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8* In ''VideoGame/AloneInTheDark3'', the corrupt sheriff under the BigBad's orders is last seen at the scene of [[spoiler:Carnby's resurrection]]. While all of the other members of the QuirkyMinibossSquad are killed by the end of the game, the sheriff isn't encountered again.
9* ''VideoGame/ANNOMutationem'': After retrieving Ryan's stolen ROM, Ann discovers he visited [[spoiler:Alan Doyle]] at some point and discovers an underground facility that has ties to [[NGOSuperpower The Consortium]]. Despite traversing through the area, [[spoiler:Doyle]] is never encountered or mentioned again even though he was somewhat working with the BigBad.
10%% Needs Context * ''VideoGame/{{Antichamber}}'': If you find and activate all of the pink cubes before finishing the game...good for you.
11* One of the numerous subplots brought up in ''VideoGame/AnotherCode R'' is that of Matt's father, who mysteriously disappeared. While all the other subplots and the main plot point are solved, his is dropped in the last two chapters and given only a vague hint as to what happened. The intent was this was going to be a SequelHook for a SpinOff game starring Matt that would answer this question, but became this trope when the company of the series went bankrupt and closed down. It would eventually be resolved when the creators returned to remake the game over a decade later.
12* Halfway through ''VideoGame/AvencastRiseOfTheMage'' the player steps through a PointOfNoReturn. This leaves the handful of survivors to deal with the remaining enemies, despite the fact that if any were capable of doing so they'd have already done it. Worse, the distress call to other academies is never addressed after it is made.
13* Towards the very beginning of ''VideoGame/BanjoTooie'', a couple of characters mention how excited they are about "the upcoming kickball game between the Jinjos and the moles" -- indeed, it's the main reason Jingaling wants to see the Jinjos rescued. The game is never mentioned again.
14** [[TheDragon Klungo]] from the first game. He only appears during the scene where Grunty is shown building the machine she will use to suck the beauty out of Banjo's sister, after which he disappears and is simply never seen, heard, or mentioned again. The only time he's ''ever'' seen again is in the NonStandardGameOver, where he actually succeeds in turning Grunty beautiful... at least, until his brief appearance in the ending sequence. He gets an expanded role in all of the other ''Banjo'' games, though.
15** Tooty, Banjo's little sister who [[BigBad Grunty]] wanted to steal the beauty of, and thus started the events of the entire series, who her older brother Banjo cared enough about to search a creepy witch's lair, climb tribal mountaintops, swim towards shark-infested islands, get swallowed by a giant sewage machine, wade through piranha-infested swamps, freeze his arse off in the North Pole, then burn his arse off in a desert, investigate a haunted residence, nearly drown in a polluted shipyard, time travel through a sky-high forest, win a fiery gameshow, and beat said witch who started it all, ''just'' to get her back, is never even seen again in the series after the first game (save for an in-joke FaceOnAMilkCarton in ''Tooie'' and a few other references). Tooty's disappearance can be chalked up to [[CreatorsPest nobody at Rare being very fond of]] a character they viewed as a walking plot device.
16* Mira being absent in ''VideoGame/BatenKaitosOrigins'' is explained by it being a VanishingVillage. Hassaleh being mysteriously absent from ''Baten Kaitos: Eternal Wings and the Lost Ocean'' is never mentioned, explained, or even referenced.
17* ''VideoGame/BatmanArkhamAsylum'': Zsasz is MIA after you save Dr. Young from him. There's the Scarecrow vision, but that's an illusion. Same thing applies to some of the named staff in Arkham after you save them, who we can only assume made a run for it considering how many guards were killed.
18* ''VideoGame/BetrayalAtKrondor'': An intriguing subplot concerning someone calling himself "The Crawler" trying to dislodge the Mockers (i.e. the thieves' guild) from Krondor and set up his own criminal empire crops up a few times in earlier chapters. After Chapter 3, however, it never gets referenced again (other than a brief sidequest at the beginning of Chapter 6). Apparently, Raymond E. Feist thought the subplot was interesting enough on its own to become the basis of the next book in the Riftwar Legacy series: ''Krondor: The Assassins''.
19* In ''VideoGame/{{BioShock 2}}'', [[spoiler: the character Tenenbaum from the first game appears very briefly, after early marketing for the game suggested she would play a far more important role. Her character's audio logs say that she's come back to figure out what is going on, but you save her from an attack, she flees, and you never hear from her again.]] This has something to do with [[ExecutiveMeddling the designers shifting the plot around at the near-last minute, and likely changed who your helpers and enemies were.]] She plays a major role and her fate is revealed in the downloadable mission pack as Subject Sigma's main ally, although it's doubtful this was planned ahead of time so much as, when they started writing the story for the mission pack, she was now simply conveniently available.
20* In ''VideoGame/BraveFencerMusashi'' Bubbles and Gingerelle, two higher ranked members of the [[TheEmpire Thirstquencher Army]], just utterly and completely ''vanish'' about halfway through the game after failing to capture Musashi. A common FanWank has it that the BigBad killed them for their failure afterwards.
21* ''VideoGame/BreathOfFireII'': During the opening sequence, Ryu's father Ganer and sister Yua disappear. Ganer plays a major role in determining which ending you earn. Yua... is never seen again. It's heavily implied [[spoiler:that she grew up to become the thief Patty, who kickstarts the main plot]], but this is never confirmed, and even if it's the case, [[spoiler:that means she was trapped in Dragnier when the gate was sealed and ''nobody cared'']].
22** Patty's fate, at very least, was finally answered in the GBA port of the game. With a still image, during the end credits, showing her gazing at the horizon, in what looks like to be on top of the hills where the sealed gate to Dragnier is.
23** ''VideoGame/BreathOfFireIV'': Ilgor, servant of Prince Morley of Ludia, vanished after his failed attempt to kidnap Ryu to use his power as a bargain chip against the Fou Empire. We do keep running into his underlings in random encounters though, so maybe he never gave up.
24%%* ''VideoGame/{{Bully}}'': Who won class president? Earnest or Ted?
25* ''VideoGame/CastlevaniaDawnOfSorrow'': While averted in the main mode in which she turns up at the tail end of the adventure, Mina Hakuba makes absolutely no appearance, nor is even mentioned in [[AnotherSideAnotherStory Julius Mode]]. [[spoiler:Considering [[KillTheCutie what kickstarts Julius Mode]] to begin with, [[SchrodingersGun the implications aren't pretty]].]]
26* ''VideoGame/TheCaligulaEffect'': The ''[[UpdatedRerelease Overdose]]'' version adds the Ostinato Musician route, where the protagonist chooses to join the eponymous group. This leads to some altered events, including the fact that [[spoiler:Shadow Knife]] actually survives their fall. But even with them actually still being alive in that route, they are completely absent in [[VeryDefiniteFinalDungeon Grand Guignol]]. They only appear in the epilogue scenes for the good ending.
27* In ''VideoGame/CallOfDutyAdvancedWarfare'', Joker and Gideon are tasked with [[spoiler:preventing Mitchell and Ilona's escape from New Baghdad]]. Gideon lets them go [[spoiler:and also performs a HeelFaceTurn of his own]], but Joker is never seen after this mission.
28* ''VideoGame/CaveStory'': The Colons. Their kidnapping is a major motivation for their adoptive mother, Curly -- until the Core fight, after which Curly never mentions them again.[[note]]Granted, most of this can be explained by her being amnesiac or too busy trying to save the world, but in the final cutscene she's neither of those.[[/note]] While the Colons themselves do get rescued by Momorin and Itoh, there's no logical way that Curly could know this.
29** Jack's fate is implied rather than shown: He's in the Plantation jail along with Sue, then he's gone by the time the plot [[CutsceneIncompetence forces you to get thrown in jail]]. The implications aren't pretty. However, it's possible to completely skip seeing Jack in the cell, rendering his disappearance from the game rather more baffling.
30* ''VideoGame/ChronoTrigger'':
31** The fate of the character [[spoiler:[[UrbanLegendOfZelda Schala]]]] is unexplained/occurs off-camera. This character's fate was most likely planned from the get-go, however, as the second and third games, ''VisualNovel/RadicalDreamers'' and ''VideoGame/ChronoCross'', explain what happened to them. However, while both games' explanations have similarities, they are radically different:
32*** In ''Radical Dreamers'', [[spoiler:Schala remained in her time, but was left alone following the Ocean Palace incident, overcome with grief and guilt over her unwilling part in the incident and said incident's results. The Frozen Flame picked up on those emotions, and responded by [[FountainOfYouth transforming the young princess into a baby]], [[LaserGuidedAmnesia erasing her memories]], and [[TimeTravel sending her to Lucca's time period]], where the latter found and raised her as Kid]].
33*** In ''Chrono Cross'', [[spoiler:Schala ended up in the Darkness Beyond Time, where she remained until Crono and his friends kicked Lavos's ass. After that, Lavos was sent to the Darkness Beyond Time as well, where it found and absorbed the young princess, slowly corrupting her mind and turning their fusion into the Time Devourer. Despite her best efforts to stay conscious, Schala couldn't resist for long, and created a clone of her with the last of her power. That clone manifested in 1,000 AD as the baby girl Lucca found at the end of ''Chrono Trigger''. Only when Serge came and defeated the Time Devourer using the Chrono Cross was Schala freed at last]]. This fate is considered as the canon one, but an easter egg suggests that the events of ''Radical Dreamers'' happened in another dimension.
34** A better example is what happened to Magus, Schala's brother. In ''VideoGame/ChronoCross'', the character Guile was supposed to be Magus still searching for his sister but Square dropped it during development. There are still several scenes from the game that Square left in from this plotline. The most obvious is a letter from Lucca that suggests that Janus (Magus' real name) was traveling with you.
35*** In the DS remake of ''Chrono Trigger'', Magus, [[spoiler:upon the realization that he could never be strong enough to deal with the Time Devourer, casts aside his memories and winds up in a forest. We never find out what happens to him afterward]]
36** In ''Chrono Cross'', the scene where Kid declares that Terra Tower has assumed its true form, after which nothing is ever mentioned of it again. It just floats there menacingly for the rest of the game.
37* ''VideoGame/CommandAndConquer: Tiberium Wars'' adds a third side to the [=GDI/Nod=] conflict with the Scrin AlienInvasion. Whatever campaign you choose, the Scrin discover that HumansAreWarriors and are chased off the planet, planning to return in greater force. They are never heard from again.
38** It could be thought that they will return when the planet really is overcome by Tiberium, since tricking them into thinking that was the case was what caused them to arrive in the first place. However, with the later development of control over the crystal growth, such a fate might be averted.
39* ''VideoGame/CultOfTheLamb'':
40** The game starts with the Lamb getting put to the blade by [[TheExecutioner a very large cultist armed with an axe]]. After The One Who Waits revives you, the executioner is nowhere to be seen, and never appears again of the entire game even though one would expect them to be some sort of Boss.
41* ''VideoGame/Cyberpunk2077'':
42** After [[PlayerCharacter V]] is betrayed by FatBastard Dexter [=DeShawn=] and his bodyguard Oleg Darkevich, the latter is nowhere to be found. However, it can be assumed that [[NobleTopEnforcer Goro]] killed him in the process of getting [=DeShawn=] to tell him [[DeathByOriginStory where he dumped V's body]].
43** We never see in-game what happened to Johnny's friends Spider Murphy and Shaitan, who were both major characters in the [[TabletopGame/{{Cyberpunk}} original game]]. However, the tabletop lore confirms that they both survived the raid, although comments by Johnny imply they didn't get the same happy endings Rogue and Kerry did.
44* In the ''Franchise/DeadSpace'' series, the fate of Lexine Murdoch, one of the protagonists of ''VideoGame/{{Dead Space Extraction}}'' and Dead Space: Severed, as well as the origin for her immunity to the Markers' signal, remain unknown. We find out that Lexine is immune to the Marker on Aegis VII during the course of Extraction, when Gabe Weller notices that she doesn't witness any hallucination, one of the many effect of the Marker, while everybody on the Ishimura did to some extent, Gabe included.
45** In Dead Space: Severed, we learn that Lexine's immunity is now at the center of a scientific project called the Oracle Project. This project, whose goal was to wait for Lexine to give birth to a child and to study the effect of the immunity on him -- presumably to spot a gene responsible for it -- is eventually scrapped when the outbreak on Titan occurs and Lexine's termination is ordered. At the end of Severed, Lexine flees to an unknown location (presumably Earth) with the help of Gabe's sacrifice. Her status in an [=EarthGov=] file shown after the credits indicates that she is still alive, missing and a target of the Earth government. She's never heard of after that, neither in the sequel or in any of its DLC.
46** Given the [[ShootTheShaggyDog ending]] of the series and the [[TheEndOfTheWorldAsWeKnowIt fate]] of Earth and Humanity (and possibly all organic life) at the end of Dead Space: Awakened, it can be safely assumed that she suffered the same fate as everyone else. Not that her immunity would have been helpful in any way to keep that, or even the whole plot of Dead Space 3, from happening.
47* In the ''VideoGame/{{Diablo}}'' series, aside from the three [[BigBadEnsemble Prime Evils]] (Mephisto, Diablo, Baal), there are the four [[QuirkyMinibossSquad Lesser Evils]]. Two of them, Andariel and Duriel, are [[ClimaxBoss act bosses]] (Andariel for Act I, Duriel for Act II) in ''VideoGame/{{Diablo}} II''. The other two, Azmodan and Belial, have never actually appeared beyond small mentions in the original game's manual and a fleeting mention in in-game lore. They finally make appearances in ''VideoGame/DiabloIII'', as the bosses of Acts II (Belial) and III (Azmodan).
48** In ''VideoGame/DiabloII'', Natalya the Assassin stays in Kurast, and leaves after Mephisto is defeated, with no explanation. In ''VideoGame/DiabloIII'', the Natalya's Vengeance item set vaguely describes her leaving assassination to become a Demon Hunter.
49* Done InUniverse in ''VideoGame/DinoCrisis''. At the start of the story, Cooper gets separated from the rest of the team and the audience sees him get eaten by the ''T. rex''. The rest of the team never learn of his fate and they don't even talk about him other than how he just disappeared. At the end of the game, Regina mentions in her report that Cooper simply went missing and they haven't heard from him since.
50* Bodahn and Sandal seem to have quietly dropped off the map in ''VideoGame/DragonAgeInquisition'', with the role of dwarven enchanter taken on by Dagna, a minor (but adorable) NPC from ''[[VideoGame/DragonAgeOrigins Origins]]''. Especially frustrating since Sandal was built up to be a very weird mystery, and then was seemingly forgotten about.
51* The mage origin of ''VideoGame/DragonAgeOrigins'' has a literal example as during your test to prove yourself in the Fade, you encounter another mage named Mouse who wants to help you. As you defeat the lesser demon you were sent to kill, Mouse reveals that he is in fact a pride demon, the most powerful and deadly type of demon. He reveals his true appearance and gives you the ominous warning. "The true dangers of the Fade are preconceptions, careless trust, pride... Keep your wits about you, mage. True tests never end." before vanishing. Despite this disturbing introduction you never see or hear from him again.
52** Mouse's true nature may have retroactively been elaborated on in later installments of the series, which reveal that spirits and demons are (or at least, can be) two sides of the same coin. In particular, ''VideoGame/DragonAgeInquisition'' reveals that pride demons are the flip side of spirits of wisdom. It's plausible that Mouse was actually a wisdom spirit administering a SecretTestOfCharacter all along, the future mage warden simply perceived them as a demon as that's what they expected to encounter.
53** [[spoiler:Sandal makes a return in the final ''Trespasser'' DLC, in the form of his diary. [[http://dragonage.wikia.com/wiki/Codex_entry:_The_Very_Private_Diary_of_Sandal_Feddic,_DO_NOT_READ!!!! It's... enlightening.]] ]]
54** There's also the case of Fergus Cousland in [[VideoGame/DragonAgeOrigins Origins]]. Barring one conversation choice just after the party arrives in Lothering, no mention is made of him at all until the epilogue.
55** ''Inquisition'' also mentions the fates of nearly every party member from the first two games, plus Shale plays a supporting role in the ''Asunder'' novel. However, nothing is mentioned of Oghren, Nathaniel, Velanna, or Sigrun from the ''Awakening'' expansion. Their absence is especially conspicuous considering the involvement of the Grey Wardens.
56* ''VideoGame/DragonQuest'':
57** ''VideoGame/DragonQuestI'': The Hero searches for several items scattered around the world by his ancestor Erdrick in ''VideoGame/DragonQuestIII''. He finds his Sword and his Armor... but Erdrick's Shield (i.e. the Shield of Heroes) is still missing. The absence of his helmet is understandable, since it's just an iron mask, but the shield is a special magical talisman like the sword and armor.
58** ''VideoGame/DragonQuestVII'': Depending on how diligent you are with talking with [=NPCs=], some plotlines appear to have a few open threads left hanging, like some NPC's fate being left unknown.
59** ''VideoGame/DragonQuestVIII'': After his defeat, it is unclear if Sir Leopold is dead or alive as he is not seen again. Signs point to him being dead though -- prior to confronting Marcello at Neos, a potential party chat with Angelo will result in him musing over the possibility of having to face and potentially kill his half-brother in battle, taking note of the fact that out of the three sceptre-bearers the party had defeated thus far, two of them ultimately perished at their hands. Since Jessica is very much alive, this seems to point to Leopold being dead after all.
60** ''VideoGame/DragonQuestXI'':
61*** Breaking Veronica's curse and returning her to her proper age beyond a cutscene and a late-game Pep Power with her and Serena -- both temporarily -- are never brought up or explored.
62*** Unlike the Gloomnivore and Tatsunaga, Avarith is nowhere to be found in the postgame despite not being a Spectral Sentinel and assumedly still being alive.
63*** After learning about Michelle's death, Queen Marina mentions having been trying to find a way to undo the curse of the Mermaid's Burden (where a mermaid who becomes human will turn into sea foam if she ever re-enters the ocean), but it's never brought up again.
64* ''VideoGame/DynastyWarriors 4'', due to its flexible mission structure, had a few of these:
65** For the forces that battle the Yellow Turbans in the first act (nearly all of them), if you play it in its entirety and then allow Zhang Jiao to escape at Yellow Turban Rebellion, you will not kill him, and you also will not get the Return of the Yellow Turbans special stage, the only other stage he shows up in. You're left with only the assurance that the threat of the Yellow Turbans is over, and Zhang Jiao just quietly fades from history. (You could assume that he succumbed to disease, since that's what actually happened.)
66** You cannot under any circumstances kill Dong Zhuo at Hu Lao Gate. Meaning that unless you're playing as Lu Bu, the only way to see his demise to get the one of the "Dong Zhuo Lives!" special stages or the "The Symbol of the Mandate" special stage. Therefore, it's very likely you'll finish the entire campaign without ever learning Dong Zhuo's fate. (Similar to Zhang Jiao, you can assume that Lu Bu eventually whacked him.)
67** If you're playing as any force other than Wei, Lu Bu, Dong Zhuo, or the Yellow Turbans, you will face Lu Bu exactly once, at Hu Lao Gate, where it's not possible to kill him. He's never mentioned again. Presumably Wei takes him out, but you only get to see this if you're playing as Wei.
68** Also as Wei, you face Yuan Shao at The Battle of Guan Du, where he'll retreat if things go badly enough. If you didn't meet the requirements for the "The Esteemed Yuan Family" special stage, that's it; he's gone for good and presumably becomes a footnote to history. (THAT, at least, doesn't require much imagination!)
69** Lu Bu, Yuan Shao, and Dong Zhuo have a single battle against each of the Three Kingdoms. Only two of them are required. How Cao Cao, Sun Jian, or Liu Bei knuckles under to your iron rule without a fight is left to your imagination.
70** As Wu, it's possible to get Race For The Nan Territory, where both you and the Shu army battle a total of four Wei generals, after Wei has already been destroyed. Since none of the four die in this battle, it's unclear what becomes of them afterward, or for that matter what the hell they're doing here in the first place.
71* ''Franchise/TheElderScrolls'' franchise, with its [[WideOpenSandbox open worlds]] featuring dozens to ''hundreds'' of plot-relevant [=NPCs=] will obviously raise this question with at least a few of them from game to game. Sometimes, the developers will drop hints to what happened to some of these characters, but a few of their fates remain unknown:
72** In ''[[VideoGame/TheElderScrollsIIDaggerfall Daggerfall]]'', Ebonarm is a [[WarGod god of war]] worshipped in the Iliac Bay region and is held in high regard by the Redguards. He is a BlackKnight with an [[BladeBelowTheShoulder ebony sword fused to his right arm]] and is [[TwentyFourHourArmor never seen without his dark ebony armor]]. He is a noted adversary to most Daedric Princes and, despite being a god of war, usually appears on the battlefield to ''prevent'' bloodshed and reconcile the opposing sides. Ebonarm hasn't been mentioned in any form since ''Daggerfall'', however. He has possibly even {{Unperson}}ed in ''[[VideoGame/TheElderScrollsOnline Online]]'', where a book from ''Daggerfall'' appears that previously mentioned him, but has all mentions of Ebonarm removed.
73** ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'':
74*** The first NPC you meet is Jiub, a fellow prisoner on the Imperial prison ship, who asks you your name and is notable for being one of the few fully voiced [=NPCs=] in the game. But after having completed the tutorial, you will never see him again, causing many people to wonder where he went. He was even popular enough to spawn all sorts of {{Game Mod}}s which add him back into the game in various roles, including as a companion. Bethesda, seeing the fan reaction, got into the act in ''Oblivion'' where asking certain characters about rumors will reveal that Jiub has become a saint in Morrowind, because he drove the [[GodDamnedBats Cliff Racers]] out of Morrowind. The ''Dawnguard'' DLC for ''Skyrim'' fully answers the question: Jiub was soul-trapped and killed by a Dremora during the Siege of Kvatch. How do you know this? Jiub tells you so himself in the Soul Cairn. You can also get a quest from him to collect his scattered memoirs so that his tale may live on.
75*** Another ''Morrowind'' character that disappeared was Caius Cosades, the Imperial SpyMaster and first major QuestGiver of the main quest. He gets recalled to Cyrodiil part way through the main quest, but is not seen in ''Oblivion'' at all, to the disappointment of some fans. [[http://www.imperial-library.info/content/ken-rolstons-texts Lore texts]] written by designer/developer [[WordOfGod Ken Rolston]] seem to indicate that Caius is alive and well following the Oblivion crisis.
76*** King Helseth is another character who vanishes from the lore after the events of the ''Tribunal'' expansion. He apparently remained King until at least the events of the Oblivion Crisis, but there is no word on his fate afterwards. Unusual for the series which likes to give at least subtle hints as to the fate of prominent characters from past games in future ones. (Given that [[ProudMerchantRace House Hlaalu]], Helseth's [[TheClan Great House]], was {{Unperson}}ed following the [[ColonyDrop Red]] [[ChekhovsVolcano Year]], as shown in ''[[VideoGame/TheElderScrollsVSkyrim Skyrim]]'''s ''Dragonborn'' DLC, maybe this one isn't too unusual after all...)
77*** Vivec, one of the [[PhysicalGod Tribunal deities]] of the Dunmer who acts as a SupportingLeader toward the end of the main quest, also disappears during the events of the Oblivion Crisis. There are conflicting reports saying that he was taken by the Daedra, was killed by [[PlayerCharacter the Nerevarine]], or that he escaped into Aetherius (the realm of magic).
78*** The fate of [[PlayerCharacter the Nerevarine]], after leaving for [[{{Wutai}} Akavir]] as rumored in ''Oblivion''. Since the Nerevarine was cured of all the [[BodyHorror negative effects]] of Corpus, but retained the [[TheAgeless positive]] [[IdealIllnessImmunity ones]], they very well could be [[ReallySevenHundredYearsOld still be alive]] and well by the time of ''Skyrim'' (which takes place about 204 years after ''Morrowind'').
79*** In ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'' you can find light helmets called Colovian Fur Helms, which presumably come from Colovia in the Imperial Province. In [[VideoGame/TheElderScrollsIVOblivion Oblivion]] players can visit Colovia, but there are no Colovian Fur Helms anywhere.
80** ''[[VideoGame/TheElderScrollsIVOblivion Oblivion]]'''s ''Shivering Isles'' DLC introduces Jyggalag, the Daedric Prince of Order, BigBad for the DLC, and the old [[MadGod Sheogorath]]'s [[LiteralSplitPersonalities Literal Split Personality]]. Despite being freed and split from Sheogorath, he does not appear anywhere after said DLC. There is no mention of him anywhere in ''Skyrim'' (where all 16 other Daedric Princes make an appearance) or any lore piece set in between the two works. Speculations about his fate are a staple in the ''Elder Scrolls'' lore community.
81** From the series' backstory is Morihaus, the [[OurAngelsAreDifferent Aedric demi-god]] described as a "winged [[OurMinotaursAreDifferent man-bull]]" who was sent to aid St. Alessia (as part of her BargainWithHeaven) in her war against the [[AbusivePrecursors Ayleids]]. He became the [[DivineDate lover and consort]] of Alessia, and was with her until her death. What happened to him after is unknown.
82** Barenziah, Queen and later Queen Mother (to the aforementioned Helseth) of Morrowind is a prominent figure in the series ranging from the time of [[GodEmperor Tiber Septim]] in the backstory to her final appearance in ''Morrowind'''s ''Tribunal'' expansion. She was known to still be alive at the end of the 3rd Era, but what happened to her after that is unknown. ''Skyrim'', set in 4E 201, has some references to her made in the past tense, implying that she died.
83* Dee, Anzel, Bill and Trot at the end of ''VideoGame/EmeraldCityConfidential''. Their storylines never get resolved as the game gradually focuses more on the main plot.
84* ''Franchise/{{Fallout}}'':
85** ''VideoGame/Fallout2'':
86*** A comedic example; you can take up a short treasure hunt, which culminates in lowering a treasure-hunting dwarf down a well to retrieve a bag of loot. It turns out to hold a fortune in bottlecaps, the now-worthless currency of the previous game. After cursing, kicking a bit of dirt and ultimately having a good laugh about it, you head off again, leaving the dwarf stuck down the well.
87*** Quite famously within the fandom, you never do rescue Sulik's sister Kurisu, find Sulik's village, or any trace of the slaver group that kidnapped her as they were all DummiedOut from the final version. Kurisu was planned to appear as a companion in the cancelled ''VideoGame/FalloutVanBuren'', but she's yet to appear in a game since. The fan-made restoration mod finally lets you save her.
88** A possible fate of Follows-Chalk in ''VideoGame/FalloutNewVegas'' if you convince him to leave tribal life to see civilization for himself. If you do he's said to leave his tribe at Dead Horse Point and never be seen again.
89** In ''VideoGame/{{Fallout 4}}'', if you convinced Madison Li to defect from the Institute to the Brotherhood of Steel, then later turn on the BOS, she seemingly vanishes from the game, never to be seen again. [[spoiler:Subverted in that she is still present in the game world: use of the GECK editor reveals that after the ''Prydwyn'' crashes, Li winds up trapped in a room under the rubble of the Boston Airport, [[AndIMustScream still alive but unable to ever escape]].]]
90* In ''VideoGame/FarCry4'' we have Darpan, one of the founding members of [[LaResistance The Golden Path]] who is captured alongside Ajay in the very beginning of the game by [[BigBad Pagan Min]]. The last we see Darpan he is strapped to a machine being tortured by De Pleur, and the last we hear about him is a passive mention of him in Durgesh Prison. After that no other character ever mentions him, we never learn if he was killed or merely imprisoned, and the game just sort of forgets about him.
91* ''VideoGame/FearEffect''. Hana encounters a frightened old woman in a fishing village. She then leaves the old woman behind and the old woman is not seen or heard from again. Really, Hana should have been given a WhatTheHellHero scolding for that!
92* ''Franchise/FinalFantasy''
93** ''VideoGame/FinalFantasyVI'':
94*** Banon starts out as leader of LaResistance against TheEmpire in the World of Balance. He is never mentioned in the World of Ruin. The most likely explanation is that he was killed after the Empire's [[ISurrenderSuckers fake surrender]], but this is never confirmed and none of the party (which includes Banon's long-time friends, Edgar and Locke) even see fit to mention his apparent death after Edgar leads the currently inactive portion of your party in a narrow ([[OffscreenMomentOfAwesome offscreen]]) escape to reunite with Locke's portion of the group. Likewise for Banon's right-hand man Arvis, also a long-time friend of Edgar and Locke.
95*** Siegfried takes that amazing treasure from the Phantom Train, practically right out of your hands... but certainly we can get it back in the World of Ruin... right? ''Nope.'' It later comes out that the goofball you met on the Phantom Train was an impostor impersonating a legendary warrior, but [[VoodooShark that only raises further questions]] that never receive answers.
96*** After Kefka poisons the people of Doma, the only survivors are Cyan and a nameless soldier, who search the castle for other survivors. Cyan finds his wife and son deceased, goes on a RoaringRampageOfRevenge, teams up with Sabin, and later joins the rest of the party. The other survivor just disappears. The Imperials did not occupy Doma Castle (Kefka poisoned the water on his own rather than being ordered to do so), so it's not inconceivable that he might have survived the siege, but he's never heard from again.
97*** The people of Narshe are nowhere to be found in the World of Ruin. There's an NPC who mentions that the town is overrun by monsters, but there's no explanation given as to why. The city looks exactly the same as it did in the World of Balance, so it wasn't hit by the Light of Judgement. No mention of whether the people died or evacuated, and if the former, how Umaro and Mog survived. Considering how important the town is to the story, you'd think ''something'' would have been said.
98** In ''VideoGame/FinalFantasyVII'', there's a QuirkyMinibossSquad called the Turks consisting of mercenaries hired by Shinra named Reno, Rude, and Tseng who antagonize you throughout the game. Each time they're defeated, they run away. During your second and final visit to Midgar, you fight them one last time, and at the end of the battle they run away as per usual. However, not long after, the Shinra corporation is completely destroyed, with its leadership either dead at the hands of Diamond Weapon or defected. Once that happens, the only thing left to do in the main story is head to the Northern Crater to kill [[BigBad Sephiroth]]. What happened to Reno, Rude, and Tseng during all this is left ambiguous.
99** In ''VideoGame/FinalFantasyIX'', much of Freya's backstory concerns her search for her lost boyfriend, Fratley. She finally finds him again about a quarter of the way through the game, only to discover he has amnesia. He then heads off before Freya can say much to him. Typically, one would think that he would reappear later and the plot would continue when he does, but no, it never happens. He appears again in the ending sequence (still amnesiac), but this seems like a hastily-added attempt at covering up the planned-but-deleted sidequest. Likewise, Prince Puck only makes a few appearances in the first quarter of the game and completely vanishes thereafter until the ending, serving little purpose beyond befriending Vivi. Bonus points for their race being anthropomorphic ''rats''.
100** Ba'Gamnan in ''VideoGame/FinalFantasyXII'' is introduced as a ruthless bounty hunter with an agenda against Balthier. The only thing he does is kidnap Penelo and chase the party through the mines and completely disappears from the story afterwards without any mention of him or his crew ever again. There is an optional boss fight against him via hunts, but unless the player actively completes hunts as they come along, it's possible to never fight him at all or even remember who he is. His appearance in ''VideoGame/FinalFantasyXIIRevenantWings'' can surprise many people who had not fought him in his optional encounter in the previous game.
101** ''VideoGame/FinalFantasyTactics'': Due to the game's mechanic, any named characters offering to join Ramza will be PutOnTheBus because of the possibilities of the offers being denied, battle deaths, or them getting laid off. While it's shown that Ramza and Alma survive the explosion in the final battle, the rest of the army isn't bothered. Likewise, ''VideoGame/FinalFantasyTacticsAdvance'' and ''VideoGame/FinalFantasyTacticsA2'' doesn't address generic party members at all and they may as well not exist according to the endings.
102** The school children in the prologue of ''VideoGame/FinalFantasyTacticsAdvance'' simply disappear when the town is transformed. The three bullies that picked on Mewt are later revealed to have become zombies (and then vampires in a post game side quest), but nothing is ever mentioned of them. The children are shown again in the ending alive and well.
103* In the ''Franchise/FireEmblem'' series:
104** In ''VideoGame/FireEmblemGenealogyOfTheHolyWar'', after the Chapter 5 WhamEpisode, [[spoiler:most of the non-major members of the army (Alec, Arden, Ayra, Azelle, Beowolf, Chulainn, Dew, Jamke, Lex, Midir, and Naoise) never have it confirmed if they survived the Battle of Belhalla or what happened to them if they did]].
105** Due to being a prequel to ''VideoGame/FireEmblemTheBindingBlade'', most characters created specifically for ''VideoGame/FireEmblemTheBlazingBlade'' have their fates left ambiguous in the former. However, because Zephiel starts a full-on war on the entire continent of Elibe 20 years later, it is likely that most of ''The Blazing Blade's'' cast were KilledOffscreen, though there is also another possibility that some didn't live to witness the Disturbance, or most likely retired. However, there are a few who avert this trope (though usually in a [[DoomedByCanon not-so-pleasant way]]), such as Canas, [[spoiler:who was killed alongside his wife in an attempt to stop a blizzard]], and Karla, [[spoiler:who passed away from an illness]].
106*** Lyn's fate in ''The Binding Blade'' is one of the biggest mysteries in the franchise's history. She didn't exist at the time that game was released, and therefore remains unmentioned. She was created specifically for ''The Blazing Blade'', and if Lyn doesn't get an A-Support with [=Eliwood/Hector=], she returns to Sacae, never to be seen again. However, regardless of the player's decision, there is a chance that Lyn is DoomedByCanon because [[spoiler:Roy's mother passed away at some point and therefore had to be wet-nursed during his infancy, Lilina's mother never gets mentioned but is most likely dead, and Bern unleashes a mass genocide on Sacae, killing many in the process]]. Considering that she is a BreakoutCharacter, this trope has become a lot more apparent over the years.
107** In ''VideoGame/FireEmblemThreeHouses'', depending on the route you pick, some characters will no-show in Part II if you don't recruit them and their fates are left unresolved.
108*** On all routes, Marianne and [[DownloadableContent the Ashen Wolves (Yuri, Constance, Hapi, Balthus)]] make no appearances in Part II if you don't recruit them.
109*** On all routes except Azure Moon, Hanneman and Manuela's fates are left unresolved if you don't recruit them.
110*** On all routes except Crimson Flower, Alois makes no appearances if you don't recruit him.
111*** On the Azure Moon and Verdant Wind routes, if you don't recruit Catherine, Cyril, Seteth, or Shamir, they are all no-shows.
112*** On the Silver Snow route, non-recruited Sylvain, Ingrid, Felix, Mercedes, Annette, Hilda, Ignatz, Raphael, Leonie, and Lysithea make no appearances.
113*** On the Verdant Wind route, Gilbert and non-recruited Annette make no post-TimeSkip appearances. If you did recruit Annette, it's at least mentioned that Gilbert was last seen at Gronder taking away [[spoiler:Dimitri's dead body]].
114*** On the Crimson Flower route, Lorenz and Raphael make no appearances if you don't recruit them. Lorenz's family sides with the Empire in the other routes, so it's likely he's fighting for you offscreen.
115* In ''VideoGame/FirstEncounterAssaultRecon'', the player character starts out partnered with a man named Jankowski. Very early in the game, Jankowski disappears, but starts appearing to the protagonist as bloody apparitions throughout the rest of the game. It's highly likely that [[spoiler: he was killed by Alma]], but no explanation is given for why his apparitions keep following the character, nor is there any conclusive evidence regarding his fate. WordOfGod confirms he is dead, but they wanted to make it a bit more mysterious, hence why his vital signs keep showing right throughout the game, though with "some kind of interference" Given how powerful Alma is, nothing is out of the question.
116* In ''VideoGame/FredbearAndFriends'', Ashley just sort of disappears when the attacks start happening. While it's likely she's been killed just like Chris and Richard, we get to see the former's VerticalKidnapping and hear the latter's SoundOnlyDeath, but nothing as to how she went out. The game lampshades it when Thomas asks the cops what happened to her, only to get no response.
117* In Chapter 16 of ''VideoGame/GhostTrick'', Sissel has to [[spoiler: prevent a torpedo that a mouse is perched in from detonating.]] After Sissel does so and moves on, [[spoiler:we never find out what happened to the mouse. A literal example of this trope.]]
118** Also, [[spoiler: Dandy and Beauty]]. The last time we see them, we learned that [[spoiler: Beauty could sense Sissel]], then we never see them again until the post-game WhereAreTheyNow segment, [[spoiler:which takes place in a different timeline.]]
119* In ''VideoGame/TheGodfather'', The Trojan is an original character who serves as one of your hit contractors. Unlike the various other original characters, most of whom are killed onscreen, he plain disappears after giving his last contract hit and doesn't receive any closure as to his ultimate fate.
120** Some ''extremely'' vague dialogue from Pete Clemenza suggests that The Trojan is working at cross purposes against the Corleone Family. This only comes about if you accept several missions from The Trojan and neglect Clemenza's contracts; at one point, you find Clemenza in the compound basement shooting empty beer bottles acting very upset. Only the farthest limb on the EpilepticTrees connects this to the character's actions, though.
121** Made more strange by the fact that in The Trojan's last hit he says he will be accompanying you, but he never shows up. A probably unrelated character named 'The Trojan' is on the family tree in the second film listed as being in prison for drug peddling so this may have been his fate.
122** Frank Pentageli's fate is left out of the sequel. You'll have to turn to the film to find out.
123* Alex's fate is deliberately left unknown at the end of ''VideoGame/GoldenSun: The Lost Age''. The fandom looked for his return in ''[[VideoGame/GoldenSunDarkDawn Dark Dawn]]''. [[spoiler:They delivered. He hid himself as Arcanus the whole time, but Kraden forces Alex to reveal his true identity near the end of the game.]]
124** Speaking of Dark Dawn, Psynergy Vortexes are a significant part of the very early plot, but you never hear one whit about them after you get Rief out of his box cage. [[spoiler:That is, until the quest is over, the initial trio return to the Goma Plateau, [[AvertedTrope and Matthew]] [[SequelHook points out over the horizon]]...]]
125** One was also ''very narrowly averted'' thanks to a HandWave in ''Golden Sun 2''. Remember Babi, the old man whose life was a major plot point in the first game, and who needed you to go to Lemuria to prolong his life? Yep, he died. That's it. You hear just once in an offhand comment that he died, and nothing more is ever said about him at any other part of the game.
126* ''VideoGame/GranblueFantasy'': While the main characters have returned to [[spoiler: Nalhegrande in the third arc, Pholia, Bai Ze, Baragona, Hal, and Alliah have not been seen in story since the second arc. Pholia and Bai Ze have their whereabouts explained in their gacha fate episodes, but the other 3 have not been mentioned since then.]]
127%%** [[spoiler:After Chapter 63 and the restoration of Orchis to the throne of Erste, the Black Knight disappears from the plot even with events like Freesia escaping jail and kidnapping Orchis which would seem pretty relevant to her character.]]
128%%** [[spoiler:The fates of several characters in Nalhegrande is left ambiguous as the main characters leave on the Grandcypher to rescue the Captain and so whether or not Monika, Lecia, Orchid, Strum, Drang, Baragona, Hal, Alliah, Leona, Bai Ze, Pholia, Cain, and Reinhardtzar manage to escape the Great Wall's destruction is unknown.]]
129* ''VideoGame/GrandTheftAuto'':
130** In ''VideoGame/GrandTheftAutoIII'' Donald Love just disappears. He does get brief appearances in both [[VideoGame/GrandTheftAutoViceCity 80s Vice City]] and [[VideoGame/GrandTheftAutoLibertyCityStories 90s Liberty City]], but these take place chronologically before [[VideoGame/GrandTheftAutoIII GTA3]] (2001).
131*** The last mission you "do" for him -- Donald's Disappearance -- is only for the purpose of showing you that he's gone.
132** ''VideoGame/GrandTheftAutoV'' has a few. For example, several missions involve Michael opposing his daughter's involvement in a talent show. He finally relents, but unless you happen to know to tune into the in-game radio at the right time, or find the right in-game Internet posting, you may never find out if she won or not.
133*** The surviving members of [[VideoGame/GrandTheftAutoIVTheLostAndDamned the Lost [=MC=]]] return, aside from Angus Martin. [[spoiler: [[SuddenSequelDeathSyndrome Lucky him]]...]]
134*** Depending on the ending that you choose there are many...
135*** [[spoiler: If you choose to kill Trevor, the game ends without ever resolving problems with Devin Weston who owes Franklin money and wants Michael dead.]]
136*** [[spoiler: If you choose to kill Michael, the game ends without ever tying up Trevor's story -- both Wei Cheng's Triads and the FIB want him dead but we never hear from them again.]]
137*** [[spoiler: Both endings in which you choose to kill one of the main characters fail to resolve Franklin's plot line; Stretch is still alive and does not get any sort of retribution for betraying Lamar and Franklin.]]
138* Corporal Adrian Shephard is the protagonist of ''VideoGame/HalfLifeOpposingForce''. At the end of the game he gets PutOnABus by the [=G-Man=], who was impressed at his survival skills. Cue ''VideoGame/HalfLife2'', and Shephard is the only character who has yet to make an appearance. Valve has recently gone on-record saying they've noticed how much of a fan-favorite he is on account of how vocal the fanbase gets about this particular mouse, so we might see him again.
139** ''Opposing Force'' was developed by Gearbox Software, so Valve may not own that character or may not consider him canon. The Race X enemies haven't reappeared either. The same could be said about Drs. Gina Cross and Colette Green in ''Half-Life: Decay''. Which is weird considering that ''Blue Shift'' was made by Gearbox, and its character Barney Calhoun ''survives'' the Black Mesa incidence and the ensuing chaos and returns in ''VideoGame/HalfLife2'' and its two Episodes.
140* ''Franchise/{{Halo}}'':
141** In the first level of ''VideoGame/HaloReach'', Noble Team comes across a young Hungarian woman named Sára. The game bothers to name her, give a short but personal conversation between her and Jorge, and connect her to a moderately important NPC, and then she is never seen or heard from again. (Given [[DoomedByCanon what happens to Reach]], is that really surprising?) According to lead concept artist Issac Hannaford, she was originally intended to have a much bigger role (namely, as Noble Team's science advisor).
142** In a series-wide example, the fate of Jun from ''Reach'' was left ambiguous; he didn't even get a mention in the 2010 reprint of ''Literature/HaloFirstStrike'', despite the fact that the book takes place right after he leaves to escort Dr. Halsey, one of ''First Strike''[='s=] main characters. Eventually, ''ComicBook/HaloInitiation'' revealed that [[spoiler:Jun did in fact manage to escape Reach]].
143* Grace in ''VideoGame/HeavyRain'' only makes a few appearances. She's prominent in the prologue where she witnesses the death of her son, Jason, but after the TimeSkip, she simply vanishes from the story and is never mentioned until she appears in the police station confront Ethan over the disappearance of their second son, Shaun. Grace does make one more appearance where she tells the police that she thinks Ethan is the Origami Killer, but she then disappears entirely for the rest of the story and is never mentioned again unless you get the ending where she and Ethan reconcile.
144* ''VideoGame/HiddenCity'' would frequently introduce new characters for the monthly events, each with unique designs, motives and relationship with the recurring cast. Once the event ends, the characters disappear with it. Occasionally, the game does provide a justification why the character will no longer be appearing (e.g. they left the city); but most of the time, there is no mention that they've left, and the character just stops appearing without reason. One example is Agent Jones, who develops an intense rivalry with the Detective (who is a core member of the cast) but then disappears without a trace and the Detective never even mentions him again.
145* At the very beginning of ''VideoGame/{{Homefront}}'', you are arrested in your home by a KPA colonel named Jeong, who seems like he will be a significant antagonist. He appears exactly one other time in the game, leaves, and is not mentioned again afterward.
146* While Jacket from ''VideoGame/HotlineMiami'' and the protagonists of ''VideoGame/HotlineMiami2WrongNumber'' have very clear fates [[spoiler:that is, dying by nuclear blasts in either Hawaii or Miami if they were not killed at the end of their storylines,]] the fate of the other protagonist of the first game Biker was not revealed, though it is likely [[spoiler:he survived, due to hiding out in the desert rather than staying in Miami.]]
147** It's also never revealed what happened to the Technician that the Biker interrogated in the first game. He could have flown away from Miami (meaning that he may still be alive) or, the more likely option, he was silenced by [[spoiler: 50 Blessings]] for giving in and revealing classified information.
148* In ''VideoGame/IAmAlive'', [[spoiler:Henry's wheelchair]] is found near the end, but the character is not seen again. The [[NoNameGiven Hero]] mentions an intention to find [[spoiler:Henry]], but it is also implied that the character has already been killed. Either way, the epilogue makes no mention of the character's fate.
149** Also, the helicopter and its pilot in the "Strangers" chapter. The hero sees a newly crashed helicopter on top of a building and theorizes that the pilot jumped out before it went down. There is no way to examine the wreckage any closer, there is never any sign of the pilot, and neither the crash or the pilot are ever mentioned again. (In fact, the incident is so strange and unrelated to anything else in the game, it's just shy of being a BigLippedAlligatorMoment.)
150* ''VideoGame/IMissTheSunrise'':
151** In Episode 1, the crew encounters a Lesser with an augmented (cybernetic) leg. They note that this should be impossible, as Lesser biology is incompatible with cybernetics, and Lessers shouldn't have the resources anyway. How the augmentation happened is never explained.
152** In Episode 2, Daszk is mentioned to be part of an ''Inquiry''-like peacekeeping force who left him for dead. They never appear.
153** Also in Episode 2, Ral at one point says the enigmatic line, "That lacertian agrees with me." We never learn who she was referring to.
154* ''VideoGame/IronHelix'': The opening cutscene shows that the ''Jeremiah Obrian'' was traveling with another ''Cerberus''-class ship, the ''John Paul Jones'', however, this other ship is never mentioned again after the opening cutscene.
155* In ''VideoGame/KatawaShoujo'', many things about Kenji. We never find out more about his ex-girlfriend (heavily implied to be [[spoiler:Yuuko]], but never confirmed), what's in the box, or if Yuuko ever found out he was stealing books from the library.
156* ''Franchise/KingdomHearts'':
157** In ''VideoGame/KingdomHeartsI'', Riku warns Sora that "we may never see our parents again" if they leave the islands. This is the second and last time their parents are mentioned in the entire series, the first being five minutes previously when Sora was called to dinner by his Mom.
158** Kairi's grandmother appears in ''VideoGame/KingdomHeartsBirthBySleep'' and in a brief flashback (of the very same scene) in the original Kingdom Hearts, but is never mentioned again.
159* ''VideoGame/Left4Dead2'' has a gun store owner named Whitaker who helps the survivors reach the mall during the Dead Center campaign if they get him a pack of cola. You never get to hear if anything happened to Whitaker once you leave, though it is presumed that he spent the rest of his days holed up in his gun store with whatever food and supplies he had left.
160* In ''VideoGame/LEGOBatman'', a cutscene shows a man preparing to propose to his girlfriend. When he produces the ring, the girl screams and ducks under the table. The man is sad, not realizing that she screamed because Joker and Scarecrow were coming up from behind him in their aircraft. The man is swept up by the planes and is last seen clinging to a steeple. We never find out if he ever got down, if Batman rescued him, or if his girl said yes.
161* ''VideoGame/TheLegendOfDragoon'' reveals in the third disc [[spoiler:Shana is the twin sister of the dead Princess Louvia, which makes her daughter of Queen Theresa and heir to the throne of Mille Seseau]]. This is never mentioned again or even touched upon for that matter. Many found it to be a glaring plot hole.
162* ''VideoGame/TheLegendOfHeroesTrailsOfColdSteel'': Scarlet is nowhere to be seen in ''Cold Steel III'' despite being defeated and rescued by Rean, only getting a single brief mention, and it's not known what happened to her after ''Cold Steel II''. In ''Cold Steel IV'', while she doesn't appear in person, one of [[spoiler:Crow]]'s bonding events reveals she went back to the Gralsritter, and is now working under [[VideoGame/TrailsFromZero Wazy]].
163* ''VideoGame/TheLegendOfSpyro'':
164** Flash and Nina, Spyro's adoptive parents, get a few lines at the start of ''A New Beginning'' and, after Spyro leaves home, are never mentioned again besides a cameo in ''The Eternal Night'' in Spyro's book.
165** ''VideoGame/TheLegendOfSpyroTheEternalNight'': At the end of their collective boss battle, after Skabb is killed and Sniff is knocked out, Scratch just flies off and is never seen again.
166* ''Franchise/TheLegendOfZelda'':
167** In ''[[VideoGame/TheLegendofZeldaCDiGames Zelda: The Wand of Gamelon]]'', Princess Zelda is constantly accompanied by her nanny Impa, who mysteriously vanishes near the end of the game and is simply never seen, heard, or mentioned again.
168** The entire premise of ''VideoGame/TheLegendOfZeldaMajorasMask'' is that Link has been detoured from his quest to find Navi. After he saves Termina, Tatl says that he should get back to what he was doing. This raises two questions: How does he get back to Hyrule, and did he ever find Navi? Neither is answered, but at least it can be assumed that the Happy Mask salesman helped him get home. But Navi is never mentioned again (or at least not till her cursor cameo in ''[[VideoGame/TheLegendOfZeldaTwilightPrincess Twilight Princess]]'' for the Wii).
169** ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' had quite a few examples of this after the seven-year time skip. The sudden disappearance of the Happy Mask salesman and his shop is an obvious one. But there are others, too, such as that kid who liked to play in Dampé's graveyard (his home was, strangely enough, where the Bazaar was relocated after [[spoiler:Hyrule Castle Town was destroyed by Ganon]]). It's probably fair to assume that they left the kingdom of Hyrule during this time ([[SerendipityWritesThePlot and that the developers needed to conserve memory on the 256 meg cart]]), but the sudden unexplained absence of these characters is pretty jarring nonetheless.
170** ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' has supporting characters from each tribe that help you board a Divine Beast (Teba, Sidon, Riju, and Yunobo). They are shown to be doing well if you check up on them after clearing a Divine Beast, but they aren't heard from again afterwards and they don't even appear in the finale and the credits. You can also wind up invoking the trope on accident or on purpose if you decide to go to the FinalBoss without resolving the problems plaguing the people of Hyrule; sure, you saved the world, but we never find out what happened to the people and events you skipped over.
171** ''VideoGame/TheLegendOfZeldaTearsOfTheKingdom'' follows up on many questions from ''Breath of the Wild'', which makes the questions it ''raises'' all the more conspicuous:
172*** All of the Sheikah tech that served as the biggest landmarks in the previous game have vanished, including the gigantic and notorious Divine Beasts, the 120 Shrines throughout the land, and the Sheikah Towers which have been replicated in different locations with no mention of the originals the new towers are based on. Even the Shrine of Resurrection, despite being hugely plot-central to the previous game, housing [[spoiler:a humongous dungeon trial]], and still being named as such on the map, exists only as a similarly shaped cave with no trace of Sheikah technology.
173*** The incredibly useful and powerful Sheikah Slate has been reverse engineered in the form of the Purah Pad, but no one ever mentions the original device it's based on and you would be forgiven for thinking it's a wholly original invention. It's also conspicuously missing the main set of powers the Sheikah Slate had in ''Breath of the Wild'', which seems odd since it does retain the fantastical ability to teleport its user. No mention is made of where the original Sheikah Slate went.
174* In ''VideoGame/LufiaIIRiseOfTheSinistrals'', Maxim's childhood friend Tia. She's your second party member and obviously is in love with Maxim and the game seems to imply a LoveTriangle beginning between her, Maxim and Selan. As ''Rise of the Sinistrals'' is a prequel to ''[[VideoGame/LufiaAndTheFortressOfDoom Forest Of Doom]]'', it's obvious that [[ForegoneConclusion Maxim and Selan will end up together]] and Tia leaves the party, and game, when the two get married. She doesn't even return to her item shop from the beginning anymore, completely gone until a small scene during the credits.
175** Tia actually stays in the remake, ''Curse of the Sinistrals'', and remains a viable part of your team throughout the whole game. She even starts dating Dekar!
176* ''VideoGame/MagicalStarsign'' has a pretty odd one; at the Starfall Festival event, a breather not-quite-cutscene, you can wander around and talk to the individual members of your party. The event only ends when you talk to Mokka the robot (if the player character is a girl) or Lassi the [[LittleBitBeastly rabbit girl]] (if the player character is a boy}. They're just about to admit to being in love with you, but your clueless HeroicMime will be hijacked by another character and poor Lassi/Mokka will confess their feelings into thin air. Before and after that, nothing. No further acknowledgement, nothing in the epilogue. Cue a massive "Huh? Why was that even put in there?" on the player's part. It could just be part of ''Magical Starsign's'' odd humour, but the nature of the scene hints that this development has a significance the game never gives it.
177** This issue pops up with Pico and Sorbet's blooming romance as well. It's pretty obvious that Pico is in love with Sorbet, and in one cutscene, they have a touching moment together, but [[spoiler: Pico drops out of the academy, and Sorbet becomes part of The Space Police]] and that little subplot remains unresolved.
178* ''VideoGame/MassEffect2'' zig-zagged this trope. In the TutorialLevel, the player learns that a minor character has betrayed an organization that plays a key role in the story, nearly killed the PlayerCharacter, and otherwise set off the events of the plot. The traitor is unceremoniously shot dead before the end of the level. No follow up was included in the game, leaving the traitor's act a complete mystery. Finally, the ''Lair of the Shadow Broker'' DLC has dossiers on the various characters, and one line in optional character [[spoiler: Legion]]'s file reveals the traitor [[spoiler: Wilson]] was a double agent for the [[spoiler: Shadow Broker]]. During the months between the game's release and the DLC, there was no explanation for any of it.
179** Speculation that Dark Energy was causiing Haestrom's star, Dholen, to prematurely enter into the Red Giant phase was heavily hinted as being an important future plot point. In the third game however, it was not mentioned at all, making this apparently an AbortedArc.
180*** Not only that, but the two characters whose final scenes in 2 implied they were going to look into the Dark Energy thing, Gianna Parasini and Kal'Reegar, don't appear in the 3rd game at all, despite nearly everyone else surviving from both prior games making an appearance. Reegar is mentioned in a report to have died in battle, while Gianna is not mentioned at all.
181*** The original plan was to have the third game reveal that the ubiquitous use of mass effect technology has a dangerous side effect, and what is happening with Haestrom's star is only the beginning. The Reapers would have been revealed as preventing the stars from being destroyed by the misuse of the technology by destroying races.
182** All of the previous (and [[AnyoneCanDie surviving]]) ''Normandy'' crew can be met in some capacity in ''3'' except for one -- Rupert Gardner, the ''Normandy SR-2'''s cook/handyman, who the game just appears to forget about [[spoiler:(unless he died, meaning his name is on the memorial wall)]].
183* In ''Videogame/TheLogomancer'', Ardus reveals at one point that the ideal {{Love Interest|s}} he created for his novel looks and acts exactly like Cynthia, even though he wrote the manuscript long before he met her. Everyone is quick to point out how weird this is, but it never comes up again.
184* ''VideoGame/MedalOfHonorVanguard'' has [[TheCaptain Lieutenant [=McCollum=]]], the leader of Keegan's platoon, who disappears after the end of the first section in ‘Predators’ when he orders Sergeant Keegan and his squad to clear Grave of the German forces within.
185%% ZCE * ''VideoGame/VampireTheMasqueradeRedemption''
186* ''VideoGame/MegaManX''
187** [[BigBad Sigma's]] "partner" who is mentioned only once in ''VideoGame/MegaManX5'', but played a key role by building Sigma's body, apparently used to be an old comrade of X, and hates him just as much as Sigma. Since the [[PlotDerailment plot was run off the rails]] in later installments by ExecutiveMeddling, this partner is never so much as referenced ever again. According to WordOfGod, had he had his way it would have been Dr. Wily in some form or another, foreshadowed by how Sigma's [[FinalBoss final battle body]] is almost identical in design to Gamma from ''VideoGame/MegaMan3''.
188** And also the fate of Dynamo from the same game. He shows up two times to fight X and Zero, once after defeating two Mavericks needed to obtain parts for the Enigma, and the second time after defeating two Mavericks needed to obtain parts for the Space Shuttle to destroy [[ColonyDrop Eurasia]]. After those two battles, however, Dynamo doesn't die, and just disappears from the plot, not showing up as a sub-boss in the Zero Space stages, and nobody even mentions him again. Even though Dynamo shows up in [[VideoGame/MegaManX6 in the next game]], he only does so as a boss in the alternate pathways after defeating all 8 Mavericks, defeating High Max or collecting 3000 Nightmare Souls. And he doesn't die at the end of the battle either, just teleports out as soon as X or Zero defeat him. None of the games that followed ''X6'' explained Dynamo's fate.
189** Dr. Cain mysteriously drops off the face of the Earth after ''VideoGame/MegaManX3''. ''VideoGame/MegaManMaverickHunterX'' eventually addresses this by retconning the story so that he's killed by Sigma prior to the start of the first game.
190** Douglas disappears without fanfare in-between ''VideoGame/MegaManX6'' and ''VideoGame/MegaManX7''. The Lifesaver robots also only appear in ''X5'' and are never mentioned again.
191** The fate of a large number of characters in-between the ''X'' and ''[[VideoGame/MegaManZero Zero]]'' series have also never been revealed. Not just Axl, Layer and Palette (who are understandable since they were introduced towards the end of the ''Zero'' series,) but also Alia and Signas.
192* ''VideoGame/MegaManXMavericks'':
193** By the end of the third game, both X and Zero note that [[spoiler:the Mother Elf]] seems familiar somehow, but she disappears after this and it's never addressed again.
194** In the fourth game, [[spoiler:Gate is never mentioned again after Alia says he'll be okay. Likewise, if you rescued Ciel or not, she has no further role after that]].
195* ''VideoGame/MetalGear'':
196** In the backstory for ''VideoGame/MetalGearSolid'', Solid Snake has taken up dog sledding in his retirement, and owns "fifty huskies" which he calls his family. Many a dog lover has been made very upset by the absence of dogs in every later game -- they are not [[ForgottenFallenFriend even mentioned]] in ''VideoGame/MetalGearSolid2SonsOfLiberty'', and in ''VideoGame/MetalGearSolid4GunsOfThePatriots'' he has three pet chickens but no dogs. It's never explained where the dogs went. (Some speculate that the dogs in ''Metal Gear Solid 4'' are the descendants of Snake's huskies, explaining their affection for him, but it's not clear why Snake would dump his 'family' on a nuclear disposal cleanup facility on a remote Alaskan island. It's more likely they are the remnants/descendants of Sniper Wolf's wolfpack, as it's implied that one of them is Sniper Wolf reincarnated.) Given that Campbell's response to the line about the huskies is "[[ImpliedDeathThreat Don't worry about your dogs"]]...
197** In ''VideoGame/MetalGearSolid'', there's a significant scene after Wolf's death where Otacon begs Snake "what are we fighting for?" and Snake responds, "if we make it out of this, I'll tell you". Snake never tells Otacon what he's fighting for (even in his big speech in the ending) and it never comes up in any of the later games. The ''VideoGame/MetalGearSolid4GunsOfThePatriots'' novelisation allows Snake to answer the question during a part that, in the game, is a gameplay sequence.
198*** Even if we never hear Snake tell Otacon this in the games, Raiden asks Snake something similar in ''VideoGame/MetalGearSolid2SonsOfLiberty'' and the rest of the game has Snake discussing in-depth about what kinds of things are worth fighting for. Seeing how Otacon seems just as resolved as Snake in the game, we can assume he received a similar lecture in between the previous game and this one.
199** Lampshaded in ''VideoGame/MetalGearSolidPeaceWalker''. Big Boss rides into the Costa Rican cloud forest on a mule, but encounters enemies who spook the mule and he runs away. While most of your support team is focused on the mission, the younger two, Paz and Chico, are more concerned with what happened to the mule. (It doesn't show up again.)
200* ''VideoGame/MoshiMonsters'':
201** In the "Spooktacular Spectacular" mission, Tamara mentions that her tail hurts and considers medicating herself with some remedy she has in her lab. We never find out what was causing the pain, or if she used the remedy.
202** In the song "Big Bad Bill is a Woolly Blue Hoodoo", Buster, Snuffy, and several of their pets are searching the jungle to find their friends, who have inexplicably disappeared. They instead find Big Bad Bill, who invites them to a party, and the friends are apparently forgotten about (provided that the events weren't AllJustADream or a magical hallucination, which the singer himself isn't sure about).
203* ''VideoGame/{{MOTHER 3}}'' gives us the Egg of Light. Early on, you retrieve it from the Osohe Castle, without its purpose explained. Then, while you're escaping the castle, you lose it, and only find it a few chapters later...at which point it never affects anything again. Its purpose is eventually explained in a late-game spoiler, but it's never used for that purpose.
204** This is a side-effect of ShootTheShaggyDog. When the Pork Army failed to get their hands on the Egg, [[spoiler: they kidnapped Leder, the only person who knew what it did and how to use it. With him out of the picture, even if the village got the Egg back, it would be useless to them. By the time you actually meet Leder, everyone is already in New Pork City. Even if it were used to give the villagers their memories back so they would all fight Porky, they are far outnumbered by the brainwashed people Porky kidnapped through time. They wouldn't stand a chance. The only thing left to do is for Lucas to pull the final needle and see what happens.]]
205* ''VideoGame/MortalKombat9'' has a lot of these:
206** [[spoiler:Kano]] is last seen frozen [[spoiler:by Cyber Sub-Zero]], but not shattered. He just disappears from the scenes, although apparently he did warn [[spoiler:Quan Chi of Cyber Sub-Zero since the ending shows him alive and well while talking to Shinnok]].
207** [[spoiler:Cyrax and Sektor]] may or may not be dead. [[spoiler:SOLVED! Cyrax and Sektor both feature in the Mortal Kombat X comic, in which Cyrax regains his humanity, Sektor is killed by the reborn Sub Zero, and then Cyrax sets his self destruct to blow up the Cyber Ninja base. So they both are and aren't dead. That's what happens when you choose to set your game after a 25 year time skip. Shit gets missed!]]
208** Also, Raiden mentions that he sent [[spoiler:Liu Kang and Kung Lao to rescue their Shaolin Masters]] near the beginning of the ''[[VideoGame/MortalKombatII MK2]]'' part of the story. It's never mentioned if they succeeded or not.
209** Given how a lot of the info in AllThereInTheManual, ''Franchise/MortalKombat'' suffers from this frequently. For example, it's been brought up in bios that the Sub-Zero bros. were abducted by their father to be taken to China and trained by the [[McNinja Lin Kuei]], leaving behind their mother and younger sister in America. The thing is, we never hear of them again, so we don't know of their current status (did they survive [[VideoGame/MortalKombat3 Shao Kahn's invasion]]?). [[VideoGame/MortalKombatDeadlyAlliance Frost]] was widely believed to be this long-lost sister of Sub-Zero, but this was disconfirmed by the creators themselves.
210* In ''[[VideoGame/NarutoClashOfNinja Naruto: Clash of Ninja Revolution 2]]'''s storyline, [[spoiler:Bando]] disappears after Jiraiya defeats him. We never even find out if [[spoiler:he's a robot or not]].
211* Several minor characters from ''VideoGame/OctopathTravelerII'' never appear again after their introductory chapter, including the masked boy and the emaciated woman from Throné's story and Reiza from Temenos's story. The masked boy and Reiza are especially notable since they [[spoiler:foreshadow Claude and want to leave the Moonshade Order behind, respectively]], so they have some small but notable impact on the plot.
212* ''VideoGame/{{Odium}}'':
213** The last you see of Anna Hutchens and another team member ([[MutuallyExclusivePartyMembers Medusa or Slavsky]]) is when they are left behind before the last level because the team leader decides it's too unsafe for them beyond this point. They are never seen or mentioned again. Especially jarring with Medusa (the mutant who retained his sanity) -- we never find out if he was ever turned back into a human, or at least re-integrated into society, or... something.
214** At one point you meet two random robbers who don't seem to be afraid of all the biomechanical monstrosities roaming around. They stand out because, other than your party members and [[spoiler:enemy soldiers near the end]], they are the only non-mutated humans you meet. Your team scolds them, takes their loot (a journal) and sends them on their way. You never find out what happened to them afterwards, or how did they get into the town and survive so long in the first place.
215* ''VideoGame/ParasiteEve'' has Police Chief Baker, who plays a small role in the story and steps up to protect Daniel's son from monsters on day 3. It's presumed that Baker stepped down to recover from his injuries, but he's never seen or brought up again for the rest of the game.
216* ''VideoGame/ParasiteEve2'' has Aya make a brief mention of Daniel from the first game, but unless you know how to trigger that particular line of thought, you'd never learn about what happened to him. Likewise, none of the supporting police officers that Aya worked with previously are ever mentioned.
217%%** You never learn exactly what happened to most of the vampires and people from Christof's early years. Though, in the case of your Cappadocian buddies, the answer is both obvious and horrible, given that clan's eventual fate...
218%%** George Thorne, the FBI agent. The second and last time you meet him, he's slumped over in the Giovanni warehouse, baffled by his enemies' inhuman abilities. Later as you pass through the same room, your party will point out that he's gone and wonder what happened to him, but he never reappears again.
219* ''VideoGame/Persona1'' has several party members you can choose from for a fifth ally, but whoever you pick, the rest simply go on their own way and are never heard from again. The students and faculty that appear in the beginning of the game vanish with their school at the beginning of the game and you never find out what exactly happened to them [[DummiedOut due to an alternate quest that could not be implemented in time]]. In the PSP port, you can play the alternate quest proper, but you'll see other characters simply disappear or never show up without any explanation. Despite never being able to recruit every main character, WordOfGod says everyone worked together.
220* In ''VideoGame/Persona3'', the next-to-last boss is [[spoiler:Takaya]], whom [=SEES=] defeats to the brink of consciousness, but doesn't outright kill. [[spoiler:He spends the entirety of the Nyx Avatar fight unconscious]], then comes back to laugh in the party's face when [[spoiler:Nyx itself is bringing The Fall to Earth. He collapses in a fit of laughter at the very top of Tartarus, the Protagonist does his thing, Tartarus (and Nyx) goes away]]... and nothing is ever said about [[spoiler:Takaya]] ever again, even though he [[spoiler:didn't die and was just as invested in the proceedings as anyone else who had the power of Persona]].
221* In ''VideoGame/PeterJacksonsKingKong'', Preston takes shelter in a small cave during the first V-Rex attack in which Lumpy is killed. Preston is never seen or mentioned again, and is the only member of the expedition who is neither shown being killed or being rescued.
222* ''VideoGame/{{Pikmin}}'':
223** ''VideoGame/Pikmin2001'': The [[MultipleEndings best ending]] has [[spoiler:a number of Onions in new colors flying into the planet's low orbit.]] The sequel drops this, as neither of the two new types of Pikmin have Onions. By the third game, the design of them is altered altogether, and [[spoiler:the new Onions]] never leads to anything aside from serving as a slight SequelHook.
224** ''VideoGame/Pikmin2'':
225*** The fate of the Purple and White Pikmin. Unlike the primary types, they live in the Hocotate Ship. That same ship that flies back to Olimar's home planet. What makes matters worse is that they are not seen in the game's true ending at all, the primary colors being the only types to appear.
226*** White and Purple Pikmin are also no-shows in ''Pikmin 3''[='s=] main story (though they do appear in Mission Mode and Bingo Battle), instead being functionally replaced by the Winged and Rock Pikmin. The fate of the White and Purple Pikmin remains ambiguous at best.
227** ''VideoGame/Pikmin3'': Captain Charlie finds a squad of thirty Yellow Pikmin at the start of the game. They run off when Charlie is attacked by the Vehemoth Phosbat, and are not seen again afterwards. When unlocking the area Charlie crashes in, Brittany only ever finds five Yellow Pikmin, who seem to not be a part of Charlie's initial squad (given that three are burried at the time).
228* ''VideoGame/PokemonMysteryDungeon'':
229** Every single comic relief baddie. They all only appear in the very beginning, and they all disappear without a trace as the series progresses. They don't even return after [[DiscOneFinalBoss Primal Dialga]] has finally been taken care of! It's implied that the main reason why they all disappeared very early is because they are actually all afraid of the series' BigBad, [[spoiler: [[OmnicidalManiac Darkrai]]]], and that Primal Dialga is the least of their worries.
230** Subverted with Gengar in the ''Rescue Team'' games. Even though he's seemingly the leader of your average GoldfishPoopGang, [[spoiler:he turns out to be far worse when he tells everyone in Pokemon Square that you're the cause of TheEndOfTheWorldAsWeKnowIt]]. His gang is almost never seen again with him, but they stick around as recurring characters. However, their original plan about ''taking over the world'' is never mentioned again after Gengar convinces the townsfolk you're a menace.
231** In ''Rescue Team'', your very first mission and storyline dungeon requires saving a Caterpie and returning it to her mother. The Butterfree is then completely erased from existence as she is never seen again. Strangely enough, Caterpie ''does'' get a role as a supporting character.
232* In ''VideoGame/PokemonRedAndBlue'' and their remakes:
233** Blue's Raticate mysteriously disappears after the third/fourth battle.
234** After getting your first Pokémon in Red/Blue, your first task is to retrieve a package for Prof. Oak, who says that it's a specially-made Pokéball. This seems to imply that it's the Master Ball, but you end up getting that from the Silph president instead; Oak's special delivery never gets an explanation. In Gold/Silver, you end up getting the Master Ball from the new region's professor after beating the Elite Four, so it seems likely that this was the original plan for the first-gen games.
235** In both the original games and their remakes ''[=FireRed=]'' and ''[=LeafGreen=]'', the "Pokemaniac"/"Pokemon Fanatic" Bill accidentally fuses with a Pokemon due to an experiment gone wrong and the player has to help him split from it. While Bill emerges from the machine, the Pokemon he fused with is nowhere to be found. In ''VideoGame/PokemonLetsGoPikachuAndLetsGoEevee'', this is rectified by showing the Pokemon (depicted here as a Nidorino) running out of the machine unharmed right before Bill himself emerges from it.
236* ''VideoGame/PokemonBlack2AndWhite2'': The Seven Sages zig-zag this trope somewhat; Ghetsis maintains his role as the BigBad, Rood has undergone a HeelFaceTurn and is the figurehead leader of Old Team Plasma, Zinzolin still works with Ghetsis, and Gorm makes a cameo in the post-game. Giallo, Ryoku, and Bronius are not seen at all.
237* In ''VideoGame/PrinceOfPersia2008'', the main character begins the story by losing his donkey, Farah. He's wandering around, calling for her when he runs into the princess. Although she is occasionally referenced, Farah is never seen again. This is later explained in the credits of the EDC for the game. [[spoiler:Farah the Donkey is dead, but the developers assure us that no real donkeys were harmed.]]
238* Midway through ''VideoGame/{{Prototype}}'', Alex's sister Dana is kidnapped by TheVirus; Alex manages to rescue her from the epicenter of the outbreak, and drops her off with Doctor Ragland, who is ''also'' never seen again. This is a bit jarring considering that Dana Mercer and Ragland were the only sympathetic characters in the entire game.
239** Dana shows up again in ''VideoGame/{{Prototype 2}}'', no worse for wear. Ragland's still unaccounted for.
240* ''VideoGame/{{Psychonauts}}'': After collecting all the things you need in order to ride the elevator, Crispin is chased off by Fred and is never seen again. [[spoiler:It is unknown if he was still in the asylum after it got destroyed.]]
241* In ''VideoGame/PuzzleQuest 2'' after you gain Rahn the guardsman as a companion (gaining the Besiege spell), you never hear from him again. He has no dialog, unlike your other companions. And when you rescue your companions from Dark Elf Arena, he's not even mentioned
242* In ''VideoGame/QuernUndyingThoughts'', Gamana never says what happened to her friends Rhoren and Tiador after their people, the Dulmar, were wiped out by civil war.
243* ''Franchise/ResidentEvil'':
244** Depending on who you choose to play as in ''VideoGame/ResidentEvil'', the fate of Barry or Rebecca won't be revealed. As Chris, the last you hear of Barry is the opening narration that states they don't know where he is, and Rebecca is never even alluded to in Jill's scenario.
245** ''VideoGame/ResidentEvilCodeVeronica'': Twice in the game, Claire runs into a mouse (first hidden in a locker, the next in a secret room). In the unlockable minigame, you have a chance of finding the mouse's diary explaining everything that happened to him.
246** In the remake of ''Resident Evil'' for Platform/NintendoGamecube, you find a unique corpse slumped against the wall in the stairwell (where there are later crows on the lights). You can examine it to read "What the hell happened in this mansion?" Later on the corpse is just... gone, you never encounter a zombie that looks like it, and [[ParanoiaFuel nobody knows where it wandered off to]].
247** In both ''VideoGame/ResidentEvil4'' and ''VideoGame/ResidentEvil4Remake'', [[TheNapoleon Ramón Salazar]] has a pair of Verdugos as his henchmen. In the original, he sends the red one to kill Leon in the sewers, and merges with the black one and the Queen Plaga to form the boss of the castle segment of the game. In the remake the red one still attacks you in the sewers, while the Queen Plaga was cut altogether and Salazar goes OneWingedAngel on you all on his own -- the black Verdugo just vanishes and is never seen again. Furthermore, in both games it's possible to escape the sewers without killing the red Verdugo -- if you do ''this'', again it just vanishes from the story and is never seen again.
248* In ''VideoGame/{{Robopon}} 2'', W-King and Lisa lampshade their unimportance to the story and disappearance from the plot.
249* In ''VideoGame/{{Scaler}}'', [[TerribleTrio Looger's Henchmen (and woman): Jazz, Rhombus, and Turbine. They appear at the start, make an appearance at the first boss, then turn up as the second boss, are shown in a beaten-up (and alive) state [[DepartmentOfRedundancyDepartment when you beat them]]... and then are promptly never seen again.
250* A really bad case of this happens in ''VideoGame/{{Scrapland}}''. Through the game, three important city officials are murdered and have their "matrix" (which allow them to be resurrected) stolen, effectively removing them from existence, the goal of the protagonist is to investigate the case and find out who's responsible. However, even after you find and defeat the guy responsible for the plan, what happened to the victims's matrix isn't addressed in any way.
251* At the very beginning of ''VideoGame/ShadowHearts'', Yuri gets his arm ripped off and is able to reattach it, and it heals instantly. He never manifests this power again, and its origin isn't explained.
252** In the same sequence, Alice is shown to have a pendent which somehow repels evil spirits. We never see or hear about it again.
253* The protagonist of ''VideoGame/{{Shockwave}}'' is unaccounted for in ''Shockwave 2.'' [[spoiler: It's likely he didn't survive the TimeSkip.]]
254* The ''VideoGame/Shrek2'' game introduces a new character called Lil' Red, who tags along with Shrek, Fiona and Donkey on their trip to Far Far Away. She appears in multiple levels throughout the story as a playable character, but abruptly vanishes after the Prison Break level and doesn't appear or get acknowledged during the ending.
255* Invoked by ''VideoGame/SilentHill1'' and ''VideoGame/SilentHill2'' with the fates of Cybil and Angela. Cybil isn't mentioned after the first game (though the only ending where her fate would be in question is Good+; in all the others, she's dead or trapped with Harry), and Angela is never seen again after [[spoiler:she ascends the staircase in the second.]] WordOfGod has stated that they wanted their fates to be open to interpretation.
256** In ''VideoGame/SilentHillDownpour'', Murphy goes through the Centennial just to meet up with a DJ named Bobby Ricks, who's been giving dedications to him through the radio for some time. Ricks claims to have a chance of escape, and Anne shows up soon after. Monsters attack, and when the lights come on, Murphy is alone. Anne reappears later and plays a key role, but Ricks is gone for good, though it can be assumed he died; there's something of a blood trail towards the fridge on the studio floor. You might think his body would be in there, but nope.
257** James himself in ''VideoGame/SilentHill2''. The game has no canon ending and the only thing that we know for sure is that he went to Silent Hill and never returned. Later games just makes passing mention to his current whereabouts i.e Douglas Cartman from ''VideoGame/SilentHill3'' saying that he was once involved in a missing person case in the Silent Hill and James' father Frank saying that he hasn't heard anything about his son since his trip to the cursed town in ''VideoGame/SilentHill4TheRoom''.
258* ''VideoGame/{{Slammed}}'': [[spoiler:Griss/Giana vanishes from the story after they help betray you.]]
259* ''[[VideoGame/SoulSeries Soulcalibur V]]'' really shook up the character list, with almost half the characters from the previous game being removed. Most have retired and passed their skills on to children or successors (Xianghua, Taki), some have just reached the end of their journey and have no reason to continue fighting (Setsuka), some are dealing with their own stuff (all the Korean characters), some are dead or lost in another world (Sophitia and Cassandra) and some have just dropped off the face of the earth. Infamously, Talim and Zasalamel have completely vanished with no explanation as to what happened to them.
260* ''VideoGame/TheSims'' had a lot of these. ''Sims 2'' had Bella Goth, who was later lampshaded. [[spoiler: She slept with her daughter's fiancée and ran away because she was ashamed, according to EA.]] She seemed like such a big character in the original game (and seems to be a mascot, of sorts, too). A more prominent example, from ''Sims 2 DS'', is Mayor Honest Jackson. After [[spoiler:Ava]] waltzes into the hotel, he completely disappears. He still calls your character with requests and romantic options, though, most of which cannot be fulfilled because he's not there.
261* Early in ''{{VideoGame/SOMA}}'', [[spoiler: the player has the option to contact Omicron Station via radio. If they choose to do so, someone will answer, and advise them to commit suicide, as "there's nothing left to live for". Later, when the player passes through Omicron, they'll discover that all of the personnel have died via [[{{YourHeadAsplode}} head-explosions]], supposedly a long time before the game's events, and no trace or mention of the man that answered the call is ever given or found.]]
262* ''Franchise/SonicTheHedgehog'': In ''VideoGame/Sonic3AndKnuckles'', if you get all the Chaos Emeralds (from the ''Sonic 3'' part) you can, in addition to turning into Super Sonic, start upgrading them into the larger "Super Emeralds" in the Sonic & Knuckles part, allowing you to become Hyper Sonic, who is like Super Sonic only even more powerful. After this one appearance, the Emeralds are only seen in their standard small form, with no mention of the Super Emeralds or Hyper Sonic, although ''VideoGame/SonicMania'' references the former by having powerless stone replicas take their place in Hidden Palace.
263* The Beetle is introduced at one point in ''VideoGame/SpiderMan2EnterElectro'' as one of Electro's goons, as well as a potential boss character. After his initial appearances he's never seen or heard from again.
264* ''VideoGame/SoundtrackAttack'': [[CharacterCustomization All versions of the player character]] mention escaping to Earth with her crew; however, no other Gems are seen throughout the course of the game, and the superior never mentions having to track down other Gems under her.
265* ''VideoGame/StarOceanTheSecondStory:'' A rather large (if technically optional) aspect of the first part of the game involves you finding an ancient text in Cross Cave and showing it to a linguist named Keith. Keith finally takes it and begins studying it, but before you learn anything about it, [[spoiler:the world explodes]]. You never find out what was actually in it, making several long-winded events and dungeons seem annoyingly pointless.
266** It's revealed in Bowman's solo ending that the text is a myth about an 'ancient paradise' called [[spoiler:Nede.]]
267** In the original ''[[VideoGame/{{StarOcean1}} Star Ocean]]'' it's strongly implied that Marvel is actually Ioshua's missing sister, and you later find said sister's body in seeming suspended animation -- in fact, one of the big clues to Marvel's identity is how strongly she reacts to this discovery. However, there is no way to actually confirm that Marvel is said sister or restore her to her original body, so nothing ever comes of it. This was one of the consequences of half the game being DummiedOut because of space constraints and was finally addressed in the PSP remake.
268* Franchise/SuperMarioBros:
269** At the end of World 5 of ''VideoGame/SuperMarioGalaxy2'', [[OverlordJr Bowser Jr.]] is blasted out of his malfunctioning Boomsday Machine, and is simply never seen, heard, or mentioned again afterwards. Obviously, he survives, given his later game appearances, but how he got back is the real question.
270** Peach's birthday in ''VideoGame/NewSuperMarioBrosWii'' is never shown happening for real in the ending, [[spoiler:which is just Mario and Peach HoldingHands, [[ButtMonkey Luigi getting left behind once again]], and the princess telling the hero about World 9.]]
271** In ''VideoGame/SuperMarioSunshine'':
272*** Bowser Jr. mentions that he got the Paintbrush from "a strange old man in a white coat" as the camera focuses on the [[VideoGame/LuigisMansion E. Gadd]] logo on F.L.U.D.D.'s side. We never find out if Bowser Jr. stole the Paintbrush from Professor Gadd or if Gadd gave it to Bowser Jr., especially because E. Gadd never makes a physical appearance.
273*** The ending of the game if you didn't get 100% shows Il Piantissimo finding the Magic Paintbrush, possibly setting up a SequelHook. He's never seen again, and Bowser Jr. has the paintbrush back in all subsequent games.
274* In the Subspace Emissary mode in ''VideoGame/SuperSmashBrosBrawl'', Link's fairy companion appears flying along with him when he's introduced, flies off out of shot when the Halberd casts a shadow... and then (outside of one of the battle taunts Link can do) never appears again.
275* In the intro of ''VideoGame/MarioAndLuigiDreamTeam'', Broggy (Broque Monsieur's dog from the last game) shows up to deliver the letter to Princess Peach's Castle inviting them to Pi'illo Island. After this however (and the point when the blimp lands), he's never seen again for the rest of the game and isn't even mentioned by anyone.
276* In the world of ''VideoGame/TeamFortress2'', the main company providing the mercenaries with their weapons and gadgets was supposed to be TF Industries, and Mann Co. was merely introduced as a division of it. Except TF Industries seemingly faded out of existence while the story immediately began to revolve around Saxton Hale, Mann Co. and the Mann family instead by the time the game got it first Halloween update.
277* ''VideoGame/{{Tekken}} 3'':
278** Jun Kazama. Her son Jin's entire motivation from the game he debuted in is to avenge his mother's "death"; the problem is in fact that he actually never sees Jun dying, and only assumes that after she stays to fight Ogre as he runs away, the God had her killed (although the wrecked and burnt surroundings from the place she's fighting is a good indication). This doubt still persists by adding more uncertainty in Jin's assumption on Jun's death, and the fact that ''WordOfGod'' deliberately keeps her fate a secret for dramatic effect doesn't help.
279** Kuma's second costume in the first two games is a polar bear. From the third onward (where Kuma is replaced by his identically named son), his second costume is another character, Panda. Nobody knows what happened to polar bear Kuma and it's never been mentioned.
280* In ''VideoGame/TelepathTactics'', Doran, Edwin, and [[spoiler:Gunther]] don't get epilogue scenes. Neither does Siripent, though one can presume that his wife Sarn's epilogue applies for him too.
281* In ''VideoGame/{{Terranigma}}'', nothing is said about what happened to the characters of [[spoiler:Meilin, Meihou, Perel, Fyda, and Roy]] after the events on Beruga's airship. The airship ends up crashing in Australia, so it's likely to assume that they all died in the resulting crash, but Ark doesn't even spare a single thought about the airship anymore. Though one could think that, since he's heading back to the Underworld for the final confrontation, he probably had other things on his mind.
282* At the end of ''VideoGame/ThereIsNoGame'', [[spoiler: everything disappears except the narrator. We never find out where they went or if they're still around.]]
283* ''VideoGame/TickTockIsle'' with all its TimeTravel and DysfunctionalFamily troubles forgets to mention if Mr. Klepsydra did actually pay Strike for the job. [[spoiler:Oh, and Klepsydra ''is'' [[TheDogWasTheMastermind a literal mouse]], although finding that may be the most obscure puzzle in the game.]]
284* In ''VideoGame/TimeCrisis: Project Titan'', not only is Kantaris alive, she appears in a couple of cutscenes. She doesn't die, or for that matter fight anyone. And she has not been seen, heard, or mentioned in any Namco game since. (For that matter, does the fact that she's alive mean that Richard Miller ''failed'' his special assignment in [=TC1=]?)
285* The ''Franchise/TombRaider'' series features a few examples. In ''The Angel of Darkness'', Gunderson, the big brute, is sent to contain the situation involving the proto-Nephilim. He is never seen or mentioned again. This is quite jarring, because he was one of the members of Eckhardt's Cabal. Also, Jean-Yves in ''VideoGame/TombRaiderTheLastRevelation'' is shown to be one of Lara's few friends she can rely upon when she needs assistance. [[BigBad Werner von Croy]] later kidnaps him and Lara does save him near the end of the game, but he vanishes from the story entirely and is never mentioned again. He is also ignored entirely in the later sequels due to the real life Jean-Yves threatening to sue Eidos for using his name and likeness without his permission.
286* In ''VideoGame/TriangleStrategy'', it's unknown what happens to Clarus in the Morality endgame after he [[spoiler:helps Frederica and co. break into Hyzante by attacking some guards]]. The other characters briefly express concern for him at one point, but Clarus is never seen in-person again.
287* "Ghost Photo Park", the second chapter of ''VideoGame/TwilightSyndrome'', is resolved in the good ending when a smaller Shinto shrine is built on the site where an older one had previously been demolished, causing a haunting to reemerge. The ones who placed the new shrine are said to be a group who had been made aware of the supernatural occurrences on the site, but despite the various other supernatural happenings in the city, the group in question never comes up again or intervenes in anything.
288* ''VideoGame/{{Utawarerumono}}'': Kamyu's blood drinking, spirit talking and... other nighttime activities never seem to go anywhere. Presumably they were supposed to be foreshadowing for Mutsumi but... she doesn't do any of that stuff either. And it's not like the original her even ''could'' have done anything like that. Plus, [[spoiler:Mutsumi is Hakuoro's surrogate daughter.]] It seems doubtful that she would do anything like she did if she's supposedly being influenced or something.
289* In ''VideoGame/ValkyrieProfileCovenantOfThePlume'', there's the question of Natalia's lost children. They're strongly implied to be [[spoiler: [[EnfantTerrible Enfants Terrible]] Mischka and Mirielle]], but the matter is never directly addressed, nor does it have much apparent bearing on the plot. Even though they meet on two of the game's story paths, and [[spoiler: Mischka and Mirielle kill Natalia in one of them.]]
290** The first ''VideoGame/ValkyrieProfile'' has an odd version, because you know what happens to the character, but no idea ''how''. Lawfer's recruitment cutscene doesn't show or even allude to how he dies, but he ends up one of your Einherjar anyway once it's finished. The manga has him turn into a vampire and get killed by Arngrim, but this doesn't fit with the events of the game.
291*** And early in the game, during Belenus's recruitment scene, Valkyrie comes across a name and keeps it in mind, yet we never see this vampire she was talking about.
292* Leafos' family history in ''VideoGame/VivaPinata'' looks like a plotline, but it never actually goes anywhere. You should, for example, be able to work out that Stardos is [[spoiler:now Dastardos]], and Leafos alludes to this... But you can't really ''do'' anything about it, or even receive further clarification beyond unlocking the diary entries as you level up. There's no way to bring the dysfunctional family back together ([[AnnoyingVideoGameHelper maybe you wouldn't want to...]]) no matter how good your garden is... And despite the long, involved history in the diary that seems to indicate that their problems are intrinsic to the game.
293* ''VideoGame/TheWalkingDead'' never resolves the fate of several characters:
294** Chet and Andre (depending on your choices), after they leave Herschel's farm.
295** Molly, after she leaves the group.
296** The Save-Lot Bandits.
297** The surviving members of the St. Johns family, if you choose not to kill them.
298** Christa after Clementine runs away in the first chapter of Season 2. And the guys who were attacking them,f or that matter.
299** Mike, Bonnie and Arvo disappear after they shoot Clementine and flee the group.
300** We don't see the cancer survivor group again after Shel and Becca leave them in 400 days.
301** In 400 Days, we don't find out what happened to Leland, Wyatt's friend Eddie, Nate or whichever prisoner escapes with Vince
302** The survivors from 400 Days who you help get to the Howe's department store.
303** We don't know if Edith, the woman from the "Wellington" ending for season two who appears in flashbacks in season three survived the bandit raid or not. We also don't know what happened to Kenny in that ending.
304** Depending on the player's choice, either Joan or Clint will die, while the other will flee. Whoever managed to escape, their status will be marked as "unknown" on the choices summary at the end of the season.
305** Season four reveals that Richmond was attacked, and Clementine can't return there. Javier and Kate, Gabe, or both, depending on player's past choices, are never heard from again, though WordOfGod confirmed that they made it out alive. Conrad can also survive the entire season, but is also never seen again.
306** [[spoiler:If the player chooses to spare Lily, she will escape on a raft from the Delta boat, using the chaos that erupted after the bomb explosion as a distraction. This is the last episode of the series, so we never see her again.]]
307** If James wasn't killed by [[spoiler:Lily]], he will separate from Clem and [=AJ=] during episode four. Again, he's never seen again, but WordOfGod confirms that he lives in the woods near the boarding school and isn't on speaking terms with Clementine.
308* ''VideoGame/{{Wandersong}}'': After Audrey Redheart [[spoiler:deals the killing blow to the corrupted Nightmare King]], she is never seen after that, not even in the PlayableEpilogue. According to WordOfGod, Audrey was originally [[spoiler:[[LaserGuidedKarma supposed to die after she delivered the final blow]], but it was scrapped because all of the visual effects happening on the screen made it hard to tell what was happening, and also because such a fate felt tonally out of place in a game about forgiveness and compassion]]. When asked by a fan about the ambiguity of her fate, A Shell In The Pit responded that [[ShrugOfGod they didn't know what happened to her either]].
309* ''TabletopGame/{{Warhammer 40000}}: VideoGame/DawnOfWar'' ends with Brother-Captain Gabriel Angelos swearing to [[spoiler:defeat the demon he had [[NiceJobBreakingItHero accidentally unsealed]] from the [[SealedEvilInACan artifact sealing it]]]]. Neither Gabe nor [[spoiler:that particular demon]] have been seen for the three expansion packs nor the sequel. Since this occurs at the end of the game, it also counts as LeftHanging.
310** Gabe's story is continued in the ''Dawn of War'' books, although he ends up dealing with Necron and Chaos, rather than [[spoiler:the demon]].
311** The real cause is an unfortunate round of ExecutiveMeddling attempting StatusQuoIsGod. In this case, Gabriel was such a popular character that GW has introduced him into the official background lore of the game as Chapter-Master of the Blood Ravens and hence he can no longer be used in the ''Dawn of War'' games because it would mess up the lore.
312** Actually this has all been resolved as of the latest Expansion pack to Dawn of War II, Retribution set a decade after the events in Chaos Rising [[spoiler: Long story short, the now corrupted Chapter Master/Chief Librarian Azariah Kyras makes an Epic FaceHeelTurn and turns half of the Chapter to Chaos, in the Space Marine campaign it's revealed that although Ulkair was responsible for allowing Kyras to GoMadFromTheRevelation it's the Maledictum Deamon -- the same one that Gabriel released in the first game -- that turns him to Khorne and leads him to slaughter millions for the Blood God so he can ascend to Daemon Princehood, in the last mission Gabriel goes one on one with the Daemon Price and promptly gets his ass kicked, though thanks to the Player Character he survives and in an AwesomeMomentOfCrowning is named Chapter Master in the final cutscene of the Space Marine Campaign]].
313* In the ''VideoGame/WorldOfWarcraft'' expansion pack ''Wrath of the Lich King'', a val'kyr (undead valkyrie) named Annhylde the Caller shows up at the end of the Utgarde Keep dungeon to revive the boss Ingvar the Plunderer as an undead. After that? She vanishes, and does not appear again. However, in a subsequent short story centred on [[spoiler:Forsaken leader Sylvanas Windrunner, it was later revealed Annhylde sacrificed herself to keep Sylvanas alive]].
314** In ''Burning Crusade'', we meet Sabellian, a black dragon who helps the player defeat a Gronn. He survives the battle and disappears afterward. Two expansions later, in the Fangs of the Father questline, the uncorrupted black dragon Wrathion is seen killing off the rest of the Black Dragonflight, claiming he is the LastOfHisKind at the end. No word was given on Sabellian's status, although an [[WordOfGod Ask CDev]] clarified that Wrathion is not all-knowing and some black dragons might have survived. Fifteen years after the ''Burning Crusade'', Sabellian would finally return in ''Dragonflight'', becoming Wrathion's rival to lead the now-uncorrupted Black Dragonflight.
315** Goriona, Warmaster Blackhorn's twilight drake mount in the Dragon Soul raid. She helps Blackhorn during the Skyfire battle, but [[ScrewThisImOuttaHere abandons him and flees]] once her health gets too low. Despite explicitly surviving the encounter, she's not seen or mentioned again afterward.
316** Many quests and [=NPCs=] were removed in the Cataclysm expansion, even the ones not overtly affected by Deathwing's re-emergence.
317** The leaders of the non-playable factions in [=WoW=] often suffer this fate. Even when there is a specific gathering of the major leaders, these guys often remain absent. Notable examples are Roanuk Icemist (leader of the taunka), Danath Trollbane (leader of stromgarde), Rexxar (champion of the horde), elder torntusk (leader of the revantusk trolls), Velog Icebellow (leader of the frostborn), Arechron (leader of the kurenai) and greatmother Geyah (leader of the mag'har). Even the playable Draenei tended to be sidelined until they were given focus again in ''Legion''.
318** The worgen storyline in their starting area is tightly plotted, but then stops very suddenly; just as they seem on the verge of reclaiming their city, the player is shipped away to Darkshore to play night elf quests instead. The continuation of the worgen story only appears in quests that are ''exclusive to the other faction''; to see the whole story, the worgen player would have to reroll a Horde character. The Alliance version of Shadowfang Keep references the events of the Horde-exclusive storyline, causing many an Alliance player to wonder who Ivar Bloodfang is, why he thinks Crowley is a coward, and why he wants the back-from-the-dead trio of Godfrey, Walden, and Ashbury killed so bad.
319** Medivh intentionally does this, disappearing off the face of the earth with no explanation beyond him feeling it wasn't his time anymore. That said, he had been used by a demon god to cause some of the worst wars in history, so he can be forgiven for wanting to step out of the limelight.
320* In ''VideoGame/TheWitcher2'', Saskia was a [[spoiler: goddamn ''dragon'' disguised as a human]] leading a rather effective peasant revolt. Given that, it's a little weird that she wasn't even mentioned in ''VideoGame/TheWitcher3'' outside of a Gwent card. One assumes that, given the massive scope of ''Witcher 3'' even without Saskia, CD Projekt RED was [[CuttingOffTheBranches cutting off some branches.]]
321* ''VideoGame/TheWitness'': Subverted. [[spoiler: The people who inhabited the Island beforehand are never brought up over the course of the game -- unless you get into the hidden areas of the mountain where it is revealed that the Island is a human-engineered LotusEaterMachine, designed to flood the senses with metaphysical thoughts to find the true purpose of existence. The previous inhabitants were the programmers who built the island. But we still don't exactly learn what happened to them either, though the walls of the monastery hint that they all fell victim to the Island in some way.]]
322* In the ''VideoGame/{{X}}-Universe'' series, the {{player character}}s of ''VideoGame/XBeyondTheFrontier'' through ''X3: Reunion'' disappear from the plot starting in ''X3: Terran Conflict''. Julian Brennan (''X2'' and ''[=X3R=]'') makes a brief PreviousPlayerCharacterCameo in ''Terran Conflict'', and the ''[[AllThereInTheManual X-Encyclopedia]]'' mentions that his father Kyle Brennan (''XBTF'' and ''X-Tension'') went back to Earth to work towards closer diplomatic ties between the Terrans and [[LostColony Argon]]. However their fates following the [[SpaceColdWar Terran Conflict]] and the Second Terraformer War (''X3: Albion Prelude'') are unknown.
323* ''VideoGame/XenobladeChronicles3'': Melia and Nia are the only characters to return from previous games. While they are both explicitly LongLived and quite possibly just outlived most of their friends, there ''are'' other immortals and near-immortals who could conceivably still be around. Mythra, Pyra, and Dromarch could easily live as long as Nia, but none of them are mentioned. [[spoiler:This gets more confusing as we discover that the timeline of events was not as simple as we thought. Due to it being unclear when "the Endless Now" began, it's entirely possible that the world was frozen just a few decades after the main games, which would mean that ''everyone'' could still be alive. There is still no mention of them, other than Nia having a picture of [[{{Polyamory}} Rex and his wives and their children]], and having Poppi safely tucked away, and an indirect mention when Melia refers to there being "countless" people who exist within Origin]]. The prequel DLC ''[[VideoGame/XenobladeChronicles3FutureRedeemed Future Redeemed]]'' features [[spoiler:Shulk and Rex]], explaining the timeline a bit more and showing where ''some'' of them went, but not all.
324* In ''VideoGame/{{Xenosaga}},'' Dr. Sellers' (one of the villains of the series) fate is left unknown. We aren't sure whether or not he survived the Merkabah being absorbed by Able's Ark.
325** Arguably with how the series likely will never be finished, the entire plot falls under more of a "What happened to the everything?"
326* For a ''long'' time, ''VideoGame/{{Ys}}'' had this in form of Raba ([[InconsistentSpelling or pick your preferred romanization]]). Appearing in the VeryDefinitelyFinalDungeon of the original game and playing a decently major role in clearing it, the last we see of him he's wounded, but not mortally so, and he could easily have survived or died. He doesn't appear nor is mentioned in ''Ys II'', and ''Ys III'' ends up taking place in a distant land. What happened to him was ''finally'' addressed in ''Ys VI''... five games and '''16 years''' after his first appearance.
327** Dogi is completely absent during ''V'' and ''Memories of Celceta'' (which takes place between ''II'' and ''The Oath in Felghana''). Flashbacks in the latter show him in Celceta with Adol (albeit unnamed), but he never makes an official appearance.
328* In ''VideoGame/YuGiOhReshefOfDestruction'', unlike the rest of Pegasus' lackeys, the Puppeteer of Doom is only seen once near the very start of the game. He's neither seen nor mentioned after that.

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