Due to the prevalence of the Interspecies Romance, half-human and other varieties of interspecies hybrid children are fairly common in fiction. These characters may in turn conceive or sire children with pure-blood members of either parent's species, producing a second generation with a majority of one species and a minority of the other.
Such individuals are likely to demonstrate various traits from their minority ancestor, though such traits are likely to be more subtle the farther back said ancestor is.
Compare Half-Human Hybrid and Non-Human Humanoid Hybrid for simple half-and-half combinations. Once three or more species get involved, you're dealing with a Heinz Hybrid. For human/nonhuman examples, compare But Not Too Foreign, where a foreigner has their nation of residence's ethnicity somewhere in their ancestry.
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Ranma ½: Herb, Lime and Mint of the Musk Empire are the distant descendants of animals cursed into humanoid women shapes and mated with human males. As a result, they've inherited animalistic traits.
Aragorn from has some elven ancestry a few thousand years prior to the events in the story due to him being the last heir of Gondor. This wasn't really mentioned in the films, however.
Both Aragorn and Luthien are also part-Maiar, the angelic order of creation, through a shared ancestor who was the mother of Luthien. Although Aragorn after many generations is mainly human, and Arwen is only a quarter or one-eighth human through her own parentage.
Late in the Labyrinths of Echo series, Max learns that most of his colleagues have non-humans down their bloodlines: Juffin, like most Kettarians, has some werefox blood in him; Shurf is descended from the elves; Melifaro has both dwarvenandgiant ancestors; Melamori has a lot of elven and faff blood. In fact, the only pure-blooded humans in Secret Investigations are Kofa and Max himself (insofar one disregards his birth in an entirely different world).
Fleur Delacour and her sister from the Harry Potter series are quarter-Veelas through their grandmother.
The Tates from the Garrett, P.I. novels have a bit of elf blood on both sides of the family, although it's not obvious from their looks.
The Ohmsford family in the Shannara books. The story starts with the half-elf, Shea, then continues with his descendants, whose elven blood becomes increasingly diluted through intermarriage with humans.
In the novels Goblin Moon and The Gnome's Engine, Lord Skelbrooke is strongly implied to have a bit of fey blood. The Duchess is secretly an inversion, with a substantial degree of fey blood from both sides of her family.
Log Horizon: There is lore about the MMO Elder Tale saying that since the Alvs had a very low population, and since they historically intermarried with humans they've basically become extinct. However Alv genes live on in Humans in the present day. Their genes are plentiful enough that occasionally a Half Alv will be born to a human family due to the Alv genes being recessive.
The Belgariad: Belgarion, who had a sorcerer grandfather and a wolf grandmother, can shapeshift into an owl and a human.
In the Star Trek: Titan novels Will Riker and Deanna Troi try several times to have children. Deanna miscarries twice, then manages to carry a quarter-Betazoid daughter to term. The Star Trek Online novel The Needs of the Many states in turn that Natasha Riker-Troi married Rene Picard (son of Jean-Luc Picard and Beverly Crusher) and had three children with him.
In "The Drumhead", Simon Tarses, an enlisted man in the Enterprise's medical department, is hounded by an admiral on a Witch Hunt on suspicion of being a spy because he has a Romulan grandfather. Tarses had claimed on his entrance application that his grandfather was Vulcan.
Worf's son Alexander Rozhenko is one quarter human, from his half-human mother's side.
In Star Trek: Voyager's final season, B'Elanna Torres, a human/Klingon hybrid, gets pregnant by her human husband Tom Paris. Their daughter Miral is born in the series finale.
In 2nd edition AD&D, products of elf/human interbreeding with claim to 50% or more elven blood always had the characteristics of half-elves, while those with less than 50% elvish ancestry were functionally human.
The various types of Planetouched are individuals that are mostly a mundane species (human, elf, orc, etc.) but have some blood from an ancestor at least one generation removed who was of extraplanar origin.
Tieflings are mostly human, but have a fiend somewhere in their ancestry. Aasimar are the celestial equivalent of Tieflings. Genasi have an elemental grandparent instead.
Fey'ri are majority-elf, minority-demon crosses.
Tanarukks are Orcs with fiendish blood.
In some versions of fluff, sorcerers get their inherent magical powers from a distant ancestor (usually draconic).
The 3.5E supplement Planar Handbook introduced heritage feats that allowed characters to have a tinge of extraplanar blood, granting various bonuses.
Diablo humans are the descendents of angels and demons.
Star Trek Online: Admiral D'Vak, a Klingon NPC who commands the USS Houston as part of Star Fleet Battle Group Omega, is the son of Alexander Rozhenko by a Klingon woman according to The Path to 2409. This makes him 1/8 human.
Devil May Cry 4 has Nero, who is implied to be a quarter-demon (with all the perks that come with it like Super Strength). Though his exact parentage is never really made clear, the story does point out that he has Sparda's blood within him.
Tieflings (human/fiend) and aasimar (human/celestial) are playable races in the original campaign. Mask of the Betrayer adds four kinds of genasi (human/elemental).
Neeshka, the party's rogue, is a tiefling stated to be 1/4 devil. Mephasm, a pit fiend in the game's recurring cast, makes various suggestions that he's her grandfather.
Recurring NPC Light of Heavens and her twin Joy are a pair of aasimar (humans with celestial blood) serving Lathander. Light of Heavens is a Divine Champion, while Joy is a dancer.
Storm of Zehir:
The background feats "Fey Heritage" and "Fiendish Heritage" allow respectively non-lawful and non-good player characters to have a tinge of fey or fiendish blood. Turns into Heinz Hybrid with half-elves, half-orcs, and planetouched.
Throughout the Assassin's Creed series, some Assassin members who can use Eagle Vision are the descendants of Those Who Came Before.
StarCraft II: The Protoss-Zerg Hybrids come in two varieties: The close-combat Reaver has more zerglike features like external mandibles and huge claws, the Destroyer looks much more like a protoss, with psionic tendrils and psychic abilities.
In Gunnerkrigg Court, Antimony discovers she's descended from a fire elemental. Aside from giving her access to some magic, she also apparently inherited her mother's "flame" meaning that after Annie was born, she suffered a sort of delayed Death by Childbirth as her vitality was transferred to her.
In the D&D comic The Order of the Stick the Draketooths were descended from a black dragon and a human. Which meant that Vaarsuvius's familicide spell that killed off roughly a quarter of the black dragon species got them too.
Humans and Neanderthals have been known to inbreed. Today, pretty much every human outside of ancestral Africa has a small percentage of Neanderthal DNA.
Bengals are a cat breed produced by breeding a domestic cat with an Asian leopard cat, a type of wild cat. These hybrids are sometimes bred with other, pure domestic cats to produce a more manageable pet. Similarly, the Savannah is a cat breed produced by crossbreeding a serval with a domestic cat. As with the Bengal, the offspring are sometimes bred with full domestic cats.
The same also sometimes happens with wolves and domestic dogs; people want a dog that looks like a wolf but behaves like a dog. A half wolf, half dog is usually too much for most people, but breeding it with another dog is done to produce dogs that behave more like dogs.
A liliger is what you get when you cross a female liger with a male lion.
Many North American buffalo herds have a small percentage of domestic cattle DNA. In fact, only about four buffalo herds are pure buffalo.
A wholphin is a cross between a female bottlenose dolphin and a male false killer whale. The first captive wholphin to survive to breeding age, a female, produced two offspring with a bottlenose dolphin.
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