo, as Sieve at least tries to be personable, while Mace is nothing but cold. She and Mace eventually get an entire episode together that puts the hatred between the two of them on full display.
* ''WesternAnimation/InspectorGadget'', has Doctor Claw, a DiabolicalMastermind who constantly swears vengeance against Gadget, unaware that it is actually Penny and Brain who do most of the work in foiling Claw's plans.
%% ** Talon to Penny in the [[WesternAnimation/InspectorGadget2015 2015 reboot]].
* ''WesternAnimation/InvaderZim'': [[Characters/InvaderZimZim Zim]] has Dib Membrane. Zim is an alien trying to TakeOverTheWorld, and Dib seeks to expose him.
* On ''WesternAnimation/JackieChanAdventures'', [[DemonLordsAndArchDevils Shendu]] is this to the Chan family as a whole, Jackie is particular. He's the BigBad of the first two seasons, the FinalBoss of Season 3, and the father of Season 5 villain Drago. He's their most dangerous and persistent enemy, and the one who seems to have the greatest grudge against them.
** Speaking of [[ConquerorFromTheFuture Drago]], he apparently had this relationship with Jade in the future, and it sorta trickles down to her present day self.
** And then, of course, there's [[OldMaster Uncle]] and [[EvilSorcerer Daolon Wong]].
* ''WesternAnimation/{{Jem}}'':
** Jerrica Benton has Eric Raymond, her corrupt business rival who schemes to take to take over Starlight Music.
** Jerrica's alter ego Jem, the lead singer of the Holograms, has Pizzazz, the lead singer of the Misfits, a rival band who antagonize the Holograms.
* ''WesternAnimation/JimmyTwoShoes'': Jimmy Two-Shoes has Lucius Heinous VII, who seeks to make people miserable and despises Jimmy for being ThePollyanna.
* We never learn the details, but as per some kind of feud stretching to before the series, Dr. Quest and Dr. Zin seem to both hate and grudgingly respect one another's guts in ''WesternAnimation/JonnyQuest''.
* ''WesternAnimation/JohnnyTest'' and Bling-Bling Boy are ''sorta'' this. They're a dubious example mainly because Johnny also doubles as his OnlyFriend.
* ''WesternAnimation/JurassicWorldCampCretaceous'': The Camp Fam have Daniel Kon, who is the President of Mantah Corp and the [[AbusiveParents emotionally abusive father]] of Camp Fam member Kenji. In Season 5, he temporarily manages to [[ManipulativeBastard turn his son Kenji against the rest of the Camp Fam]], and in the GrandFinale, he reveals that [[spoiler:he had Kash D. Langford blackmail Sammy's family.]]
* ''WesternAnimation/KidVSKat'': Coop has Kat, with Coop being the only one wary of Kat's plans of world domination and his bent on stopping and exposing him.
* Dr. Drakken is WesternAnimation/KimPossible's self-proclaimed arch foe, although [[ItsPersonalWithTheDragon Shego]] is her {{foil}} and the one she actually [[DarkActionGirl locks fists with]]. More specifically Drakken is an arch foe and Shego is the nemesis.
** Kim also has Professor Dementor, who sought her Battle Suit. He hijacked control of the Battle Suit while Kim's boyfriend Ron was using it, and forced Ron to attack her. He later kidnapped Kim's cousin Larry.
** [[Characters/KimPossibleRonStoppable Ron Stoppable's]] Arch Foe is Monkey Fist, but that's mostly because Fist is the only one who recognizes Ron's name; that and the "Mystical Monkey Power."
*** There's also Gil, [[NeverMyFault who blames Ron]] for his mutation.
* ''WesternAnimation/KungFuPandaLegendsOfAwesomeness'':
** Po has Temutai and Hundun.
*** Temutai is a warrior king who Po prevented from enslaving a princess. Temutai later attacks the Jade Palace in both "Owl Be Back" and "Master and the Panda".
*** Hundun has a vendetta against Po for causing his to lose his job as a guard for the Chorh-Gom Prison by Tai Lung, who was the sole person incarcerated there. Although Po befriended and trained Hundun in an effort to help him get his life back on track, Hundun [[UngratefulBastard turned on Po]] once he found out Po was the Dragon Warrior who defeated Tai Lung, and even threatened Po's father Mr. Jing. Hundun's attempt at revenge results in his horn being broken, and him being incarcerated at Chorh-Gom Prison. In Challenge Day", Hundun escapes prison and seeks to replace Po as the Dragon Warrior.
** Shifu has Junjie, has EvilFormerFriend.
* ''WesternAnimation/TheLegendOfVoxMachina'': Percival de Rolo has Lord Sylas and Lady Delilah Briarwood, who massacred most of his family.
* [[BigBad Imperiex]] and Franchise/{{Superman}} clone Kell-El in ''WesternAnimation/LegionOfSuperHeroes2006''.
* ''Franchise/LiloAndStitch'' have Jacques von Hämsterviel (the treacherous former partner of Stitch's creator) and Gantu (who was forcibly retired from his job as a Captain of the Galactic Federation after his conflict with them in the first film) as their most prominent enemies.
* ''Franchise/TheLionKing'': Simba has Scar, his EvilUncle who killed his father and usurped the kingdom Simba was supposed to inherit.
* ''Franchise/TheLittleMermaid'': King Triton has Ursula, who seeks to usurp him.
* ''WesternAnimation/TheLoudHouse'': Lincoln Has Chandler. Chandler refused to allow Lincoln and Clyde to come to them party after scamming him for money from Lincoln's oldest sister Lori at Gus's games and grub in Chandler's debut episode "The Waiting Game". As of Season 5, they are also bitter classmates since "Schooled".
* ''WesternAnimation/LooneyTunes'':
** Bugs Bunny and Daffy Duck have Elmer Fudd, a hunter who keeps trying to kill them. Yosemite Sam is also a prominent recurring foe to Bugs.
** Even though they only encountered each other in one of the classic shorts, subsequent media often pitted Duck Dodgers against Marvin the Martian (referred to as X-2 in the [[WesternAnimation/DuckDodgers 2003 animated series]]).
** Tweety has Sylvester, a cat who keeps trying to eat him.
** The Road Runner has Wile E. Coyote, who keeps trying to eat him, often by using Acme Corporation equipment, which constantly backfires of Wile E. Coyote.
* Dr. Pretorius to ''WesternAnimation/TheMask'' in the animated series, at least for being the most recurring villain.
* ''Franchise/MastersOfTheUniverse'':
** ''WesternAnimation/HeManAndTheMastersOfTheUniverse1983'' He-Man has Skeletor, an EvilSorcerer who is constantly thwarted by He-Man.
** ''WesternAnimation/SheRaPrincessOfPower'': She-Ra has Hordak, who kidnapped her as an infant and made her one of his minions, only for Adora to join the Rebellion against him after making a HeelFaceTurn.
* ''WesternAnimation/MaxSteel'': Max Steel has Psycho, who [[CreateYourOwnHero caused the accident that gave Josh his superpowers]].
* ''WesternAnimation/MaxSteel2013'':
** Max [=McGrath=] has Miles Dredd, his parents' treacherous former associate.
** Steel has Makino, the the leader of the Ultralinks, who Steel [[MySpeciesDothProtestTooMuch betrayed]].
* ''WesternAnimation/MenInBlackTheSeries": Agent J and K have Alpha, one of the founders and the original leader of MIB, who's now the most recurrent and dangerous enemy of the Men In Black. Kay in particular has a very deep and personal feud with Alpha, as Alpha was his friend and mentor before the rogue agent betrayed and nearly-murdered him.
* ''WesternAnimation/{{Metalocalypse}}'':
** Dethklok have Mr. Salacia and Magnus Hammersmith.
*** Mr. Salacia is the leader of [[TheConspiracy the Tribunal]], an organization which spies on Dethklok. [[spoiler:In Season 4, Salacia kills TheTeamBenefactor Roy Cornickelson.]]
*** Magnus Hammersmith is a former member of Dethklok who seeks revenge against them for kicking him out.
** Charles Foster Offdensen has several encounters with the Metal Masked Assassin. In one of their encounters, Offdensen break's the Assassin's arm, stabs his back, and kicks him into a bay. In a later encounter, [[spoiler:the Assassin cuts Offdensen's cheek.]]
* ''Franchise/MickeyMouse'':
** [[CatsAreMean Pete]] typically acts as the ArchEnemy to either WesternAnimation/MickeyMouse, WesternAnimation/DonaldDuck, and/or WesternAnimation/{{Goofy}}, depending on the cartoon.
** [[DiabolicalMastermind The Phantom Blot]] is one of Mickey's most prominent and dangerous foes in the ComicBook/MickeyMouseComicUniverse. Albeit less so in animation, where he's typically a VillainOfTheWeek.
* ''WesternAnimation/MightyMax'':
** Max and Virgil have Skullmaster, who is both the villain Max is destined to defeat, and the [[spoiler:EvilFormerFriend and the [[APupilOfMineUntilHeTurnedToEvil former apprentice]] of Vergil.]]
** Norman has Spike, who killed his father thousands of years before the events of the series.
* ''WesternAnimation/MiloMurphysLaw'': Milo Murphy has King Pistachion, an EvilOverlord who was created when a sentient blob inadvertently created by Milo merged with a pistachio plant. Milo later has the Alien Commander, who spies on, and later kidnap Milo twice. [[spoiler:Their conflict ends when Milo helps her save her home planet, which was the reason she was trying to capture him in the first place.]]
* ''WesternAnimation/MiraculousLadybug'':
** [[Characters/MiraculousLadybugMarinetteDupainCheng Ladybug]] and [[Characters/MiraculousLadybugAdrienAgreste Cat Noir]] have a collective one in [[Characters/MiraculousLadybugHawkMoth Hawk Moth]], who seeks to take their Miraculouses and use their power to achieve a world-altering wish. For the latter he also doubled as a ArchnemesisDad, though neither father or son are aware of this.
** Ladybug/Marinette also has Lila Rossi, who despises both of her identities despite not knowing they are the same person. Both of them have crushes on Adrien, which led to Lila developing a vendetta against Ladybug for exposing her lies to him, and when Marinette made it clear she wouldn't take any of Lila's verbal bait, she sought to turn all of her friends against her, at one point even getting Marinette expelled.
* ''WesternAnimation/MoralOrel'': Orel Puppington has his [[AbusiveParents abusive father]] Clay, who seeks to raise Orel into becoming like him. Despite his abuse, [[BrokenPedestal Orel looked up to Clay until]] he (Clay) shot Orel in a hunting trip, [[NeverMyFault blamed Clay for it]], ripped his lucky shirt, joked about his (Clay's) "lucky gun [trumping] [Orel's] lucky shirt", and drunk a bottle of rubbing alcohol to spite him.
* WesternAnimation/MrPickles has the titular demonic Border Collie and Grandpa Henry Gobbleblobber who dedicates his time trying to expose Mr. Pickles for what he was.
* WesternAnimation/MyLifeAsATeenageRobot: Jenny to Vexus and Vexus to Jenny.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'':
** Although the show works on a MonsterOfTheWeek format that discourages recurring enemies, [[Characters/FriendshipIsMagicPrincessCelestia Princess Celestia]] is only ever shown to have personal animosity towards one individual: [[Characters/FriendshipIsMagicDiscord Discord]]. He was the first character Celestia ever actually sent the Mane Six to defeat, and [[OoCIsSeriousBusiness the first time we ever see her angry or genuinely surprised]] are when he steals the Elements of Harmony. [[ForTheEvulz He, of course, thinks this is all great fun.]] [[spoiler:Now that Discord has pulled a HeelFaceTurn, this probably no longer applies, even if he's still a loose cannon.]]
** Diamond Tiara and (occasionally) Silver Spoon to the Cutie Mark Crusaders (but mostly Apple Bloom). Diamond Tiara does ''not'' like Apple Bloom one bit and all of her appearances show her trying to hurt and humiliate the "blank-flank". [[spoiler:She eventually makes a HeelFaceTurn too, though she quickly suffers from DemotedToExtra for the remainder of the series.]]
** [[Characters/FriendshipIsMagicSpike Spike]] and Garble have an intense, personal, and mutual hatred of each other -- Spike hates Garble for being a violent bully, and Garble hates Spike for being a CategoryTraitor. All three of Spike's trips to the Dragon Lands have had him put Garble in his place. [[spoiler:His fourth trip ends with the two burying the hatchet.]]
** [[Characters/FriendshipIsMagicApplejack Applejack]], the living embodiment of honesty, has a heated rivalry with {{Snake Oil Salesm|an}}en Flim and Flam. It doesn't help that at least two of their cons have involved personally screwing over her and her family.
** For the Mane Six as a whole, [[Characters/FriendshipIsMagicQueenChrysalis Queen Chrysalis]] is the most prominent threat who refuses to either a. [[HeelFaceTurn turn good]] or b. [[KilledOffForReal stay down]].
** Discord and [[Characters/FriendshipIsMagicLordTirek Lord Tirek]] both share an intense, mutual hatred. Tirek took great pleasure in manipulating and betraying Discord. Discord is the one who seals Tirek's ultimate fate of being turned into stone. And it's implied that the two of them have met long before and not on good terms.
* ''WesternAnimation/MyGymPartnersAMonkey'': Adam has the school's resident bully, Bull Sharkowski.
* Jack Skellington and Oogie Boogie in ''WesternAnimation/TheNightmareBeforeChristmas'', with their rivalry originating from the prequel games.
* ''WesternAnimation/{{Ninjago}}'':
** [[BigBad Garmadon]] is this to [[TheHero Lloyd]], Master Wu, and the Ninja as a whole.
** Garmadon also has Clouse. They were both rivals under the tutelage of Master Chen, and Clouse resents Garmadon for receiving the title of "Lord" instead of him.
** [[GreaterScopeVillain The Overlord]] was this to The First Spinjitsu Master in the past but eventually becomes Lloyd's nemesis in the present. As well as the Ninja's most powerful and most dangerous enemy.
** Kai has [[LaughablyEvil Master Chen.]]
** Zane has [[SmugSnake General Cryptor and General Vex.]]
** Jay has [[JackassGenie Nadakhan]] and [[AIIsACrapshoot Unagami.]]
** Cole has [[ManipulativeBastard The Skull Sorcerer]]
** Nya has [[TheEvilPrince Prince Kalmaar.]]
** Master Wu has Aspheera.
* ''WesternAnimation/OKKOLetsBeHeroes'': K.O. has his ArchnemesisDad Professor Venomous, [[spoiler:and Venomous' alter ego Shadowy Figure]]. K.O. also has Lord Boxman, who seeks to destroy Lakewood Plaza Turbo, which is where K.O. works.
* ''WesternAnimation/TheOwlHouse'':
** Eda Clawthorne and Lilith Clawthorne had not seen eye to eye for years largely because of Lilith working for the Emperor's Coven. Worse, "Agony of a Witch" reveals that [[spoiler: Lilith cursed Eda]] so she could have a likelier chance to win a position. Lilith had to do ''a lot'' to regain her relationship with her sister.
** Boscha is this to Willow having bullied her for years and is still hellbent on terrorizing her even when Amity started to defend her.
** [[Characters/TheOwlHouseLuzNoceda Luz Noceda]] and [[Characters/TheOwlHouseEmperorBelos Emperor Belos]]. This is sealed when Luz [[spoiler: uses fire glyphs to destroy the portal to the human world]] thus earning Belos' fury. Their further encounters in the second season only make this worse, as Luz has to [[spoiler: live with the realization she helped Belos rise to power in a stable time loop]] while Belos [[spoiler: gets tricked and branded by Luz in the Season 2 finale, putting him at risk of his own genocide plan]].
** Amity Blight's relationship with her mother [[EvilMatriarch Odalia]] was always tense, but Amity disowns her in the season 2 episode "Clouds On The Horizon" when Odalia [[spoiler: reveals that she is backing Belos in achieving the Day of Unity under the notion that she (primarily) and her family would rule as lesser royalties in the new world]]. She also finds out that Amity [[spoiler: was dating Luz and tries to drive a wedge into it]].
* ''WesternAnimation/ThePenguinsOfMadagascar'': The titular penguins, especially Skipper, Dr. Blowhole, a MadScientist dolphin who they have multiple encounters with. Even before Blowhole's first onscreen introduction, Skipper refers to him as "my mad dolphin nemesis" in the episode "Eclipsed", during which he belives Blowhole as having blown out the sun when he sees a solar eclipe. In "Dr Blowhole's Revenge", he kidnaps King Julien under the belief he is Skipper's best friend.
* ''WesternAnimation/PennZeroPartTimeHero'': Penn Zero has Rippen, who trapped his parents in the Most Dangerous World Imaginable.
* Perry the Platypus and [[Characters/PhineasAndFerbHeinzDoofenshmirtz Dr Doofenshmirtz]] from ''WesternAnimation/PhineasAndFerb'' are acknowledged to be this, though Perry likely doesn't really respect Doofenshmirtz as a nemesis. Even so, the relationship is very important to both of them, and any time it's interrupted is [[DoesThisRemindYouOfAnything treated like a romantic break-up]].
* ''Franchise/{{Popeye}}''
** Bluto, despite only appearering in one storyline in the original comic strip, became by far the most recurring antagonist in the [[Creator/MaxAndDaveFleischer Fleischer Studios]] and Creator/FamousStudios cartoons, and has been Popeye's go-to archenemy ever since. He has appeared in multiple cartoons and comics, and was even the BigBad of the [[Film/{{Popeye}} 1980 live-action film]].
** The Sea Hag is an even earlier villain than Bluto, serving as the primary and most recurring antagonist in the original comics. She was absent from the [[Creator/MaxAndDaveFleischer Fleischer Studios]] and Creator/FamousStudios cartoons, but later became one of Popeye's primary foes in 1960s Popeye television series. In ''The All-New Popeye Hour'', the Sea Hag was much less-frequent as an adversary than Bluto, but usually served as a more serious threat. She is the BigBad of ''Popeye's Voyage: The Quest for Pappy''.
* ''WesternAnimation/ThePowerpuffGirls1998'':
** Mojo Jojo for all 3 girls. Not only is he the girls' most common enemy, as well as the one who most consistently comes close to actually defeating them, he's also connected to their origins since not only did he gain his super-intelligence from the same accident that created the girls (which he himself caused), but as ''WesternAnimation/ThePowerpuffGirlsMovie'' shows, he's also the first villain they stopped, which led to the girls using their powers to become heroes.
** Princess Morbucks for Blossom.
** HIM for Bubbles.
** The Gangreen Gang for Buttercup.
** In the [[WesternAnimation/ThePowerpuffGirls2016 2016 series]], Buttercup has Manboy, a HeManWomanHater who targets her for defeating him.
* ''WesternAnimation/RandyCunninghamNinthGradeNinja'': Randy Cunningham has the Sorcerer, who repeatedly turns his fellow students into monsters.
* ''WesternAnimation/ReBoot'': Bob, Enzo Matrix, Dot Matrix, and Hexedecimal have Megabyte.
** Megabyte betrays Bob during the Web War, resulting in Bob being stranded in the Web, and who later impersonates Bob and nearly marries Dot.
** Enzo Matrix is forced to assume the role of Mainframe's Guardian when Megabyte banishes Enzo's idol and predecessor Bob into the Web. [[spoiler:After Megabyte takes over the city of Mainframe, Matrix confronts and defeats Magabyte in one-on-one combat (with a help of a trident [=AndrAIa=] tosses to Matrix).]]
** Dot Matrix was nearly tricked by Megabyte in to marrying her. Later, when Megabyte took over Mainframe and renamed it Megaframe, Dot formed a rebellion against him with the help of Mouse.
** Megabyte has a violent SiblingRivalry with his sister Hexadecimal, who is the [[OrderVersusChaos Chaos to Megabyte's Order]].
* ''WesternAnimation/RegularShow'':
** Pops is eventually revealed to have one in the form of [[spoiler:Anti-Pops]].
** Benson arguably has Gene, the manager of a rival park that is engaged in a constant prank war for the main characters.
** Skips has Klorgbane, who [[spoiler:killed his girlfriend]] and with whom he engages in an epic cosmic battle every 157 years.
* ''WesternAnimation/TheRenAndStimpyShow'': Ren and Stimpy hads Victor, a bully who beats them up.
* ''WesternAnimation/RickAndMorty'': The Council of Ricks and the Galactic Federation for [[Characters/RickAndMortyRickSanchez Rick Sanchez C-137]].
** The first episode of Season 5 introduces Rick's personal arch-nemesis, Mr. Nimbus. Funnily enough, neither his family nor [[RememberTheNewGuy the viewers]] ever heard about him until then.
** Rick used to have Tammy Guterman, a Galactic Federation agent who shot his friend Birdperson in the Season 2 finale. [[spoiler:Rick eventually kills her in the Season 4 finale.]]
** Rick also has [[Characters/RickAndMortyEvilMorty Evil Morty]], TheManInFrontOfTheMan to Evil Rick, the first person to hack into Rick's portal gun. [[spoiler:Evil Morty later hacks into Rick's portal gun again, preventing him from teleporting, and leaves Rick and Morty stranded in space until they are rescued by Space Beth.]]
** Rick's most personal adversary, however, is Rick Prime, who [[spoiler:killed his original family.]]
* ''WesternAnimation/RobotChicken'': Chicken has Fritz Hühnermörder, the MadScientist who reanimated him as a cyborg and [[AndIMustScream forced him to watch television]] for the first five seasons of the show. When Chicken escapes, Fritz kidnaps Chicken's wife Cluckerella, which sends Chicken on a RoaringRampageOfRescue. This results in Chicken defeating Fritz, who is subjected to the same torture he inflicted on Chicken.
* ''WesternAnimation/{{Robotboy}}'': Robotboy has Dr. Kamikazi, a MadScientist who seeks to capture him.
* ''WesternAnimation/RockosModernLife'': Rocko Rama has his antagonistic neighbor Ed Bighead.
* ''WesternAnimation/RockyAndBullwinkle'': Rocky and Bullwinkle have Fearless Leader, whose evil plans repeatedly bring him into conflict with the duo.
* ''WesternAnimation/{{Rugrats}}'': Tommy has his selfish older cousin Angelica, but there many episodes of the show where he doesn't think of her as a enemy and usually repeats her regardless of how she normally is.
** For Chuckie its Coco from the second movie, she almost became his mother when she seduced his father Chas and temporarily stole his teddy bear.
* ''WesternAnimation/SamuraiJack'': [[Characters/SamuraiJackJack Jack's]] arch-enemy is the shapeshifting demonic BigBad [[Characters/SamuraiJackAku Aku]], who is responsible for both destroying Jack's old kingdom and killing his father, as well as flinging him into the BadFuture where Aku believed he would have no trouble dispoosing of the "FOOLISH SAMURAI!". Deconstructed in Season 5, where it's shown that both have gotten plain tired from being in a stalemate for the last 50 years.
* ''WesternAnimation/ScaredySquirrel'' gives us [[ButtMonkey Scaredy]], [[StupidSexyFlanders Nester]] and [[FakeUltimateHero Paddy]]
* ''WesternAnimation/ScoobyDooMysteryIncorporated'': Scooby-Doo has Professor Pericles, the overall BigBad of the series and Scooby's EvilCounterpart. Both Scooby and Pericles are Anunnaki, and Pericles is the for mascot of the original Mystery Incorporated (who Pericles betrayed). In ''Where Walks Aphrodite'', Pericles uses Scooby as a pawn. When Season 1 ends with Pericles in an advantageous position over the heroes, Scooby vows to come after him.
-->'''Scooby-Doo''':''I'll get the gang back together, Pericles, we'll be coming for you, or my name isn't Scooby-Dooby-Doo!''
* ''WesternAnimation/TheSecretSaturdays'': The Saturday family has V.V. Argost, who is responsible for the deaths of several of Doc's friends, and who killed Drew's parents (and by extension Zak's maternal grandparents).
* ''WesternAnimation/SheRaAndThePrincessesOfPower'': [[Characters/SheRaAndThePrincessesOfPowerAdora Adora]] and [[Characters/SheRaAndThePrincessesOfPowerCatra Catra]]. The two were raised together, and are functionally sisters in all but blood, but the manipulations of their mother-figure [[AbusiveParents Shadow Weaver]] left a ''lot'' of deepset issues between them. Namely, that Adora feels anything Catra does is her responibility, while Catra believes she's AlwaysSecondBest to Adora. After Adora's HeelRealization and defection to the Rebellion, Catra feels personally betrayed, and becomes increasingly determined to finally "win" over Adora, no matter the cost, even sacrificing her chance to start a new life as a crime-lord in the Crimson Wastes where everyone admired her strength. This finally reaches it's breaking point in the Season 3 finale when [[spoiler:Catra triggers TheEndOfTheWorldAsWeKnowIt just so she can ''finally'' "beat" Adora at something, with only Queen Angella's HeroicSacrifice preventing it]]. After that, Adora makes it clear that whatever their previous relationship may have been, Catra's dead to her now.
* Eric Needles and Professor Pampelmoose in ''WesternAnimation/{{Sidekick}}''.
* Mon*Star to Stargazer, Quicksilver and the ''WesternAnimation/SilverHawks''. (Funny part is that they were voiced by the same actor.)
* ''WesternAnimation/TheSimpsons'':
** [[Characters/TheSimpsonsBartSimpson Bart Simpson]] has several archenemies, varying from simple school rivalries with fellow students and teachers to much more serious life-and-death scenarios:
*** In Season 1, Bart has [[TheBully Nelson Muntz]], a fellow elementary school student who bullies him leading to Bart raising an army of fellow victims to fight back against him. In later seasons, Nelson's character is [[CharacterizationMarchesOn softened]] and the pair become [[FriendlyEnemy Friendly Enemies]], although DependingOnTheWriter Nelson can sometimes return to being Bart's bully.
*** [[DeanBitterman Principal Seymour Skinner]], who has no patience for Bart's pranks and efforts to bring chaos to the school and seeks instead to bring order.
*** Sideshow Bob, who Bart had put in jail after Bob attempted to frame Krusty the Clown for armed robbery. This is a much more serious and deadly relationship with Bob trying to kill Bart in revenge and Bart trying to put Bob back in jail. Bob has even admitted that he would have [[AndThenWhat no idea what to do with his life]] if he ever actually succeeded in killing Bart.
*** According to a [[NoodleIncident throw-away gag]] in one episode, he also has Creator/DrDemento, though Demento is yet to appear in person on the show.
** In the movies-within-the-show, [=McBain=]'s archrival is Mendoza. [[BigNo Mendoza!!!!!!!]]
** Even Maggie has the the one-eyebrowed Baby Gerald.
** [[Characters/TheSimpsonsHomerSimpson Homer Simpson's]] archenemies are Mr. Burns, Ned Flanders, Frank Grimes, and Patty and Selma.
*** Although with Grimes it's mainly one sided, Homer seemed to actually quite like him. It's also one-sided with Homer and Flanders, since Flanders considers him to be a close friend.
*** Homer has also repeatedly come into conflict with the mob boss Fat Tony. In ''Homie the Clown'', Tony mentions that Homer once "crashed his car through the wall of [his gang's] club." In ''Mayored to the Mob'', Homer learns Fat Tony is secretly selling rat milk to the school his children attend. Homer convinces Mayor Quimby to shut down the operation, and later foils Tony's attempt to have Quimby assassinated in retaliation. In ''Poppa's Got a Brand New Badge'', Homer establishes a security company which arrests Fat Tony, who tries to kill Homer in retaliation. In ''Donnie Fatso'', Homer infiltrates Fat Tony's syndicate on behalf of the FBI. [[spoiler:Fat Tony dies of a heart attack after discovering Homer's betrayal.]]
** PlayedForLaughs, along with ViolentGlaswegian, when Groundskeeper Willie attributes this status to Scotland and a variety of other countries...including Scotland.
--->Damn Scots! They ruined Scotland!
* Skysurfer One and Cybron from ''WesternAnimation/SkysurferStrikeForce''. On the one hand, Cybron is responsible for stealing a an experimental computer brain from an A.I. lab, then blowing it to kingdom come, letting Sky's father (who Cybron may have also killed) take the blame. On the other hand, Skysurfer One and the other Skysurfers routinely stop his attempts to TakeOverTheWorld.
%% * Mrs Boots is Buckley's in ''WesternAnimation/SlackerCats''.
* [[Characters/SouthParkEricCartman Eric Cartman]] and [[Characters/SouthParkKyleBroflovski Kyle Broflovski]] from ''WesternAnimation/SouthPark''. It was mostly onesided on Cartman's side earlier on, but the two snowballed into mortal enemies somewhere in the fifth season, and has jumped up a notch with every subsequent season. Cartman even acknowledges that he and Kyle are arch enemies in "Grounded Vindaloop".
** Also, Scott Tenorman to his half-brother Cartman.
** Wendy Testaburger probably also considers Cartman her archenemy.
** Cartman's alter-ego the Coon is this to Mysterion ([[Characters/SouthParkKennyMcCormick Kenny McCormick]]).
** [[Characters/SouthParkStanMarsh Stan Marsh's]] Arch Enemy is his abusive sister, Shelley, until she gets overshadowed by their father Randy, who becomes the Arch Enemy for both of them. In ''[[Recap/SouthParkS16E12ANightmareOnFaceTime A Nightmare on Face Time]]'', Randy forces his family to work at a Blockbuster store he bought, which prevents Stan from trick-or-treating. Shelley ends up burning the store down. In Season 22, Randy uproots him family from South Park so [[ItsAllAboutMe he can become a weed farmer]], which eventually causes so much friction between Randy and the rest of the family that by the time of the Season 23 episode ''[[Recap/SouthParkS23E6SeasonFinale Season Finale]]'', Stan, Shelley, and their mom/Randy's wife Sharon [[AndThereWasMuchRejoicing celebrate Randy's arrest]]. In the BadFuture of Season 24, Stan burns Tegridy Farms down, accidentally killing Shelley in the process, which [[DrivenToSuicide drives Sharon to suicide]], with Stan and Randy both [[NeverMyFault blaming each other for their deaths]].
** Nathan is this to Jimmy Valmer and, to a lesser extent, Timmy.
** Season 19's BigBad [[spoiler: Leslie Meyers]] is this to PC Principal.
** President Herbert Garrison is this to Tweek Tweak.
** The Boys have their on-and-off teacher, Mr. Garrison (temporarily known as Mrs. Garrison). In ''[[Recap/SouthParkS1E2WeightGain4000 Weight Gain 4000]]'', he accidentally kills Kenny. In ''[[Recap/SouthParkS6E14TheDeathCampOfTolerance The Death Camp of Tolerance]]'', his attempts to intentionally get fired result in Stan, Kyle, Cartman, and many of their fellow students being sent to tolerance camp when they try to complain about his conduct. In ''[[Recap/SouthParkS9E10FollowThatEgg Follow That Egg]]'', Garrison, now a woman, attempts to sabotage the science project she gave Stan and Kyle as part of a plot to prevent the legalization of gay marriage. In ''[[Recap/SouthParkS10E12GoGodGo Go God Go]]'', she pushes for the abolition of religion, creating the BadFuture which Cartman is stranded in. After becoming a man again, Mr. Garrison becomes a PresidentEvil after being fired from teaching, spending several seasons as one of the show's [[BigBad Big Bads]]. In ''[[Recap/SouthParkS21E9SuperHardPCness Super Hard PCness]]'', Kyle inadvertently convinces President Garrison to nuke Canada, leaving Kyle horrified. In ''[[Recap/SouthParkThePandemicSpecial The Pandemic Special]]'', Garrison prolongs the COVID-19 pandemic by sabotaging efforts to find a vaccine, which eventually leads to Stan, Kyle and Cartman dissolving their friendship in ''Recap/SouthParQVaccinationSpecial''. An older Kenny blamed the dissolution of said friendship for the BadFuture seen in ''[[WesternAnimation/SouthParkPostCovid Post Covid]]''.
** Gerald Broflovski has Lennart Bedrager during Season 20. Gerald is an online troll who goes by [=SkankHunt42=], while Lennart is the CEO of [=TrollTrace=], a company developing technology that can trace the identities of online trolls. Lennart tests this technology on Fort Collins, resulting in Gerald's associate Anthony Webster being burned alive by the father of a disabled girl he insulted. Lennart later captures Gerald and other fellow trolls, [[spoiler:and reveals to Gerald that his ultimate goal is to use [=TrollTrace=] to start World War III ForTheEvulz, which [[EvenEvilHasStandards horrifies Gerald]].]]
* ''Franchise/TheSmurfs'': [[EvilSorcerer Gargamel]] is the most recurring villain in the franchise and the one who causes the Smurfs the most trouble in his quest to capture them.
%% * WesternAnimation/SpaceGhost has Zorak.
* In ''WesternAnimation/SpongeBobSquarePants'':
** Mr. Krabs and Plankton.
** For a couple episodes in the first season, [=SpongeBob=] himself had Bubble Bass; a slimy, devious and notoriously hard-to-please connoisseur who served as a {{Foil}} to [=SpongeBob=], the workaholic, perfectionist fry cook. This relationship faded out after Bubble Bass [[ChuckCunninghamSyndrome vanished from the series]], though it's since returned in full force after the latter fully returned.
** The FlyingDutchman is one of [=SpongeBob=]'s most dangerous recurring enemies. He attempts to steal the souls of [=SpongeBob=] and/or his friends on multiple occassions.
** Sometimes: [=SpongeBob=] and Plankton.
** Squidward has his far more successful rival, Squilliam Fancyson.
** Mermaid Man and Barnacle Boy have Man-Ray.
* ''WesternAnimation/SquirrelBoy'': Andy and Rodney have their bullies, Kyle and Salty Mike.
* ''WesternAnimation/StarTrekLowerDecks'': The Gelrakians (a crystal-based society) consider the inhabitants of Mavok Prime (a wood-based society) to be their sworn enemies.
* ''WesternAnimation/StarVsTheForcesOfEvil'':
** While not always a THREAT, Star Butterfly's arch enemy is the bird man Ludo. He's always sending monsters out to take her wand in Season 1. Then in Season 2, things got more interesting when Ludo TookALevelInBadass, and also became her EvilCounterpart complete with [[spoiler: half of star's original wand that he uses for dark magic]].
** Star's mother Moon Butterfly's most hated enemy is BigBad Toffee. [[spoiler:Toffee murdered her mother. In exchange, Moon earned her moniker "the Undaunted" when she used dark magic she acquired from Eclipsa to take out his finger and prevent its regeneration, terrifying the army of monsters that were about to invade Mewni alongside him. Toffee's schemes are all ultimately driven by his bitterness over Moon's humiliation of him all those years ago]].
** Marco's archenemy is Miss Heinous[[spoiler:/Meteora Butterfly]]. He started the rebellion that shut down her BoardingSchoolOfHorrors, and she repeatedly tries to get revenge on him and take back the school. [[spoiler: Even when her goals change after she remembers her true identity, she still goes out of her way to try and kill Marco.]] The feeling is mutual for most of the series, but after [[spoiler: [[RaiseHimRightThisTime Meteora is reverted to infancy]], it becomes one-sided on her part, with Baby Meteora maintaining an IrrationalHatred of Marco]].
* ''WesternAnimation/StevenUniverse'':
** Steven Universe has Yellow Diamond, the most actively antagonistic member of the Great Diamond Authority in the first three seasons of the show, who seeks to destroy Earth to avenge her sister Pink Diamond, who was supposedly killed by Steven's mother Rose Quartz [[spoiler:(who was actually a disguised Pink Diamond)]], and since Steven has Rose's gem in his body, he is incorrectly assumed to be Rose. In the Season 5 episode "The Trial," Yellow has Steven tried in a KangarooCourt for Pink's death.
** Lapis Lazuli has Jasper. Two two spent [[AndIMustScream several months fused together at the bottom of the ocean]].
** Peridot has Yellow Diamond, her former superior who she defies and [[FantasticSlur insults]] in "Message Received", angering Yellow Diamond and effectively making Peridot a traitor to Homeworld. This causes Peridot to suffer SanitySlippage in the following episode, "Log Date 7 15 2". When Peridot confronts Yellow Diamond in "Reuinited", however, Peridot confronts Yellow Diamond again, she [[ButForMeItWasTuesday denies remembering Peridot]] and [[OneHitKill poofs]] her.
* In ''WesternAnimation/{{Stormhawks}}'', [[TheHero Aerrow's]] Arch Enemy is ''not'' the BigBad Cyclonus; rather, it's TheDragon Dark Ace. Cyclonus is the EvilCounterpart and Arch Enemy of Piper.
* ''WesternAnimation/SuperRobotMonkeyTeamHyperforceGo'': The Hyperforce, especially Chiro, have the Skeleton King, who seeks to take over their homeworld of Shuggazoom, and who created the five Robot Monkeys before his turn to evil. Chiro is the one who found the five Robot Monkeys and awakened them, becoming TheLeader of the Hyperforce opposing the Skeleton King. In "The Sun Riders", the Skeleton King sends the titular Sun Riders, who Chiro was a fan of, to destroy the Hyperforce. Despite the Sun Riders' failure, the Skeleton King takes comfort in [[BrokenPedestal Chiro losing his faith for the Sun Riders]]. The Skeleton King also had a StalkerShrine consisting of Chiro's stuff.
* The Warden of ''WesternAnimation/{{Superjail}}'' has both [[DistaffCounterpart the Mistress]] and [[CardCarryingVillain Lord Stingray]]. Although the Mistress debuted first, it's [[LampshadeHanging lampshaded that while the Warden considers her an archenemy, he barely gets to see her that often]]. The Mistress and Stingray even teamed up and attempted their own relationship in the Season 3 premiere (after taking over the jail), though the relationship fell through.
* ''WesternAnimation/SuperTed'' has Texas Pete, whose plans [=SuperTed=] repeatedly foils.
* ''WesternAnimation/SWATKats'': Chance "T-Bone" Furlong and Jake "Razor" Clawson have Dark Kat. An ill fated confrontation between the duo and Dark Kat led to T-Bone and Razor being discharged from the Enforcers.
* Tak, Cheif and [[{{Gonk}} Lok]] in ''WesternAnimation/TakAndThePowerOfJuju''.
* ''Franchise/TalesOfArcadia'':
** Jim Lake Jr. has Bellroc and Gunmar the Black.
*** Bellroc is the overall BigBad of the franchise, who sends the Green Knight to capture Jim, resulting in him being turned into a full troll which gets turned into a pawn, while Jim's human soul is trapped in the Shadow Realm. [[spoiler:It is Jim who ultimately kills Bellroc.]]
*** Gunmar the Black seeks to kill Jim's loved ones as retaliation for Jim killing his son Bular.
** Douxie has Bellroc, Skrael, and their servant the Green Knight for attacking Camelot at the beginning of ''Wizards'', and later for [[spoiler:the Green Knight killing Merlin.]]
** Aja and Krel Tarron have General Morando, who took over their homeworld and caused their parents to lose their physical bodies.
** Bellroc and Skrael are also this to their former ally Nari.
* ''Franchise/TeenageMutantNinjaTurtles'':
** In almost all incarnations of the franchise, the Shredder has always been at odds with the Turtles and Splinter, and always at a deeply personal level. However, the one who arguably displays this trait strongest is the Utrom Shredder of the 2003 TMNT cartoon series. His hatred of them was ''so deep'' that it culminated into the climax of the ''WesternAnimation/TurtlesForever'' movie, where [[spoiler:he was willing to destroy the [[TheMultiverse multiverse]] to destroy all turtles, even at the cost of his own life and that of his daughter Karai, the only other living being that he honestly cares about.]]
*** In the 1987 series, Oruku Saki (the future Shredder) was responsible for the banishment of Hamato Yoshi (the future Splinter) from the Foot Clan. The Shredder later attempts to kill Yoshi with mutagen, which instead turns Yoshi into Splinter, and [[CreateYourOwnHero turns Yoshi's pet turtles into the Ninja Turtles]]. To a lesser extent, the Ninja Turtles also have the Shredder's partner Krang, who also repeatedly comes into conflict with the Turtles. In "Turtles on Trial", Krang prevents the Shredder from having the Turtles taken out so that Krang can kill them himself on national television.
*** The 2012 version was most definitely this to Splinter as well, willing to go to truly insane lengths to make his former brother suffer. In the same series, Leonardo has a [[DatingCatwoman love-hate relationship]] with Karai [[spoiler:before her HeelFaceTurn]], with both of them betraying the other at some point. Also in the same series, Raphael struck up quite the rivalry with Fishface, aka Xever, though it got downplayed as time went on.
** In the 2003 series, General Blanque, the military head of the Federation, as Zanramon, the leader of the Triceraton Republic, who the Federation are at war with. Even after their respective factions make peace, and both induviduals are imprisoned in adjacent cells, Blanque and Zanramon still try to continue their conflict.
** In the 2012 series, Dr Victor Falco aka the Rat King is Splinter's second nemesis and the only enemy toward who Splinter has a blood feud, having subjected him to MindRape several times in order to make him forsake his humanity and turn him into his servant, having managed to control him for a short time and made him hurt his students/sons during that time.
** In the 2012 series, Bishop has his brother Kraang Subprime.
** In the 2012 series, Alopex has her brother Tiger Claw, whose tail she cut off and kept as a CreepySouvenir.
** Although personalities and histories are different in ''WesternAnimation/RiseOfTheTeenageMutantNinjaTurtles'', the Turtles and Splinter have their own specific enemies they have the most feud with.
*** Baron Draxum is Splinter's most personal enemy due to Oroku Saki's role being different. Draxum is the one who mutated him and the Turtles, taking away any chance he had at having a normal life.
*** The Foot Clan as a whole remain this way to the Turtles, due to the Lieutenant and the Brute being the most recurring villains in the show and the ones involved in many of the major events, from the Shredder's resurrection to the Krang invasion.
*** The Krang become this to Leonardo in the movie, especially Krang One, after Raph is captured during a HeroicSacrifice to save him.
* While Diesel from ''WesternAnimation/ThomasAndFriends'' is [[FantasticRacism antagonistic towards all of the steam engines]], he shares most of his enmity and rivalry towards Thomas in the later seasons. In his debut appearance, Diesel's original enemy was Duck.
* In ''WesternAnimation/ThunderCats1985'' and ''WesternAnimation/ThunderCats2011'' Mumm-Ra (the Ever Living) to Lion-O and the [=ThunderCats=]. The latter series also had Grune and Panthro after the former betrays him and leaves him for dead, and in the backstory, it seemed like Slythe and King Claudus had this sort of arrangement, at least on the side of Slythe.
* Mocked (unsurprisingly) by ''WesternAnimation/TheTick'':
-->'''The Tick:''' Oh, for crying out loud...\\
'''Brainchild:''' So, at last, The Tick, my arch enemy, sits helpless before me!\\
'''The Tick:''' 'Arch enemy'? You must be joking, Charles. I mean, I don't like you and everything but if I ever ''do'' have an arch enemy it's not going to be some creepy little brat with a glass head.
* ''WesternAnimation/ElTigreTheAdventuresOfMannyRivera'': Sartana of the Dead to Manny Rivera, who accidentally scarred himself in a confrontation with her.
* ''WesternAnimation/TomAndJerry'' are each other's longtime foes. Tom often tries to catch Jerry, and Jerry sometimes goes out of his way to antagonize Tom.
* ''WesternAnimation/ToxicCrusaders'': Toxie has Dr. Killemoff, who endeavors to pollute Toxie's hometown.
* In ''Franchise/{{Transformers}}'', Megatron is Optimus Prime's Arch Enemy. Or [[WesternAnimation/BeastWars Optimus Primal's]], depending on the series.
** This refers to two different Megatron's. They are in the same contunity -- the Megatron who is the archenemy of Primal is a LegacyCharacter who took up his name.
** ''WesternAnimation/TransformersPrime'' uses this trope a lot -- in addition to [[BigBad Megatron]] and [[TheHero Optimus]], there's [[TheBrute Breakdown]] and [[TheBigGuy Bulkhead]], Airachnid and [[TheLancer Arcee]], and in the background mythology, [[GodOfEvil Unicron]] and [[BigGood Primus]].
** ''WesternAnimation/TransformersAnimated'' subverts the usual rivalries. Megatron's actual enmity is with ''Starscream'' in this show, and Megatron considers Optimus Prime an afterthought until the series finale.
*** Ratchet and Lockdown also have this dynamic through the series.
** Rampage and Depth Charge in ''WesternAnimation/BeastWars''. Rampage put special effort into destroying everything Depth Charge cared about, and Depth Charge [[HeWhoFightsMonsters no longer cares about anything other than hunting down and killing his allegedly-immortal tormentor.]]
* ''WesternAnimation/{{Underdog}}'': Underdog has Simon Bar Sinister, a MadScientist whose plans are constantly thwarted by Underdog.
* ''WesternAnimation/{{Unikitty}}'': The AllLovingHero Unikitty has Master Frown, who seeks to spread misery to others.
* The Monarch from ''WesternAnimation/TheVentureBros'' wants to be Doctor Venture's Arch Enemy, but Doctor Venture doesn't consider him a threat.
-->'''Hank''': ''What's your problem with our dad anyway?!''\\
'''The Monarch''': ''(awkwardly) Well, I- he- he's my nemesis. My Arch Enemy.''\\
'''Dean''': ''I don't think pop thinks you're his Arch Enemy.''\\
'''The Monarch''': ''Come on, I'm sure the walls of the Venture Compound are practically caked with the lingering curses of the Monarch's name.''\\
'''Dean''': ''Uhh, no. I've never even heard him mention you.''\\
'''Hank''': ''Yeah, I always thought Baron Underbheit was dad's arch-enemy.''\\
'''The Monarch''': ''(astounded) Underbheit!?! Why, that dime-store Doctor Doom isn't fit to -- just you wait till your father calls me back!!''
** Initially, at least. The Monarch quickly revealed himself to be a NotSoHarmlessVillain and an actual DiabolicalMastermind over the course of the first and second seasons. He was also involved in a vicious feud with Underbheit over who could kill Venture (before they decided upon a VillainTeamUp). By the end of the second season, Rusty wasn't willing to bury the hatchet, even though the Monarch was (though it's all back to the same routine by the later season).
** Phantom Limb actually became this to The Monarch ''and '' Dr. Venture towards the end of Season 1, but underwent VillainDecay after his defeat.
** Underbheit, on the other hand, has made very rare appearances now and again, until LaResistance deposed him of his throne.
** And, as of Season 3's "Home Is Where The Hate Is", Dr. Venture's new Arch Enemy was Sergeant Hatred, who was assigned by the [[WeirdTradeUnion Guild of Calamitous Intent]]. His actual goal is to be as ''nice'' to Dr. Venture as possible, so as to annoy the Monarch and pay him back for his henchmen robbing him. However Hatred eventually becomes the new Venture Bodyguard and Monarch gets himself a free pass to antagonize Venture once again.
** The shiow has an interesting system wherein archrivalries are assigned, not chosen, by the OSI and Guild of Calamitous Intent (hence the coinage of a term: 'arching' to describe the act of being an archnemesis). In Season 3, it's revealed that a reason for Dr. Mrs. The Monarch's attraction to her husband is that The Monarch's archrivalry of Venture doesn't stem from this stodgy system, but actual, living, breathing, unfounded hatred.
** August St. Cloud is the archnemesis of Billy Quizboy. He eventually joins the Guild just to make things official, bribing Watch and Ward to get Quizboy assigned as his arch.
* ''WesternAnimation/VoltronLegendaryDefender'': Team Voltron has Haggar, who remains a [[TheHeavy threat to them]] across all nine seasons, and becomes the FinalBoss for the team to defeat.
** Shiro, the pilot of the Black Lion, has Emperor Zarkon, the former Black Paladin.
* In ''WesternAnimation/{{Wakfu}}'', [[spoiler:Qilby the Traitor]] has deeply personal conflicts with the people who were once his closest friends and companions [[spoiler:namely the other original Eliatropes and their Dragon siblings]]. Those who still remember him loathe him utterly, while those who have forgotten are quickly reminded of why they hated him so much. The twisted part is that [[spoiler:deep down Qilby really wants them all to be friends again, which is why he subconsciously hampers his own efforts with overly complex plans. Too bad for him he burned those bridges a ''long'' time ago.]]
* Examined and deconstructed in ''WesternAnimation/WanderOverYonder''. Lord Hater considers Wander his archenemy, but it's a very one-sided situation as Wander is too much of a NiceGuy to hate Hater. Over the course of the series, as Wander inadvertently foils more of Hater's plans, Hater goes into a gradual VillainousBreakdown and becomes increasingly obsessed with beating Wander, to the exclusion of actually taking over the galaxy like he's supposed to be doing. At the start of the show Lord Hater is poised to succeed in taking over everything and is feared by many; by the end of Season 2 he's lost what little territory he controlled and is seen as a complete joke by all the other supervillains.
** Wander himself has a legitimate archenemy in Doctor Screwball. Also, at least two instances show that some deep down part of Wander considers Lord Hater to be an archenemy as well, saying he's a "bad guy" and he's going to "stop him".
*** In one instance he [[NotHimself had his venerable side stripped out of him,]] leaving him to briefly take on a more overtly heroic personality and announce that as a "good guy", he has to "Stop that heartless evildoer Lord Hater once and for all".
*** In another instance, in a desperate bid to help in a town full of people that didn't need any, he drops the friendly act and flat out tells Hater straight up that he's going to stop him from taking over the planet. Turns out Hater was just there for lunch and blows Wander off.
* In ''WesternAnimation/WinxClub'', [[WickedWitch the Trix]] serve as this for the Winx, especially [[TheHero Bloom]]. They have been the Winx's most consistent foes throughout the entire series, having went from stealing Bloom's powers and attempting to conquer Magix in the first season to serving as TheDragon to various {{Arc Villain}}s in most of the succeeding seasons just for an opportunity to destroy the Winx and [[TakeOverTheWorld take over the Magic Dimension]].
* ''WesternAnimation/WoodyWoodpecker'' frequently comes into conflict with the con man Buzz Buzzard.
* ''WesternAnimation/XiaolinShowdown'': Omi has Chase Young, who spent Season 2 trying to corrupt him.
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