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3* SugarWiki/AwesomeMusic: The song that plays over the end credits:
4--> ''Darlin', I love you, but leave me the fuck alone...''
5* CultClassic: Even before James Gunn made it big with ''Film/GuardiansOfTheGalaxy2014'', many people have come to agree the film is criminally underrated.
6* EnsembleDarkhorse: The temperamental and foul-mouthed Mayor is likely the most popular character in the film.
7* HilariousInHindsight:
8** Hey, Creator/MichaelRooker just got impaled by [[Film/GuardiansOfTheGalaxy2014 a flying arrow]] in a Creator/JamesGunn film! Not to mention that its [[Film/GuardiansOfTheGalaxyVol2 sequel]] features an AssimilationPlot... with Rooker as [[spoiler: one of the ''good'' guys.]]
9** This wouldn't be the [[Series/{{The Walking Dead|2010}} last]] [[VideoGame/CallOfDutyZombies time]] Creator/MichaelRooker found himself in the thick of a ZombieApocalypse.
10** This wouldn't be the [[Film/TheSuicideSquad last James Gunn movie]] featuring an alien monster with {{parasite zombie}}s [[spoiler:that all die when the monster controlling them is killed]]. Bonus points for reuniting Michael Rooker, Creator/NathanFillion, and [[ProductPlacement Mr. Pibb]].
11** During the middle third of the film, Grant strongly resembles [[VideoGame/Fallout3 a newly designed Centaur]].
12** This is a film where Nathan Fillion fights a BodyHorror-happy alien parasite. In April 2022, the ''Master Chief Collection'' port of ''VideoGame/Halo3ODST'' (which features Fillion as playable character Gunnery Sergeant Buck) had its Firefight mode updated to include the Flood, meaning Fillion's back at it 16 years later.
13* SpiritualSuccessor:
14** Given the fact that both films center around alien slugs that turn people into {{Parasite Zombie}}s by entering in their mouths, ''Slither'' works as a distant remake of ''Film/NightOfTheCreeps''.
15** The movie can be seen as an adaptation of ''VideoGame/ResidentEvil4''. Both are about a parasite taking control of a small town farm land and both have the main leader have a attraction for the main girl.
16* SugarWiki/HeartwarmingMoments: The way the alien possessing Grant starts to genuinely care about Starla, even falling in love with her despite wanting to take over the world. He stops himself from infecting her while she was in the shower. Later, he apologizes to her through one of the zombies explaining that he never knew love before he came to Earth and was afraid of losing her. When Bill tells her to shoot him, the alien could easily use a tentacle to stop Starla from doing it, but instead of snarling or attacking he only exchanges a final sad look at her showing that he truly cares about her in the end.
17* MemeticBadass: According to the wrap-up tape, Bill Pardy ended up as this for the cast and production staff of the film.
18* TearJerker:
19** The first animal that Grant targets is a pet dog, which barks at him until Grant's silhouette takes over the screen blacking it out as we hear the dog's dying whines in the darkness.
20** Kylie trying to get to her little sisters' room to save them, only to be too late.
21** The look Starla and Grant share before [[spoiler:she has to blow him up]].
22* TheyWastedAPerfectlyGoodCharacter: The rest of Bill's posse, who provide some decent lines before being infected a little too quickly and unceremoniously.
23* SugarWiki/VisualEffectsOfAwesome: This movie has an under-appreciated great blend of practical effects and CGI.
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