This is just something I thought about today and can name four examples off the top of my head. Probably not enough examples, and I'm probably bugging out, but if anyone else has seen it, feel free to add examples and discuss. ______________ A rose by any other name would smell just as sweet. And a Rose by any other name would probably have a happy ending to her romantic relationship. But alas, it seems that being named "Rose" is a deal-breaker on a cosmic level, because events tend to conspire to ruin her romantic relationships. In a tragic, death-y sort of way. This is often a Death Trope, so Spoilers will be unmarked.
- Martin the Warrior, a central figure of the Redwall series, fell in love with one Laterose of Noonvale, who was eventually killed in battle with the Big Bad of the book.
- Jack and Rose's romance in Titanic is stopped cold by the former freezing to death when the eponymous ship goes down.
- Jake and Rose in American Dragon: Jake Long had something of a Romeo And Juliet Plot going on. Rose is a member of a clan of dragon hunters called the Huntsclan. Jake is (if you couldn't tell from the show title) a dragon. Twhw Huntsclan's ultimate goal was to find an artifact that trants wishes and wish all dragons out of existence, and they very nearly succed, but Rose jumps in at the last second and wishes all of the Huntsclan members out of existence. Before she can poof away, though, Jake wishes she was never taken by the Huntsclan in the first place. This saves her, but because she only met him because of her being taken by the clan, she grew up with her own family and never got to meet Jake in the first place and has no memory of him.
- Steven Universe has Rose Quartz, the mother of the title character, who had to give up her physical form for Steven to be alive. Everyone dealing with her loss is one of the more prominent themes of the story, but special attention is given to Greg, Steven's human father, and to Pearl, a gem who was deeply in love with her.
Hello, Unknown Troper. You'll need to get known to lend a hand here.