Planetary-scale Extinction of the dominant Species on the planet, via unnatural causes (ie: someone did something, [[HoistByHisOwnPetard human]] or [[AliensAreBastards otherwise]]).

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!!Examples:

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[[folder:Multiple Media]]
* The planet Golgafrincham in ''Franchise/TheHitchhikersGuideToTheGalaxy'': after getting rid of those useless Telephone Sanitisers, its civilisation is wiped out by a virus contracted from a dirty telephone.
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[[folder:Anime and Manga]]
* The ultimate goal of the Dragons of Earth in ''{{X1999}}''.
* What will be the outcome in ''Manga/{{Gantz}}'' if the Giant aliens succeed in their invasion. To make a long story short, [[spoiler: they're turning us into snack food, like an alien equivalent to wings or potato chips.]]
* It becomes an important plot point in ''{{Utawarerumono}}'' that scientists accidentally roused a malignant god in the distant past and brought about one of these.
* In the ''Anime/ReadOrDie'' OVA, the villain plans to play [[LudwigVanBeethoven Beethoven's]] lost [[BrownNote "Death Symphony"]] worldwide to wipe out the human race via induced suicide.
* The Tuffle race in ''DragonBall'' is wiped out by the Saiyans who become giant apes at the full moon. They work under Frieza's planet trade to do this as a career choice.
** Also done when Buu unleashes a BeamSpam of epic proportions from the Lookout and kills every human '''NOT''' on the Lookout. He turned them into food and subsequently ate them. He did all that [[ForTheEvulz just because he could]].
* SuperAtragon: The BigBad is attempting this to the Earth's surface by building a giant ring that--once complete--will cook the Earth's surface with radiation bombardment. Note that this method that would've actually caused a Class 5 if it was achieved.
* This is the BigBad's goal in ''[[Anime/MobileSuitGundamSeed Gundam SEED]]''. Due to his [[NukeEm method o]][[KillSat f choice]], it just might reach Class 4 or Class 5.
* ''Anime/AfterWarGundamX'' came ''very'' close to this. It is established that a massive ColonyDrop killed 99% of the Human race at the end of the last war. It has recovered since then, however.
* ''Anime/PuellaMagiMadokaMagica'': It is explained in episode 10 that [[spoiler: Madoka herself can cause this. After a few timeline loops, she begins to transform into the incredibly powerful Kriemhild Gretchen, who will wipe out all human life in a matter of days.]]
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[[folder:Comicbooks]]
* ''YTheLastMan'' is a 3.5, as every male ''mammal'' on the planet dies, save for Yorick and his pet helper monkey and two male astronauts in space. The cause has been vague, but options include an ancient curse or a [[ScienceIsBad biological experiment gone wrong]]. The comic even mentions that, 7 months after the disaster struck, the first species has gone extinct as its reproductive cycle has flown by. It should be noted that the actual short-term effects look more like a Class 1. The looming fact that this is the last generation as far as most of humanity knows barring serious reproductive breakthroughs is anything but glossed over. [[spoiler:Thankfully, in the DistantFinale, we see that Dr. Mann's cloning research has paid off, and it looks like humanity has made a mostly complete recovery -- complete with roughly the same political problems as before -- making this a Class 1 with a recovery period in the decades.]] In addition, [[spoiler:even after rats should have died out with no males to propagate the species -- almost five years on -- some are seen on the streets of Asia, which stuns Mann.]]
* In current MartianManhunter continuity, this is what Malefic did to Mars, using a virus to kill all Green Martians.
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[[folder:Films]]
* ''Film/IAmLegend'' revolves around one of these. Mankind is either dead or zombified to a man, except for Will Smith [[spoiler:and a few other people]]. However, the animals are doing just fine, and in fact have escaped the zoos and colonised the streets of New York. (There are ''lions''.) [[Literature/IAmLegend The original book]], however, is a 3b.
** In the movie, dogs and rats are also affected by the virus, although it's not made clear how they're doing in the larger sense. One would assume they had a dieback/zombie rate similar to humans, at least in populated areas, but nothing's said about it one way or the other.
* ''TwelveMonkeys'' had a virus exterminate 99% of humanity and render the surface uninhabitable to them due to viral residues. No other lifeforms were affected, and the animals have reclaimed the surface.
* The plot of the JamesBond film ''Film/{{Moonraker}}'' is that the villain wants to use a DepopulationBomb to kill all humans on Earth and repopulate it with a select group of people under his leadership.
* ''PlanetOfTheApes'' and its sequels.
* This is essentially what happened to the planet of Miranda in ''Film/{{Serenity}}'' as the result of a botched Alliance experiment. [[spoiler:The chemical that they created to try to curb people's violent impulses, the Pax, [[GoneHorriblyRight worked a little too well]], causing nearly the entire population to simply lie down and die. The tiny percentage that survived had the exact opposite reaction to the Pax, becoming the psychotically violent and cannibalistic Reavers]].
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[[folder:Literature]]
* [[CthulhuMythos Cthulhu]] will do this [[CosmicHorrorStory when The Stars Are Right]]. {{Eldritch Abomination}}s running rampant usually falls somewhere between here and Class 5.
* ''Literature/IHaveNoMouthAndIMustScream'' by HarlanEllison. A giant supercomputer has nuked the Earth and kept the remaining [[IWantThemAlive few humans alive]] in order [[AndIMustScream to torture them]]. [[FromBadToWorse Things get]] [[AndIMustScream worse]].
* Patrick Tilley's ''The AmtrakWars'' are set in an America that has recovered ecologically centuries after a nuclear war. A civilization of underground cities has developed from nuclear bunkers, and they are now spreading out to wage a genocidal war against the hunter-gatherer civilization that lives in the open.
* In Creator/TomClancy's novel ''Literature/RainbowSix'', the environmentalist extremists plan this with an engineered disease to wipe the planet clean of all humans except for their own community.
* Margaret Atwood's ''OryxAndCrake''.
* In StephenBaxter's ''Titan'', [[spoiler: China drops an asteroid in the Atlantic to destroy America, but underestimates its force and causes TheEndOfTheWorldAsWeKnowIt]].
* In ''Eva'' by Creator/PeterDickinson, just about everything is done by machines, various animal species have gone extinct, and humanity has basically gotten bored with living. So huge numbers of people just commit suicide, and the titular main character, [[spoiler:who inhabits the body of a chimpanzee after an accident left her original body paralyzed, is left alone with the monkeys.]]
* In ''{{Haunted}}'' by Chuck Palahniuk is a short story called "Obsolete." In it, humans have discovered that souls that die on Earth appear on Venus, which is heaven. However, as long as people are still alive on Earth, souls will return to them. So the governments do the only logical thing to do in a Chuck Palahniuk novel and order everyone to commit suicide or be murdered so everyone gets to go to paradise. [[spoiler: The protagonist are teenage Goth kids who rebel the only way left: not committing suicide.]]
* The basic backplot of OrsonScottCard's ''Homecoming'' sequence, although it takes four books before you actually find that out ...
* The "Final War," a major thread in the ''Literature/{{Bolo}}'' series of short stories, is very aptly named: the Terran Concordiat and Melconian Empire pull a Class 3 or ''worse'' on every inhabited planet either government has. Usually from ground level, with [[TankGoodness huge tanks]]. The overall effect is effectively a Class 2 on a ''Galactic'' scale.
* Mephisto, a recurring BigBad from Michael Slade's RCMP thrillers, plays XanatosSpeedChess with this as his objective.
* Creator/FrankHerbert's novel ''The White Plague'' reversed the usual pattern of wiping out males, using an engineered virus to wipe out most of the females on the planet, except for those who were isolated at the start of the outbreak.
* In Creator/GregEgan's novel ''Literature/{{Diaspora}}'', most humans have been voluntarily converted to software, beginning around 2065.
* In Creator/VernorVinge's ''Literature/MaroonedInRealtime'', we find that anyone not in stasis vanished circa 2204. Many hypotheses are raised, without resolution by the author.
* Signal to Noise by Eric S. Nylund ends with the world as a barren wasteland due to deceleration - the engineered part comes from [[spoiler: the alien that gave humans the technology that caused the deceleration in the first place - in the second book]] A Signal Shattered explains that [[spoiler: Wheeler specifically caused the destruction of earth so that the protagonist would have something in common with a group of aliens on the run from Wheeler - to lubricate the brokering of a deal!]]
* MargaretAtwood's "Flood" trilogy had a engineered disease that was intended to be a Class 3 - wiping out humans and replacing them with a genetically modified humanoid species, but, as of the publishing of the first two books, it seems that it will be a Class 2 bordering on high Class 1
* Towards the end of the 54-book ''Literature/{{Animorphs}}'' series, the Andalite military thinks that the only way to stop the Yeerk invasion of Earth is to release a quantum virus that will kill all humans on the planet.
* In OctaviaButler's ''{{Xenogenesis}}'' trilogy, the last few human survivors of a nuclear war are rescued by aliens; but, although they'll be returned to a fixed-up Earth, [[spoiler:they won't be human any more]].
* Geologist Dougal Dixon wrote (and illustrated) the literally science fictional ''After Man'', a really quite detailed description of the various ecosystems of Earth 50 million years from now, with the base assumption that humans go extinct some time "soon" in geological terms (i.e. within the next 100,000 years or so).
* ''Spiral'', the second book in Koji Suzuki's ''{{Ring}}'' trilogy ends like this. [[spoiler: Sadako's curse will inevitably spread across the world, destroying the human species. That is, of course, until the next book turned everything on its head by revealing that it all took place inside of a computer]]
* In [[BenCroshaw Ben "Yahtzee" Croshaw]]'s ''Literature/{{Jam}}'', a regional version happens to Australia as the titular substance is accidentally unleashed upon the continent, and swallows every organic being that isn't above ground level.
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[[folder:Live-Action TV]]
* In ''Series/StarTrekVoyager'', the Krenim had developed a weapon to delete people from history. Any offworld colonies they would have made [[CosmicRetcon would be retroactively removed]] from history. Addendum: If these civilizations had {{Terraform}}ed any uninhabitable worlds, those would become Class 5 as the habitable world would never have been made habitable in the first place (at least by the people who made them so in the original timeline). It might fit Class X-2 more, because it shows that it's able to erase inorganic objects as well (Chakotay's talk with Annorax regarding simulation of erasing a comet), but the main show of the weapon is to specifically delete races, but left the planet intact for the Krenims to get it in new timeline.
* An environmentalist conspiracy called "The Dawn" was alleged to be plotting to achieve this, in the short-lived TV series ''Strange World''.
* New ''Series/DoctorWho'' series 1 ending: the Daleks are back, and their plan is pretty much this. The Doctor's solution to save humanity? [[spoiler:Kill at least ALL intelligent life on or near Earth, Dalek and human (granted, he didn't have time to actually remove the 'and human' bit from the weapon). And he squicked at holding a ''gun'' on a guy. The Daleks ''talk him out of doing this'' because it'd give him ANOTHER genocide on his record.]]
** The gaseous Gelth plan to kill all humans, and inhabit their corpses.
* In ''{{Lost}}'', [[spoiler:if the Man in Black manages to escape the Island after being stuck there for two millenia, he plans to wipe out all human life.]]
* According to Rich, In the ''Series/{{Community}}'' episode "[[Recap/CommunityS2E06Epidemiology Epidemiology]]", a Type 3 would occur within a year and a half. However, seeing as everyone is cured by turning the thermostat down to 58 degrees, one suspects this virus might have a little trouble making it out of Colorado.
* In the 2000 two part episode of ''TheOuterLimits'' "Final Appeal" it's revealed that all episodes are alternate timelines and futures and that while many of them actually are tied together into semi coherence. the episode ends with a time traveler with a grudge detonating a fusion bomb taking out most of the eastern seaboard, rendering their arguing about this timeline's rejection of tech stronger than a light bulb pretty much moot.
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[[folder:Music]]
* In the FlightOfTheConchords song The Humans are Dead, the robots acquired poisonous gases. [[TurnedAgainstTheirMasters And they poisoned their asses]].
* {{Buckethead}}' s album ''Population Override'' manages to portray this scenario ... without saying a word! The whole album is instrumental.
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[[folder:Tabletop Games]]
* Known to happen in ''TabletopGame/{{Warhammer 40000}}'', if rarely - the setting's instruments of devastation tend to be... not as picky as this type of apocalypse requires. Nevertheless, the Eldar, especially of Craftworld Biel-Tan, are fond of utterly excising any human/ork/anyone colonies on the Maiden Worlds and returning the planets to their pristine state, conveniently erasing any sign that the world is under Eldar protection.
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[[folder:Theater]]
* In ''Theatre/{{RUR}}'', the robots [[TurnedAgainstTheirMasters turn against their masters]] and KillAllHumans except for one. One is too few to reproduce, but the robots don't know how to do that either. So the lone survivor creates an Adam and Eve robot couple who will repopulate the world with their descendants.
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[[folder:Videogames]]
* The second and third endings of ''VideoGame/{{Drakengard}}'' fall into this sort of apocalypse. The third has a [[BittersweetEnding glimmer of hope]] that it can still be averted.
** The fifth ending causes this in [[VideoGame/NieR another world]].
* The main objective of the villains in Tom Clancy's ''RainbowSix''. A group of eco-terrorists genetically engineered a weaponized, airborne-contact delayed-incubation version of Ebola so that humanity would be extinct and Mother Nature would eventually reclaim the planet. Although the ''real'' genocide was intended to come from the ''vaccine'' - as the boss villain owned the biotech corporation that had just created a useful Ebola vaccine, the initial plague outbreak would have spurred everyone surviving on Earth to buy some. Pity they were all going to be buying more plague virus in relabeled syringes...
* ''VideoGame/{{Persona 3}}'''s bad ending is strongly implied to be this -- the end of all human life on Earth, due to the collective nihilism of man.
* ''StarControl 2'' has several variants. First, the Dnyarri (psychic slavers) ordered the destruction of the Taalo, who were immune to psychic control; it's implied that the Taalo may have slid to another dimension or universe, though. Much later, the Androsynth poke around that area of space, and are then replaced by the Orz, who don't like to talk about it. The Ilwrath will wipe out the Pkunk if you don't intervene, and the Ur-Quan Kohr-Ah -- former slaves of the Dnyarri -- will wipe out everyone if you don't solve the game.
* In the original ''[[FreeSpace Descent: FreeSpace]]'', the NighInvulnerable Shivan mothership ''Lucifer'' blasted the Vasudan homeworld of Vasuda Prime to an uninhabitable ruin, killing four billion Vasudans (and considering that Vasuda Prime was largely an extremely arid desert, there could not have been much more than four billion people there). [[spoiler:They almost did the same to Earth, but the ''Lucifer'' was destroyed in subspace, where its shields were down, mere minutes before arriving in the Sol System. Unfortunately, the only subspace node leading out from Sol was destroyed in the process, meaning that Earth was cut off from the rest of human civilization, and vice versa.]]
* The final foe in ''VideoGame/TalesOfVesperia'', while mostly apathetic towards humanity throughout the game, attempts this when things hit the fan in an attempt to preserve the planet at the cost of those who have done the most damage to it.
* The entire plot of ''FragileDreams'', where almost all humans are dead as a result of [[spoiler: the failure of the "Glass Cage Experiment," intended to make language unnessessary and eliminate conflict by giving humans the ability to empathize with others' thoughts and emotions. When it was first activated on a large scale, everyone went to sleep...and did not wake up. The BigBad, Shin, now a ghost, is still trying to re-activate the experiment, which will eliminate any survivors.]]
* In ''VideoGame/WingCommander III'', Class 3 is the potential fate for Locanda IV [[spoiler:(Robin "Flint" Peters' homeworld)]] due to Kilrathi bioweapons aboard missiles fired at the planet. As per the {{novelization}}, canonically the ''Victory'''s wing fails to intercept the bioweapons.
* The crux of Wesker's ultimate plan in ''VideoGame/ResidentEvil5'', wherein he attempts "complete global saturation" of Ouroboros (as he puts it) to rid humanity of its weaker kin and leaving those who can endure it's horrifying effects to inherit the land.
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[[folder:Webcomics]]
* BobAndGeorge [[http://www.bobandgeorge.com/archives/041128c We're willing to kill everyone on the planet to stop you!]] This being BobAndGeorge, people at the site of the asteroid strike survive.
* Webcomic/{{Jack}}. The full story still hasn't been presented, but apparently humanity was killed in a jihad by genetically engineered furries. Although it's hinted that [[spoiler: by reincarnation and God arranging for history to repeat itself, the furries basically became humanity and vice-versa]]
* In ''{{Homestuck}}'', [[EldritchAbomination Gl'Bgolyb]]'s death caused the Vast Glub, a psychic shockwave that killed every Troll in the universe. The 12 Players only survived because they weren't in the universe at the time. [[spoiler: Her Imperious Condescension and The Handmaid also survived]].
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[[folder:Web Original]]
* If [[http://www.scp-wiki.net/scp-1101 SCP-1101]] of the Wiki/SCPFoundation breaks containment, it's possible that humanity will go extinct as every single human on the planet neglects basic bodily needs in favor of debating a particular subject, like whether or not tomatoes are a fruit or vegetable.
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[[folder:Western Animation]]
* In the 1939 animated short ''PeaceOnEarth'', a civilization of cute little animals springs up after the human race wipes themselves out in endless trench warfare. In the 1955 remake ''Goodwill Towards Men'', naturally, it's The Bomb that did mankind in.
* Though it wasn't his intention, Vandal Savage did this in the ''JusticeLeague'' episode Hereafter (Part II). Being immortal, he ends up very lonely.
* Implied in WesternAnimation/AdventureTime, considering how there are sunken cities and atom bombs littered on the ground.
* While technically not a human example, the Martians in InvaderZim worked themselves to extinction turning their planet into a giant spaceship. [[RuleOfCool "Because it's cool!"]]
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