* In ''[[VideoGame/{{Banjo-Kazooie}} Banjo-Tooie]]'', Biggafoot, who guards a pair of Claw Clamber Boots on the icy side of Hailfire Peaks, limps away clutching his big foot after Chilly Willy sends an ice ball in his direction.
* Characters in ''[[VideoGame/SoulSeries Soul Calibur II]]'' react this way after being attacked in the foot.
* ''VideoGame/TeenageMutantNinjaTurtlesTurtlesInTime''
** If you run over spikes (while riding your jetboard!), your character does the Foot Pain Hop while saying "My toes! My toes!".
** Can also happen if they're hit by one of the ground flame attacks in the game, which also causes their foot to be set on fire.
** One boss in the game attempts to do this by throwing honest to goodness ''lobsters'' at you. He's comically vulnerable to HoistByHisOwnPetard.
* ''Franchise/SuperMarioBros''
** Mario and Luigi in ''VideoGame/MarioAndLuigiSuperstarSaga''.
*** As well as all other games in the MarioAndLuigi series, if you jump on a spiky or flame covered enemy. Interestingly, VideoGame/MarioAndLuigiDreamTeam can have this happen to Dreamy Luigi when you jump on a horde of enemies (half of which have spikes) in the Dream World. Cue half the clones safely bashing enemy heads in and the other half hopping away in pain.
** This also happens in the ''VideoGame/PaperMario'' series when you attempt to jump on a spiked enemy without the Spike Shield badge.
* Franchise/TheElderScrolls has this in the supplemental material, where St. Alessia has mangled feet from WalkingTheEarth after becoming a demigod/saint. Strangely, despite the amount of walking in the games themselves it is pretty much not mentioned anywhere else.
* In ''VideoGame/KnightsOfTheOldRepublic'', the player encounters a computer console which only outputs in an ancient language. The ''proper'' way to deal with it is to talk to it until it understands your language, but one option is to simply kick the computer. Doing so only gives you this:
-->'''Console:''' You kick the computer. Your foot hurts.
* When knocking off the manhole cover over King Hippo's belly in the Wii ''VideoGame/PunchOut'' game, it lands on his foot, causing him to hop up and down while holding it.
* The "foot stomp" is an actual move that can be pulled off in ''VideoGame/SonicTheFighters''.
* Sometimes, if you take too long but still manage to get to a person's destination in ''VideoGame/CrazyTaxi'', they'll kick your taxi then hold their wounded foot.
* The first boss of ''VideoGame/MaximoGhostsToGlory'' is fought by first stabbing his foot, then (once he starts jumping) the ''other'' foot. Once he falls over, you hit him in the head.
* During the boss fight against Zant in ''VideoGame/TheLegendOfZeldaTwilightPrincess'', at one point he becomes a giant, and in order to defeat him, you must swing the iron ball and chain into his foot. As he hops around holding his foot in pain, he shrinks back down to regular size, which is when you attack him.
* Happens to the minions in ''VideoGame/{{Overlord}}'' quite often, but only when setting down an Object on the waypoint to the tower.
* Done to K.Rool in ''VideoGame/DonkeyKong64'', courtesy of a [[ItMakesSenseInContext shrunken Tiny Kong shooting his toes with a feather crossbow.]]
* Appears in ''BattleChess'' when a pawn captures an enemy pawn. The former stomps the butt of his spear on the latter's foot, and after he hops around for a few seconds, gets stabbed through the visor.
* In ''VideoGame/MassEffect2'', a Renegade Shepard during the bar scene with Conrad Verner can shoot him in the foot.
-->'''Shepard:''' ''(levelling his or her gun at Conrad)'' Let me make this perfectly clear...\\
''(brings the gun down and shoots Conrad in the foot)''\\
'''Shepard:''' This is not acceptable.
* ''Spot Goes to Hollywood'': After Spot is done carving the Sega logo at the start of the game, he twirls his hammer in his hand, only to accidentally drop it right on his foot.
* In ''VideoGame/{{Gruntz}}'', this trope is said word for word as a random quote when your gruntz step on [[SpikesOfDoom Spikez]].
* This is one of the ways to die in ''VideoGame/LeisureSuitLarry 6: Shape Up or Slip Out!'' This involves Larry dropping a dumbbell on his foot.
-->'''Narrator:''' [[{{Squick}} Gangrene is such a terrible way to go!]]
* ''VideoGame/DieHard'' for the NES includes a separate health meter for John's feet, representing the injuries he sustained through the course of the film.
* ''VideoGame/KidIcarusUprising'' has a boss, the Great Reaper, that is fought in a two story battlefield. Each floor has a corresponding weak point, his head and his toes.
* Two examples from ''VideoGame/TeamFortressClassic'':
** The Scout could scatter caltrops behind him to hinder pursuit. If stepped on, they slightly damage you to the point they can kill you. They also give you the "broken feet" debuff, which slows you down until cured by the Medic.
** The Sniper can do the same thing by shooting an opponent's legs.
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