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8* Can happen in ''Series/TwentyFour'' quite often, but Jack Bauer gives a couple good ones on Day Four [[spoiler:after Habib Marwan kills himself. He was needed alive, as he was the only one who knew where a nuclear missile was currently headed within the country.]]
9%%* [[https://www.youtube.com/watch?v=1tEeg7kJKCs&t=1m22s This moment]] on ''Series/ThirdRockFromTheSun''.
10%%-->'''Nina''': You're taking it better than I thought you would.
11* Don Gilberto of ''Series/AlFondoHaySitio'' does a rather disturbing big "NO!" when [[spoiler:Nelly dies]].
12* Played straight (and generally approved of) near the end of ''Series/{{Angel}}'''s Season Three. Possibly helped by the hero sobbing so hard he can barely get the word out.
13* In the ''Series/AreYouAfraidOfTheDark'' episode "The Tale of the Renegade Virus" a virus attempts to enter Simon's brain, via plugging in the serial port embedded in Simon's hand, leading Simon to scream "NO!" The virus also does this a few times after Simon defeats him by "pressing any key to escape".
14** One girl does this in "The Tale of the Many Faces" when she is threatened with the "Punishment Book".
15* ''Series/AshesToAshes2008'', [[spoiler:when Alex fails to prevent her parents' death, compounded by the knowledge it was her father who had done the deed.]]
16* ''Series/BabylonFive'':
17** This particularly gratifying exchange in "[[Recap/BabylonFiveS04E06IntoTheFire Into the Fire]]", with [[SmugSnake Morden]] finally being broken of his smugness:
18---> '''Mollari:''' Your ships are very impressive in the air, or in space, but right now they are ''[[SittingDuck on the ground]].''\
19'''Morden:''' So? They can sense an approaching ship from miles away. So what are you going to do, Mollari? [[TemptingFate Blow up the island?]]\
20'''Mollari:''' Actually...now that you mention it...\
21'''Morden:''' NOOOOOOOO!\
22''[Londo presses a button on a small remote detonator he takes out of his pocket, and a distant explosion is heard]''
23** In "[[Recap/BabylonFiveS04E17TheFaceOfTheEnemy The Face of the Enemy]]", an increasingly upsetting season-long arc culminates in a brainwashed Mr. Garibaldi betraying his friends in a big public way, leading to the capture and torture of the captain. Guess what happens when Garibaldi snaps out of the brainwashing and realizes that everything he loves is gone and all his friends believe he betrayed them?
24* A surprisingly effective one (and rare foreign-language variant) is heard in the 1967 ''Series/Batman1966'' episode "The Mad Hatter Runs Afoul." At the start of the episode, Batman and Robin, having been placed in a fluoroscopic cabinet by the Mad Hatter's goons, appear to have had the flesh fried off their bodies by deadly radiation (when, in fact, the costumed skeletons are just dummies set up by the Dynamic Duo as a ruse against Hatter). Commissioner Gordon and Chief O'Hara shed ManlyTears when they hear the supposed news, and then get the word out to various world leaders, all of whom are momentarily absent and having their calls taken by a SexySecretary of the respective nationality. The Soviet secretary's reaction is probably the single most genuinely dramatic moment in the series' history:
25-->'''Russian Secretary:''' Pennsylvania 6-5-0-0-0...''[[BilingualBonus Nyet]]''...''Nyet''!...''NYET''!
26* In ''Series/BattlestarGalactica2003'', Lee Adama gets a very effective one when [[spoiler: Starbuck is apparently killed]] somewhat spoiled when they used it in recap clips for the rest of the season.
27* ''Series/BetweenTheLions'': After Cliffhanger finally gets off the cliff in "The Last Cliffhanger", Lionel screams, "NOOOOOOOOO!"
28* In the ''Series/BigTimeRush'' 2-part special ''Big Time Concert'', when Gustavo hears that James already left for LA with Hawk, he begins to scream a Big No, but briefly runs out of breath, stops, and takes some water from Kelly. Then, after he drinks it, he continues to scream so loud and the view shows that it can be heard from space.
29* Parodied on ''Series/BigTrain'' when Chaka Khan has a western-style shootout with Music/TheBeeGees - when Robin Gibb (1849-1880) is gunned down by Chaka Khan (1850-1920), Barry Gibb (1847-1880) gives one up that lasts nearly half a minute. Then he does a second one. (During that time, Robin takes upwards of 70 bullets from Chaka's six-shooter. RuleOfFunny in full effect, of course.)
30* ''Series/BigWolfOnCampus'' makes fun of it. When an attempt to save Merton's life seems to fail and Merton just lies still, everyone goes quiet... and then Merton goes "That's it? No tears? No wailing? No protracted moan of nooooooooooooooooooooooooo?"
31* ''Series/BreakingBad'': Jesse exclaims this in "[[Recap/BreakingBadS5E5DeadFreight Dead Freight]]" when he sees Todd draw his gun on Drew Sharp, a teenage boy on his dirtbike who witnessed their train heist. [[spoiler:Todd kills the boy without missing a beat, traumatizing Jesse to the point that he wants out of Walt's meth business entirely.]]
32* Ilana does this in the ''Series/BroadCity'' episode "Bedbugs" when she realizes her mattress is infested with bedbugs.
33* Played with in ''Series/BrooklynNineNine'', in which the Big No is actually more of a ''Long'' No. After Jake learns that he's inadvertently invited Amy's boyfriend Teddy to join her for a romantic evening without realising that Amy intends to dump him, Jake's perfectly restrained when he says "Oh, no!", and says it at a perfectly reasonable volume. But he makes the 'no' part last for at least ten full seconds (and possibly even longer, since he only gets cut off by the commercial break starting).
34* ''Series/BuffyTheVampireSlayer'':
35** Parodied in "[[Recap/BuffyTheVampireSlayerS7E16Storyteller Storyteller]]". When Andrew is trying to convince Buffy--and himself--that [[spoiler: his murder of Jonathan was actually accidental, or he was possessed]] both his imagine spots end with an over-the-top Big No.
36** The Master does one of these at the end of "[[Recap/BuffyTheVampireSlayerS1E2TheHarvest The Harvest]]" when Buffy kills Luke, ruining the Harvest.
37** Collin's last words.
38** Combined with a rather twisted AwLookTheyReallyDoLoveEachOther, Amy lets out a big no when the Seed of Wonder is destroyed and she loses her powers, causing Warren to fall apart in front of her eyes, since he had only been held together by her magic.
39* ''Series/{{Cheers}}'':
40** As Rebecca goes into her office, Woody is about to leave the bar and tells her he's going out to ask her boss' daughter out for a date. Rebecca, not really listening, says "Okay." and closes her door. Then a second later, she runs out of her office and across the bar, screaming "Nooooooooo!!!!", jumps on Woody's back and tackles him just before he reaches the door.
41** In one episode from the last season, Carla has one (it lasts through an entire commercial break) when she realizes that she slept with [[spoiler: Paul]].
42* In ''Series/{{Chuck}}'', Sarah lets a loud one out when Michael Clark Duncan's character drops Chuck head-first off the roof of a building.
43** Chuck returns the favor in slow-mo as he takes a bullet meant for Sarah in the series' penultimate episode.
44* ''Series/{{Community}}'' has several first-season "mini episodes" that take place during study breaks. In one, Abed asks Pierce, the creepy offensive member, to play Truth or Dare. When Pierce chooses Truth, Annie yells, NOOOO. She calms herself and apologizes. Then Abed asks Pierce what he's ever done that he's ashamed of and the whole group yells NOOOO.
45** In "Advanced Criminal Law", when Chang is about to announce that the entire class will receive a zero for a quiz since the person who wrote the crib notes he found didn't fess up, Annie screams, "NOOOOOOOOO!" When everyone looks at her, she says she's never gotten a zero before.
46** In "Remedial Chaos Theory", the alternate timeline where Troy goes for the pizza ends up being the darkest one; when he returns, the place is in chaos, the Serbian rum catching the apartment ablaze, Pierce with a fatal bullet wound, everyone freaking out, and Pierce's troll figurine in the middle of it all, leering at Troy, who hollers "NOOOOOOOO!!!"
47* Creator/ConanOBrien let one out on his first show on Creator/{{TBS}} once he learns that he'll [[ScrewedByTheNetwork never work on Network TV again]].
48* ''Series/ControlZ'':
49 ** Raúl and Quintanilla give one out as Gerry punches Luis and he falls unconscious.
50** Martha yells one out after her son Luis flatlines at the hospital, with Gerry feeling guilty and silently apologizing to her as he walks out.
51* Played for laughs in the Britcom ''Series/{{Coupling}}'' twice: when Jane finds out her boyfriend is opposed to premarital sex, and when Patrick encounters 'The Melty Man'.
52* Used to great effect on ''Series/TheDailyShow'' during, of all things, the 2000 election aftermath. At the end of a long montage involving the host and correspondents working through 37 days of hell, during which they [[ImAHumanitarian turn to cannibalism]] and Jon and Stephen [[HoYay apparently fall in love]], Al Gore concedes and it looks like it's all over -- when suddenly Stephen is shot dead. "NOOOOOOOO!!!!!"
53** The ''Even Stephven'' segments occasionally had these when Carell and Colbert were explaining their positions:
54--->"No!" "Yes!" "NOOOOOOOOOOOOOOOOOOOOOOOO!"
55** Creator/StephenColbert regularly uses them for comic effect. He is well known to be a huge fan of both ''Franchise/StarWars'' and ''Literature/TheLordOfTheRings'', so it's obviously an homage. For example, in his "audition tape" for the post of White House press secretary, where Colbert repeatedly uses this as he is pursued by Helen Thomas.
56* ''Series/Daredevil2015'': Played for laughs in [[Recap/Daredevil2015S2E1Bang the season 2 premiere]]. The Nelson & Murdock trio is playing an after-work game of pool at Josie's. Foggy at one point leaves to use the bathroom. While he's away, Karen takes this time to [[HandsOnApproach teach Matt how to play]]. Karen has just helped Matt line up a shot, and he takes it, just as Foggy comes back from the bathroom, causing Foggy to exclaim "NOOOO!!"
57-->'''Matt Murdock:''' That good, huh?\
58'''Karen Page:''' You sunk the eight-ball.\
59'''Matt Murdock:''' ''[grins]'' [[DoubleEntendre Well, something went in.]]\
60'''Karen Page:''' I tell you what, you boys re-rack. I will, uh, buy rounds for the rematch. ''[Karen heads off to the counter; an annoyed Foggy turns to Matt]''\
61'''Foggy Nelson:''' [[LeaveTheTwoLovebirdsAlone I leave you two alone for ONE minute!]]\
62'''Matt Murdock:''' [[SheIsNotMyGirlfriend She wanted to teach me!]] ''[Foggy smirks at him]'' [[EveryoneCanSeeIt What?]] ''[Matt takes another turn, and manages to sink two balls at once]''\
63'''Foggy Nelson:''' Showoff... ''[Matt laughs]''
64* ''Series/TheDarkCrystalAgeOfResistance'': Rian gets multiple ones in the first season, one from watching Mira's essence being taken and the last bits drunken by the Skeksis Chamberlain and the other from watching his father perform a Heroic Sacrifice to keep the Hunter away from his son.
65* ''Series/DoctorWho'':
66** One of the more effective uses of this in the old series is in [[Recap/DoctorWhoS10E1TheThreeDoctors "The Three Doctors"]], when Omega has only just realized that he is little more than a walking ghost — partly because his denial is also followed up by a very tortured primal scream that sounds disturbingly realistic.
67** [[Recap/DoctorWhoS13E3PyramidsOfMars "Pyramids of Mars"]]: Sutekh, whose end is hilariously interspersed throughout [[http://io9.com/5018136/doctor-who-was-never-about-showing-mercy this]] compilation.
68** [[Recap/DoctorWhoS14E4TheFaceOfEvil "The Face of Evil"]]: Xoanon turns it into a [[ClusterFBomb Cluster No Bomb]].
69** [[Recap/DoctorWhoS23E4TheUltimateFoe "The Ultimate Foe"]]: The Sixth Doctor screams a Big No when he is slowly disappearing into sand with hands grabbing him.
70** In [[Recap/DoctorWhoTVMTheTVMovie the TV movie by FOX]], the Eighth Doctor yells it when the Master kills Chang Lee and again when the Master kills Grace Halloway.
71** [[Recap/DoctorWhoS28E6TheAgeOfSteel "The Age of Steel"]]: After being turned into the Cyber-Controller, John Lumic does this twice: once when the Doctor and Mickey put an end to his plans of planetary conversion, and once when he's falling to his death.
72** [[Recap/DoctorWhos28E7TheIdiotsLantern "The Idiot's Lantern"]]: The Wire's last words before the Doctor traps it on a videotape, preventing it from stealing millions of faces to regain physical form.
73** Used very effectively in [[Recap/DoctorWhoS28E13Doomsday "Doomsday"]], though it isn't so much heard as conveyed though Ten's expression, when [[spoiler:Rose loses her grip and is nearly sucked into the VoidBetweenTheWorlds]].
74** [[Recap/DoctorWho2006CSTheRunawayBride "The Runaway Bride"]]: The Racnoss Empress' reaction when the Doctor uses the contents of the River Thames to drown her ravenous children.
75** [[Recap/DoctorWhoS29E4DaleksInManhattan "Daleks in Manhattan"]]: The Doctor gives one when Frank is captured by the Daleks' pig-slaves.
76** [[Recap/DoctorWhoS29E11Utopia "Utopia"]]: Lieutenant Atillo does one when Jake is disintegrated by radiation while attempting to set important machinery for the rocket.
77** [[Recap/DoctorWhoS29E13LastOfTheTimeLords "Last of the Time Lords"]]: The Tenth Doctor upon [[spoiler:the Master's death]]. The last of his kind, again.
78** Used at least twice in [[Recap/DoctorWho2007CSVoyageOfTheDamned "Voyage of the Damned"]] by... go on have a guess from the sacrifice made [[spoiler:by Foon Van Hoff]] to stop [[spoiler:one of the Host as well as Astrid when she]] {{tak|ingYouWithMe}}es [[spoiler: [[TakingYouWithMe Max Capicorn]]]] [[TakingYouWithMe with her]] [[spoiler: into the nuclear engine.]] The second was also unheard and accented with music just like [[Recap/DoctorWhoS28E13Doomsday "Doomsday"]].
79** [[Recap/DoctorWhoS30E2TheFiresOfPompeii "The Fires of Pompeii"]] has at least two characters Big-Noing ''simultaneously'' at its climax, the High Priestess and Lucius.
80** [[Recap/DoctorWhoS30E9ForestOfTheDead "Forest of the Dead"]] has several:
81*** Donna does it a few times when her virtual children disappear.
82*** Lux, when he learns that the Library's SelfDestructMechanism has been activated.
83*** The Doctor does it at least four times when CAL shuts down Dr. Moon and stops the Library's systems from working, making it that much harder to halt the self-destruct.
84** [[Recap/DoctorWhoS30E13JourneysEnd "Journey's End"]]: Martha shouts one when she is teleported [[spoiler:to the Crucible before she can activate the Osterhagen Key, a SelfDestructMechanism for ''the entire Earth'']].
85** [[Recap/DoctorWhoS30E15PlanetOfTheDead "Planet of the Dead"]]:
86*** The Doctor when he sees Christina jump down a shaft in the wrecked spaceship, despite the fact that she's harnessed to a winch.
87*** DI [=MacMillan=] when Christina flies off in the bus at the end.
88** [[Recap/DoctorWhoS31E8TheHungryEarth "The Hungry Earth"]]: The Doctor does it a few times when Amy is sucked into the ground.
89** Eleven actually shouts "Big no!" during [[Recap/DoctorWhoS31E11TheLodger "The Lodger"]].
90** Yelled quite a few times by [[spoiler:Rory, after Amy's death]] in [[Recap/DoctorWhoS31E12ThePandoricaOpens "The Pandorica Opens"]].
91** [[Recap/DoctorWhoS32E1TheImpossibleAstronaut "The Impossible Astronaut"]] has not one, not two, but [[RuleOfThree three]] Big Nos: [[spoiler:The first, from Amy as the Doctor is shot. The second, shortly after from River as the Doctor is shot mid-regeneration, killing him for real. The third, from the Doctor as Amy shoots the astronaut without realising who it is.]]
92** [[Recap/DoctorWhoS33E5TheAngelsTakeManhattan "The Angels Take Manhattan"]]: The Doctor [[spoiler:doesn't take the Ponds' death well.]]
93** [[Recap/DoctorWhoS33E11TheCrimsonHorror "The Crimson Horror"]]: Mrs. Gillyflower does it a few times, one example being when Clara jams the controls for the rocket carrying the Red Leech venom with a chair.
94** The Twelfth Doctor yells a gigantic one to the heavens in [[Recap/DoctorWhoS36E11WorldEnoughAndTime "World Enough and Time"]], when he is [[spoiler:reluctantly regenerating]]. It's actually much more saddening when the context is revealed in [[Recap/DoctorWhoS36E12TheDoctorFalls "The Doctor Falls"]].
95* ''Series/DontEatTheNeighbours'': Rabbit in one episode, after realizing that he has lost a bet he made earlier with Wolf and has to wear 'I Love Wolves' clothes.
96* The cliffhanger ending of season 2 of ''Series/{{Farscape}}'' has left Aeryn dead, John an unintelligible vegetable on an operating table, and Scorpius walking away having killed the doctor and recovered the neural chip from John's head. He tries to let out a big no. As his speech center has been carved out along with the chip it's more of a "FWWOOOOOOO", but the effort was there.
97* ''Series/{{The Flash|2014}}'':
98** Barry screams one of these when Blackout is about to kill Dr. Wells. The emotional surge reawakens his powers, allowing him to outrun Blackout's lightning bolts.
99** Killer Frost screams one as Cicada is about to stab Barry, awakening and blasting the villain with a cold blast. [[spoiler:The big shock here is that Killer Frost still has her powers despite Cicada's power-draining dagger.]]
100* Played for laughs in ''Series/{{Frasier}}'' in Part Two of "[[http://www.geocities.com/Hollywood/Derby/3267/624.html Shut Out in Seattle]]" -- and in slo-mo! -- when Faye asks Cassandra's name, undoing Frasier's double-episode-long SnowballLie that was keeping his relationship from exploding. He also dashes across Cafe Nervosa in slo-mo as he shouts it, scattering tables along the way, but doesn't get there in time to avoid disaster.
101%%* ''Series/TheFreshPrinceOfBelAir'': [[https://www.youtube.com/watch?v=lFuKgleL63M&feature=related "MAMA NOOOOOOOOOO!"]]
102%%** Also memorably, [[https://www.youtube.com/watch?v=b74BPt3T05g&feature=related this]] by Carlton in a NoFourthWall moment.
103* Monica gives one on ''Series/{{Friends}}'' when she and Rachel lose the trivia contest and have to give their apartment to Joey and Chandler as a result.
104* ''Series/GameOfThrones'':
105** Right after Joffrey gives Ser Ilys the order to [[spoiler:execute Ned Stark for treason,]] a witnessing Sansa screams several of these in her FreakOut.
106** In the last seconds of the episode "A Man Without Honour", [[spoiler: Maester Luwin upon seeing what he believes to be the charred corpses of Bran and Rickon Stark]].
107** Cersei when Tyrion arranges for her daughter Myrcella to be shipped off to Dorne.
108** Brienne yells this in "The Ghost of Harrenhal" after Renly is stabbed through the heart.
109** Stannis' attempt to rally his routed troops at the end of the Battle of the Blackwater quickly devolves into this.
110** Brienne's desperate screams as she is about to be raped by Locke and his men in "Walk of Punishment".
111* Parodied to the max in ''Series/GarthMarenghisDarkplace'', in which practically every dramatic / tragic moment in the series will be punctuated by someone -- usually Rick Daglass -- screaming "''Nooooooo''!!!" at the top of his lungs, in slow motion, for at least a full minute. Usually more than once.
112* ''Series/GreenWing'': Sue White's reaction to Mac withdrawing from the slave auction.
113* ''Series/HenryDanger'':
114** In Part 1 of "Space Invaders", Piper screams one when her Fred Lobster commercial is preempted a third time.
115** In "Danger Games", Piper gives one when she sees Jana Tetrazini gave the foreign prince the money he wanted.
116** In "Grand Theft Otto", Henry screams this when Ray accidentally lasers Jasper's mustache off.
117* Used often on ''Series/HerculesTheLegendaryJourneys'', particularly the episode "Not Fade Away".
118* In the season 3 finale of ''Series/{{Heroes}}'', [[spoiler:Angela Petrelli]] gives a ([[{{Narm}} possibly]]) frightening Big No upon seeing the bloody corpse of [[spoiler:Nathan]].
119* ''Series/{{Highlander}}'' plays it straight with Duncan [=MacLeod=] shouting [[spoiler: "DARIUS!"]] upon finding his dead body.
120** Duncan delivers one in the episode "Star Crossed" when Kalas has defeated and is about to kill [[spoiler: Fitz]].
121* ''Series/HoratioHornblower'', "The Wrong War": Horatio cries big no when his French TemporaryLoveInterest dies on a bridge, being shot in her back. So close to being rescued.
122* Parodied in ''Series/HotInCleveland'' when Victoria lets one out... after gaining one pound.
123* Wilson does this in "Out of the Chute" when he sees ''Series/{{House}}'' jump off of a hotel balcony, thinking he's committing suicide. Turns out he was just jumping into a pool.
124** [[https://www.youtube.com/watch?v=CrP0YznxKw8&t=2m0s CAAAAANNONBAAAAALL!!!!]]
125* ''Series/HowIMetYourMother'':
126** Blah Blah makes Ted say moderately big BigNo when she blackmails him into telling Marshall and Lily that he (Ted) remembers their romantic meeting with LoveAtFirstSight and similar sweet stuff quite differently, and that he and Lily were actually making out at a party.
127** Barney has a habit of doing Big No to close episodes. For example, when he learns that Marshall started a web page which is a count down to his next slap (Marshal having won the right to slap him five times whenever he chooses in a bet).
128** When Barney gets banned from Laser Tag, only a few tickets away from winning the remote-controlled helicopter, he drops to his knees and lets one out as he pulls a long string of tickets from his pockets.
129** Barney gets a silent one (complete with a skyward glance and camera pullout) in the beginning of "The Final Page" when, after two years since his last encounter, he is silenced by Marshall calling him on a jinx.
130** Parodied in "The Magician's Code":
131--->'''Barney''': What am I gonna be coming home to?\
132(fantasy) '''Quinn''': How would you like to have an eight-way with me and my six hottest stripper friends?\
133(real life) '''Robin''': How is that a punishment?\
134'''Barney''': Wait for it....\
135(fantasy) '''Quinn''': But I forbid you from filming it with your overhead camera that zooms in on whoever's being the loudest.\
136''[Barney sinks to his knees, and the camera zooms in on his "NOOOOOOOO!"]''
137* ''Series/{{iCarly}}'':
138** In "iKiss", iCarly presents a fake movie trailer for ''Kelly Cooper: Terrible Movie''; in the trailer, Natalie (played by Sam) tells Kelly (played by Carly) she will never fit in with the popular crowd, and this is her reaction as she runs out.
139** Carly gives one in "iGo One Direction" when she stops Freddie from drinking out of her water bottle which has her contagious jungle worm saliva.
140** In "iLost My Head in Vegas", Carly and Sam scream one in unison when Chumlee eats their potato chip shaped like Texas.
141%%* ''Series/{{Jeopardy}}'''s Alex Trebek gives one here: [[https://www.youtube.com/watch?v=h03QVlrwI_s]]
142* ''Franchise/KamenRider'':
143** ''Series/KamenRiderGaim'': Kouta has one upon not being able to save [[spoiler: team Raid Wild leader, Hase]] from being killed.
144** ''Series/KamenRiderBuild'' has a belt that normally punctuates his transformations with a loud "YEAH!" until he gets the Hazard Trigger adapter for it, which causes it to instead let out a "[[OhCrap YABEI (OH NO)!]]". [[TheBerserker Given what the resulting form is like,]] it's easy to see why it would prompt such a radical change of heart.
145*** In the same series, Kazumi has one as he futilely runs to try and prevent the above form from killing [[spoiler:his comrade, Aoba]].
146* ''Series/LegendsOfTomorrow''. Parodied when the cast are TrappedInTVLand in a ''Star Trek'' expy show.
147-->'''Spock!Ava:''' ''(bridge is in flames)'' The crew has perished.
148-->'''Kirk!Sara:''' ''(clutching dead RedShirt)'' NOOOOOOOOOOOOOOOOOO!
149-->'''Spock!Ava:''' There is no need to vocalize at that decibel. They're androids.
150-->'''Kirk!Sara:''' Oh, right. ''(drops Redshirt with an audible 'clunk')''
151* In the ''Series/{{Leverage}}'' episode "The Second David Job", the {{flashback}} showing Nate's reaction to the death of his son features a particularly harrowing use of this trope.
152** Hardison gets one in the ColdOpen to "The Grave Danger Job" after realizing he's been BuriedAlive.
153* In the Creator/DisneyChannel TV movie ''Film/TheLuckOfTheIrish'', the villain has one when he's tricked into being banished to Cleveland. "OHIO?!?! NOOOOOOOOOOO!!"
154* ''Series/{{MacGyver|1985}}'':
155** In "Flame's End", when [=MacGyver=]'s NewOldFlame's car blows up, the action slows down as [=MacGyver=] rushes toward the car, the soundtrack mutes, and [=MacGyver=] shouts her name.
156** When, in the VerySpecialEpisode "Blood Brothers", Jason Priestly's character accidentally shot himself, things went slow-mo and [=MacGyver=] yelled not that character's name, but the name of his childhood friend who died after accidentally getting shot.
157%%* Done hilariously in [[https://www.youtube.com/watch?v=qceSR5eZEec this MadTV skit]].
158* ''Series/MagnumPI'': In "Echoes of the Mind", Magnum lets out one as the Dupre sisters (played by Creator/SharonStone) kill themselves off screen in the last moment of the episode.
159* ''Series/{{Merlin|2008}}'' has one (well, two close together) at the very end of season 1, when [[spoiler: [[DisneyDeath he thinks]] Gaius is dead.]]
160** Also Sir Leon in series 3 when [[spoiler: Morgana has her men shoot into a crowd of innocent citizens after the knights refuse to swear loyalty to her.]]
161* ''Series/MiamiVice'' episode "Calderone's Demise" features a string of no less than eight successive iterations of the slow-motion Big No.
162** The episode "No Exit" concludes with Crockett shouting a Big No when [[spoiler: [[VigilanteExecution Rita shows up and shoots Amato when he's about to get off scot-free]].]]
163** Also Tubbs in "Little Miss Dangerous" when [[spoiler:[[DrivenToSuicide Jackie shoots herself]]]].
164* In the first episode of ''Series/TheMiddleman'', the MadScientist gives a Big No when Wendy and the Middleman thwart his plans.
165* Jack does this twice in the first ''Series/MidnightCaller'' episode after he realizes [[SelfOffense he's shot and killed his own partner]].
166* ''Series/MimpiMetropolitan'':
167** In episode 54, after Bambang proves his relationship with Melani and Melani outright says that she loves Bambang, [[LoveTriangle Alexi and Juna]] together let out a big "No!"
168** Dian screams a big "NOOO!" in episode 60 after confirming that the unattractive woman approaching him is indeed his date Niken.
169** After Pipin gives Bambang a "special" congee in episode 63, a jealous Alan goes outside to cry and exclaim a big "No!".
170* ''Series/MonarchLegacyOfMonsters'': In the flashback to [[Film/Godzilla2014 the destruction of San Francisco on G-Day]] in [[Recap/MonarchLegacyOfMonstersS1E1Aftermath episode 1]], Cate Randa can only scream a couple very loud no's and perform a FutileHandReach when she watches a bus full of schoolchildren plummet into San Francisco Bay as a result of the military spooking Godzilla knocking loose a piece of debris.
171* During a Mystery Lab segment on ''Series/MysteryHunters'', Doubting Dave, having showing how to make a homemade metal detector, drops the key for a chest of gold coins down a drain grate and then accidently closes the chest. He then proceeds to give a Big No.
172* Ned Bigby from ''Series/NedsDeclassifiedSchoolSurvivalGuide'' has used the Big No when things were going badly for him.
173** Notable in one episode where Ned starts yelling NOO! in a classroom before the opening credits begin and is still yelling it afterwards at Moze's locker he is still yelling NOO! until she shoves a sock in his mouth.
174* ''Series/TheOfficeUS'':
175** Michael has this reaction when he discovers Toby has returned from Central America. The fact that it's interrupted by the opening credits makes it ''funnier''. [[https://www.youtube.com/watch?v=umDr0mPuyQc Behold]].
176** Classic one with Pam after discovering Michael [[spoiler: is sleeping with her mother.]] Like the example above, made funnier by a break; in this case, she runs out of the office in a Big No, and the show soon cuts to a commercial break and upon return, she's still in the midst of her Big No in the parking lot.
177** Dwight gets a truly epic one when he gets the news that a billboard with himself and Andy in a rather unfortunate position has been defaced. [[https://www.youtube.com/watch?v=Rx6cLt13ndk In all it's glory.]]
178* ''Series/OnceUponATime'': In [[Recap/OnceUponATimeS5E6TheBearAndTheBow "The Bear and the Bow"]], [[WesternAnimation/{{Brave}} Merida]] yells one, while firing her arrow to save Harris, Hubert, and Hamish from the death penalty by the United Clan Lords.
179* ''Series/{{Oz}}'': Happens a few times.
180** The most notable one would be when Keller commits suicide and leaves Beecher thinking that he's the one who killed Keller.
181** Shirley Bellinger does this right before [[spoiler: she's hanged]].
182* ''Series/PairOfKings'': When Lanny learned there was another cousin he needed to get rid of to become King of Kinkow, he would have shouted one but somebody hit him with a coconut.
183* Pee-Wee Herman does it repeatedly in an episode of ''Series/PeeWeesPlayhouse'', after Jambi tells him that there is only one wish per show.
184* ''Franchise/PowerRangers'':
185** Kimberly screams this at the end of Part 1 of the ''Series/MightyMorphinPowerRangers'' episode "Ninja Quest", as the Rangers watch helplessly as the Thunder Megazord and the Tigerzord are destroyed by Rito.
186** ''[[Series/MightyMorphinPowerRangers Mighty Morphin Alien Rangers]]'': In the final episode of this arc, Billy [[https://www.youtube.com/watch?v=cHbBoTkijMM&feature=PlayList&p=351595918771688B&playnext=1_from=PL&index=49 shouts]] this when the Command Center is about to be blown up.
187** Jen yells this in the first episode of ''Series/PowerRangersTimeForce'', "Force From the Future", when Alex, the original Red Ranger, is mortally wounded by Ransik.
188** This happens a few times from Venjix when a plan fails in ''Series/PowerRangersRPM''.
189** Yelled by Void Knight twice before he is seemingly destroyed in the first season finale of ''Series/PowerRangersDinoFury''.
190* Played straight in ''Series/{{Primeval}}''. In episode 4 of Season 2, PluckyComicRelief Connor attempts to get around a particularly nasty creature to rescue his friend/crush Abby. The creature smacks him across the room, where he hits a wall and then drops out of sight, resulting in Abby uttering the Big No. While it was probably {{Narm}} to some viewers, actress Hannah Spearritt deserves serious credit here. The anguish on her face and in her voice actually makes the line '''work.'''
191* Daniel Grayson gets one in the ''Series/{{Revenge}}'' episode "Atonement" when [[spoiler: Kate, FBI agent and daughter of BigBad Malcolm Black, is about to shoot a beaten Emily - he gets in front of Emily, and Kate shoots him. Jack bursts in very shortly afterwards and takes down Kate, but by that time poor Daniel's become the latest example why on ''Revenge'' AnyoneCanDie]].
192* In ''Series/RizzoliAndIsles'', Maura's reaction to Hoyt threatening to kill Jane.
193* ''Series/RunningMan'':
194** Cast member Lee Gwang Soo is famous for screaming these out, [[RunningGag usually at the wrong time]]. The other cast members tend to be irritated when he does it [[ButtMonkey and don't hesitate to show it to him]].
195* ''Series/SabrinaTheTeenageWitch'': One of Salem Saberhagen's catchphrases in almost every season.
196* This is the CatchPhrase of ''Series/SaturdayNightLive'''s Mr. Bill.
197* ''Series/SavedByTheBellTheNewClass'': PlayedForLaughs when it takes place while the cast is at space camp in the Season 4 episode "The Fifth Wheel". Eric is supposed to be in a simulation space shuttle with a girl he has a crush on, but, on the day said simulation is set to take place, she becomes ill and can't attend, so Screech and Mr. Belding go in her place. Eric is unaware of the changes until Screech and Mr. Belding walk into the simulation shuttle.
198-->'''Eric''': *off-screen* Screech?! Mr. Belding?! NOOOOOOOOOOOOOOO!!
199* From ''Series/{{Scrubs}}'',
200** Dr. Cox: "nyet; negatory; mm-mm; nuh-uh; oh-oh; man-falling-off-of-a-cliff's No: [[https://www.youtube.com/watch?v=3zNjQecyjE8 Nooooooooooooo… Pffft".]] And [[http://youtu.be/unDTXk74uWo?t=2m38s this lil' gem.]]
201** Elliot when she sees a man she had made out with telling his wife. She does a slow motion NO while watching him mime a very tongue-heavy kiss and point to her.
202* A ''Series/{{Seinfeld}}'' episode ended with one from George when his plan to get his girlfriend to break up with him by suggesting a '[[ThreeWaySex menage-a-trois]]' backfires.
203* In ''Series/ShakeItUp'' "Protest It Up", this was [=CeCe=]'s reaction to the announcement of a SuddenSchoolUniform.
204* ''Series/{{Skins}}'' has a particularly odd one, when Sid wakes up after an alcohol-induced stupor to find pictures of his ex-girlfriend kissing another boy taped to his entire body.
205* Used as the season one cliffhanger of ''Series/{{Sliders}}'' (when [[spoiler:Quinn is shot and then cradled in Wade's arms -- Sabrina Lloyd can ''scream'']]), and again in season two (when Wade dreams of her past-life self being shot and cradled in her lover's arms).
206* ''Series/{{Smallville}}'':
207** In "[[Recap/SmallvilleS04E01Crusade Crusade]]", Kal-El lets one out after Martha exposes him to Black Kryptonite and causes him to split from Clark.
208** Clark does this several times as he cradles [[spoiler:Alicia's]] body in "[[Recap/SmallvilleS04E12Pariah Pariah]]"
209** In "[[Recap/SmallvilleS06E12Labyrinth Labyrinth]]", he also does one when [[spoiler:Chloe]] [[DiedInYourArmsTonight died in his arms]].
210** In the GrandFinale, "[[Recap/SmallvilleS10E21E22Finale Finale]]", Chloe does this when she notices that [[spoiler:Oliver, possessed by Darkseid, gave Lois a gold kryptonite ring to put on Clark's finger.]] Borders on SlowNo.
211* ''Series/{{Spaced}}'':
212** Parodied when Tim screams "NOOOO!!!" at the top of his lungs when cradling the body of his fallen best friend Mike, who has just been shot whilst saving Tim from an ambush by a hated rival and has just given a moving eulogy. It's worth noting, however, that this is merely a ''paintball'' game, and Mike, having merely been shot by a gob of paint, is far from dead; indeed, the scene immediately cuts to the two of them leaving the paintball centre casually chatting about how much fun they had.
213** Later parodied again in the first episode of the second season, in which Tim, recounting events in voice-over, introduces Mike -- who runs to the centre of the pavement, falls to his knees, and angstily screams [[BigWHY "WHYYYYYYY?!?!?!"]] at the top of his lungs ''for absolutely no reason whatsoever''. According to the ''Spaced'' Season 2 DVD'S ''Homage-o-meter'', this moment is a reference to ''Film/{{Platoon}}''.
214** Another one, when Tim fails to prevent Tyres from delivering his portfolio to a prospective employer (having learnt that it still contains an unflattering drawing of said prospective employer, having earlier turned down Tim's work, describing himself as a 'massive wanker'). Tim's dramatic Big No is rather undercut when Mike runs up seconds later asking with cheerful obliviousness whether he's managed to retrieve it. He and Tyres then ignore Tim entirely and start chatting amiably.
215* ''Series/StargateSG1'':
216** DiscOneFinalBoss Sokar does an inarticulate roar when he realizes that Apophis has outmaneuvered him, while making use of the Goa'uld "deep voice" effect. It comes off as pretty badass.
217** And then Apophis himself utters one as his [[GreyGoo Replicator]]-infested ship careens out of control into the fortress world he stole from Sokar.
218** Also done well when Anubis sees his fleet destroyed by Earth's Ancient defense weapon. He gets in one good big NO before his ship blows up. (Same actor, incidentally.)
219* ''Series/StarTrekTheOriginalSeries'':
220** In "[[Recap/StarTrekS1E27TheAlternativeFactor The Alternative Factor]]", Lazarus lets out a Big No when Kirk vanishes into an antimatter universe.
221** In "[[Recap/StarTrekS3E14WhomGodsDestroy Whom Gods Destroy]]", Kirk does this three times after he is forbidden to beam aboard the Enterprise after Scotty tells him to answer the chess problem. It turns out to actually be Garth of Izar in disguise.
222* ''Series/StarTrekTheNextGeneration'':
223** Worf gets a Big No in "[[Recap/StarTrekTheNextGenerationS1E4TheLastOutpost The Last Outpost]]", and Riker does it a moment later.
224** In "[[Recap/StarTrekTheNextGenerationS1E9HideAndQ Hide and Q]]", Q does this when he is called back to his people. Worf does it earlier in the episode when a Klingon woman appears and wants to have sex with him.
225** Data does this when he punches Picard in "[[Recap/StarTrekTheNextGenerationS2E6TheSchizoidMan The Schizoid Man]]".
226** In "[[Recap/StarTrekTheNextGenerationS3E23Sarek Sarek]]", Picard yells this after the mind-meld with Sarek.
227** Picard gets another Big No moment in "[[Recap/StarTrekTheNextGenerationS4E17NightTerrors Night Terrors]]" when he hallucinates that the turbolift ceiling is bearing down to crush him.
228** In "[[Recap/StarTrekTheNextGenerationS5E2Darmok Darmok]]", Picard does this when the transporter snatches him away.
229** Counsellor Troi screams a Big No in her hallucination in "[[Recap/StarTrekTheNextGenerationS5E12Violations Violations]]", and again as an old woman when the alien ambassador heads for the transporter room in "[[Recap/StarTrekTheNextGenerationS6E3ManOfThePeople Man of the People]]" and once more when Data stabs her shoulder in the turbolift in "[[Recap/StarTrekTheNextGenerationS7E5Phantasms Phantasms]]".
230** In "[[Recap/StarTrekTheNextGenerationS6E19FrameOfMind Frame of Mind]]", Riker screams a Big No before waking up from a nightmare.
231** In "[[Recap/StarTrekTheNextGenerationS6E23Timescape Timescape]]", Picard succumbs to temporal narcosis after laughing and repeatedly lets out a Big No.
232** Hugh does this at the climax of "[[Recap/StarTrekTheNextGenerationS6E24S7E1Descent Descent, Part 2]]" when Lore is going to kill Data.
233** Wesley Crusher screams this in the climax of "[[Recap/StarTrekTheNextGenerationS7E19JourneysEnd Journey's End]]".
234* ''Series/StarTrekDeepSpaceNine'':
235** In [[Recap/StarTrekDeepSpaceNineS01E20InTheHandsOfTheProphets the season one finale]], Sisko does this while charging towards an assassin. The scene is in slow motion, making his already deep voice ''[[{{Narm}} hilariously]]'' deep.
236** "[[Recap/StarTrekDeepSpaceNineS04E03TheVisitor The Visitor]]" has probably one of the best delivered "NO!"s ever when Jake sees his father disappear right before his eyes.
237** Gul Dukat does this when his daughter is killed in "[[Recap/StarTrekDeepSpaceNineS06E06SacrificeOfAngels Sacrifice of Angels]]".
238** Quark in "[[Recap/StarTrekDeepSpaceNineS06E12WhoMournsForMorn Who Mourns for Morn?]]" when he finds out that his newly won bounty of gold-pressed latinum actually has no latinum within it.
239* ''Series/StarTrekVoyager'':
240** In "[[Recap/StarTrekVoyagerS2E23TheThaw The Thaw]]", Kim screams "NOOOOOO!" when the Clown is about to cut him with a scalpel [[spoiler:before being stopped by the Doctor]].
241** In "[[Recap/StarTrekVoyagerS4E23One One]]", Seven screams this trope after the Doctor goes offline, leaving her to deal with the [[spoiler:hallucinations she's having, plus the fact that every system is failing]] by herself.
242** From the WorldOfHam holoprogram ''Film/TheAdventuresOfCaptainProton'' in "[[Recap/StarTrekVoyagerS5E1Night Night]]":
243--->'''Chaotica:''' Your once proud country will fall to its knees. How ironic that I am using your rocket ship to lead my space force into battle!\
244'''Kim:''' You're wrong, Chaotica. Before you came on board, someone pushed the [[SelfDestructMechanism self destruct button]]. In three minutes, we'll all be dead.\
245'''Chaotica:''' ''[with appropriate LargeHam body language]'' NOOOOOOOOOOOOOOOOOOOOOO!
246* ''Series/StarTrekPicard'':
247** In "[[Recap/StarTrekPicardS1E01Remembrance Remembrance]]", Picard yells out "No!" when [[spoiler:Dahj is blown up in front of him]].
248** In "[[Recap/StarTrekPicardS1E08BrokenPieces Broken Pieces]]", [[spoiler:Seven of Nine as a Borg Queen]] shouts a VoiceOfTheLegion "NO!" when the unprocessed Borg are ejected into space. Not only does she lose thousands of drones, but she can also feel them die because her mind is connected to theirs.
249* ''Series/{{Supernatural}}'':
250** Sam lets one out at the end of [[Recap/SupernaturalS01E01Pilot the pilot episode]] when Jessica dies.
251** In [[Recap/SupernaturalS02E19FolsomPrisonBlues "Folsom Prison Blues"]], the guard who is killed in the teaser screams, "No... no... No! No! Nooo! No! No! Nooo! Aah! Nooooo!"
252** In "[[Recap/SupernaturalS02E21AllHellBreaksLoosePartOne All Hell Breaks Loose, Part 1]]", Dean lets out one when he just finally found Sam and seen him get stabbed in the back. Helped by the fact that the viewers are probably feeling the same thing and his look of complete panic and devastation at the sight of his little brother getting knifed.
253** This is Gordon's reaction in "[[Recap/SupernaturalS03E07FreshBlood Fresh Blood]]" as he's being [[spoiler:turned into a vampire]].
254** Dean reacts this way in "[[Recap/SupernaturalS05E22SwanSong Swan Song]]" when Sam/Lucifer telepathically snaps [[spoiler:Bobby Singer]]'s neck.
255* In the SciFi miniseries ''Series/TinMan'', Wyatt Cain does a Big No during a FlashbackNightmare.
256* On an episode of ''Series/TopGearUK'' in which Richard Hammond was driving the Bugatti Veyron in a two-way drag race against a Eurofighter Typhoon jet when said plane overtook him on the home-stretch to cross the finish-line first.
257* ''Series/{{Torchwood}}'': In "[[Recap/TorchwoodS1E5SmallWorlds Small Worlds]]", Gwen lets out a slightly small one when Jack gives Jasmine up to the Faeries. Jasmine's mother Lynn ''howls'' two of them when she hits her RageBreakingPoint a few moments later.
258* ''Series/TheTwilightZone1985'': In "[[Recap/TheTwilightZone1985S2E9 Private Channel]]", Mr. Williams gets one when he realizes that blowing up the plane would ruin other people's lives in the same way that his life was ruined after his wife and daughter were killed.
259* Played straight in ''Series/TwinPeaks'', when sheriff Truman breaks the sad news to Laura's parents.
260* ''Series/{{V 2009}}'' has not one, but TWO of epic proportions when Anna experiences her first human emotion in the Season 1 finale.
261* In ''Series/TheVampireDiaries'', a handful of characters did this, but without a doubt, Stefan's defiant "'''NO!'''" to Klaus in 3x05 takes the cake:
262-->'''Klaus:''' Turn. It. Off.\
263'''Stefan:''' ''[shoving Klaus]'' '''NO!'''
264* ''Series/TheWalkingDead2010'':
265** Rick let out a [[{{Narm}} particularly infamous one]] upon learning that [[spoiler:his wife Lori [[DeathByChildbirth died during childbirth]]]]. [[https://www.youtube.com/watch?v=_KEJSQYv-uM See it here]].
266** And again along with Maggie [[spoiler:when the Governor partially decapitates Hershel in front of everyone at the prison]].
267*** Maggie wails one again [[spoiler:in horror and grief when she witnesses Negan executing Glenn]], and again [[spoiler:with anger when Rick eventually decides to spare Negan.]]
268** Daryl yells one [[spoiler:when trying to shield Carol from seeing that Henry, her adopted son, was killed and beheaded by Alpha.]]
269* ''Series/TheWheelOfTime2021'': Nynaeve shouts this after [[spoiler:Lan is mortally injured in the fight to recapture Logain. She then channels enough to heal him and everyone else in the room simultaneously]].
270* ''Series/WithoutATrace''. An FBI agent lets out one of these when a Middle Eastern doctor suspected of being a terrorist is sniped by the police, because the guy was actually trying to ''warn'' people about an impending attack and the agent had almost convinced him to surrender when he did something the cops mistook as a threatening gesture. Unusually, the audience doesn't hear the "No", but it's obvious from his body language and reading his lips.
271* ''Series/TheXFiles'':
272** In "[[Recap/TheXFilesS06E14Monday Monday]]", Scully and Mulder are doomed to endlessly repeat the Big No, as they are trapped in a GroundhogDayLoop which always results in their deaths.
273** "[[Recap/TheXFilesS08E14ThisIsNotHappening This is Not Happening]]" has a heart-wrenching version of this trope, made all the more tear-jerking by Gilliam Anderson's performance. Scully has spent nearly a year desperately searching for Mulder, who was abducted by aliens. Finally, Mulder is returned, but not alive. The scene when Mulder's body is returned is emotional enough, with Scully insisting he needs medical attention and Doggett physically restraining her and dragging her away from the area. When Scully manages to break free, she runs at full speed to find the supernatural healer she had been investigating; he had been bringing abductees back from the brink of death. She bursts into the compound to find that he and his followers are gone. Emotionally and physically exhausted, she collapses on the floor, screams a BigNo and wails in anguish.
274* ''Series/{{Yellowjackets}}'':
275** Shauna lets out a particularly chilling one of these in the season 1 finale when she [[spoiler: discovers Jackie’s body]]. Doubles as HowlOfSorrow and [[spoiler: DeathWail]].
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