When, at the end of Journey's End, the Doctor is forced to wipe Donna's memories and leave her behind at home, while he has to go back to travelling alone in the TARDIS.

"I don't want to go."

Doctor: "REGENERATE!"
Master: "No."

The end of Cold Blood, Rory's death and then Amy desperately trying to remember him

• Rose: "How was that sentence going to end?"
• Ten: "Does it need saying?"

• Rose: You just leave us behind. Is that what you're going to do to me?
• The Doctor: No. Not to you.
• Rose: But Sarah Jane... you were that close to her once and now... you never even mention her. Why not?
• The Doctor: I don't age. I regenerate. But humans decay. You wither and you die. Imagine watching that happen to someone you...
• Rose: What, Doctor?
• The Doctor: You can spend the rest of your life with me. But I can't spend the rest of mine with you. I have to live on. Alone. That's the curse of the Time Lords.

Doctor who 2x03 - School Reunion

Doomsday. When the Doctor's crying. :(

The Waters of Mars. The entire episode. Period.

Father's Day. Everything about it.

Amy's Choice. When Rory gets hit by the alien's mist breath and turns to dust. It turned out to be just a dream, but still!

"Voyage of the Damned", which is insanely death-heavy to begin with, ends with a dedication to Verity Lambert. That's right, they chose the episode with a ship disaster with only three (technically four) survivors to inform you that the show's co-creator passed away. Cue the waterworks.

The end of Earthshock

removed duplicate entry