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1[[quoteright:350:https://static.tvtropes.org/pmwiki/pub/images/osmosis_jones_poster_6.jpg]]
2 [[caption-width-right:350:He's one ''cell'' of a guy, and his partner's a real pill.]]
3
4->''"Every body needs a hero."''
5-->-- '''{{Tagline}}'''
6
72001's ''Osmosis Jones'' is a hybrid live action-animated [[BuddyCopShow Buddy Cop Movie]] featuring Creator/ChrisRock as the eponymous character and Creator/DavidHydePierce as his cold pill partner. The two are paired up to stop a nasty criminal (played by Creator/LaurenceFishburne) from destroying the city of Frank, hindered by the self-centered mayor Phlegmming (Creator/WilliamShatner), whose assistant (R&B singer {{Music/Brandy}}) is the main love interest.
8
9[[AnthropomorphizedAnatomy Also, this all takes place inside a human body]].
10
11Osmosis Jones is a white blood cell cop who lost his reputation after a nasty incident that ruined Frank [=DeTorre=] (the human this movie takes place in, played by Creator/BillMurray) out in the real world. Frank eats a contaminated egg that carried a deadly virus by the name of Thrax, whose goal is to kill Frank within 48 hours.
12
13After Thrax starts doing some damage, Jones is paired up with a cold pill named Drix. The two clash frequently, as most new cop partners do in movies, until Drix sees Thrax himself, and takes Ozzy's side.
14
15Meanwhile, while all this is happening in the animated world of the City of Frank, we get a few peeks at what Frank is going through, in the live-action sequences of the movie, trying to care for his health-conscious daughter Shane.
16
17This movie spawned a spinoff cartoon called ''WesternAnimation/{{Ozzy and Drix}}''.
18
19One of the two animation directors was Tom Sito, who had previously been a lead animator on [[Film/WhoFramedRogerRabbit another, more successful live action/animation hybrid film]].
20
21----
22!!''Osmosis Jones'' provides examples of:
23* ActorAllusion: In the climactic fight scene between Ozzy and Thrax, the camera briefly freezes and rotates around them; a la ''Franchise/TheMatrix''. Thrax is voiced by Creator/LaurenceFishburne, who played Morpheus.
24** Thrax's outfit is similar to Morpheus's, as well, right down to the BadassLongcoat and CoolShades.
25* AllOfTheOtherReindeer: Ozzy is seen as the butt of the joke in the police department due to his CowboyCop personality, not to mention [[spoiler:his role in causing Frank to puke on Shane's teacher]]. Only the Police Chief seems interested in trying to convince Ozzy to improve his reputation.
26* {{Animesque}}: Not as much as the spin-off cartoon, but still. Heck, [[Anime/PokemonTheSeries Pikachu]] makes a cameo in one scene (the Pokémon anime aired on the [[Creator/TheWB WB network]] back then).
27* AnthropomorphicPersonification: See below.
28* AnthropomorphizedAnatomy: One of the most iconic examples of this trope. Cells are the citizens, the body is the city, a pimple is a shady nightclub--the sky's the limit when it comes to this movie.
29* ApocalypseHow:
30** Well, while Frank's death wouldn't even make a dent in our society, for the ''cells'' that live in Frank it'd be the equivalent of a ApocalypseHow/Class6, maybe ApocalypseHow/ClassX depending on what the doctors choose to do with his body afterward.
31** Thrax has done this at least three times before, which in terms of casualties is the equivalent of burning an entire world to the ground ''three thousand times over''.
32* ArsonMurderAndJaywalking: Mayor Phlegmming lists three ways Jones had pissed him off before firing him in his WhatTheHellHero speech.
33-->'''Mayor Phlegmming:''' Disregarding orders, destruction of public flesh, popping a pimple without a permit!
34* ArtisticLicenseBiology: All anthropomorphization aside, anyone who's passed high school biology knows that viruses don't work even remotely like they're depicted in the film. Though they can be harmful to the organisms that they infest, they don't deliberately destroy the host body, because that would kill them too. Like all living organisms, their instinct is to spread and replicate, and they do this (highly simplified) by mutating a host's cells into copies of themselves. The cells then can't do their original job, they do the Virus's job, which is to spread and replicate and find a way to spread to other bodies so that they can spread and replicate some more. If Thrax actually behaved like a virus, he would have spent the movie making an army of Thrax-clones or pulling GrandTheftMe on other cells à la ''Film/InvasionOfTheBodySnatchers'', not trying to kill Frank by stealing his hypothalamus.
35** Though, to be fair, it might be implied that Thrax is a plague rather than an ordinary virus. Plagues also don't deliberately destroy the host body, but they still end up destroying it because they have jumped species from animals to humans. This is reinforced by Thrax entering Frank by way of the monkey pen. What might cause a mild cold in a monkey could be deadly to a human. However, if this were the case, the more realistic scenario would be [[ObliviouslyEvil Thrax causing destruction by accident]] rather than deliberately attempting to kill Frank (and others).
36* AttackItsWeakPoint: Thrax goes after the Hypothalamus, causing his poor victim to undergo a life-threatening fever. At cellular level, this is represented as ''the city burning down.''
37* AwardBaitSong: Debelah Morgan's "Why Did You Have To Be"--as written by Diane Warren.
38* BadassBoast: Thrax gives one when encountering Scabies and his goons in the armpit sauna.
39--> '''Scabies:''' [[UnderestimatingBadassery Look who thinks he's the Ebola virus! HA!]]\
40'''Thrax:''' (''scowls'') "Ebola"? Let me tell you something about ''Ebola'', baby. [[SuddenlyShouting EBOLA IS A CASE OF]] ''[[SuddenlyShouting DANDRUFF]]'' [[SuddenlyShouting COMPARED TO ME!]]
41* BadassLongcoat: Thrax. It's also practical: he can spread it to act as wings or a [[ImprovisedParachute parachute]].
42* BeastlyBloodsports: Ozzy breaks up a "chicken pox" fight to get to TheInformant, namely, a flu-shot. The chicken pox viruses are depicted as, well, chickens.
43* BecomingPartOfTheImage: A car crashes on a billboard for "the Land Down Under" (Frank's butt), the car wedged right in the crack.
44* BerserkButton: Do NOT compare Thrax to the Ebola virus.
45** Also, NEVER get in the way of his goal of making it into the medical books. His goons made that mistake when they suggested that they incubate since they were few in numbers. [[YouHaveOutlivedYourUsefulness It was their]] ''[[YouHaveOutlivedYourUsefulness last]]'' [[YouHaveOutlivedYourUsefulness mistake.]]
46* BigBad: Thrax.
47* BigGuyLittleGuy: Drix and Ozzy, respectively.
48* BigNo: On their way to Buffalo, Bob notices Frank growing delirious and feverish. Through Frank, Mayor Phlegmming tries to convince Bob he's just fine, and though Frank is too far gone to speak, Bob won't have it and calls off their trip to Buffalo, causing Phlegmming to say "The trip is off?" and then scream this, as the trip was his ticket to being re-elected.
49* BigRedButton:
50** The incident that ruined Ozzy's reputation? Causing Frank to forcefully vomit on a teacher. How did Ozzy do this? By hitting the large, glowing button in The Stomach labeled (of course) "VOMIT".
51** At the end of the movie, Phlegmming ([[spoiler:having been impeached and now demoted to cleaning the bowels]]) sees a big red button and pushes it, [[spoiler:only to be farted out of Frank's body.]]
52* {{Bizarrchitecture}}: Frank's subconscious definitely counts.
53* BlackBugRoom: Thrax accidentally stumbles into Frank's towards the climax, [[TooSpicyForYogSothoth which freaks him out]].
54-->'''Thrax:''' ''[stunned]'' WHEW! This cat was sick before I even got here.
55* BrainWithAManualControl: Mayor Phlegmming uses the manual override on Frank's speech control to instruct Frank to say that he'll take a cold pill for his initial symptoms, rather than seeing a physician as he'd intended. This introduces special agent Drix to Frank's body, where he teams up with the titular white blood cell.
56* BrickJoke: During his campaign ad, Tom Colonic puts his hand on a boy's head and spins it around 180 degrees. Later, when he and his staff are watching the mayor's speech, the boy can be seen wearing a neck brace.
57* ByTheBookCop: Drix.
58* CallingTheOldManOut: Shane blames Frank and his unhealthy habits for Maggie's untimely death, and calls him out for deciding to take her to a chicken wing FanConvention instead of the hiking trip she was looking forward to. [[spoiler:She reconsiders her words once she sees Frank in critical condition being rushed to the hospital in a fever-induced coma]].
59* TheCameo: [[http://postimage.org/image/3o6ohiasl/ Pikachu makes an appearance]] at the bladder. No, [[{{Franchise/Pokemon}} Pikachu]] was NOT photoshopped there.
60* CassandraTruth: Osmosis is the only one who knows about Thrax's plans... and can't convince anyone of the threat. Thrax himself finds this ''hilarious''.
61-->'''Thrax:''' They're making this [[TooDumbToLive too easy]]! (''laughs'') You know, in all the bodies I've been in, no-one has ever gotten wise to me, and now for the ''first time'', an immunity cell has figured out everything, and they don't believe him! (''laughs again'') Can you ''taste'' the irony in that?
62* CastOfPersonifications: The human body is depicted as a city and the various cells as its citizens. White blood cells, like the title character, are cops, while germs and viruses are criminals.
63* ChairmanOfTheBrawl: During the fight at the Zit, a random germ tries to take out Drix by smashing a chair over his back. [[NoSell Drix doesn’t even notice]].
64* ChekhovsGun:
65** When Thrax is destroying the saliva boat, he's humming [[http://youtu.be/X7_k_0dKknA "Fever"]], which gives you [[spoiler:his method of killing making this a classic use of this trope]] .
66** There's also [[spoiler:Frank's allergy to pollen pods. Thrax uses it to escape Frank's body.]]
67** The false eyelash that Shane's friend gives her. [[spoiler:In the climax, Ozzy and Thrax duke it out on top of it. Thrax doesn't realize that it's fake until he gets his hand stuck in it...just before it falls off of Shane's eye into a beaker of alcohol. Cue dramatic death scene.]]
68* ChekhovsSkill: Ozzy's ability to change shape comes in very handy in the climax.
69* CoolCar: Thrax's car.
70* CoversAlwaysLie: Due to contract issues, the Farrelly Brothers (of ''Film/DumbAndDumber'' fame) are listed as primary directors. They only did the live-action footage, and didn't have any input on the animation and script.
71* CowboyCop: Osmosis, leading to him getting chewed out by...
72* DaChief: "JONES! IN MY OFFICE!"
73* DeathOfAChild: Thrax not only plans to kill Shane, but reminisces about killing a "little girl" who didn't like to wash her hands.
74* DeceasedParentsAreTheBest: Averted. We don't hear much about her, but Shane's mother was apparently even ''worse'' to her body than Frank is, and presumably died for it.
75* DespairEventHorizon: Drix almost flushes himself out of Frank's organism via the bladder, before [[spoiler:Ozzy talks him out of it, and informs him Thrax is still at large]].
76* TheDividual: Played With. The cells in Frank's body will sometimes refer to Frank using collective first-person pronouns, usually whenever it pertains to something that affects the body as a whole. Justified since a living organism's cells are just as much the organism itself as they are a part of it.
77--> '''Pilot:''' I told City Hall we need more sleep!
78--> '''Police Chief:''' The papers are calling it the most powerful cramp since Shane made us try that Tae Bo workout!
79* DisneyDeath: There are actually 3 of these in this movie. [[spoiler:First, in a rare instance where a villain suffers a Disney Death, but is KilledOffForReal later on, after Osmosis Jones and Thrax blew up The Zit, they thought Thrax was dead, but when Osmosis goes to the movie theater, he finds out Thrax is alive. Second, Frank's near-death caused by a high fever. And finally, after Ozzy travels back to Frank in a tear drop, he appears to be dead, but wakes up.]]
80* DisneyVillainDeath: [[spoiler:Thrax falls to his death into a beaker of alcohol.]] Although we see the death. And it is horrifying.
81* DisproportionateRetribution: Mrs. Boyd gets embarrassed due to Frank throwing up on her after eating some bad oysters (which was revealed to be Ozzy flushing a virus out of his system) and places a ''restraining order'' against him for it. Who knows what the magistrate was thinking when he thought that this justified passing the order?
82** Also, she starts screaming at him and refuses to remove said order when his zit pops on her. Yes, it's disgusting, but it's not like Frank did it on purpose.
83* DoubleEntendre: [[DoesThisRemindYouOfAnything "This cat was sick before I even got here!"]]
84* EstablishingCharacterMoment: The first thing Thrax does upon being introduced is to [[KickTheDog casually murder two harmless workers]], [[FamilyUnfriendlyDeath at least one in an incredibly gruesome way]]. He then proceeds to [[WalkingWasteland burn their entire boat by merely scratching its surface with his index finger claw while he is walking]].
85* EvenEvilHasStandards: Thrax is nothing short of ''disgusted'' to be in Frank's subconscious, which is fraught with bad memories and nightmares. ''He's'' a murderous and sadistic virus, and even he thinks Frank was "sick before [he] got [in]".
86* EveryoneHasStandards:
87** [[ParentsAsPeople Frank]] may not be the best of fathers, but he does question if his brother Bob is going to be a good guardian for Shane, especially when he offhandedly claims he'll kick his niece out by the time she's ''16''.
88** Ironically, even ''Bob'' has better standards than Mayor Phlegmming when it comes to Frank's well-being. Bear in mind, this is the same guy who's idea of drinking fluids is "drowning a cold" with ''beer''. But on their way to Buffalo, Bob notices Frank growing delirious and feverish. Through Frank, the Mayor tries to convince Bob he's just fine, only to find that Frank is too far gone to even speak. Bob immediately calls off their trip to Buffalo and took his brother to the hospital.
89** The Police Chief has a look of surprise when Phlegmming relieves Ozzy of his badge.
90* EvilLaugh: Thrax pulls off one hell of a wicked cackle when he succeeds in stealing the DNA bead.
91* FamilyUnfriendlyDeath and FamilyUnfriendlyViolence: Used rather disturbingly for a PG movie--cells exploding into red lava goo and the villain [[spoiler:turning sickly green and becoming hideously warped in a beaker of alcohol]], although the latter happened to a being of pure evil...
92* FamousForBeingFirst: A brief MythologyGag occurs while a press corps is questioning Mayor Phlegming. As they pursue him, they pass a statue of a single spermatozoa on a pedestal. It's labeled "Our Founder" in honor of the gamete that was first to attain the ovum, which began the world called Frank.
93* FanDisservice: That picture of the chief's disgustingly obese wife in a bikini, which can be seen during the scene when Ozzy is first seen talking his boss. The shot lingers long enough to ''make sure'' you've seen it and absorbed its grandeur.
94** Also, the dancers in the Zit nightclub. They wear bikinis and are modeled after strippers, but the way they are portrayed (eyeball in the bellybutton, two rods in place of a head, etc) is intended to be weird rather than arousing.
95* FantasticVoyagePlot: From Drix's perspective, at least; the characters who are cells are already permanently inside the body. From Thrax's [=POV=] it's an inversion: he enters Frank's body to ''kill'' him.
96* FauxAffablyEvil: Thrax. At least at first. As the film progresses, he slips more and more frequently into a bloodthirsty, manic persona until he hits a full-on VillainousBreakdown.
97* FirehouseDalmatian: The "firefighter" white blood cells trying to cool down the inflammation in Frank's throat have a Dalmatian cell.
98* FiveSecondRule: Ultimately what kickstarts the plot. When Frank gets his egg stolen by a monkey, he has a fight for it until it falls to the ground in which he picks it up claiming this before eating it in spite of his daughter rightfully pointing out how filthy it is. Given the egg had already been in the monkey's mouth for longer than five seconds before hitting the ground, it proved that Frank was TooDumbToLive.
99* FootPopping: Leah does this as she and Ozzy share their BigDamnKiss.
100* FreezeFrameBonus: The backgrounds offer plenty of sight gags, such as signs reading "Rectum - Exit Only", "Slow - Sore Throat", "Ulcer Repair", and "Danger - Open Nerve".
101** For a brief moment, after Thrax killed the two blood cells managing the hypothalamus, you can see the dead body of one cells leaning over the console with several of the hypothalamus' thermometers in his posterior. You get a clearer image when the gland is freaking out later.
102* FunnyXRay: Ozzy goes through an X-ray machine while entering the stomach to meet Drix. The X-ray shows his gun, and he gets a pass by showing his badge. The guy behind him, however, is a tough looking sailor who is revealed to be wearing women's underwear.
103* GetOut: Yelled word-for-word by Mrs. Boyd after parts of [[spoiler:Frank's zit landed on her lip]].
104%% * GettingCrapPastTheRadar: Due to overwhelming and persistent misuse, GCPTR is on-page examples only until 01 June 2021. If you are reading this in the future, please check the trope page to make sure your example fits the current definition.
105* GreenAroundTheGills: Ozzy has a germ drinking phlegm for a beverage in the club. In addition to this trope, this causes his head to twist and stretch as well.
106* HeroicBSOD: Ozzy falls into one [[spoiler:after he is forcibly fired from the police force by Mayor Phlegmming]].
107* {{Homage}}:
108** [[spoiler:Thrax's death is extremely reminiscent of T-1000's bath in molten metal.]] Also, the part where Jones reassembles himself after getting split in two looks a lot like the part in ''Film/Terminator2JudgmentDay'' where the T-1000 pulls its head back together after getting blasted point blank by a shotgun.
109** The fight on Shane's eye, and Thrax's design are shout outs to ''Film/TheMatrix''. (Not to mention the fact that Thrax is voiced by Laurence Fishburne)
110** [[Film/{{Titanic 1997}} "Gentlemen, it's been a pleasure playing with you this evening."]] Including the fact that this line is followed by the band playing "Nearer My God To Thee".
111** Film/TheGodfather scene in the armpit.
112** "El Muerte Roja" or "The Red Death" possibly refers to Creator/EdgarAllanPoe's "Literature/TheMasqueOfTheRedDeath", also, both diseases are written in without much identity other than that they kill in awful ways.
113* HateSink: Mayor Phlegmming. He lacks the charismatic traits of even Thrax, instead showing himself to be a self-centered, power-hungry, and bigoted idiot who cares more about his re-election than his own people.
114* HurricaneOfPuns: The dialogue is full of those ("When you grow up on the [[WrongSideOfTheTracks wrong side of the digestive tract]], you ain't got no money for no fancy schools."). And even the DVD menu does this when an option isn't highlighted. "Play movie" becomes "[[ToiletHumor Bowel Movie]]", "Choose A [[GrossOutShow Foul Scene]]" (Scene Selection based on body part) becomes "Frank's Gross Anatomy", "Scene Selections" becomes, "Spleen Cellections", "Special Features" becomes, "Smelly Feetures", and "Languages" becomes "Lunguages".
115* AnIcePerson: Drix's painkilling abilities are represented this way. Inevitably, this leads to the line "[[HumanPopsicle You just soothed my witness into a germsicle]]!"
116* ImpliedDeathThreat: After the incident at the nose dam, Mayor Phlegmming dismisses Ozzy’s claims of seeing a virus at the scene of the crime due to his past record, and lets him off with this warning.
117-->'''Mayor Phlegmming:''' Listen; from now on, keep those opinions in that mushy little head of yours, or you’re going to find yourself in our next ''nosebleed''. Understood?
118* ImprobableAimingSkills: Shane's tear with Ozzy in it precision strikes the hole in the uvula.
119* TheInformant: Chill the flu shot
120-->'''Drix''': That's funny. He doesn't look [[IncrediblyLamePun fluish]].
121* InkSuitActor:
122** Osmosis Jones has Creator/ChrisRock's ecstatic grin, thick eyebrows and goatee.
123** Drix has David Hyde Pierce's expressive stoik eyes and roundish head.
124** Thrax has Creator/LaurenceFishburne's broad cheeks and slight gap in his teeth.
125** [[Music/KidRock Kidney Rock]]. He even had a hypeman played by Joe C.
126* {{Irony}}: It's a subtle joke that all the white blood cells are voiced by black actors.
127* {{Jerkass}}: Mayor Phlegmming. It's largely thanks to him that Frank's health and family relationships are such a wreck.
128* JerkassHasAPoint
129** Ozzy's CowboyCop approach to curbing crime always seems to make things worse, and the chief frequently and rightfully calls him out for it.
130** While it was said in the most insensitive way possible, Mayor Phlemming correctly points out that Drix isn't a cure for anything, just a temporary relief for cold symptoms.
131* KickedUpstairs: As punishment for causing Frank to have leg cramps, Ozzy is forced to work with Drix in investigating a sore throat.
132* KickTheDog: Not only does Mayor Phlemming have Osmosis lose his badge, but he treats Drix as disposable and points out (in the most insensitive way) that he's only meant for temporary relief, not for helping someone get better.
133* KillItWithFire: Thrax's way of dealing with people.
134* LaserGuidedKarma: [[spoiler:After his actions nearly got Frank killed, Mayor Phlegmming is impeached and thrown out of office, stuck working as a lowly worker down in Frank's bowels. And then he presses the button that causes Frank to fart...]]
135* LaughWithMe: Thrax tells his last two goons sharing a laugh with him about no one being there to stop his murder of Frank to shut up.
136* {{Leitmotif}}: Thrax has one in the form of [[https://youtu.be/JGb5IweiYG8 "Fever"]] by Peggy Lee, which he can be heard humming throughout the movie.
137* LeftStuckAfterAttack: This is how Thrax meets his end, having his FingerPokeOfDoom stuck in a false eyelash that falls into vial of alcohol.
138* LogoJoke: The Warner Bros. logo appears as a one-celled organism floating in a dark background.
139* LovecraftLite: The movie and animated series presents the immune system's struggle to keep the body alive as this, since the body's cells are constantly fighting against viruses, bacteria, and other beings that can corrupt and ruin the very world (aka the body) around them.
140* MasturbationMeansSexualFrustration:
141-->'''Osmosis:''' What you talkin' 'bout? I'm a legend, girl! Chicks line up to divide with me!\
142'''Leah:''' Oh, really? Because to me, you look like the kind of cell who mostly divides with himself.
143* MayorPain: Phlegmming.
144* MeaningfulEcho: You want Osmosis? You got Osmosis!
145* MediumBlending: The entire concept behind this movie. Live action humans and cartoon insides ''a la'' ''Film/FantasticVoyage.''
146* MissingMom: Shane's mom, Frank's wife, is dead by the time the movie begins, and from what Shane says she had similar habits to Frank and died because she didn't change.
147* TheMole: Chill who hangs out with germs while providing info to Frank's Finest.
148* MonstrousGerms: Germs are portrayed as humanoid creatures with mismatched body parts and often reptilian features.
149* MoodWhiplash: The briefing scene at the Zit is rather disorienting, swinging from Thrax's ominous plan and rant to Ozzy's ridiculous attempts to trick information from him.
150* MostWritersAreHuman: The cells have romantic relationships and a democracy, of all things.
151* MyGodWhatHaveIDone:
152** Mayor Phlegmming when he sees [[spoiler:the City of Frank getting burned up]]. His expressions say it all.
153** Shane calling out Frank's selfishness, unhealthy lifestyle, and contributing role in Maggie's death may have been justified, but when Frank is dying at the hospital, [[PartingWordsRegret she frantically takes it all back, afraid it will be the last thing she ever said to him]].
154* Mystical108: Ozzy warns that if Frank's fever hits 108 degrees Fahrenheit, Shane'll be orphaned. TruthInTelevision, as 108 is the real-life threshold for when a fever often becomes lethal.
155* NearDeathExperience: Frank briefly flatlines from a high fever until Ozzy gets the hypothalamus working again. He tells Shane he saw her mother and she says hello.
156* NearVillainVictory: Boy, is it ever.
157* NeverSayDie: {{Downplayed|Trope}} for the most part. While they do say “die” a few times, there are other moments where they don’t.
158** Nonchalantly {{inverted|Trope}} by Thrax when he’s discussing his past victims.
159--->'''Thrax:''' Then there’s this old guy in Philly; I killed him in 72 hours.
160* NiceJobBreakingItHero: He did the right thing [[spoiler:causing Frank to vomit, thereby saving him from a contaminated oyster]], but it caused Frank to lose his job and the respect of the local community, and [[NoGoodDeedGoesUnpunished got Ozzy suspended for "use of unnecessary force"]].
161* NiceJobFixingItVillain: [[spoiler:During the final fight, Thrax tries to use his chain, which holds Frank's as well as his previous victims' hypothalamus chromosome, to strangle Ozzy. However, Shane winds up blinking (they're fighting on her eye) separating the two with the chain still around Ozzy's neck. After Thrax's last attack fails, Ozzy manages to escape with the chain while Thrax falls into a bottle of alcohol. Also counts as a HoistByHisOwnPetard, as had Thrax merely killed Ozzy using his [[TouchOfDeath acidic claw,]] he would have won handily.]]
162* NotWearingPantsDream: Frank has a recurring one, and its implied to have happened so many times that he's not even fazed by it anymore.
163* NowOrNeverKiss: Ozzy gives Leah one before [[spoiler:he has himself shot out of Frank's body to stop Thrax.]]
164* ObstructiveBureaucrat: Mayor Phlegmming. Who only cares about his upcoming election and [[spoiler:nearly inadvertently kills Frank with his negligence.]]
165* OddNameOut: Osmosis Jones', being a normal last name and a human-body-themed first name instead of other cells' like "Tom Colonic" and "Leah Estrogen". "Drixobenzo Methapherdramine" also counts as one.
166* OfficialCouple: By the end of the film, [[spoiler:Ozzy and Leah]] are in a relationship.
167* OhCrap:
168** Thrax's reaction when Drix's massive grenade gets uncapped.
169** Leah has this expression when she quite literally bumps into Thrax.
170* OhMyGods: Cells use "Frank" either as their term for "God" or as an expletive.
171* OmnicidalManiac: Thrax, on a cellular scale. His stated goal is to kill Frank in two days, faster than any other virus has ever killed, and give himself a whole new chapter in the medical books.
172* OOCIsSeriousBusiness: Part of Bob's character is that he contributes to Frank's unhealthy habits. Heck, when Frank was showing onset symptoms of hyperthermia, his idea of "drinking fluids" was to urge Frank to drink ''beer''. But when he notices his brother is feverish and delirious, he starts to show ''worry''. And despite Mayor Phlemming insisting that Frank is "fine", Bob calls off the very roadtrip they had been planning for weeks.
173* OurFounder: A sperm cell, naturally. Also doubles as ParentalBonus, since many children will not see the statue in the shot, much less recognize it for what it is.
174* PaperThinDisguise: Drix disguises himself to get into the Zit... by wearing a frozen germ on his head. And ''it works''.
175* PartingWordsRegret: It's implied that Shane feels partially responsible for Frank's death after he flatlines, believing he lost the will to live after she blamed him for her mother's death by the same unhealthy habits.
176* PhlebotinumRebel: Drix rebels on his function of being a temporary relief by throwing away his description after Ozzy convinces him to stay for his confrontation with Thrax.
177* PhotoOpWithTheDog: Mayor Phlegmming poses with a boy in a wheelchair, and promptly pushes him offscreen once it's done.
178* PlatoIsAMoron: When Scabies mockingly compares Thrax to the Ebola virus, Thrax responds that Ebola is a case of dandruff compared to him.
179* PovertyForComedy: Jones was raised on the "wrong side of the digestive tract."
180-->'''Ozzy:''' I'm not kidding man, my high school was Crack Central. No, it was ''IN'' the crack. Right in the stanky, pucky center. We were so poor, we lived off peanut butter and cellulite sandwiches. You ever try to blow dry your hair with a fart?\
181'''Drix:''' OK, I get it, you were poor.\
182'''Ozzy:''' You bet I was. You ever try to make a snowman with toilet paper cling-ons? Now, ''that's'' poor.\
183'''Drix:''' OK, please, you're going to make me vomit.\
184'''Ozzy:''' Vomit? We couldn't afford no vomit, that's for rich folks.\
185'''Drix:''' Excuse me while I wipe my eyes\
186'''Ozzy:''' Ah, you wanna talk about wipin'?\
187'''Drix:''' NO!!!
188* ProtagonistTitle: Osmosis Jones is the main character of the film.
189* PunchCatch: Thrax pulls this while taking over the local "mafia".
190* ReasonableAuthorityFigure: The Police Chief. Unlike his bureaucratic boss, he takes Frank's health more seriously and does trust Ozzy to do what's right for the city despite the latter's destructive tactics.
191* TheReasonYouSuckSpeech:
192** Leah gives one to Mayor Phlegmming about how he doesn't care about Frank's well-being and everyone else's lives so much as he does getting re-elected.
193** Paralleling that, Shane gives her father a subtle one about how unhealthy his lifestyle is, and maybe [[TearJerker her mother would still be alive if they had taken their health more seriously]]. Doubles as PartingWordsRegret.
194* RedOniBlueOni: Ozzy is the confident, instinctual, and impulsive Red to Drix’s calm, intellectual, and logical Blue.
195** ColourCodedForYourConvenience: One of the rare times that it’s {{inverted|Trope}}.
196* ReminiscingAboutYourVictims: Thrax rattles off a few of his previous victims and how long it took to kill them to his cohorts, including a very disturbed undercover Osmosis.
197* RightlySelfRighteous: Frank's daughter Shane constantly scolds him about not taking care of his body due to his disgusting habits. You can hardly blame her.
198* RogerRabbitEffect: Surprisingly averted. For most of the movie, the two worlds have no direct interaction. There are a couple moments, such as Frank's subconscious, and the fight on the fake eyelash, although that uses rather poor CGI rather than live action.
199* ScaryBlackMan: Thrax, in a way. What else can you expect from Lawrence Fishburne?
200* SeekerWhiteBloodCells: The film anthropomorphizes the entire human body, giving all the various cells and such names and allowing them to speak and develop friendships with other cells. The white blood cells are treated like the police, so they get a lot of chase scenes with equally anthropomorphic pathogens.
201* SesquipedalianSmith: Osmosis Jones.
202* ShoutOut:
203** When Ozzy and Drix return to the police station from [[spoiler:blowing up The Zit]], Ozzy accidentally calls Leah "Brandy", which is the name of her voice actor (Chris Rock unintentionally ad-libbed that line and the filmmakers decided to [[ThrowItIn put it in]]).
204** It might have only been intended to be NauseaFuel, but Jones' and Drix's first conversation is very similar to the Four Yorkshiremen sketch, at least for Jones' part of it.
205** [[spoiler:Thrax being knocked into cleaning alcohol]] is a recreation of the T-1000's death in ''Film/Terminator2JudgmentDay''.
206** In the online game ''Mystery of the Rash Outbreak'', a female cell tells the player that the password for the Zit is [[Film/EyesWideShut fidelio]].
207** Also one to the Ohio Players. When Thrax and his Mooks are gloating over the newspaper article about the heroes stopping the cold. When asked about the possibility of the protagonists intervening, Thrax responds: "Fire".
208** [[spoiler:As Frank's body begins to die, one violinist tells the other violinists and cellist, "[[ItHasBeenAnHonor Gentlemen, playing with you has been the greatest pleasure of my life]]," [[Film/Titanic1997 and they begin playing "Nearer My God to Thee"]].]]
209* ShownTheirWork: The portrayal of anatomy is pretty impressive for a movie where ''everything'' in the body is anthropomorphic, such as Osmosis mentioning his ancestors coming over on the umbilical cord. Also, the creators worked with a professional martial artist to make Thrax's fighting more accurate.
210* SideEffectsInclude: Drix spouts off his commercial disclaimer upon arriving in the stomach.
211-->"Drixenol! The brand that eases your coughs and sneezes! Warning: Do not exceed recommended dosage. If symptoms persist, consult a physician. May cause drowsiness. Do not attempt to operate heavy machinery. Pregnant women should not handle broken tablets."
212* SlasherSmile:
213** Thrax at points; and though probably unintentional, Ozzy does it at times.
214** Drix dons one when they are trying to intimidate the flu shot.
215* SpockSpeak: Subverted--in a flashback, Frank speaks to a kid at a science fair who talks in this manner about his project to leach the toxins out of polluted oysters. Certain that the kid's a genius and the project worked, Frank picks one out of the container and ''eats it raw''. Then finds out the kid is actually of very low intelligence and the oysters are ''still'' polluted. (This, incidentally, is what led to Jones's disgrace--he saw a dangerous-looking germ on the oysters in the stomach before anyone else and pressed an emergency "puke" button at exactly the wrong time, plus he did it so quickly that no-one else saw the germ.)
216* {{Spoiler}}: Invoked.
217-->'''Osmosis:''' ''[seeing Thrax in Frank's subconscious in a movie theater]'' Thrax is alive! Thrax is alive and he's in the brain!\
218'''Makeout teen:''' Oh, great, pal! Spoil the ending!
219* StealthPun: After Thrax first appears, he saunters along the boat while humming the melody from "Fever".
220* StockSoundEffects: Apparently, cells use [[Franchise/{{Ghostbusters}} proton packs]] to clean out the germs during digestion.
221* StrangeMindsThinkAlike: It seems that neither Osmosis or Phlegmming know what a hypothalamus gland is, when it is by Thrax and Leah that they ask in confused tone.
222* SwissArmyTears: Justified--[[spoiler:after defeating Thrax, Osmosis jumps into one of Shane's tears that falls into Frank's mouth to return the hypothalamus chain.]] It probably appeared this way to the doctors, though.
223* TenMinuteRetirement: Ozzy goes through this after Mayor Phlegmming instead of thanking them for supposedly stopping Thrax, fires Ozzy from the police department after blowing up The Zit, using his poor record and breaking of regulations as a smokescreen to cover up the existence of Thrax's infection which would've kept him from being re-elected, and orders Drix to leave Frank's body. Fortunately, both of them come around when Thrax makes Frank's body go to hell in a handbag, and they end up getting their jobs back.
224* ThisIsGonnaSuck: The Spanish germ, who had just recently thawed out from his last run in with Drix’s coolant, has this reaction when the Zit explodes, and he sees a massive wave of the coolant heading right for him.
225-->'''Spanish Germ:''' Oh no, not again…
226* TooDumbToLive:
227** Frank. Eating raw, polluted oysters; eating an egg dropped in a filthy monkey cage, where not even the ten second or even the ONE second rule should apply--especially since THE EGG HAD ALSO BEEN IN THE MONKEY'S MOUTH. All his knowledge goes to promoting his laziness or retaining sports statistics. (Well, considering that Mayor Phlegmming has been running his brain...)
228** Scabies, the mob germ boss. Even after being eviscerated by Thrax, Scabies' disembodied mouth ''still continues to insult him'' before being sucked down the drain.
229* TorsoWithAView: Self-invoked by Osmosis to avoid succumbing to the trope below.
230* TouchOfDeath: One of Thrax's primary weapons. Everything he even so much as pricks with his long claw seems to burn up.
231* TwoKeyedLock: Manual control of the brain requires two keys, and naturally Mayor Phlegmming has both of them.
232* UnflinchingWalk: Thrax pulls one off particularly well.
233* UngratefulBastard: The Mayor does not give Ozzy and Drix the credit they deserve for finding and trying to stop Thrax.
234* VileVillainSaccharineShow: Due to the previously mentioned [[ExecutiveMeddling sanit]][[IncrediblyLamePun izing]], as the movie became a light-hearted comedy, Thrax didn't change much, resulting in a disproportionately dark villain. It gives an odd feeling of MoodWhiplash when he is placed up against the goofy protagonists.
235* VillainousBreakdown: Thrax has a subtle one during the final confrontation on Shane's eye. His normally slick dreadlocks fall out of place, his voice gets rougher, and his EvilLaugh gets a lot more disturbing.
236* VisualPun: All the signs and graffiti throughout the movie contain these.
237* VoluntaryShapeshifting: Most cells have a limited variant of this--for instance, when Osmosis wants to fit in with a looser crowd, he makes himself one-eyed. Drix ''cannot'' do this, so he winds up using a [[HumanPopsicle small frozen cell]] as a hat.
238* VomitIndiscretionShot: Though the actual scene isn't shown, it's shown on the front page of the paper in all its disgusting glory.
239* WhatTheHellHero: The chief frequently berates Ozzy for his CowboyCop tactics in trying to catch criminals.
240-->'''Ozzy''': Man, I was right there! I could've done it--
241-->'''Chief''': Right. 78 trillion cells in the body, all working together, you're the only one who thinks he can do it alone! You ever think that might be your problem, Jones?
242* WhatWereYouThinking:
243** Mayor Phlegmming reads Ozzy (and by extension, Drix) the riot act for blowing up The Zit.
244** Ozzy says this verbatim upon hearing over dispatch that Leah’s been kidnapped by Thrax.
245--->'''Osmosis:''' Oh no! Leah, girl, what were you thinking?!
246* WhiteBreadAndBlackBrotha: Parodied by the partnership between CowboyCop Ozzy (voiced by the black Creator/ChrisRock) and ByTheBookCop Drix (voiced by the white Creator/DavidHydePierce).
247* WitnessProtection: Chill the Flu Shot brushes off Osmosis threatening him by reminding him that he's in the Virus Protection Program.
248* WittyBanter: Provided by two cells who act as newscasters.
249* WorstNewsJudgementEver:
250** Somehow, an ill man who ate a bad oyster and throws up on a teacher becomes a huge story, so huge that Frank lost his job and the teacher's daughter had to transfer schools.
251** When Frank is near death, one of the NNN anchors gives a desperate broadcast, mentioning that they've lost contact with the outer extremities. His co-anchor cheerfully tries to segue into a segment about household appliances that can improve your golf swing. He then yells at her for being so dense, causing them to fight and then a "WeAreExperiencingTechnicalDifficulties" card appears.
252* WouldHurtAChild: Apparently, one of Thrax's victims was a little girl that didn't enjoy washing her hands. Also, after infecting Frank with a deadly fever, he mentions to Osmosis Jones that he's going to break his current record by killing Shane even faster.
253* YetAnotherBabyPanda: Parodied with panda animal crackers.
254* YouHaveOutlivedYourUsefulness:
255** No killing here, but the Mayor said that Drix is only temporary.
256--->'''Mayor Phlegmming:''' Son, do me a favor and read what it says on your arm.\
257'''Drix:''' 'For the temporary relief of symptoms associated with... '\
258'''Mayor Phlegmming:''' Exactly! ''Temporary''. [[TheReasonYouSuckSpeech You're nothing but a wannabe, a placebo, a generic brand, marked-down, over-the-counter, useless Tic-Tac!]] [[GetOut Now, get out of MY BODY!]]
259** Thrax burns Joe Cramp and Bruiser alive once they become a hindrance (they suggest that they incubate, which would mean Thrax wouldn't be able to break his record).
260--->'''Thrax:''' [[WrittenByTheWinners Medical books aren't written about losers!]]
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