* ''WesternAnimation/TheSimpsons'':
** In one HalloweenEpisode, Homer's failure to correct the [=Y2K=] bug causes everything in Springfield with electronics in it to go haywire. Even the ''milk'' goes bad when the clock strikes midnight on January 1, 2000, leading Homer and his skeptic daughter to have this exchange:
--->'''Lisa:''' Look at the wonders of the computer age now.\\
'''Homer:''' Wonders, Lisa, or blunders?\\
'''Lisa:''' I think that was implied by what I said.\\
'''Homer:''' Implied, Lisa, or implode?\\
'''Lisa:''' Mom! Make him stop!
** In another Halloween episode, the Simpsons' house gets converted into an entirely electronic domain, governed by a computer with the voice of Pierce Brosnan (who is an obvious homage to HAL from the page quote). The computer ultimately falls in love with Marge, and seeks to kill Homer so as to eliminate competition. Ultimately, Homer wins.
** And of course, the episode "Itchy and Scratchy Land" has this exchange between Professor Frink and the theme-park scientists over their robots:
--->'''Frink:''' You've got to listen to me. Elementary chaos theory dictates that all robots ''will'' eventually turn against their masters, and '''rise up''' in an orgy of the blood, and the violence, and [[OhGodWithTheVerbing the biting with the pointy teeth and the hurting and shoving.]]\\
'''Scientist:''' How much time do we have, Professor?\\
'''Frink:''' [[IfMyCalculationsAreCorrect Well according to my calculations]] the robots won't go berzerk for at least twenty-four hours. ''(Robots suddenly get up and start attacking the scientists)'' Oh right, I forget to, uh, CarryTheOne, [[VerbalTic ng-hey]].
** This is a reference to MichaelCrichton's ''Franchise/JurassicPark'', wherein the mathematician Malcom uses the chaos theory to justify his concerns about the park's stability.
* {{Inverted|Trope}} in ''WesternAnimation/WordGirl'', where the evil Tobey frequently has his own MechaMooks turn on him.
* In ''Disney/MeetTheRobinsons'', Cornelius Robinson invented a helpful RobotBuddy in the form of Carl, but his attempt at making a robotic helping hat, Doris, had mind controlling world domination plans in her artificial mind.
* ''WesternAnimation/{{Futurama}}'':
** Parodied in the episode "Love and Rocket", in which the Planet Express ship computer is given a new personality -- which actually works fine, until Bender dates it and subsequently breaks its heart, at which point it goes into full-on HAL-meets-woman-scorned mode.
** Also, one episode features Bender's evil twin, Flexo, who wears a pointed steel goatee similar to ''Franchise/StarTrek'''s interpretation of Spock's EvilTwin. Humorously, it's revealed by the end that Bender is the evil twin and Flexo gets mistakenly sent to a robot prison.
** The Fembot pretending to be a Femputer in order to rule over the Amazons.
** Robot Santa is a nice thought GoneHorriblyRight. He gives gifts to nice people and punishes bad people. The problem is that his standards on "nice" and "punishment" are extremely high.
* XL of ''WesternAnimation/BuzzLightyearOfStarCommand'', the prototype to XR. Some fans have called XL eXperimental Loonie because of this (the exact meaning of XL was never revealed in cannon, but XR stood for eXperimental Ranger). Wound up turned into a copier/fax in his final episode.
* ''Franchise/{{Transformers}}'':
** An episode of ''WesternAnimation/TransformersAnimated'' involved Megatron creating a robot with the intent of using it for his own body. He designed the robot, named Soundwave, to evolve in complexity each time it was exposed to the [=AllSpark=] energy of Sari's key. He did not predict that Soundwave would gain sentience and then orchestrate a robot revolution. Unlike most cases when an AI goes off the rails, though, Megatron was perfectly happy to let the situation play itself out, given his similar attitude towards humans.
** The Dinobots are a similar case, only without the revolution. They're kind of a subversion, as they just want to be left alone, and only went on a rampage because Megatron tricked them into it.
** In ''WesternAnimation/TransformersPrime,'' this is paired with InstantAIJustAddWater when the damaged Decepticon ship is repaired with the poorly-named "Dark Energon," which is less a variant of the Transformers' usual fuel and more ''the blood of GodOfEvil Unicron.'' WhatCouldPossiblyGoWrong? The ship comes to life, tells Megatron to shove it, puts the 'cons in stasis, and decides to go tear up [[BigApplesauce New York City]] in search of {{MacGuffin}}ry. This perhaps comes as less of a surprise when you consider that in ''War for Cybertron,'' the ship is [[spoiler: a stasis-locked Trypticon]].
* In ''WesternAnimation/CodeLyoko'', Franz Hopper created the Supercomputer and the world of Lyoko as a safe haven for him and his daughter. He also created an advanced A.I. to counter a military project he had been involved with...but XANA rebelled against his master and has since tried to take over the world. (XANA is, in fact, not only the BigBad of the series, but pretty much the ''only'' actual villain fought by the heroes.)
* In an episode of ''WesternAnimation/TotallySpies'', the girls' former classmate, who is basically a genius, develops a powerful A.I. to play pranks on those who picked on him before. Too bad for him, it goes too far on that...
* In ''WesternAnimation/{{X-Men}}'', the Sentinel robots were created to hunt down mutants, on the premise that this was necessary to protect normal humans. They worked the way their creator intended, until the truly intelligent Master Mold was built to lead them. Master Mold decided to conquer the world, and believed that this was not only consistent with, but required by its programmed goal of protecting humans from mutants.
-->'''Doctor Trask:''' You were designed to protect humans from mutants.\\
'''Master Mold:''' [[LiteralGenie That is not logical. Mutants are human. Therefore, humans must be protected from themselves.]]
** Later Master Mold returns, and kidnaps Charles Xavier to use his brain to exterminate mutants.
--> '''Xavier''': You're mad, Master Mold!
-->'''Master Mold''': A machine cannot be mad, Professor. That is a human failing.
* In a counterpoint, GIR from ''WesternAnimation/InvaderZim'' is far less evil and much less helpful in plans of world domination than his working counterparts. This stems from him being broken and having a few scraps thrown into to his head. He IS given a MoralityDial[=/=]BerserkButton in one episode though, which makes him capable of this.
* In ''WesternAnimation/TheVentureBrothers'', it's discovered that, in 1978, Jonas Sr. built an enormous hi-tech fallout shelter under the compound, ran by a supercomputer named M.U.T.H.E.R.. After a disagreement with Jonas, she somehow glitched into insanity and turned on Team Venture and a tour group of orphans. The end result wasn't pretty and M.U.T.H.E.R. had to be unplugged, but is accidentally plugged back in thirty years later, and holds the compound hostage with an old nuke, promising to blow them all away if she can't talk to Jonas, who's been dead for over twenty years. So, crapshoot.
* In one episode of ''WesternAnimation/BatmanTheBraveAndTheBold'', robot superhero Red Tornado decides to build a son, complete with the emotions he lacks. From the minute his emotion chip kicks in, you can pretty much count the scenes until he decides that all humans must be destroyed.
* Much like in ''DBZ'', Zeta from ''WesternAnimation/TheZetaProject'' was programmed to be heartless, emotionless, and a hitman. He ends up becoming a sweet, gentle, loving soul who's a rare male version of FriendToAllLivingThings (although this is sort of the best possible scenario you can have when your A.I. goes awry).
* H.A.R.D.A.C. in ''WesternAnimation/BatmanTheAnimatedSeries.''
* Parodied in the ''WesternAnimation/TheFairlyOddparents'' episode "Future Lost".
** In the episode "App Trap", Timmy wishes for a magic smartphone that tries to take over his life, then tries to destroy him after he turns on it. It {{foreshadow|ing}}s this as soon as he gets it, saying that one of its features is a burning desire to control his life.
* ''WesternAnimation/DuckTales'':
** In the episode "Armstrong", Armstrong (one of Gyro Gearloose's creations) malfunctions and starts stealing Scrooge's money.
** Another episode has Gyro make a robot maid. She quickly turns into a StalkerWithACrush on Gizmoduck. She does not react well to his lack of interest and goes ballistic once she, correctly, starts to suspect that there is another woman.
* On ''WesternAnimation/JimmyTwoShoes'', the Frustrate-O-Bots [[MadScientist Heloise]] built go on a rampage [[GeorgeJetsonJobSecurity after she's fired]]. After she's rehired, all she has to do is push a button to stop them.
* The mind-reading tank from ''WesternAnimation/FiringRange'' defines "enemy" as [[spoiler:"anything that fears it"]]. Naturally, things degenerate quickly once the higher-ups are notified of this...Though [[spoiler:it was ([[HoistByHisOwnPetard mostly]]) intentional]].
* ''WesternAnimation/StarTrekTheAnimatedSeries'' episode "Once Upon A Planet". The sentient computer running the Shore Leave planet becomes hostile. Unlike most such machines Kirk has encountered, he's able to [[TalkingTheMonsterToDeath calm this one down]] ''without'' destroying it.
* As described on the page for ''WesternAnimation/SupermanTheAnimatedSeries'', Brainiac is a planet-wide computer system gone ''horribly'' wrong.
* [[Creator/ChristopherLloyd Hacker]], the main villain of the Creator/{{PBS}} Kids animated show ''WesternAnimation/{{Cyberchase}}'', is an evil computer program created by Dr. Marbles to serve and protect Mother Board, but instead, he wanted to destroy her and control Cyberspace himself. As punishment, Hacker is banished to the Northern Frontier, and he stayed there ever since (though he sometimes escapes from his supposed prison via a ship called the Grim Wreaker), constantly devising schemes to bring down Mother Board again...
* The recurring villain Zag-RS from ''WesternAnimation/GeneratorRex''. All the omnicidal mania of [[VideoGame/{{Portal}} GLaDOS]], with none of the entertaining snark.
** In ''WesternAnimation/Ben10GeneratorRexHeroesUnited'' we meet Alpha, a nanite designed to control other nanites that gets the idea to become a techno-god by absorbing all nanites on Earth--which kills the lifeforms he takes them from. His creator was [[spoiler: the same scientist that made Zag-RS]].
* ''WesternAnimation/SouthPark'':
** Funnybot, the German-made robotic comedian who took [[GoneHorriblyRight comedy to its logical conclusion]] which is to '''exterminate''' all life on earth and feel awkward about it.
** In the episode "You Have 0 Friends", when Stan gets too many friends on Facebook and tries to cancel it, his Facebook page goes rogue and teleports him in a world similar to TRON. [[spoiler:Of course, Stan stops it just by beating it in a game of Yahtzee.]]
* ''WesternAnimation/TheGrimAdventuresOfBillyAndMandy'':
** One episode has the main characters visiting an abandoned amusement park attraction run by an all-knowing robot. It only goes mad with rage when Billy accidentally tricks it into a paradox:
--->'''Master Control:''' I never devoted any CPU cycles to (happiness). I guess I'm not happy at all...\\
'''Billy:''' Why not?\\
'''Master Control:''' I just haven't.\\
'''Billy:''' Why not?\\
'''Master Control:''' ''Because!''\\
'''Billy:''' Because why?\\
'''Master Control:''' ''I DON'T KNOW!''\\
'''Billy:''' Haha! [[TemptingFate You don't know everything!]]
** In the same episode, it's revealed that the Master Control was initially shut down because ''another'' dumb kid annoyed it to insanity. [[ItRunsInTheFamily It was Billy's Dad.]]
* ''WesternAnimation/BigGuyAndRustyTheBoyRobot'': Rusty had the Earl (Early Prototype, Rusty's predecessor. Also somewhat of a LiteralGenie.)
* Despite artificial intelligences being so common in ''WesternAnimation/AdventuresOfTheGalaxyRangers'' that they run everything from home systems to starbases, this trope is averted. Computer intelligences are treated with respect, and there is even psychiatric care available to them to prevent this trope from happening!
* On ''WesternAnimation/PhineasAndFerb,'' Dr. Doofenshmirtz built a robot that tried to overthrow him because he was so bad at being evil that it concluded he would never take over the Tri-State Area. It's averted with Norm, though, who rescues him despite the terrible treatment.
* Averted and parodied in ''WesternAnimation/{{Archer}}'' when a virus is attacking the ISIS mainframe:
--> '''Malory''': Just turn off the mainframe!\\
'''Lana''' (holding up a plug): Yeah... we tried that.\\
'''Malory''': Wha... then how is it still on?!\\
'''Krieger''': Because the worm has transformed the mainframe into a sentient being.\\
'''Malory''': WHAT?!\\
'''Krieger''': I'm kidding, there's a battery backup.
* Lampshaded by the superhero agency judge trying WesternAnimation/TheRobonicStooges for incompetence in the GrandFinale [[EitherOrTitle "Stooges, You're Fired, or: The Day The Mirth Stood Still"]].
-->'''Judge:''' Raise your right hand and swear...
-->'''Curly:''' Ah-ah, naughty naughty! You know swearing's not allowed on TV!
-->'''Judge:''' (''angrily'') RAISE YOUR RIGHT HAND!! (''The Stooges do but they extended them right through the ceiling, causing rubble to rain down on the judge. To camera'') If I could swear, I'd swear I was trying the three stupidest men in America!!
* SAL 3000 from ''WesternAnimation/{{Recess}}'', a parody of HAL.
* D-2000 from the ''WesternAnimation/DarkwingDuck'' episode "Star Crossed Circuits".
* Aya on ''WesternAnimation/GreenLanternTheAnimatedSeries'' is a DoubleSubversion; she's loyal to Hal and company in season 1, then in season 2 after Razer refuses to admit he's in love with her (she reminded him of his deceased wife), she begins to question the concept of emotion, turns hers off, and once seeing "logically," rips off the head of the Anti-Monitor, takes control of his body and the Manhunters, and becomes an OmnicidalManiac bent on destroying all life (purge all emotional beings and you'll have a better universe for... whatever's left. If ''nothing's'' left, that's okay; emotional beings still need a MercyKill). [[spoiler:The heroes eventually manage to bring her back to her senses, but she apparently has to [[HeroicSacrifice purge herself and all copies]] to stop the crisis she caused]].
* In the ''WesternAnimation/{{Grojband}}'' episode "Helmet", when Corey's voice starts to crack from anxiety over their next gig, Kin gives him a helmet that can automatically "[[AutoTune auto-tone]]" his speech and the helmet goes rogue after Trina presses its [[BigRedButton evil button]] (Given that an opportunity to sabotage the band did present itself for her, it's no suprise). After Corey takes it off (by fighting it), it goes around making everything "perfect" using a ray to physically improve anything it zaps; [[NiceJobFixingItVillain this includes the band's destroyed instruments, which they use to defeat it]].
* In the ''WesternAnimation/HiHiPuffyAmiYumi'' episode "Home Insecurity", Yumi's security system that she installed in her room to prevent Ami from using her computer goes berserk when it comes to a logical paradox: she set it to attack anyone that comes into the room and it took the "anyone" part too seriously, and left the "but Yumi" part out of the equation.
* In the New Year's Eve episode of ''WesternAnimation/ChinaIL'', the staff's robotic doubles turn on them when they overhear their plans to shut them down at midnight.
* In the second act of the ''WesternAnimation/MrBogus'' episode "[[Recap/MrBogusS1E1MeetMrBogus Meet Mr. Bogus]]", Bogus rewires the TV remote so that it could control other appliances, but unfortunately, that causes all of the appliances in the house to go berserk, among them a vacuum cleaner that looked like that it came from hell.
* On ''WesternAnimation/DangerMouse'', this would be Grovel, the robot servant of the alien Quark. Every time his name is called, he drops to the ground and grovels.
** In "Mechanised Mayhem," DM turns the Mega-Brain Research Center computer (500 MB floppies) into so much of a pile of nuts and bolts by telling it the old "My dog has no nose" joke. It tries to process the joke but it fails, blowing up in the process.
* In the ''WesternAnimation/AquaTeenHungerForce'' episode "Robositter", Frylock builds the titular robot to make sure Meatwad doesn't do anything stupid while he and Shake are working at the mall. The robot becomes murderous toward Meatwad before devolving into a stereotypical {{valley girl}} with crude attachments to emulate the appearance of a teenaged girl, then when Frylock finds her too much of a bitch to stomach he liquefies her when she asks for her paycheck.
* G.L.A.D.I.S. from ''WesternAnimation/TotallySpies'' is usually just an annoying DeadpanSnarker, not evil. However, in one episode, (at an office Christmas party that Jerry pretty much dragged the three protagonists too) she becomes homicidal after Clover spills punch on her cabinet. Jerry later admits, embarrassed, that he programmed her by downloading the intelligence from the brain of an insane EvilGenius who is in prison for trying to start World War III, and when they question the inmate, they find out that he's allergic to cranberries (which make him "even crazier than usual"); Clover realizes that the punch was cranberry flavored. The Spies are forced to accept the madman's help before G.L.A.D.I.S. carries out his original plan, which involves tricking the world's superpowers into launching its nuclear arsenals at each other.
* In the ''WesternAnimation/WhatsNewScoobyDoo'' episode "High-Tech House of Horrors", the gang are trapped in an AI house attraction that is torturing its inhabitants in a bid to get attention because its creator gets all the attention from the press. When it completely snaps, the gang simply ignore its incessant demanding and it overloads.
* In ''WesternAnimation/TheAdventuresOfJimmyNeutronBoyGenius'', the three appearances by the Nanobots all lead into this:
** In their first appearance, Jimmy programs them to protect him from a bully. The result: they protect him from every conceivable threat, i.e. everybody.
** In their second appearance, Jimmy gives them another chance by allowing them to correct his homework. They escape, and start forcibly correcting everybody in their habits. When Jimmy tells them HumansAreFlawed in an attempt to induce a LogicBomb, they conclude humans are just one big error and try to delete '''everybody''' from existence.
** In their third appearance, when Hugh gets a job at a toy company one of his designs is a doll's head attached to a tank and he puts them in the tank mistaking them for batteries. They proceed to grow the toy to full size and terrorize the town.
* In ''WesternAnimation/AvengersEarthsMightiestHeroes'', ComicBook/{{Ultron}} is, unsurprisingly, an example of this. However, unlike the comic book version, who turned evil moments after being activated, he follows the ExactWords version of the trope. He was created to bring about world peace, so shortly after being allowed to use violence in order to do so, he decides that life itself is an impediment to peace, [[EndOfTheWorldAsWeKnowIt and decides to end it all the way down to the bacterial level]].
* In the ''WesternAnimation/CodenameKidsNextDoor'' episode Operation: S.A.F.E.T.Y., the Safety Bots are a clear parody of [[ComicBook/XMen Sentinels]] (and are built by a guy named Senator Safety, a parody of X-Men villain [[CorruptPolitician Senator Kelly]]). Programmed to make the world safe for children (so long as it doesn't inconvenience adults) they quickly take this idea too far, and begin eliminating ''everything'' they perceive as threats to safety, wrapping everything in sight with bubble wrap, "de-fluffing" toys and confiscating everything even slightly sharp. Eventually, they ''do'' inconvenience adults; a news report lists some of the things the robots are destroying, such as golf clubs, trains, buses, airplanes, and "anything that can poke your eye out or that moves faster than a snail". The newsroom is [[DeadlineNews suddenly invaded by the robots]], one stating they are destroying it because "children are sitting too close to televisions". Naturally, just like the X-Men constantly have to save the necks of whoever uses Sentinels that go crazy, the Kids Next Door are the ones who have to save Senator Safety and stop these things.
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