In works of fiction, the undead are common enemies for the heroes to face. A common trait of them is for the undead in question to be portrayed as poisonous or filled with disease, and they may spread death wherever they go. On the surface, this seems a perfectly logical conclusion. Zombies are likely going to be rotting corpses with bodies filled with who-knows-what types of disease. In the world of gaming, this gives undead enemies an elemental affinity with disease and poisons, though darkness is another common trait. General status ailments are also liable to be in their arsenal of attacks. This overall makes the undead, which tend to be weak and easily dispatched, more dangerous without necessarily making them more powerful in direct combat. Compare Zombie Infectee, The Virus, Poisonous Person
- In Yu-Gi-Oh!, Yami Yugi forces a Fusion Dance between his undead Mammoth Graveyard and Kaiba's Blue-Eyes Ultimate Dragon. The improper fusion between a living and undead creature causes the Blue-Eyes to become diseased and begin to decay and lose strength every turn.
- In Twilight, vampires don't merely drain their victims of blood, they transform them by injecting them with actual venom that infects and transforms them. Said venom can be extracted from a vampire and injected to turn someone without needing to bite them.
- Vampire: The Masquerade. Some products noted that vampires could act as carriers of blood-borne diseases. This meant they could infect any human they fed upon if the vampire didn't drain enough blood to kill the victim.
- Dungeons & Dragons, many types of undead can inflict poison, disease, and other debilitating ailments like level drain.
- Dragon issue #25, article "Varieties of Vampires" . A human spattered by the blood of an Anananngel vampire is afflicted by sores and diseases that incapacitate them.
- Mummies inflict a rotting disease by touch that drains 2 points of Charisma per month, neutralizes Cure Wound spells, reduces the natural healing rate to 10% of normal and is fatal in 1-6 months.
- Warhammer 40,000 has plague zombies, who are humans who have fallen victim to one of Nurgle the plaguefather's many plagues. The diseases they are infected by allow them to become almost incapable of feeling pain, making them walking meatshields.
- Shadowrun. Several Awakened creatures were the basis for Earthly legends of the undead (ghouls, vampires, wendigos, etc.). All of them were human beings infected with a magical disease that caused their condition: the HMHVV (Human Meta Human Vampiric Virus), with many variants that each created a specific undead.
- Final Fantasy, undead enemies often inflict status ailments.
- In Final Fantasy VI where Poison is treated as one of the eight elemental affinities, the Skull Dragon represents poison but is clearly an undead entity, and fights with status ailment attacks.
- In the same game, the undead Phantom Train uses status attacks, most prominently Diabolical Whistle, which inflicts one random status ailment on each party member. When the Phantom Train reappears as a Guardian Force in Final Fantasy VIII, its special attack inflicts every status ailment in the game on enemy parties.
- Pseudo-example in Fallout 3 and Fallout: New Vegas. The Ghouls are actually humans who have been heavily mutated, but look, act, and are regarded by many as traditional zombies. Their attacks infect the player with radiation damage.
- Appears in some of the Heroes of Might and Magic games:
- In III and V, zombies can be upgraded to inflict diseases when they attack living enemies, reducing the damage they do.
- In VI, the necromancer armies deploy lamasu, zombie sphinxes which are infected with plague magic and then sent to spread disease amongst the enemy army.
- There are mummified undead enemies in Diablo II which release a cloud of toxic corpse gas when defeated.
- The Undead faction in Warcraft III can research the Miasma ability, which lets their Abominations and siege weapons create clouds of poisonous gas when attacking.
- The Elder Scrolls series treats vampirism as a disease. There are different strains of the disease with names like Porphyric Hemophilia and Sanguinare Vampiris, which will cause the PC to mutate into a vampire if they are infected with them and don't cure themselves quickly enough.
- The undead provinces in the browser MMORTS Utopia usually have the "Spreads plague" property, which means that every time you attack or steal from them (or vice versa), there is a chance of carrying The Plague into your province, which can then spread into other provinces the same way.
- In Shadowrun Returns, ghouls are able to infect characters (including robots) they hit with their claws and deal Damage Over Time.
- In the earlier Disgaea games, many Zombie skills can inflict the poison status. By the third game, the Poisonous Person class has been relegated to the Slimes.
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