History Main / WithGreatPowerComesGreatInsanity

28th Feb '17 4:54:15 AM LegitimateIdiot
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* In an episode of ''Franchise/{{Ninjago}}'''s fourth season, Kai briefly becomes corrupted by the power of [[EvilMentor Master Chen]]'s Staff of Elements and it causes his suppressed envy of [[TheChosenOne Lloyd]] becoming the Green Ninja to surface. Fortunately, it doesn't last long.

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* In an the episode "The Forgotten Element" of ''Franchise/{{Ninjago}}'''s ''WesternAnimation/{{Ninjago}}'''s fourth season, Kai briefly becomes corrupted by the power of [[EvilMentor Master Chen]]'s Chen's Staff of Elements and it causes his suppressed envy of [[TheChosenOne Lloyd]] becoming the Green Ninja to surface. Fortunately, it doesn't last long.
27th Feb '17 11:20:06 PM BattleMaster
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* This is the hat of pretty much ever version of Galvatron that's ever appeared in any iteration of ''WesternAnimation/TheTransformers''. He's usually a powered-up version of Megatron, and he's also usually [[AxCrazy batshit insane]].
16th Feb '17 1:53:33 PM rafi
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* ''Franchise/{{Batman}})'':

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* ''Franchise/{{Batman}})'':''Franchise/{{Batman}}'':
16th Feb '17 1:53:12 PM rafi
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* '''Franchise/{{Batman}})'':

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* '''Franchise/{{Batman}})'':''Franchise/{{Batman}})'':
16th Feb '17 1:52:47 PM rafi
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* During an episode of ''[[Anime/PrettySammy Magical Project S]]'', Misao dreams about having magic powers and the "fun" she would have using them. When she actually ''got'' said powers, she becomes the arguably insane persona of Pixy Misa (who tortures the entire main cast).
* In ''LightNovel/HaruhiSuzumiya'', the titular character is kept LockedOutOfTheLoop regarding the fact that her friends are all examples of the very weirdness she seeks to find for this very reason. Already a JerkAss {{Tsundere}}, they're afraid that if she discovers that aliens, espers, dimension/time travellers and other such entities are real, she will manage to make the intuitive leap and realise that she is a RealityWarper of such power that she is, in all practical terms, a goddess. Given how much strain she can put on the fabric of reality even while she's unaware of her power, they naturally fear that allowing someone of her attitudes and ethics full control of her abilities would effectively bump her to EldritchAbomination status.
* ''Anime/CowboyBebop'', "Pierrot le Fou": A government test subject is given superhuman assassin skills, and then goes crazy as a side-effect. Given [[PlayingWithSyringes the methods shown]] (the fact that no explanation of any sort is given for what, precisely, is being done, it's all the more disturbing), it's not too surprising.

to:

* During an episode of ''[[Anime/PrettySammy Magical Project S]]'', Misao dreams about having magic powers and Anime classic ''Manga/{{Akira}}'' centers around the "fun" she would have using them. When she actually ''got'' said powers, she becomes the arguably insane persona results of Pixy Misa (who tortures the entire main cast).
* In ''LightNovel/HaruhiSuzumiya'', the titular character is kept LockedOutOfTheLoop regarding the fact that her friends are all examples of the very weirdness she seeks to find for this very reason. Already a JerkAss {{Tsundere}}, they're afraid that if she discovers that aliens, espers, dimension/time travellers and other such entities are real, she will manage to make the intuitive leap and realise that she is a RealityWarper of such power that she is, in all practical terms, a goddess. Given how much strain she can put on the fabric of reality even while she's unaware of her power, they naturally fear that allowing someone of her attitudes and ethics full control of her abilities would effectively bump her to EldritchAbomination status.
* ''Anime/CowboyBebop'', "Pierrot le Fou": A
government test subject is given superhuman assassin skills, experimentation on a Japanese gang member with a serious inferiority complex. As a result, the newly created BigBad Tetsuo runs amok with his telekinetic powers until he mutates, explodes, and then goes crazy as forms either a side-effect. Given [[PlayingWithSyringes new universe [[GainaxEnding or... something]].
* In ''Manga/{{Berserk}}'',
the methods shown]] (the fact main character finds that no explanation of he can enter into an UnstoppableRage like never before due to his recently obtained UpgradeArtifact. However, he finds himself BlessedWithSuck due to the [[PowerDegeneration incredible physical strain it puts on his body]], and he could [[TheCorruption accidentally]] FaceHeelTurn at any sort is given for what, precisely, is being done, it's moment and kill all the more disturbing), it's not too surprising.of his companions.



* ''Anime/MobileSuitGundam'': A common theme in the franchise, most notably ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'' and ''[[Anime/MobileSuitGundamZZ Gundam ZZ]]'' where all Newtypes are often mentally unstable in some fashion, may have forms of amnesia, be brainwashed, though in some other cases they're just plain stubborn. This is particularly true of "Cyber-Newtypes", people who originally had no special powers but had their brains surgically altered (almost always against their will) to become Newtypes.
** ''[[Anime/MobileSuitGundamSeed Gundam SEED]]'' plays on this by giving [[PsychoSerum performance-enhancing drugs]] and treatments to criminals who are doing it in exchange for a full pardon. Naturally, this drives them to insanity in combat... which is what was planned. As a result, they are given drugs in such doses that by the time combat is over, they are having withdrawal symptoms and are manageable again. Withdrawal will also kill them if they are deprived of the drugs for too long, thus ensuring their loyalty.
** In ''[[Anime/MobileSuitGundamSEEDDestiny Gundam SEED Destiny]]'', Blue Cosmos has been attempting to create "Artificial Coordinators" through depraved combinations of surgery, hypnosis, [[TrainingFromHell insane training]], drugs, and other horrors. Of the dozens of children selected for the project, only a few survived, and those seen in the series are all, understandably, raving mad and almost incapable of functioning normally in life. Without routine "maintenance", their bodies break down and they die. The sad thing is that in comparison to ''SEED'''s pre-Extended (see above), they're all poster children for Mental Health Week: Stellar Louissier, for example, is a sweet [[PsychopathicManchild if incredibly childish]] [[TheWoobie and still very sympathetic]] young woman who loves to dance, as long as you don't [[BerserkButton tell her that either she or her friends will die]], in which case [[SuperpoweredEvilSide an alternate personality emerges that could give even the drug-enhanced pilots of the previous series some lessons in brutality]].
** In ''[[Anime/MobileSuitGundamWing Gundam Wing]]'', the ZERO System gives the person who uses it incredible reaction times and tactical predictions bordering on prescience. The problem is, without any guidance, the System evaluates ''everything'' as a potential threat, and plugs into the user's mind all of the possible attacks that could happen. If he can't focus his mind and give the System the necessary context (which is hard to do when you're conflicted as to why you're fighting), those violent predictions start afflicting whatever he starts thinking about (like, say, his girlfriend, or that nice peaceful space colony over there), and soon enough he's a psychopath slaughtering whatever the System says is his enemy.
* Similarly, ''Anime/{{Gasaraki}}'' has mecha pilots who were given a cocktail of boosting drugs in order to improve their battle performance (without their knowledge or consent, and said drugs was actually fluid extracted from the muscles of a 1000 year old demon), and the inevitably go berserk from the effects, before either lapsing into a coma or suffering cardiac arrest.

to:

* ''Anime/MobileSuitGundam'': A common theme in the franchise, most notably ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'' and ''[[Anime/MobileSuitGundamZZ Gundam ZZ]]'' where all Newtypes are often mentally unstable in some fashion, may have forms of amnesia, be brainwashed, though in some other cases they're just plain stubborn. This is particularly true of "Cyber-Newtypes", people who originally had no special In ''Manga/{{Bleach}}'', Ichigo's powers but had their brains surgically altered (almost always against their will) to become Newtypes.
** ''[[Anime/MobileSuitGundamSeed Gundam SEED]]'' plays on this by giving [[PsychoSerum performance-enhancing drugs]] and treatments to criminals who
are doing it in exchange for a full pardon. Naturally, this drives them to insanity in combat... which is what was planned. As a result, they are given drugs in such doses that by the time combat is over, they are having withdrawal symptoms and are manageable again. Withdrawal will also kill them if they are deprived of the drugs for too long, thus ensuring their loyalty.
** In ''[[Anime/MobileSuitGundamSEEDDestiny Gundam SEED Destiny]]'', Blue Cosmos has been attempting to create "Artificial Coordinators" through depraved combinations of surgery, hypnosis, [[TrainingFromHell insane training]], drugs, and other horrors. Of the dozens of children selected for the project, only a few survived, and those seen in the series are all, understandably, raving mad and almost incapable of functioning normally in life. Without routine "maintenance", their bodies break down and they die. The sad thing is that in comparison to ''SEED'''s pre-Extended (see above), they're all poster children for Mental Health Week: Stellar Louissier, for example, is a sweet [[PsychopathicManchild if incredibly childish]] [[TheWoobie and still very sympathetic]] young woman who loves to dance, as long as you don't [[BerserkButton tell her that either she or her friends will die]], in which case
greatly amplified when his [[SuperpoweredEvilSide an alternate personality emerges that could give even the drug-enhanced pilots of the previous series some lessons in brutality]].
** In ''[[Anime/MobileSuitGundamWing Gundam Wing]]'', the ZERO System gives the person who uses
inner Hollow]] is released, but he suppresses it incredible reaction times and tactical predictions bordering on prescience. The problem is, without any guidance, the System evaluates ''everything'' as a potential threat, and plugs into the user's mind all of the possible attacks that could happen. If he can't focus his mind and give the System the necessary context (which is hard to do when you're conflicted as to why you're fighting), those violent predictions start afflicting whatever he starts thinking about (like, say, his girlfriend, or that nice peaceful space colony over there), and soon enough he's a psychopath slaughtering whatever the System says is his enemy.
* Similarly, ''Anime/{{Gasaraki}}'' has mecha pilots who were given a cocktail of boosting drugs
in order to improve preserve his sanity. Even then, suppressing it doesn't work in the long run. It takes a major BattleInTheCenterOfTheMind for him to gain control over it. [[spoiler:During the third battle, the Hollow isn't trying to hurt Ichigo, his goal is to make Ichigo accept him as part of his soul instead of suppressing him. Once Ichigo does that, he becomes a PhysicalGod.]]
** Aizen has never been entirely sane, but his insanity slowly becomes more and more obvious the greater his power becomes. [[spoiler:By the time he's fused with the Hougyoku, he's fullblown crazy.]]
** Kouga (from the third anime filler arc) fits this trope perfectly. His power to ([[spoiler:force others' zanpakutou to do his bidding]]) is truly enormous, and he quickly goes insane. Kouga had plenty of external help on that trip to insanity, but his obsession with his own great power made him a little unbalanced even when he was still one of the good guys.
* Human-type homunculi of ''Manga/BusouRenkin'' are a borderline example, as while becoming a homunculus does grant a human great power, none of the ones seen seem like they were particularly sane beforehand. Victor, though, is a dead-on example, as becoming a Victor made him do a FaceHeelTurn from an alchemic warrior to a demigod attempting to destroy all alchemy.
* In ''Manga/ChronoCrusade'', Joshua Christopher is given the horns of a demon by the BigBad. The power is too much for the small boy, however -- within minutes he's gone completely insane, using his powers to freeze everyone around him in time and destroy the orphanage he lived in. It gets '''so''' bad that later [[spoiler:he can't even remember his own sister]].
** It's even worse than that in the manga. [[spoiler:It turns out that a demon's horns, in addition to granting them direct access to the Astral line, are also what connect them to
their battle performance (without "mother", Pandemonium]]. That constant, painful noise that Joshua was complaining about? [[spoiler:It was an EldritchAbomination ''constantly [[MindRape mind-raping]] him.'']]
** In the anime, though the horns did damage his mind on
their knowledge or consent, own, the "noise" he complained of was the thoughts of every human around him. In other words, uncontrollable telepathy that forced him to hear what every single person around him was thinking, all at once, all the time. No wonder he went mad if he had to be near people.
* ''Manga/{{Claymore}}'': A Claymore who activates her demonic powers (i.e. "Awakens") gains great power but stands a chance of losing her humanity
and said drugs was actually fluid extracted from the muscles of a 1000 year old demon), and the inevitably go berserk from the effects, before either lapsing turning into a coma or suffering cardiac arrest.human flesh-craving demon permanently.
* ''Anime/CowboyBebop'', "Pierrot le Fou": A government test subject is given superhuman assassin skills, and then goes crazy as a side-effect. Given [[PlayingWithSyringes the methods shown]] (the fact that no explanation of any sort is given for what, precisely, is being done, it's all the more disturbing), it's not too surprising.



* Anime classic ''Manga/{{Akira}}'' centers around the results of government experimentation on a Japanese gang member with a serious inferiority complex. As a result, the newly created BigBad Tetsuo runs amok with his telekinetic powers until he mutates, explodes, and forms either a new universe [[GainaxEnding or... something]].

to:

* Anime classic ''Manga/{{Akira}}'' centers around the results Contractors in ''Anime/DarkerThanBlack'' appear to have "complete lack of government experimentation on a Japanese gang member with a serious inferiority complex. As a result, the newly created BigBad Tetsuo runs amok with his telekinetic conscience" as one side-effect of gaining their powers until he mutates, explodes, (and their powers are usually destructive in nature). Even the sanest among them are AffablyEvil or {{Anti Hero}}ic at best and forms either a new universe [[GainaxEnding or... something]].have no problems with taking lives, though whether it is the powers themselves that cause it or the result of the extensive {{masquerade}} surrounding them and how their fellow humans treat them is up to debate.



* In ''Manga/DevilmanLady'', the entire story centres around evolution and the gaining of vast, beast-like powers by ordinary people, many of whom go insane. The main character, Jun, for much of the series appears to be descending into insanity herself despite her best efforts not to. The climax moment of this aspect of the series is when, having been prevented from indulge her bloodlust by the Human Alliance, she attacks a nurse, but ultimately overcomes her instincts by drawing her own blood.
* Both played straight and averted in Franchise/{{Digimon}}. On the one hand, you have Digimon like Omnimon, who are immensely powerful, but perfectly sane, noble, and benevolent. On the other hand, you have Beelzemon and Diaboromon, who are driven only by their desire to gain power and cause destruction.
** Myotismon is already incredibly powerful, but becoming his mega form, the colossal VenonMyotismon, turns him from TheChessmaster to an all devouring mindless monster.



* In ''Manga/{{Bleach}}'', Ichigo's powers are greatly amplified when his [[SuperpoweredEvilSide inner Hollow]] is released, but he suppresses it in order to preserve his sanity. Even then, suppressing it doesn't work in the long run. It takes a major BattleInTheCenterOfTheMind for him to gain control over it. [[spoiler:During the third battle, the Hollow isn't trying to hurt Ichigo, his goal is to make Ichigo accept him as part of his soul instead of suppressing him. Once Ichigo does that, he becomes a PhysicalGod.]]
** Aizen has never been entirely sane, but his insanity slowly becomes more and more obvious the greater his power becomes. [[spoiler:By the time he's fused with the Hougyoku, he's fullblown crazy.]]
** Kouga (from the third anime filler arc) fits this trope perfectly. His power to ([[spoiler:force others' zanpakutou to do his bidding]]) is truly enormous, and he quickly goes insane. Kouga had plenty of external help on that trip to insanity, but his obsession with his own great power made him a little unbalanced even when he was still one of the good guys.
* Itsuki's Glam Sight in ''LightNovel/RentalMagica'' gives him his CrouchingMoronHiddenBadass ability that makes him just the right sort of leader for his team of mages. However, the more he uses it, the more it eats away at his sanity. Thus, Honami and the others warn him not to use it as much as possible.

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* In ''Manga/{{Bleach}}'', Ichigo's powers are greatly amplified when his [[SuperpoweredEvilSide inner Hollow]] is released, but he suppresses it Any Diclonius in order to preserve his sanity. Even then, suppressing it doesn't work in ''Manga/ElfenLied'', except Nana. [[spoiler:Maybe. It's heavily implied that their murderous tendencies might actually be a result of abuse, particularly at the long run. It takes a major BattleInTheCenterOfTheMind for him to gain control over it. [[spoiler:During the third battle, the Hollow isn't trying to hurt Ichigo, his goal is to make Ichigo accept him as part of his soul instead of suppressing him. Once Ichigo does that, he becomes a PhysicalGod.Institute. Might. It's ultimately left ambiguous.]]
* ''Manga/FairyTail'':
** Aizen has never been entirely sane, This was the result of Elfman's failed Take Over spell against a monster called The Beast a few years before the story started. In order to save his older sister, he used his magic on a gigantic magical monster, but wasn't quite strong enough to control it. He saved his insanity slowly older sister, and killed the younger [[spoiler:they thought)]]. Out of fear of this happening again, he stopped using full-body Take Over magic (eventually, he becomes more and more obvious the greater able to control his power becomes. [[spoiler:By power).
** By
the time he's fused Natsu fights Laxus during the Battle of Fairy Tail arc, Laxus has officially become so mad with the Hougyoku, he's fullblown crazy.]]
** Kouga (from the third anime filler arc) fits
power that he loses all reason, and tries to destroy everything and everyone. His state of madness is generally indicated by BlankWhiteEyes, and he regains his irises and pupils during his brief moments of lucidity.
* In ''LightNovel/FateZero'' and ''VisualNovel/FateStayNight'', both Berserker got Mad Enhancement, a Class Skill that trades one’s sanity for added power.
* In ''Anime/FullmetalAlchemist'', Ed gets a power overload from contact with a huge amount of unfinished Philosopher's Stone and goes full-on uncontrollable with so much power it is described that if
this trope perfectly. His goes on, he can attain enough power to ([[spoiler:force others' zanpakutou be god-like (even freaking out the Homunculi) until a CooldownHug snaps him out of it.
* Played with in ''Manga/FutureDiary'', where some individuals who're not so mentally sound
to do his bidding]]) is truly enormous, begin with are given the ability to predict the future and he quickly told by God to kill each other [[ThereCanBeOnlyOne Highlander style]]. Whether the ability, situation, or just generally being that nuts before drives them [[AxCrazy crazy]] is up for interpretation.
* ''Anime/{{Gasaraki}}'' has mecha pilots who were given a cocktail of boosting drugs in order to improve their battle performance (without their knowledge or consent, and said drugs was actually fluid extracted from the muscles of a 1000 year old demon), and the inevitably go berserk from the effects, before either lapsing into a coma or suffering cardiac arrest.
* In ''Manga/GetBackers'', Ginji and [[spoiler:Kazuki]] have this as a side effect of their {{Superpowered Evil Side}}s. Ginji's "Lightning Lord" aspect is quiet, cold, and utterly ruthless, while [[spoiler:Kazuki
goes insane. Kouga had plenty of external help on that trip to insanity, but his obsession with his own great power made him a little unbalanced even absolutely berserk when he was still one of releases the good guys.
seal on his "Stigma," becoming vicious and blood-thirsty]]. They're always sorry afterward.
* Itsuki's Glam Sight in ''LightNovel/RentalMagica'' gives In ''New ''Anime/GetterRobo'', Ryouma lets himself get hopped up on Getter Energy, powering him his CrouchingMoronHiddenBadass ability that makes him just and New Getter-1 to new heights to combat the right sort of leader for his team of mages. Four Heavenly Kings. However, Ryouma loses himself and Hayato and Benkei have to try to reel him back in before his actions get them killed.
* In ''LightNovel/HaruhiSuzumiya'',
the more he uses it, titular character is kept LockedOutOfTheLoop regarding the more it eats away at his sanity. Thus, Honami fact that her friends are all examples of the very weirdness she seeks to find for this very reason. Already a JerkAss {{Tsundere}}, they're afraid that if she discovers that aliens, espers, dimension/time travellers and other such entities are real, she will manage to make the others warn him not to use it as intuitive leap and realise that she is a RealityWarper of such power that she is, in all practical terms, a goddess. Given how much as possible.strain she can put on the fabric of reality even while she's unaware of her power, they naturally fear that allowing someone of her attitudes and ethics full control of her abilities would effectively bump her to EldritchAbomination status.
* The previous GameMaster from ''Manhua/InfinityGame'' was driven completely insane by the infinite power he wielded in his world, so he drove everybody else insane and made them kill each other. He eventually grew bored of it and killed everybody.



* Contractors in ''Anime/DarkerThanBlack'' appear to have "complete lack of conscience" as one side-effect of gaining their powers (and their powers are usually destructive in nature). Even the sanest among them are AffablyEvil or {{Anti Hero}}ic at best and have no problems with taking lives, though whether it is the powers themselves that cause it or the result of the extensive {{masquerade}} surrounding them and how their fellow humans treat them is up to debate.
* Human-type homunculi of ''Manga/BusouRenkin'' are a borderline example, as while becoming a homunculus does grant a human great power, none of the ones seen seem like they were particularly sane beforehand. Victor, though, is a dead-on example, as becoming a Victor made him do a FaceHeelTurn from an alchemic warrior to a demigod attempting to destroy all alchemy.
* [[StrawNihilist Sensui]] from ''Manga/YuYuHakusho'' would probably count, as he seems to have been at least ''slightly'' cracked before he [[FaceHeelTurn officially]] [[StartOfDarkness went insane on the mission to the Black Black Club]]. (As a child, he says that he is the [[WellIntentionedExtremist "warrior for justice"]]. Wondering why demons only attacked you as opposed to other people, and knowing about the extent of your own power to destroy other living things leads to this trope.)
* In ''Manga/ChronoCrusade'', Joshua Christopher is given the horns of a demon by the BigBad. The power is too much for the small boy, however -- within minutes he's gone completely insane, using his powers to freeze everyone around him in time and destroy the orphanage he lived in. It gets '''so''' bad that later [[spoiler:he can't even remember his own sister]].
** It's even worse than that in the manga. [[spoiler:It turns out that a demon's horns, in addition to granting them direct access to the Astral line, are also what connect them to their "mother", Pandemonium]]. That constant, painful noise that Joshua was complaining about? [[spoiler:It was an EldritchAbomination ''constantly [[MindRape mind-raping]] him.'']]
** In the anime, though the horns did damage his mind on their own, the "noise" he complained of was the thoughts of every human around him. In other words, uncontrollable telepathy that forced him to hear what every single person around him was thinking, all at once, all the time. No wonder he went mad if he had to be near people.
* Due to [[PhlebotinumBreakdown metatron poisoning]], Radium of the ''VideoGame/ZoneOfTheEnders'' {{O|riginalVideoAnimation}}VA, ''Idolo'', goes completely off the deep end after spending just a moment too long in the cockpit of the Idolo. [[DownerEnding This does not end well for anyone.]] The same can be said for Ridley Nohman with his Anubis, from a rather immoral rebel leader (in ''Dolores, I'') into destruction-obsessed guy (''ZOE: The 2nd Runner'').
* In ''Manga/DevilmanLady'', the entire story centres around evolution and the gaining of vast, beast-like powers by ordinary people, many of whom go insane. The main character, Jun, for much of the series appears to be descending into insanity herself despite her best efforts not to. The climax moment of this aspect of the series is when, having been prevented from indulge her bloodlust by the Human Alliance, she attacks a nurse, but ultimately overcomes her instincts by drawing her own blood.
* In ''Manga/TenjhoTenge'', characters who possess supernatural powers are remarked as always being in danger of becoming insane. A classic example of this is Natsume Shin, Maya and Aya's elder brother who was overwhelmed by his powers and started killing random people. This leads to powers being referred to as "Dragons" that will devour their wielder's sanity. Because of this, there is a tremendous social stigma attached to the possession of supernatural abilities, which naturally only serves to aggravate the problem even more.
* ''Anime/SCryed'' shows this one off pretty well, with most (if not debatably all) of the Alter Power users being completely insane to some degree. Particular samples include Straight Cougar, most of the one-shot villains, and our main Kazuma (whose personality initially flips between JerkWithAHeartOfGold and nice-guy… only for the nice guy to completely vanish by the final battle). It's worth noting that both Cougar and Kazuma are rare ''heroic'' examples of this trope. They're clearly bonkers, but they're still the good guys.

to:

* Contractors in ''Anime/DarkerThanBlack'' appear In ''LightNovel/KumoDesuGaNaniKa'' the Skills corresponding with the SevenDeadlySins ''and'' SevenHeavenlyVirtues grant the bearer powerful abilities and Ruler authority at the cost of slowly warping their soul to have "complete lack of conscience" as one side-effect of reflect the sin or virtue. The only way to avoid this is by not activating the Skill or gaining their Heresy Resistance, which reduces the damage to the soul.
* During an episode of ''[[Anime/PrettySammy Magical Project S]]'', Misao dreams about having magic
powers (and their powers are usually destructive in nature). Even and the sanest among them are AffablyEvil or {{Anti Hero}}ic at best and have no problems with taking lives, though whether it is the powers themselves that cause it or the result of the extensive {{masquerade}} surrounding them and how their fellow humans treat them is up to debate.
* Human-type homunculi of ''Manga/BusouRenkin'' are a borderline example, as while becoming a homunculus does grant a human great power, none of the ones seen seem like they were particularly sane beforehand. Victor, though, is a dead-on example, as becoming a Victor made him do a FaceHeelTurn from an alchemic warrior to a demigod attempting to destroy all alchemy.
* [[StrawNihilist Sensui]] from ''Manga/YuYuHakusho''
"fun" she would probably count, as he have using them. When she actually ''got'' said powers, she becomes the arguably insane persona of Pixy Misa (who tortures the entire main cast).
* In ''Manga/MagicalRecordLyricalNanohaForce'', this is happens to everyone who succumbs to Eclipse disease. Aside from AntiMagic and [[HealingFactor insane regeneration]], the Eclipse
seems to have been at least ''slightly'' cracked before he [[FaceHeelTurn officially]] [[StartOfDarkness went insane a rather [[MindRape detrimental effect on the mission to victim's mind]] by [[TookALevelInJerkass stripping them of their morality]] and them into [[TheSociopath sociopathic]] [[{{Jerkass}} assholes]]. In particularly bad cases, the Black Black Club]]. (As a child, he says that he is the [[WellIntentionedExtremist "warrior for justice"]]. Wondering why demons only attacked you as opposed to other people, and knowing about the extent of your own power to destroy other living things leads to this trope.)
* In ''Manga/ChronoCrusade'', Joshua Christopher is given the horns of a demon by the BigBad. The power is too much for the small boy, however -- within minutes he's gone
infectees [[LossOfIdentity completely insane, using his powers to freeze everyone around him in time and destroy the orphanage he lived in. It gets '''so''' bad that later [[spoiler:he can't even remember his own sister]].
** It's even worse than that
forget who they are]], picking up FakeMemories in the manga. [[spoiler:It turns out that a demon's horns, in addition to granting them direct access to the Astral line, are also what connect them to process. Finally, once they [[DrunkWithPower start abusing their "mother", Pandemonium]]. That constant, painful noise that Joshua was complaining about? [[spoiler:It was an EldritchAbomination ''constantly [[MindRape mind-raping]] him.'']]
** In the anime, though the horns did damage his mind on their own, the "noise" he complained of was the thoughts of every human around him. In other words, uncontrollable telepathy that forced him to hear what every single person around him was thinking, all at once, all the time. No wonder he went mad if he had to be near people.
* Due to [[PhlebotinumBreakdown metatron poisoning]], Radium of the ''VideoGame/ZoneOfTheEnders'' {{O|riginalVideoAnimation}}VA, ''Idolo'',
regeneration]], [[PowerIncontinence it goes completely off the deep end after spending just a moment too long in the cockpit of the Idolo. [[DownerEnding This does not end well for anyone.]] The same can be said for Ridley Nohman with his Anubis, from a rather immoral rebel leader (in ''Dolores, I'') into destruction-obsessed guy (''ZOE: The 2nd Runner'').
* In ''Manga/DevilmanLady'', the entire story centres around evolution
haywire]] [[AndIMustScream and the gaining of vast, beast-like powers by ordinary people, many of whom go insane. The main character, Jun, for much of the series appears to be descending into insanity herself despite her best efforts not to. The climax moment of this aspect of the series is when, having been prevented from indulge her bloodlust by the Human Alliance, she attacks a nurse, they become nothing but ultimately overcomes her instincts by drawing her own blood.
* In ''Manga/TenjhoTenge'', characters who possess supernatural powers are remarked as always being in danger
a lump of becoming insane. A classic example of this is Natsume Shin, Maya and Aya's elder brother who was overwhelmed by his powers and started killing random people. This leads to powers being referred to as "Dragons" that will devour their wielder's sanity. Because of this, there is a tremendous social stigma attached to the possession of supernatural abilities, which naturally only serves to aggravate the problem even more.
* ''Anime/SCryed'' shows this one off pretty well, with most (if not debatably all) of the Alter Power users being completely insane to some degree. Particular samples include Straight Cougar, most of the one-shot villains, and our main Kazuma (whose personality initially flips between JerkWithAHeartOfGold and nice-guy… only for the nice guy to completely vanish by the final battle). It's worth noting that both Cougar and Kazuma are rare ''heroic'' examples of this trope. They're clearly bonkers, but they're still the good guys.
flesh]].



%%* The cyclone-riders in ''Manga/{{Uzumaki}}''.
* ''Manga/{{Claymore}}'': A Claymore who activates her demonic powers (i.e. "Awakens") gains great power but stands a chance of losing her humanity and turning into a human flesh-craving demon permanently.

to:

%%* The cyclone-riders * ''Anime/MobileSuitGundam'': A common theme in ''Manga/{{Uzumaki}}''.
* ''Manga/{{Claymore}}'': A Claymore
the franchise, most notably ''[[Anime/MobileSuitZetaGundam Zeta Gundam]]'' and ''[[Anime/MobileSuitGundamZZ Gundam ZZ]]'' where all Newtypes are often mentally unstable in some fashion, may have forms of amnesia, be brainwashed, though in some other cases they're just plain stubborn. This is particularly true of "Cyber-Newtypes", people who activates her demonic originally had no special powers (i.e. "Awakens") but had their brains surgically altered (almost always against their will) to become Newtypes.
** ''[[Anime/MobileSuitGundamSeed Gundam SEED]]'' plays on this by giving [[PsychoSerum performance-enhancing drugs]] and treatments to criminals who are doing it in exchange for a full pardon. Naturally, this drives them to insanity in combat... which is what was planned. As a result, they are given drugs in such doses that by the time combat is over, they are having withdrawal symptoms and are manageable again. Withdrawal will also kill them if they are deprived of the drugs for too long, thus ensuring their loyalty.
** In ''[[Anime/MobileSuitGundamSEEDDestiny Gundam SEED Destiny]]'', Blue Cosmos has been attempting to create "Artificial Coordinators" through depraved combinations of surgery, hypnosis, [[TrainingFromHell insane training]], drugs, and other horrors. Of the dozens of children selected for the project, only a few survived, and those seen in the series are all, understandably, raving mad and almost incapable of functioning normally in life. Without routine "maintenance", their bodies break down and they die. The sad thing is that in comparison to ''SEED'''s pre-Extended (see above), they're all poster children for Mental Health Week: Stellar Louissier, for example, is a sweet [[PsychopathicManchild if incredibly childish]] [[TheWoobie and still very sympathetic]] young woman who loves to dance, as long as you don't [[BerserkButton tell her that either she or her friends will die]], in which case [[SuperpoweredEvilSide an alternate personality emerges that could give even the drug-enhanced pilots of the previous series some lessons in brutality]].
** In ''[[Anime/MobileSuitGundamWing Gundam Wing]]'', the ZERO System gives the person who uses it incredible reaction times and tactical predictions bordering on prescience. The problem is, without any guidance, the System evaluates ''everything'' as a potential threat, and plugs into the user's mind all of the possible attacks that could happen. If he can't focus his mind and give the System the necessary context (which is hard to do when you're conflicted as to why you're fighting), those violent predictions start afflicting whatever he starts thinking about (like, say, his girlfriend, or that nice peaceful space colony over there), and soon enough he's a psychopath slaughtering whatever the System says is his enemy.
* In ''Manga/{{Naruto}}'', Sasuke seems to grow progressively more irrational the stronger he gets (as, to a lesser extent, do Itachi and [[spoiler:Obito]]). Eventually it's revealed that this is part of how their powers work; whenever a member of the Uchiha clan experiences strong emotion, it creates a burst of energy that increases the power of their Sharingan… and also damages their brain. In short, the best way for an Uchiha to become extremely powerful is to MindRape themselves into oblivion, ''a lot''.
** [[spoiler:The Sage of Six Paths]] explains that this happened to his mother and [[spoiler:Madara]] when they gained the power of [[spoiler:the God-Tree]]. Not coincidentally, both struck upon the idea of executing an AssimilationPlot where they would effectively become gods [[spoiler:because a servant of Kaguya had deliberately planted information to recreate said plan]].
* ''Manga/PokemonSpecial'' uses this in the R/S arc. The Red and Blue Orbs can be wielded by mortals to control Groudon and Kyogre, but sufficient willpower is required to prevent loss of self. One Magma Elite tried and was driven mad; Archie and Maxie were so consumed by their lust for power that the Orbs wielded them. [[spoiler:To prevent the same from happening to their (unknowing at the time) new hosts, Juan, Liza, and Tate used the temporal abnormalities of Mirage Island to temper Ruby and Sapphire's collective resolve. Ruby foolishly coaxed the Blue Orb from Sapphire for his own use, but he turned out to have enough strength of will to calm both titans once more.]]
** The anime has Oakley in ''Anime/PokemonHeroes'', who loses it and tries to destroy the world once she
gains great control of a machine powered by Latios. Even her partner Annie is startled by the change.
** The anime also has it in the form of Korrina's Lucario. It's unable to control the
power but stands a chance of losing her humanity Mega Evolution, and turning into thus whenever it Mega Evolves it goes insane, though it's training in an attempt to gain control over itself.
* In ''Anime/PuellaMagiMadokaMagica'', almost all magical girls [[spoiler:lose it in varying degrees due to
a human flesh-craving demon permanently.combination of having awesome power and still not getting what they wanted, having to fight constantly and lose any semblance of a social life, having their souls sucked out and put in a gem, and then finding out that the enemies they've been fighting all this time used to be magical girls themselves]]. Prime examples include [[spoiler:Sayaka, and Mami in another timeline]]. More to the point, [[spoiler:witches are magical girls that have succumbed to despair and insanity]].
* Itsuki's Glam Sight in ''LightNovel/RentalMagica'' gives him his CrouchingMoronHiddenBadass ability that makes him just the right sort of leader for his team of mages. However, the more he uses it, the more it eats away at his sanity. Thus, Honami and the others warn him not to use it as much as possible.
* In ''LightNovel/TheRisingOfTheShieldHero'' the Curse series of the Legendary Weapons tend to provide power boosts and functions not normally available, such as Naofumi's Wrath shield giving him an actual attack. Each Curse is associated with one of the [[SevenDeadlySins sins]] and activating it runs the real risk of the wielder's mind becoming overwhelmed with that sin.



* In ''Manga/GetBackers'', Ginji and [[spoiler:Kazuki]] have this as a side effect of their {{Superpowered Evil Side}}s. Ginji's "Lightning Lord" aspect is quiet, cold, and utterly ruthless, while [[spoiler:Kazuki goes absolutely berserk when he releases the seal on his "Stigma," becoming vicious and blood-thirsty]]. They're always sorry afterward.

to:

* In ''Manga/GetBackers'', Ginji and [[spoiler:Kazuki]] have ''Anime/SCryed'' shows this as a side effect one off pretty well, with most (if not debatably all) of their {{Superpowered Evil Side}}s. Ginji's "Lightning Lord" aspect is quiet, cold, the Alter Power users being completely insane to some degree. Particular samples include Straight Cougar, most of the one-shot villains, and utterly ruthless, while [[spoiler:Kazuki goes absolutely berserk when he releases our main Kazuma (whose personality initially flips between JerkWithAHeartOfGold and nice-guy… only for the seal on his "Stigma," becoming vicious nice guy to completely vanish by the final battle). It's worth noting that both Cougar and blood-thirsty]]. Kazuma are rare ''heroic'' examples of this trope. They're always sorry afterward.clearly bonkers, but they're still the good guys.
* Possibly a coincidence, but the three most powerful [[Franchise/SailorMoon Sailor Soldiers]] are the less unhinged:
** Sailor Venus is the most powerful of the 'normal' Sailor Soldiers, a GenkiGirl on steroids and an hell of StepfordSmiler;
** Sailor Moon is one of the two candidates to the title of most powerful of the Sailor Senshi, and her personality is ''extremely'' similar to Sailor Venus ({{justified|Trope}} as she's Venus' {{Expy}}), the main differences being that Venus is a born DramaQueen and LargeHam and Moon's happiness is genuine;
** Sailor Galaxia is the other candidate to the title of most powerful Sailor Senshi (and in the anime she ''is''), and she's an OmnicidalManiac.
* In ''Manga/{{Saikano}}'', this more or less happens to [[spoiler:[[WoobieDestroyerOfWorlds Chise]], who loses her sanity as the [[BodyHorror weapon of mass destruction inside her]] grows and apparently slowly takes over her brain, turning her into a [[AxCrazy killing machine]] against her will.]] She gets [[ThePowerOfLove better]]. [[FromBadToWorse But]] [[TheEndOfTheWorldAsWeKnowIt then]] [[DownerEnding again]]...



* In ''Manga/{{Berserk}}'', the main character finds that he can enter into an UnstoppableRage like never before due to his recently obtained UpgradeArtifact. However, he finds himself BlessedWithSuck due to the [[PowerDegeneration incredible physical strain it puts on his body]], and he could [[TheCorruption accidentally]] FaceHeelTurn at any moment and kill all of his companions.
* Played with in ''Manga/FutureDiary'', where some individuals who're not so mentally sound to begin with are given the ability to predict the future and told by God to kill each other [[ThereCanBeOnlyOne Highlander style]]. Whether the ability, situation, or just generally being that nuts before drives them [[AxCrazy crazy]] is up for interpretation.
* ''Manga/PokemonSpecial'' uses this in the R/S arc. The Red and Blue Orbs can be wielded by mortals to control Groudon and Kyogre, but sufficient willpower is required to prevent loss of self. One Magma Elite tried and was driven mad; Archie and Maxie were so consumed by their lust for power that the Orbs wielded them. [[spoiler:To prevent the same from happening to their (unknowing at the time) new hosts, Juan, Liza, and Tate used the temporal abnormalities of Mirage Island to temper Ruby and Sapphire's collective resolve. Ruby foolishly coaxed the Blue Orb from Sapphire for his own use, but he turned out to have enough strength of will to calm both titans once more.]]
** The anime has Oakley in ''Anime/PokemonHeroes'', who loses it and tries to destroy the world once she gains control of a machine powered by Latios. Even her partner Annie is startled by the change.
** The anime also has it in the form of Korrina's Lucario. It's unable to control the power of Mega Evolution, and thus whenever it Mega Evolves it goes insane, though it's training in an attempt to gain control over itself.
* In ''Manga/{{Naruto}}'', Sasuke seems to grow progressively more irrational the stronger he gets (as, to a lesser extent, do Itachi and [[spoiler:Obito]]). Eventually it's revealed that this is part of how their powers work; whenever a member of the Uchiha clan experiences strong emotion, it creates a burst of energy that increases the power of their Sharingan… and also damages their brain. In short, the best way for an Uchiha to become extremely powerful is to MindRape themselves into oblivion, ''a lot''.
** [[spoiler:The Sage of Six Paths]] explains that this happened to his mother and [[spoiler:Madara]] when they gained the power of [[spoiler:the God-Tree]]. Not coincidentally, both struck upon the idea of executing an AssimilationPlot where they would effectively become gods [[spoiler:because a servant of Kaguya had deliberately planted information to recreate said plan]].
* ''Manga/FairyTail'':
** This was the result of Elfman's failed Take Over spell against a monster called The Beast a few years before the story started. In order to save his older sister, he used his magic on a gigantic magical monster, but wasn't quite strong enough to control it. He saved his older sister, and killed the younger [[spoiler:they thought)]]. Out of fear of this happening again, he stopped using full-body Take Over magic (eventually, he becomes able to control his power).
** By the time Natsu fights Laxus during the Battle of Fairy Tail arc, Laxus has officially become so mad with power that he loses all reason, and tries to destroy everything and everyone. His state of madness is generally indicated by BlankWhiteEyes, and he regains his irises and pupils during his brief moments of lucidity.
* Any Diclonius in ''Manga/ElfenLied'', except Nana. [[spoiler:Maybe. It's heavily implied that their murderous tendencies might actually be a result of abuse, particularly at the Institute. Might. It's ultimately left ambiguous.]]
* Both played straight and averted in Franchise/{{Digimon}}. On the one hand, you have Digimon like Omnimon, who are immensely powerful, but perfectly sane, noble, and benevolent. On the other hand, you have Beelzemon and Diaboromon, who are driven only by their desire to gain power and cause destruction.
** Myotismon is already incredibly powerful, but becoming his mega form, the colossal VenonMyotismon, turns him from TheChessmaster to an all devouring mindless monster.
* In ''Manga/{{Saikano}}'', this more or less happens to [[spoiler:[[WoobieDestroyerOfWorlds Chise]], who loses her sanity as the [[BodyHorror weapon of mass destruction inside her]] grows and apparently slowly takes over her brain, turning her into a [[AxCrazy killing machine]] against her will.]] She gets [[ThePowerOfLove better]]. [[FromBadToWorse But]] [[TheEndOfTheWorldAsWeKnowIt then]] [[DownerEnding again]]...
* In ''Anime/FullmetalAlchemist'', Ed gets a power overload from contact with a huge amount of unfinished Philosopher's Stone and goes full-on uncontrollable with so much power it is described that if this goes on, he can attain enough power to be god-like (even freaking out the Homunculi) until a CooldownHug snaps him out of it.
* In ''Anime/PuellaMagiMadokaMagica'', almost all magical girls [[spoiler:lose it in varying degrees due to a combination of having awesome power and still not getting what they wanted, having to fight constantly and lose any semblance of a social life, having their souls sucked out and put in a gem, and then finding out that the enemies they've been fighting all this time used to be magical girls themselves]]. Prime examples include [[spoiler:Sayaka, and Mami in another timeline]]. More to the point, [[spoiler:witches are magical girls that have succumbed to despair and insanity]].
* If piloting a {{Super Robot|Genre}} counts as "Great Power", then ''Anime/NeonGenesisEvangelion'' speaks for itself. The pilots, Shinji particularly, go mad from the experience of piloting the Evas.
* In ''Manga/MagicalRecordLyricalNanohaForce'', this is happens to everyone who succumbs to Eclipse disease. Aside from AntiMagic and [[HealingFactor insane regeneration]], the Eclipse seems to have a rather [[MindRape detrimental effect on the victim's mind]] by [[TookALevelInJerkass stripping them of their morality]] and them into [[TheSociopath sociopathic]] [[{{Jerkass}} assholes]]. In particularly bad cases, the infectees [[LossOfIdentity completely forget who they are]], picking up FakeMemories in the process. Finally, once they [[DrunkWithPower start abusing their regeneration]], [[PowerIncontinence it goes haywire]] [[AndIMustScream and they become nothing but a lump of flesh]].
* The witches of ''Manhwa/WitchHunter'' are a bag of mixed nuts. The magic powers they wield have different affects on all of them. Some stay the same sweet person they were before, the only change they undergo being the magic they now wield and their now immortal bodies... Others not so much. The main character's sister went completely insane upon gaining her powers, murdered her own father, her brother's beloved mentor, and ''countless'' tens of thousands of people and only approaches her normal mentality as she uses her magic too much and starts running out. Almost ''all'' witches introduced who are not on the side of the humans are sadistic and cruel, viewing human life as something deserving of only destruction, despite all of them having once been human.
* In ''LightNovel/FateZero'' and ''VisualNovel/FateStayNight'', both Berserker got Mad Enhancement, a Class Skill that trades one’s sanity for added power.
* In ''New ''Anime/GetterRobo'', Ryouma lets himself get hopped up on Getter Energy, powering him and New Getter-1 to new heights to combat the Four Heavenly Kings. However, Ryouma loses himself and Hayato and Benkei have to try to reel him back in before his actions get them killed.

to:

* In ''Manga/{{Berserk}}'', the main character finds that he can enter into an UnstoppableRage like never before due to his recently obtained UpgradeArtifact. However, he finds himself BlessedWithSuck due to the [[PowerDegeneration incredible physical strain it puts on his body]], and he could [[TheCorruption accidentally]] FaceHeelTurn at any moment and kill all of his companions.
* Played with in ''Manga/FutureDiary'', where some individuals who're not so mentally sound to begin with are given the ability to predict the future and told by God to kill each other [[ThereCanBeOnlyOne Highlander style]]. Whether the ability, situation, or just generally being that nuts before drives them [[AxCrazy crazy]] is up for interpretation.
* ''Manga/PokemonSpecial'' uses this in the R/S arc. The Red and Blue Orbs can be wielded by mortals to control Groudon and Kyogre, but sufficient willpower is required to prevent loss of self. One Magma Elite tried and was driven mad; Archie and Maxie were so consumed by their lust for power that the Orbs wielded them. [[spoiler:To prevent the same from happening to their (unknowing at the time) new hosts, Juan, Liza, and Tate used the temporal abnormalities of Mirage Island to temper Ruby and Sapphire's collective resolve. Ruby foolishly coaxed the Blue Orb from Sapphire for his own use, but he turned out to have enough strength of will to calm both titans once more.]]
** The anime has Oakley in ''Anime/PokemonHeroes'',
''Manga/TenjhoTenge'', characters who loses it and tries to destroy the world once she gains control of a machine powered by Latios. Even her partner Annie is startled by the change.
** The anime also has it in the form of Korrina's Lucario. It's unable to control the power of Mega Evolution, and thus whenever it Mega Evolves it goes insane, though it's training in an attempt to gain control over itself.
* In ''Manga/{{Naruto}}'', Sasuke seems to grow progressively more irrational the stronger he gets (as, to a lesser extent, do Itachi and [[spoiler:Obito]]). Eventually it's revealed that this is part of how their
possess supernatural powers work; whenever a member of the Uchiha clan experiences strong emotion, it creates a burst of energy that increases the power of their Sharingan… and also damages their brain. In short, the best way for an Uchiha to become extremely powerful is to MindRape themselves into oblivion, ''a lot''.
** [[spoiler:The Sage of Six Paths]] explains that this happened to his mother and [[spoiler:Madara]] when they gained the power of [[spoiler:the God-Tree]]. Not coincidentally, both struck upon the idea of executing an AssimilationPlot where they would effectively become gods [[spoiler:because a servant of Kaguya had deliberately planted information to recreate said plan]].
* ''Manga/FairyTail'':
** This was the result of Elfman's failed Take Over spell against a monster called The Beast a few years before the story started. In order to save his older sister, he used his magic on a gigantic magical monster, but wasn't quite strong enough to control it. He saved his older sister, and killed the younger [[spoiler:they thought)]]. Out of fear of this happening again, he stopped using full-body Take Over magic (eventually, he becomes able to control his power).
** By the time Natsu fights Laxus during the Battle of Fairy Tail arc, Laxus has officially become so mad with power that he loses all reason, and tries to destroy everything and everyone. His state of madness is generally indicated by BlankWhiteEyes, and he regains his irises and pupils during his brief moments of lucidity.
* Any Diclonius in ''Manga/ElfenLied'', except Nana. [[spoiler:Maybe. It's heavily implied that their murderous tendencies might actually be a result of abuse, particularly at the Institute. Might. It's ultimately left ambiguous.]]
* Both played straight and averted in Franchise/{{Digimon}}. On the one hand, you have Digimon like Omnimon, who
are immensely powerful, but perfectly sane, noble, and benevolent. On the other hand, you have Beelzemon and Diaboromon, who are driven only by their desire to gain power and cause destruction.
** Myotismon is already incredibly powerful, but
remarked as always being in danger of becoming his mega form, the colossal VenonMyotismon, turns him from TheChessmaster to an all devouring mindless monster.
* In ''Manga/{{Saikano}}'',
insane. A classic example of this more or less happens to [[spoiler:[[WoobieDestroyerOfWorlds Chise]], is Natsume Shin, Maya and Aya's elder brother who loses her sanity as the [[BodyHorror weapon of mass destruction inside her]] grows was overwhelmed by his powers and apparently slowly takes over her brain, turning her into a [[AxCrazy started killing machine]] against her will.]] She gets [[ThePowerOfLove better]]. [[FromBadToWorse But]] [[TheEndOfTheWorldAsWeKnowIt then]] [[DownerEnding again]]...
* In ''Anime/FullmetalAlchemist'', Ed gets a power overload from contact with a huge amount of unfinished Philosopher's Stone and goes full-on uncontrollable with so much power it is described
random people. This leads to powers being referred to as "Dragons" that if this goes on, he can attain enough power to be god-like (even freaking out the Homunculi) until a CooldownHug snaps him out will devour their wielder's sanity. Because of it.
* In ''Anime/PuellaMagiMadokaMagica'', almost all magical girls [[spoiler:lose it in varying degrees due to
this, there is a combination of having awesome power and still not getting what they wanted, having to fight constantly and lose any semblance of a tremendous social life, having their souls sucked out and put in a gem, and then finding out that the enemies they've been fighting all this time used to be magical girls themselves]]. Prime examples include [[spoiler:Sayaka, and Mami in another timeline]]. More stigma attached to the point, [[spoiler:witches are magical girls that have succumbed to despair and insanity]].
* If piloting a {{Super Robot|Genre}} counts as "Great Power", then ''Anime/NeonGenesisEvangelion'' speaks for itself. The pilots, Shinji particularly, go mad from the experience
possession of piloting the Evas.
* In ''Manga/MagicalRecordLyricalNanohaForce'', this is happens to everyone who succumbs to Eclipse disease. Aside from AntiMagic and [[HealingFactor insane regeneration]], the Eclipse seems to have a rather [[MindRape detrimental effect on the victim's mind]] by [[TookALevelInJerkass stripping them of their morality]] and them into [[TheSociopath sociopathic]] [[{{Jerkass}} assholes]]. In particularly bad cases, the infectees [[LossOfIdentity completely forget who they are]], picking up FakeMemories in the process. Finally, once they [[DrunkWithPower start abusing their regeneration]], [[PowerIncontinence it goes haywire]] [[AndIMustScream and they become nothing but a lump of flesh]].
* The witches of ''Manhwa/WitchHunter'' are a bag of mixed nuts. The magic powers they wield have different affects on all of them. Some stay the same sweet person they were before, the
supernatural abilities, which naturally only change they undergo being serves to aggravate the magic they now wield and their now immortal bodies... Others not so much. The main character's sister went completely insane upon gaining her powers, murdered her own father, her brother's beloved mentor, and ''countless'' tens of thousands of people and only approaches her normal mentality as she uses her magic too much and starts running out. Almost ''all'' witches introduced who are not on the side of the humans are sadistic and cruel, viewing human life as something deserving of only destruction, despite all of them having once been human.
* In ''LightNovel/FateZero'' and ''VisualNovel/FateStayNight'', both Berserker got Mad Enhancement, a Class Skill that trades one’s sanity for added power.
* In ''New ''Anime/GetterRobo'', Ryouma lets himself get hopped up on Getter Energy, powering him and New Getter-1 to new heights to combat the Four Heavenly Kings. However, Ryouma loses himself and Hayato and Benkei have to try to reel him back in before his actions get them killed.
problem even more.



* Possibly a coincidence, but the three most powerful [[SailorMoon Sailor Soldiers]] are the less unhinged:
** Sailor Venus is the most powerful of the 'normal' Sailor Soldiers, a GenkiGirl on steroids and an hell of StepfordSmiler;
** Sailor Moon is one of the two candidates to the title of most powerful of the Sailor Senshi, and her personality is ''extremely'' similar to Sailor Venus ({{justified|Trope}} as she's Venus' {{Expy}}), the main differences being that Venus is a born DramaQueen and LargeHam and Moon's happiness is genuine;
** Sailor Galaxia is the other candidate to the title of most powerful Sailor Senshi (and in the anime she ''is''), and she's an OmnicidalManiac.
* In ''LightNovel/TheRisingOfTheShieldHero'' the Curse series of the Legendary Weapons tend to provide power boosts and functions not normally available, such as Naofumi's Wrath shield giving him an actual attack. Each Curse is associated with one of the [[SevenDeadlySins sins]] and activating it runs the real risk of the wielder's mind becoming overwhelmed with that sin.
* Similarly, in ''LightNovel/KumoDesuGaNaniKa'' the Skills corresponding with the SevenDeadlySins ''and'' SevenHeavenlyVirtues grant the bearer powerful abilities and Ruler authority at the cost of slowly warping their soul to reflect the sin or virtue. The only way to avoid this is by not activating the Skill or gaining Heresy Resistance, which reduces the damage to the soul.
* The previous GameMaster from ''Manhua/InfinityGame'' was driven completely insane by the infinite power he wielded in his world, so he drove everybody else insane and made them kill each other. He eventually grew bored of it and killed everybody.

to:

%%* The cyclone-riders in ''Manga/{{Uzumaki}}''.
* Possibly The witches of ''Manhwa/WitchHunter'' are a coincidence, but bag of mixed nuts. The magic powers they wield have different affects on all of them. Some stay the three most powerful [[SailorMoon Sailor Soldiers]] are same sweet person they were before, the less unhinged:
** Sailor Venus is the most powerful of the 'normal' Sailor Soldiers, a GenkiGirl on steroids and an hell of StepfordSmiler;
** Sailor Moon is one of the two candidates to the title of most powerful of the Sailor Senshi, and her personality is ''extremely'' similar to Sailor Venus ({{justified|Trope}} as she's Venus' {{Expy}}), the main differences
only change they undergo being that Venus is a born DramaQueen the magic they now wield and LargeHam and Moon's happiness is genuine;
** Sailor Galaxia is the other candidate to the title of most powerful Sailor Senshi (and in the anime she ''is''), and she's an OmnicidalManiac.
* In ''LightNovel/TheRisingOfTheShieldHero'' the Curse series of the Legendary Weapons tend to provide power boosts and functions not normally available, such as Naofumi's Wrath shield giving him an actual attack. Each Curse is associated with one of the [[SevenDeadlySins sins]] and activating it runs the real risk of the wielder's mind becoming overwhelmed with that sin.
* Similarly, in ''LightNovel/KumoDesuGaNaniKa'' the Skills corresponding with the SevenDeadlySins ''and'' SevenHeavenlyVirtues grant the bearer powerful abilities and Ruler authority at the cost of slowly warping
their soul to reflect the sin or virtue. now immortal bodies... Others not so much. The only way to avoid this is by not activating the Skill or gaining Heresy Resistance, which reduces the damage to the soul.
* The previous GameMaster from ''Manhua/InfinityGame'' was driven
main character's sister went completely insane by upon gaining her powers, murdered her own father, her brother's beloved mentor, and ''countless'' tens of thousands of people and only approaches her normal mentality as she uses her magic too much and starts running out. Almost ''all'' witches introduced who are not on the infinite power side of the humans are sadistic and cruel, viewing human life as something deserving of only destruction, despite all of them having once been human.
* [[StrawNihilist Sensui]] from ''Manga/YuYuHakusho'' would probably count, as
he wielded in his world, so seems to have been at least ''slightly'' cracked before he drove everybody else [[FaceHeelTurn officially]] [[StartOfDarkness went insane on the mission to the Black Black Club]]. (As a child, he says that he is the [[WellIntentionedExtremist "warrior for justice"]]. Wondering why demons only attacked you as opposed to other people, and made them kill each other. He eventually grew bored knowing about the extent of it and killed everybody.your own power to destroy other living things leads to this trope.)
* Due to [[PhlebotinumBreakdown metatron poisoning]], Radium of the ''VideoGame/ZoneOfTheEnders'' {{O|riginalVideoAnimation}}VA, ''Idolo'', goes completely off the deep end after spending just a moment too long in the cockpit of the Idolo. [[DownerEnding This does not end well for anyone.]] The same can be said for Ridley Nohman with his Anubis, from a rather immoral rebel leader (in ''Dolores, I'') into destruction-obsessed guy (''ZOE: The 2nd Runner'').



!!!Franchise/TheDCU
*'''Franchise/{{Batman}})'':
** An interesting case concerning ComicBook/{{Azrael}}. When Jean-Paul Valley was born, he was implanted with a brainwashing trance of sorts known as The System, which would grant him amazing strength and agility when he donned the gear of Azrael, though it made him BrainwashedAndCrazy, pushing him to want to kill the guilty. When he first abandoned that role, he functioned pretty well... until the Scarecrow doused him with Fear Gas when JP [[ComicBook/{{Knightfall}} took up the Mantle of the Bat in Bruce Wayne's place]]. The entirety of the subsequent ''Knightquest'' storyline has Jean-Paul constantly fighting The System until he lets Abattoir die. When he does, he finally submits to The System and becomes a fearful mixture of Batman and Azrael and forces Bruce to take back the Mantle.
** Happen to Batman when he get Superman's power during a battle with the Silver Banshee in a ''ComicBook/SupermanBatman'' story. Batman uses his new powers to bring complete fear and order to Gotham's criminal underworld and eventually sets his sight to the world, but he became increasingly aggressive. With the aid of the Justice League, Superman is able to bring himself and The Dark Knight back to normal.
* Interesting case with Comicbook/BlackAdam. His powers don't drive him crazy (he went crazy on his own, [[FaceHeelRevolvingDoor and sometimes comes back from that insanity]]...[[AntiHero partially]]), but he can share them, and anyone who would take them on immediately turns evil. ''Anyone'', including [[spoiler:the goddess of love]].
* ''Comicbook/DoomPatrol'': Mento wasn't the most stable/mentally healthy guy to begin with. Then he starts tinkering with a helmet that cranks his PsychicPowers UpToEleven and takes up superheroing. But his wife and her team die, and it REALLY sent him downhill [[FaceHeelTurn until he's doing stints as a supervillain]] and trying to kill his own adopted son! When that heroing team was led by a fellow {{retcon}}ned into a MadScientist and MagnificentBastard, it was damn near inevitable.
* ''Franchise/TheFlash'': Hunter Zolomon spent his life in a TraumaCongaLine, but he remained a good cop until Gorilla Grodd crippled him and the Flash, whom Hunter considered a friend, refused to use time travel to undo the damage. Hunter attempted to use the Flash's cosmic treadmill himself, but it blew up in his face. The resulting super powers had the side effect of scrambling his thought processes, until he decided that the best way to help his friend the Flash was to make him a better hero through tragedy as Zoom. Hunter still thinks he's helping the Flash, although he gets occasional flashes of MyGodWhatHaveIDone when Wally foils his plans.
* Retconned for Doctor Magnus, the leader of the ''Comicbook/MetalMen''. He needs a careful application of medicine in order to stay stable and good. He's kidnapped along with genuine mad scientists and they cancel his meds, intending for him to regress to his previous level of insane creativity, in which he created a horrific weapon of mass destruction, the Plutonium Man. Though he ''does'' recreate the Plutonium Man, he destabilizes ''very'' quickly, and with the help of several sentient robots he'd managed to cook up in his lab, invents a gun with ''living'' ammo and goes on a rampage (against evil men only), screaming about how he '''''really''''' needed his meds.
* The Psycho-Pirate, a villain with the emotion-changing Medusa Mask, actually had three of them, one for a single emotion, before deciding to combine all three to control all emotions. Unfortunately, continued use ended up driving him insane -- he's first seen in ''ComicBook/CrisisOnInfiniteEarths'' locked away in an insane asylum.
* ''Franchise/{{Superman}})'':
** Arguably [[InvertedTrope completely inverted]] in ''ComicBook/AllStarSuperman'': [[spoiler:Lex Luthor temporarily gains Superman's powers, and while he predictably rampages, he finds himself stopping to examine the amazing perspective his newfound powers and super-senses give him. He eventually concludes that having the level of power and insight that Superman does would make people care for their fellow human beings, and mellows out considerably after losing the powers]].
** The newest Kryptonite Man is a scientist who thinks Kryptonite ([[KryptoniteIsEverywhere there is now a lot of it on Earth]]) can be used as a safe energy source. When he himself becomes that energy source, he decides to show the world how effective it can be by... a murderous rampage. That never ends well. Later, in the same storyline, another scientist goes cuckoo bananas when he gains control over an oversized amoeba. Or so it seems. Superman subdues the guy, who says he didn't want to do it, but Intergang, a powerful criminal organization, made him.
* Matthew Cable from ''ComicBook/SwampThing''. His PsychicPowers and his spiraling alcoholic insanity both stem from the same illicit electroshock treatments.
* Dr Manhattan in ''Comicbook/{{Watchmen}}'' is a subtler and relatively benign variation of the trope; it's implied that he was more at home dealing with elementary particles than other people even before the FreakLabAccident turned him into an [[WeAreAsMayflies immortal]] PhysicalGod who can see the future [[YouCantFightFate but not change any of it, even]] ''[[YouCantFightFate his own actions]]''. However, instead of suffering a spectacular HeroicBSOD and subsequent FaceHeelTurn, he's one of the least emotionally damaged people in the entire cast, whilst still being [[BlueAndOrangeMorality almost entirely disconnected from normal human thought patterns]].

!!!Franchise/MarvelUniverse
* The evil and non-evil versions of insanity pop up in a ''lot'' of the Marvel Universe's more powerful human characters, apparently as a way of HoldingBackThePhlebotinum. Scarlet Witch, Phoenix, Comicbook/TheSentry, or anyone else like that being able to use their maximum power levels while fully themselves would remove all drama. Comicbook/ScarletWitch is currently the most powerful and resultantly has it the worst. We haven't seen her mind in stable condition for quite some time now that her power's gone from "[[WindsOfDestinyChange I point and my opponent slips on a banana peel]]" to "[[RealityWarper whatever I decide simply]] ''[[RealityWarper is.]]''" She'll ''never'' get to have that kind of power and the ability to think "Wouldn't it be nice if the Skrulls (okay, except [[Comicbook/{{Runaways}} Xavin]], [[ComicBook/FantasticFour Lyja]], and [[ComicBook/XMen Cadre K]], and the Super Skrull if [[HeelFaceTurn he keeps playing nice]]) turned into rice pudding?" at the same time.
* When the Canadian government was looking for people to join Comicbook/AlphaFlight, they initially had trouble finding recruits. The people in charge of the program decided to try creating their own superbeings, and they got the bright idea to experiment on a SerialKiller who got a pardon in exchange for agreeing to participate. The result was a crazed monster with deadly psychic abilities calling itself Bedlam. {{Wolverine}} had initially signed on to join Alpha Flight, but this debacle was what caused him to leave the group in disgust.



** If you're a scientist introduced by name in the Spider-Man comics, you're usually one issue away from your experiments turning you into a deranged {{Supervillain}}. Especially if [[StevenUlyssesPerhero your name conveniently sounds a lot like the type of experiment you're conducting...]]



* SelfDemonstrating/{{Deadpool}} was probably messed up before developing terminal cancer, but the Weapon X program (which initially ''failed'' to give him a HealingFactor) gives him a hard shove in that direction. Then Dr. Killebrew experiments on and tortures him to the point of having visions of (and ''falling in love with'') [[TheGrimReaper Death]]. What finally demolishes his sanity is when Killebrew orders him killed, his healing factor finally kicks in, saving his life, making his disfigurement permanent, and causing Death to reject him. Depending on the writer, he's a mix of AxCrazy, DeadpanSnarker, gleeful GenreSavvy, and MediumAwareness.
* ''Comicbook/IncredibleHulk''. The gamma bomb gave Bruce Banner huge power and exacerbated his multiple personality syndrome. Plus, the madder he gets, the stronger he becomes.
** Interestingly, for both ''The Mask'' and Marvel's gamma ray mutants, what happens to the subject's mind depends on what part of their personality they had dissociated themselves from. Most people who get the Mask unlock their evil side, but the fellow in TheMovie didn't ''have'' an evil side, only a chaotic side, so he essentially became a WesternAnimation/LooneyTunes character. Marvel goes into more detail -- Banner suppressed the rage that came from being abused as a child, Comicbook/SheHulk suppressed [[MsFanservice her sexuality]], Doc Samson suppressed his desire to be a hero, and the Abomination suppressed his self-hatred.
* Handled interestingly with [[Comicbook/TheSentry Sentry]]. His [[SuperpowerLottery powers]] are like some ridiculous combination of {{Franchise/Superman}} and [[ComicBook/FantasticFour Franklin Richards]], making him technically unstoppable and all-powerful. He's also a paranoid schizophrenic who managed to convince himself that there was an evil galactic power called The Void that would destroy the earth if he stayed a superhero... and then ''actually created it out of thin air'', making a problem for ComicBook/TheAvengers to handle while ComicBook/EmmaFrost gave him some emergency psychotherapy. During this time, he also managed to {{Retcon}} himself out of his own universe, so that his [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] exploits all became some comic writer's fantasy. In something of a subversion, Sentry's not a villain: in current canon, he works to use his powers for a great deal of good. Unfortunately, his psychosis still isn't fully under control, and it's a disability that is sometimes just impossible to work around.
** Later developments suggest that the Sentry is an inversion of this trope. Robert Reynolds was ''already'' a mentally unstable drug addict ''before'' taking the serum that gave him his powers, so it's more like someone with great insanity given great power. Furthermore, [[spoiler:Reynolds didn't become the Sentry and create the Void, it was the other way around..]].
*** [[spoiler:An alternate interpretation is that Reynolds splits into the Sentry and the Void, neither of which are more physically or psychologically real than the other.]]
*** As of ''Uncanny Avengers'', he's back as the Horseman of Death (the Void apparently got bored and wandered off) and is even crazier than ever.



** If you're a scientist introduced by name in the Spider-Man comics, you're usually one issue away from your experiments turning you into a deranged {{Supervillain}}. Especially if [[StevenUlyssesPerhero your name conveniently sounds a lot like the type of experiment you're conducting...]]



* In ''ComicBook/{{Hellboy}}'', losing control of one's powers and/or humanity was a major theme of the series, especially for Liz Sherman and Hellboy himself. That is to say: Liz burned her family to death by accident as a kid, and Hellboy doesn't and can't and won't use his flashier superpowers, since they mostly involve ending the world, but occasionally they get stolen, one way or another. His crown, his Name, his right hand, ALL THE BLOOD IN HIS BODY...
* In ''ComicBook/GoldDigger'', dragon hybrids between the tribes (Platinum, Gold, Copper, and Iron) are extremely rare and extremely powerful. Every single one has gone insane, however, with the sole exception being one of the comic's supporting cast, D'bra. And then, most dragons believe her temper is a sign that it's only a matter of time.



* The evil and non-evil versions of insanity pop up in a ''lot'' of the Franchise/MarvelUniverse's more powerful human characters, apparently as a way of HoldingBackThePhlebotinum. Scarlet Witch, Phoenix, Comicbook/TheSentry, or anyone else like that being able to use their maximum power levels while fully themselves would remove all drama. Comicbook/ScarletWitch is currently the most powerful and resultantly has it the worst. We haven't seen her mind in stable condition for quite some time now that her power's gone from "[[WindsOfDestinyChange I point and my opponent slips on a banana peel]]" to "[[RealityWarper whatever I decide simply]] ''[[RealityWarper is.]]''" She'll ''never'' get to have that kind of power and the ability to think "Wouldn't it be nice if the Skrulls (okay, except [[Comicbook/{{Runaways}} Xavin]], [[ComicBook/FantasticFour Lyja]], and [[ComicBook/XMen Cadre K]], and the Super Skrull if [[HeelFaceTurn he keeps playing nice]]) turned into rice pudding?" at the same time.

to:

* The evil and non-evil versions of insanity pop up in a ''lot'' of the Franchise/MarvelUniverse's more powerful human characters, apparently as a way of HoldingBackThePhlebotinum. Scarlet Witch, Phoenix, Comicbook/TheSentry, or anyone else like In ''[[Comicbook/TheNewUniverse newuniversal]]'', which is also by Creator/WarrenEllis, John Tensen gains telepathic powers that being able to use their maximum power levels while fully themselves would remove all drama. Comicbook/ScarletWitch is currently the most powerful and resultantly has it the worst. We haven't seen her mind in stable condition for quite some let him "see" a person's misdeeds or ignoble intentions. The first time now he used these abilities, he discovered that her power's gone from "[[WindsOfDestinyChange I point his own nurse was planning to poison him. Tensen, not surprisingly, became AxCrazy and my opponent slips on a banana peel]]" to "[[RealityWarper whatever I decide simply]] ''[[RealityWarper is.]]''" She'll ''never'' get to have that kind of power and is now the ability "worst serial killer in New York City history," to think "Wouldn't it be nice if the Skrulls (okay, except [[Comicbook/{{Runaways}} Xavin]], [[ComicBook/FantasticFour Lyja]], and [[ComicBook/XMen Cadre K]], and the Super Skrull if [[HeelFaceTurn he keeps playing nice]]) turned into rice pudding?" at the same time.quote a minor character.

!!!Other



* Matthew Cable from ''ComicBook/SwampThing''. His PsychicPowers and his spiraling alcoholic insanity both stem from the same illicit electroshock treatments.

to:

* Matthew Cable from ''ComicBook/SwampThing''. His PsychicPowers and Inverted ([[ZigZaggingTrope or not]]) in ''Comicbook/TheAuthority'', where the Doctor gives up his spiraling alcoholic insanity both stem from powers to a [[LegacyCharacter previous]] Doctor, who was relieved of his duties for being a [[OmnicidalManiac psychotic maniac]]. As soon as the same illicit electroshock treatments.full extent of his powers kicked in, he was [[VillainousBSOD overwhelmed]] by the empathy for every living thing in existence. Super-empathy being part of the Doctor's role as the world's shaman, makes you wonder why this guy was psychotic [[FridgeLogic in the first place]].
** Every Doctor gets a new power, added to the ones the previous Doctor who had the job had all the way back to the first one. After he went psycho, the next guy got super empathy, which he used A LOT of heroin to deal with.



* In ''[[Comicbook/TheNewUniverse newuniversal]]'', which is also by Creator/WarrenEllis, John Tensen gains telepathic powers that let him "see" a person's misdeeds or ignoble intentions. The first time he used these abilities, he discovered that his own nurse was planning to poison him. Tensen, not surprisingly, became AxCrazy and is now the "worst serial killer in New York City history," to quote a minor character.

to:

* In ''[[Comicbook/TheNewUniverse newuniversal]]'', which ''ComicBook/GoldDigger'', dragon hybrids between the tribes (Platinum, Gold, Copper, and Iron) are extremely rare and extremely powerful. Every single one has gone insane, however, with the sole exception being one of the comic's supporting cast, D'bra. And then, most dragons believe her temper is also by Creator/WarrenEllis, John Tensen gains telepathic a sign that it's only a matter of time.
* In ''ComicBook/{{Hellboy}}'', losing control of one's
powers and/or humanity was a major theme of the series, especially for Liz Sherman and Hellboy himself. That is to say: Liz burned her family to death by accident as a kid, and Hellboy doesn't and can't and won't use his flashier superpowers, since they mostly involve ending the world, but occasionally they get stolen, one way or another. His crown, his Name, his right hand, ALL THE BLOOD IN HIS BODY...
* A rather mundane case of this appears in ''[[ComicBook/{{Irredeemable}} Incorruptible]]''. Max Damage becomes [[SuperStrength stronger]] and [[NighInvulnerability more invulnerable]] the longer he stays awake. If he stays awake for say, a week, his powers reach PhysicalGod levels. However, he is still vulnerable to the effects of sleep deprivation. The result is someone who is mentally exhausted and strong enough to topple buildings -- an unnerving combination. Dealing with the numbness his invulnerability brings with it for years has also taken its toll on Max's sanity. Given
that the premise of the story is Max's attempt at a HeelFaceTurn to save the world from an [[BewareTheSuperman evil Superman]] {{Expy}}, this causes even more problems. He needs to be strong enough to fight the Plutonian yet not let his insanity push him "see" back toward a person's misdeeds or ignoble intentions. The first time he used these abilities, he discovered that his own nurse was planning to poison him. Tensen, not surprisingly, became AxCrazy life of evil.
* ''ComicBook/TheMask'' is this trope. Summary of every Mask story: Person finds the mask, puts it on, discovers they're a {{Nigh Invulnerab|ility}}le VoluntaryShapeshifting RealityWarper, starts using their powers in pursuit of some logical goal, loses sight of their goal
and engages in wanton violence ForTheEvulz, is now either tricked into removing the "worst serial killer in New York City history," to quote mask or removes it after a minor character.WhatHaveIBecome moment.



* SelfDemonstrating/{{Deadpool}} was probably messed up before developing terminal cancer, but the Weapon X program (which initially ''failed'' to give him a HealingFactor) gives him a hard shove in that direction. Then Dr. Killebrew experiments on and tortures him to the point of having visions of (and ''falling in love with'') [[TheGrimReaper Death]]. What finally demolishes his sanity is when Killebrew orders him killed, his healing factor finally kicks in, saving his life, making his disfigurement permanent, and causing Death to reject him. Depending on the writer, he's a mix of AxCrazy, DeadpanSnarker, gleeful GenreSavvy, and MediumAwareness.
* Creator/DCComics.
** The newest Kryptonite Man is a scientist who thinks Kryptonite ([[KryptoniteIsEverywhere there is now a lot of it on Earth]]) can be used as a safe energy source. When he himself becomes that energy source, he decides to show the world how effective it can be by... a murderous rampage. That never ends well. Later, in the same storyline, another scientist goes cuckoo bananas when he gains control over an oversized amoeba. Or so it seems. Superman subdues the guy, who says he didn't want to do it, but Intergang, a powerful criminal organization, made him.
** Retconned for Doctor Magnus, the leader of the ''Comicbook/MetalMen''. He needs a careful application of medicine in order to stay stable and good. He's kidnapped along with genuine mad scientists and they cancel his meds, intending for him to regress to his previous level of insane creativity, in which he created a horrific weapon of mass destruction, the Plutonium Man. Though he ''does'' recreate the Plutonium Man, he destabilizes ''very'' quickly, and with the help of several sentient robots he'd managed to cook up in his lab, invents a gun with ''living'' ammo and goes on a rampage (against evil men only), screaming about how he '''''really''''' needed his meds.
** The Psycho-Pirate, a villain with the emotion-changing Medusa Mask, actually had three of them, one for a single emotion, before deciding to combine all three to control all emotions. Unfortunately, continued use ended up driving him insane -- he's first seen in ''ComicBook/CrisisOnInfiniteEarths'' locked away in an insane asylum.
* Handled interestingly with [[Franchise/MarvelUniverse Marvel's]] [[Comicbook/TheSentry Sentry]]. His [[SuperpowerLottery powers]] are like some ridiculous combination of {{Franchise/Superman}} and [[ComicBook/FantasticFour Franklin Richards]], making him technically unstoppable and all-powerful. He's also a paranoid schizophrenic who managed to convince himself that there was an evil galactic power called The Void that would destroy the earth if he stayed a superhero... and then ''actually created it out of thin air'', making a problem for ComicBook/TheAvengers to handle while ComicBook/EmmaFrost gave him some emergency psychotherapy. During this time, he also managed to {{Retcon}} himself out of his own universe, so that his [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] exploits all became some comic writer's fantasy. In something of a subversion, Sentry's not a villain: in current canon, he works to use his powers for a great deal of good. Unfortunately, his psychosis still isn't fully under control, and it's a disability that is sometimes just impossible to work around.
** Later developments suggest that the Sentry is an inversion of this trope. Robert Reynolds was ''already'' a mentally unstable drug addict ''before'' taking the serum that gave him his powers, so it's more like someone with great insanity given great power. Furthermore, [[spoiler:Reynolds didn't become the Sentry and create the Void, it was the other way around..]].
*** [[spoiler:An alternate interpretation is that Reynolds splits into the Sentry and the Void, neither of which are more physically or psychologically real than the other.]]
*** As of ''Uncanny Avengers'', he's back as the Horseman of Death (the Void apparently got bored and wandered off) and is even crazier than ever.
* Mento wasn't the most stable/mentally healthy guy to begin with. Then he starts tinkering with a helmet that cranks his PsychicPowers UpToEleven and takes up superheroing. But his wife ([[Comicbook/DoomPatrol and her team]]) die, and it REALLY sent him downhill [[FaceHeelTurn until he's doing stints as a supervillain]] and trying to kill his own adopted son! When that heroing team was led by a fellow {{retcon}}ned into a MadScientist and MagnificentBastard, it was damn near inevitable.
* ''ComicBook/TheMask'' is this trope. Summary of every Mask story: Person finds the mask, puts it on, discovers they're a {{Nigh Invulnerab|ility}}le VoluntaryShapeshifting RealityWarper, starts using their powers in pursuit of some logical goal, loses sight of their goal and engages in wanton violence ForTheEvulz, is either tricked into removing the mask or removes it after a WhatHaveIBecome moment.
* ''Comicbook/IncredibleHulk''. The gamma bomb gave Bruce Banner huge power and exacerbated his multiple personality syndrome. Plus, the madder he gets, the stronger he becomes.
** Interestingly, for both ''The Mask'' and Marvel's gamma ray mutants, what happens to the subject's mind depends on what part of their personality they had dissociated themselves from. Most people who get the Mask unlock their evil side, but the fellow in TheMovie didn't ''have'' an evil side, only a chaotic side, so he essentially became a WesternAnimation/LooneyTunes character. Marvel goes into more detail -- Banner suppressed the rage that came from being abused as a child, Comicbook/SheHulk suppressed [[MsFanservice her sexuality]], Doc Samson suppressed his desire to be a hero, and the Abomination suppressed his self-hatred.
* Interesting case with Comicbook/BlackAdam from DC. His powers don't drive him crazy (he went crazy on his own, [[FaceHeelRevolvingDoor and sometimes comes back from that insanity]]...[[AntiHero partially]]), but he can share them, and anyone who would take them on immediately turns evil. ''Anyone'', including [[spoiler:the goddess of love]].
* When the Canadian government was looking for people to join Comicbook/AlphaFlight, they initially had trouble finding recruits. The people in charge of the program decided to try creating their own superbeings, and they got the bright idea to experiment on a SerialKiller who got a pardon in exchange for agreeing to participate. The result was a crazed monster with deadly psychic abilities calling itself Bedlam. {{Wolverine}} had initially signed on to join Alpha Flight, but this debacle was what caused him to leave the group in disgust.

to:

* SelfDemonstrating/{{Deadpool}} was probably messed up before developing terminal cancer, but ''ComicBook/{{WITCH}}'' has the Weapon X program (which initially ''failed'' to give him a HealingFactor) gives him a hard shove in Heart of Kandrakar, an artifact of immense power that direction. Then Dr. Killebrew experiments on and tortures him to may drive its Keeper mad just by being ''that'' powerful. While the point of having visions of (and ''falling in love with'') [[TheGrimReaper Death]]. What finally demolishes his sanity is when Killebrew orders him killed, his healing factor finally kicks in, saving his life, making his disfigurement permanent, and causing Death to reject him. Depending on the writer, he's a mix of AxCrazy, DeadpanSnarker, gleeful GenreSavvy, and MediumAwareness.
* Creator/DCComics.
** The newest Kryptonite Man
protagonist, Will, is a scientist who thinks Kryptonite ([[KryptoniteIsEverywhere there is now sane and well-adjusted person and her [[ClingyJealousGirl extreme jealousy]] has a lot of it on Earth]]) can be used as a safe energy source. When he himself becomes that energy source, he decides to show good FreudianExcuse, the world how effective it can be by... a murderous rampage. That never ends well. Later, in the same storyline, another scientist goes cuckoo bananas when he gains control over an oversized amoeba. Or so it seems. Superman subdues the guy, who says he didn't want to do it, but Intergang, a powerful criminal organization, made him.
** Retconned for Doctor Magnus, the leader
BigBad of the ''Comicbook/MetalMen''. He needs a careful application of medicine in order to stay stable and good. He's kidnapped along with genuine mad scientists and they cancel his meds, intending for him to regress to his second story arc was the previous level of insane creativity, in which he created a horrific weapon of mass destruction, Keeper and ''has'' been driven mad, and Will has the Plutonium Man. Though he ''does'' recreate the Plutonium Man, he destabilizes ''very'' quickly, and with the help occasional moment of several sentient robots he'd managed to cook up in his lab, invents a gun with ''living'' ammo and goes on a rampage (against evil men only), screaming about how he '''''really''''' needed his meds.
** The Psycho-Pirate, a villain with the emotion-changing Medusa Mask, actually had three of them, one for a single emotion, before deciding to combine all three to control all emotions. Unfortunately, continued use ended up driving him insane -- he's first seen in ''ComicBook/CrisisOnInfiniteEarths'' locked away in an insane asylum.
* Handled interestingly with [[Franchise/MarvelUniverse Marvel's]] [[Comicbook/TheSentry Sentry]]. His [[SuperpowerLottery powers]] are like some ridiculous combination of {{Franchise/Superman}} and [[ComicBook/FantasticFour Franklin Richards]], making him technically unstoppable and all-powerful. He's also a paranoid schizophrenic who managed to convince himself that there was an evil galactic power called The Void that would destroy the earth if he stayed a superhero... and then ''actually created it out of thin air'', making a problem for ComicBook/TheAvengers to handle while ComicBook/EmmaFrost gave him some emergency psychotherapy. During this time, he also managed to {{Retcon}} himself out of his own universe, so that his [[UsefulNotes/TheGoldenAgeOfComicBooks Golden Age]] exploits all became some comic writer's fantasy. In something of a subversion, Sentry's not a villain: in current canon, he works to use his powers for a great deal of good. Unfortunately, his psychosis still isn't fully under control, and it's a disability that is sometimes just impossible to work around.
** Later developments suggest that the Sentry is an inversion of this trope. Robert Reynolds was ''already'' a mentally unstable drug addict ''before'' taking the serum that gave him his powers, so it's more like someone with great insanity given great power. Furthermore, [[spoiler:Reynolds didn't become the Sentry and create the Void, it was the other way around..]].
*** [[spoiler:An alternate interpretation is that Reynolds splits into the Sentry and the Void, neither of which are more physically or psychologically real than the other.]]
*** As of ''Uncanny Avengers'', he's back as the Horseman of Death (the Void apparently got bored and wandered off) and is even crazier than ever.
* Mento wasn't the most stable/mentally healthy guy to begin with. Then he starts tinkering with a helmet that cranks his PsychicPowers UpToEleven and takes up superheroing. But his wife ([[Comicbook/DoomPatrol and her team]]) die, and it REALLY sent him downhill [[FaceHeelTurn until he's doing stints as a supervillain]] and trying to kill his own adopted son! When that heroing team was led by a fellow {{retcon}}ned into a MadScientist and MagnificentBastard, it was damn near inevitable.
* ''ComicBook/TheMask'' is this trope. Summary of every Mask story: Person finds the mask, puts it on, discovers they're a {{Nigh Invulnerab|ility}}le VoluntaryShapeshifting RealityWarper, starts using their powers in pursuit of some logical goal, loses sight of their goal and engages in wanton violence ForTheEvulz, is either tricked into removing the mask or removes it after a WhatHaveIBecome moment.
* ''Comicbook/IncredibleHulk''. The gamma bomb gave Bruce Banner huge power and exacerbated his multiple personality syndrome. Plus, the madder he gets, the stronger he becomes.
** Interestingly, for both ''The Mask'' and Marvel's gamma ray mutants, what happens to the subject's mind depends on what part of their personality they had dissociated themselves from. Most people who get the Mask unlock their evil side, but the fellow in TheMovie didn't ''have'' an evil side, only a chaotic side, so he essentially became a WesternAnimation/LooneyTunes character. Marvel goes into more detail -- Banner suppressed the rage that came from being abused as a child, Comicbook/SheHulk suppressed [[MsFanservice her sexuality]], Doc Samson suppressed his desire to be a hero, and the Abomination suppressed his self-hatred.
* Interesting case with Comicbook/BlackAdam from DC. His powers don't drive him crazy (he went crazy on his own, [[FaceHeelRevolvingDoor and sometimes comes back from that insanity]]...[[AntiHero partially]]), but he can share them, and anyone who would take them on immediately turns evil. ''Anyone'', including [[spoiler:the goddess of love]].
* When the Canadian government was looking for people to join Comicbook/AlphaFlight, they initially had trouble finding recruits. The people in charge of the program decided to try creating their own superbeings, and they got the bright idea to experiment on a SerialKiller who got a pardon in exchange for agreeing to participate. The result was a crazed monster with deadly psychic abilities calling itself Bedlam. {{Wolverine}} had initially signed on to join Alpha Flight, but this debacle was what caused him to leave the group in disgust.
slight (and useful) madness.



* Arguably [[InvertedTrope completely inverted]] in ''ComicBook/AllStarSuperman'': [[spoiler:Lex Luthor temporarily gains Superman's powers, and while he predictably rampages, he finds himself stopping to examine the amazing perspective his newfound powers and super-senses give him. He eventually concludes that having the level of power and insight that Superman does would make people care for their fellow human beings, and mellows out considerably after losing the powers]].
* Similarly inverted ([[ZigZaggingTrope or not]]) in ''Comicbook/TheAuthority'', where the Doctor gives up his powers to a [[LegacyCharacter previous]] Doctor, who was relieved of his duties for being a [[OmnicidalManiac psychotic maniac]]. As soon as the full extent of his powers kicked in, he was [[VillainousBSOD overwhelmed]] by the empathy for every living thing in existence. Super-empathy being part of the Doctor's role as the world's shaman, makes you wonder why this guy was psychotic [[FridgeLogic in the first place]].
** Every Doctor gets a new power, added to the ones the previous Doctor who had the job had all the way back to the first one. After he went psycho, the next guy got super empathy, which he used A LOT of heroin to deal with.
* Dr Manhattan in ''Comicbook/{{Watchmen}}'' is a subtler and relatively benign variation of the trope; it's implied that he was more at home dealing with elementary particles than other people even before the FreakLabAccident turned him into an [[WeAreAsMayflies immortal]] PhysicalGod who can see the future [[YouCantFightFate but not change any of it, even]] ''[[YouCantFightFate his own actions]]''. However, instead of suffering a spectacular HeroicBSOD and subsequent FaceHeelTurn, he's one of the least emotionally damaged people in the entire cast, whilst still being [[BlueAndOrangeMorality almost entirely disconnected from normal human thought patterns]].
* A rather mundane case of this appears in ''[[ComicBook/{{Irredeemable}} Incorruptible]]''. Max Damage becomes [[SuperStrength stronger]] and [[NighInvulnerability more invulnerable]] the longer he stays awake. If he stays awake for say, a week, his powers reach PhysicalGod levels. However, he is still vulnerable to the effects of sleep deprivation. The result is someone who is mentally exhausted and strong enough to topple buildings -- an unnerving combination. Dealing with the numbness his invulnerability brings with it for years has also taken its toll on Max's sanity. Given that the premise of the story is Max's attempt at a HeelFaceTurn to save the world from an [[BewareTheSuperman evil Superman]] {{Expy}}, this causes even more problems. He needs to be strong enough to fight the Plutonian yet not let his insanity push him back toward a life of evil.
* An interesting case concerning ComicBook/{{Azrael}}. When Jean-Paul Valley was born, he was implanted with a brainwashing trance of sorts known as The System, which would grant him amazing strength and agility when he donned the gear of Azrael, though it made him BrainwashedAndCrazy, pushing him to want to kill the guilty. When he first abandoned that role, he functioned pretty well... until the Scarecrow doused him with Fear Gas when JP [[ComicBook/{{Knightfall}} took up the Mantle of the Bat in Bruce Wayne's place]]. The entirety of the subsequent ''Knightquest'' storyline has Jean-Paul constantly fighting The System until he lets Abattoir die. When he does, he finally submits to The System and becomes a fearful mixture of Batman and Azrael and forces Bruce to take back the Mantle.
* [[Franchise/TheFlash Hunter Zolomon]] spent his life in a TraumaCongaLine, but he remained a good cop until Gorilla Grodd crippled him and the Flash, whom Hunter considered a friend, refused to use time travel to undo the damage. Hunter attempted to use the Flash's cosmic treadmill himself, but it blew up in his face. The resulting super powers had the side effect of scrambling his thought processes, until he decided that the best way to help his friend the Flash was to make him a better hero through tragedy as Zoom. Hunter still thinks he's helping the Flash, although he gets occasional flashes of MyGodWhatHaveIDone when Wally foils his plans.
* ''ComicBook/{{WITCH}}'' has the Heart of Kandrakar, an artifact of immense power that may drive its Keeper mad just by being ''that'' powerful. While the protagonist, Will, is a sane and well-adjusted person and her [[ClingyJealousGirl extreme jealousy]] has a good FreudianExcuse, the BigBad of the second story arc was the previous Keeper and ''has'' been driven mad, and Will has the occasional moment of slight (and useful) madness.
16th Feb '17 1:22:55 PM ILikeRobots
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** Lyon also TookALevelInBadass from creating the Dark Stone, and almost immediately went mad as a result. (Mad enough to think that destroying the [[RestrainingBolt Sacred Stones]] would be a good idea, at least.) In Eirika's route, he becomes completely possessed; in Ephraim's route, he manages to resist the Demon King's attempts to brute-force his mind and body, but he still clearly has almost every screw loose.
** Also Karel in ''[[VideoGame/FireEmblemElibe Fire Emblem: The Blazing Sword]]''. His madness drove him to constantly seek out and kill the strongest people he could find.
** This is why most of the dragons in ''VideoGame/FireEmblemAkaneia'' made the decision to take on human forms and seal away their true forms within dragonstones. Those who didn't eventually lost their minds and became feral beasts.

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** Lyon in ''The Sacred Stones'' also TookALevelInBadass from creating the Dark Stone, and almost immediately went mad as a result. (Mad enough to think that destroying the [[RestrainingBolt Sacred Stones]] would be a good idea, at least.) In Eirika's route, he becomes completely possessed; in Ephraim's route, he manages to resist the Demon King's attempts to brute-force his mind and body, but he still clearly has almost every screw loose.
** Also The swordsmaster Karel in ''[[VideoGame/FireEmblemElibe Fire Emblem: The Blazing Sword]]''.''Videogame/FireEmblemTheBlazingBlade''. His madness drove him to constantly seek out and kill the strongest people he could find.
** This is why most of the dragons [[OurDragonsAreDifferent dragons]] in ''VideoGame/FireEmblemAkaneia'' ''VideoGame/FireEmblemShadowDragonAndTheBladeOfLight'' and ''Videogame/FireEmblemMysteryOfTheEmblem'' made the decision to take on human forms and seal away their true forms within dragonstones. Those who didn't eventually lost their minds and became feral beasts.
6th Feb '17 9:45:24 AM JoeMerl
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*** The crown has been driving people insane since it was first created, apparently. [[spoiler: [[MadnessMantra Gunther, no! Gunther, no! Gunther, no! Gunther, no! Gunther, no! Gunther, no...!]]]]

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*** The crown has been driving people insane since it was first created, apparently. [[spoiler: [[MadnessMantra [[spoiler:[[MadnessMantra Gunther, no! Gunther, no! Gunther, no! Gunther, no! Gunther, no! Gunther, no...!]]]]


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** An early episode had Finn don a pair of [[SmartPeopleWearGlasses magical glasses]] that make him TheOmniscient. By the end of the episode he's done a science experiment that threats to kill them all, and is cackling cheerfully about the whole thing until [[EmperorScientist Princess Bubblegum]] snaps him out of it. [[spoiler:Amusingly, we then learn that the glasses let him ''know'' that he was going to go insane, so PB's help was part of his BatmanGambit]].
17th Jan '17 3:05:03 PM AnonFangeekGirl
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* In ''Roleplay/RubyQuest'', as the Cure [[LovecraftianSuperpower mutates]] its victims, they become progressively more powerful but also more unhinged.
7th Jan '17 5:45:13 PM Blazer
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** The Psycho-Pirate, a villain with the emotion-changing Medusa Mask, actually had three of them, one for a single emotion, before deciding to combine all three to control all emotions. Unfortunately, continued use ended up driving him insane -- he's first seen in ''ComicBook/CrisisOnInfiniteEarths'' locked away in an insane asylum.
4th Jan '17 9:42:16 PM AnonFangeekGirl
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* Jacen Solo in the ''Franchise/StarWars'' "Literature/LegacyOfTheForce" novels seems to get crazier and crazier the more he falls to the Dark Side of the Force. He first justifies his actions as necessary sacrifices for the good of the galaxy, but by the end of "Fury," [[spoiler:he uses the Force to break an underling's neck for failing him]]. They don't call it TheDarkSide for no reason. The same applies to Anakin/Vader and a host of other ExpandedUniverse characters.

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* [[Franchise/StarWars Sith philosophy]] encourages not controlling one's emotions, so this trope happens a lot. For specific examples:
**
Jacen Solo in the ''Franchise/StarWars'' "Literature/LegacyOfTheForce" novels seems to get crazier and crazier the more he falls to the Dark Side of the Force. He first justifies his actions as necessary sacrifices for the good of the galaxy, but by the end of "Fury," [[spoiler:he uses the Force to break an underling's neck for failing him]]. They don't call it TheDarkSide for no reason. The same applies to Anakin/Vader and a host of other ExpandedUniverse characters.
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http://tvtropes.org/pmwiki/article_history.php?article=Main.WithGreatPowerComesGreatInsanity